The actual chords and structure people always mess up
The chord progression for this one is actually pretty standard once you strip away the production. E minor to C major to G to D. That's it. Four chords. Loop it and you're 90% there. The trick isn't the harmony, it's the timing on the verse melody. Bono drags the vocal slightly behind the beat on most of the lines, which throws people off when they try to play along. If you lock your strumming strictly to the grid, it's going to sound stiff and wrong. I've seen a lot of guitar tutorials online that just slap this into a simple fingerpicking pattern, but it doesn't really work if you're trying to match the feel. The original has this rolling arpeggio underneath that's more syncopated than people realize. Play it straight downstrokes and it sounds like a completely different song. I spent about three weeks trying to nail the guitar part in my garage band days and finally gave up on copying it exactly and just learned to play around it instead.
With Or Without You Lyrics for reference
With or without you / With or without you / Oh, the night comes / Will the sun rise / With or without you / With or without you That's basically the whole lyrical structure. The verses build tension and then release into the chorus, which is just that repeating title phrase. No hidden verses, no second pre-chorus. A lot of cover bands add unnecessary material because they think the song needs more, but the minimalism is what makes it work. The lyrics themselves are pretty straightforward — it's about wanting something or someone but not being able to have them. Common theme, handled better here than in most other pop songs.
Where most people go wrong
The biggest issue I see is tempo. The original sits somewhere around 115 to 120 beats per minute, but when beginners pick it up they usually rush it. It's got this slow-burn quality that gets lost if you play it too fast. Start at 90 BPM and work your way up. The song rewards patience more than speed. Another thing: the E minor to C major movement. Most people voice those chords open position, which sounds fine but loses the darkness the original has. Try lifting the bass note on the E minor up to the tenth fret instead of playing it open. The G rings differently and it sits closer to the original's tonal palette. There's also the issue of the bridge section. A lot of guitarists skip it or just repeat the main progression. The bridge actually shifts to the relative major — G major — and stays there for two bars before cycling back. If you don't hit that key center change, the tension never resolves properly and the song just flattens out. I lost a gig once because I messed this up. The drummer was clearly waiting for the change, I just kept going through the same four chords. Awkward stuff.
Get the Full Details

The bassline on the original is pretty distinctive too. It's not just following the root notes. On the verse it does this descending pattern that moves from E down through C and G, hitting the fifth of each chord rather than the root. Learn it separately before you try to play it with the guitar, otherwise it just turns into muddled noise. If you want tab or chord charts, there's a bunch of places to grab them online, but most of them aren't great. The ones on Ultimate Guitar are usually decent but often have mistakes in the chord voicings. I'd recommend cross-referencing with the actual recording rather than trusting any single source. The song has been covered so many times that some arrangements drift further from the original with each new version. Stick to the Achtung Baby era version if you want accuracy.