Getting rid of a mouse problem isn't complicated, but most people make it harder than it needs to be by using the wrong approach from the start.
I'm going to walk you through what actually works, what doesn't, and the specific thing most homeowners miss that's probably why their mouse problem keeps coming back. Start by finding where they're getting in. This is the part everyone skips. They buy traps, set them, catch one or two, and then a week later there are still three more. The issue isn't that you don't have enough traps. It's that the access point is still open and new mice are walking in every night. Mice can squeeze through an opening the size of a dime. That gap under your garage door? The crack around your dryer vent? The hole where the gas line enters the wall? Those are all highway on-ramps. Use a flashlight at night with the lights off and look for dark grease marks on baseboards. Mice run the same paths repeatedly and leave oily smears from their fur. Those marks point directly to entry points.
Once you've identified the entry, seal it with steel wool and caulk or expanding foam that contains steel fibers. Caulk alone fails because mice chew through it. Duct tape fails in two days. Silicone caulk over packed steel wool is about as good as it gets for a DIY seal.
Trapping: What Actually Works Versus What You See At The Store
Traditional snap traps work if you use them correctly. The cheap plastic ones you grab at the hardware store are fine. Set them along walls, perpendicular to the wall with the bait side facing the wall. Mice don't walk into open spaces. They move along edges. That's biology, not preference. Glue traps are available but I don't recommend them as a first solution. They cause prolonged suffering, which creates a sanitation problem if the mouse dies inside a wall cavity and goes undiscovered. A decomposing mouse in your wall can smell for three to four weeks and attract flies. Nobody wants that experience. Electronic traps kill quickly but they're expensive to buy and require batteries. They work well in low-infestation situations. For a serious problem with multiple mice, I'd stick with snap traps because you can set out ten of them for the price of one electronic unit and cover significantly more perimeter.
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Here's something most guides won't tell you: peanut butter is not actually the best bait. Cotton balls dipped in a small amount of peanut oil work better. Mice have an instinct to gather soft materials for nesting. They'll hang on the cotton ball longer, giving the trap more time to trigger. Peanut butter attracts them to lick it and sometimes steal it without setting off the mechanism. With the cotton ball approach, they have to tug and that triggers the snap every time.
Why Your First Round Of Trapping Failed And What To Do Next
If you set traps and caught nothing, you probably have a few issues going on. Bait shyness is real. Mice are naturally suspicious of new objects in their environment. If a trap just appeared overnight with food on it, some of them will avoid it entirely for several days while they assess whether it's a threat. Leave unset traps near their pathways for two days to let them get comfortable with the presence. Then bait and set them. Another common failure point: you're placing traps in the middle of the floor or in corners where mice aren't traveling. They run along baseboards and wall edges. Place traps five to six feet apart along those pathways. You want at least two traps near any entry point because a single trap only gives you one chance per night. I had a situation last winter where I'd sealed all visible entry points, set twelve snap traps, and caught exactly one mouse over nine days. The house was old, 1950s construction, and I'd missed something behind the kitchen cabinets. The workaround was to remove the kickplate along the bottom of the cabinets and find a gap between the subfloor and the bottom plate of the wall that was maybe half an inch wide. Steel wool and caulk fixed it. Caught three more mice the following night.
When You Should Call A Professional
If you've sealed entries, set traps properly for two weeks, and are still seeing daily activity, you likely have a larger colony than you realize. Mice reproduce fast. One pair can become a dozen in a single season. Professional pest control has access to bait stations and tracking compounds that let them map active pathways inside walls where you can't see. They also know which structural areas to inspect that a homeowner would never think to check. The downside of professional treatment is cost, usually between $200 and $500 depending on the severity and the company. The upside is that a proper exclusion job done right should keep mice out for years if you maintain the seals.

Poison: What Everyone Gets Wrong
Rodenticide baits exist but I genuinely don't recommend them for residential use. The primary reason is the death location problem. A mouse that ingests anticoagulant bait will feel sick and seek a dark sheltered place to die. That place is often inside your walls, behind your refrigerator, or under your floorboards. The odor from a single decomposing mouse is noticeable and can persist for weeks. There's also the secondary poisoning risk to pets and wildlife. Hawks, owls, and foxes will eat a poisoned mouse. Dogs and cats can be exposed if they find a dead rodent. Even if you're not worried about that, the neighbors' pets might be, and that's a liability conversation you don't want to have. If you absolutely must use bait, do it exclusively in tamper-resistant bait stations placed in areas completely inaccessible to children and pets. And check those stations every single day. Removing dead mice promptly prevents the smell issue even though the remaining body in the wall might not be noticeable for a while.
Prevention Going Forward
After you've eliminated the current problem, the goal is to make your property unattractive and inaccessible. Keep firewood and debris piles at least twenty feet from the house. Trim tree branches that overhang the roof. Seal any new cracks that appear with the same steel wool and caulk method. Install door sweeps on exterior doors and make sure your dryer and exhaust vents have properly fitted mouse-proof covers. Interior prevention is simpler than most people expect. Store all dry goods, including pet food, in glass or heavy plastic containers with tight lids. Cardboard boxes are nesting material and food storage in one package for a mouse. Clean up crumbs and spills promptly. Install fine mesh screens over any ventilation openings larger than a quarter inch. The bottom line is that getting rid of a mouse permanently requires treating the symptoms and the cause at the same time. Traps remove the current population. Sealing entry points prevents reinvasion. Skip the poison unless you have no other option, and if the problem is beyond a couple of mice, call someone in who deals with this regularly. Doing it yourself multiple times and still having a problem just wastes your time and extends the infestation.