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| chelation therapy for thalassemia: Iron Chelation Therapy Chaim Hershko, 2002 Within the last few years, iron research has yielded exciting new insights into the understanding of normal iron homeostasis. Such development, and the evolution of improved strategies of Iron Chelating Therapy require better understanding of the pathophysiology of iron toxicity and the mechanism of action of iron chelating drugs. The timeliness of the present volume is underlined by several significant developments in recent years. New insights have been gained into the molecular basis of aberrant iron handling in hereditary disorders and the pathophysiology of iron overload. This volume highlights the impact of long term Iron Celating Therapy using deferoxamine or the new, but controversial oral iron chelator deferiprone based on experience gained by multicenter trails, with special emphasis on survival, morbidity and drug toxicity; it reviews the development of the new and improved orally effective chelators suitable for clinical use in the near future and examines novel strategies of iron chelating treatment for the control of cell proliferation in malignant disease or malaria. |
| chelation therapy for thalassemia: Essential Metals in Medicine: Therapeutic Use and Toxicity of Metal Ions in the Clinic Peggy L. Carver, 2019-01-14 Volume 19, entitled Essential Metals in Medicine: Therapeutic Use and Toxicity of Metal Ions in the Clinic of the series Metal Ions in Life Sciences centers on the role of metal ions in clinical medicine. Metal ions are tightly regulated in human health: while essential to life, they can be toxic as well. Following an introductory chapter briefly discussing several important metal-related drugs and diseases and a chapter about drug development, the focus is fi rst on iron: its essentiality for pathogens and humans as well as its toxicity. Chelation therapy is addressed in the context of thalassemia, its relationship to neurodegenerative diseases and also the risks connected with iron administration are pointed out. A subject of intense debate is the essentiality of chromium and vanadium. For example, chromium(III) compounds are taken as a nutritional supplement by athletes and bodybuilders; in contrast, chromate, Cr(VI), is toxic and a carcinogen for humans. The benefi cial and toxic effects of manganese, cobalt, and copper on humans are discussed. The need for antiparasitic agents is emphasized as well as the clinical aspects of metal-containing antidotes for cyanide poisoning. In addition to the essential and possibly essential ones, also other metal ions play important roles in human health, causing harm (like the metalloid arsenic, lead or cadmium) or being used in diagnosis or treatment of human diseases, like gadolinium, gallium, lithium, gold, silver or platinum. The impact of this vibrant research area on metals in the clinic is provided in 14 stimulating chapters, written by internationally recognized experts from the Americas, Europe and China, and is manifested by approximately 2000 references, and about 90 illustrations and tables. Essential Metals in Medicine: Therapeutic Use and Toxicity of Metal Ions in the Clinic is an essential resource for scientists working in the wide range from pharmacology, enzymology, material sciences, analytical, organic, and inorganic biochemistry all the way through to medicine ... not forgetting that it also provides excellent information for teaching. |
| chelation therapy for thalassemia: Chelation Therapy in the Treatment of Metal Intoxication Jan Aaseth, Guido Crisponi, Ole Anderson, 2016-04-18 Chelation Therapy in the Treatment of Metal Intoxication presents a practical guide to the use of chelation therapy, from its basic chemistry, to available chelating antidotes, and the application of chelating agents. Several metals have long been known to be toxic to humans, and continue to pose great difficulty to treat. These challenges pose particular problems in industrial settings, with lead smelting known to be associated with hemopoietic alterations and paralyses, and the inhalation of mercury vapor in mercury mining being extremely detrimental to the central nervous system. Clinical experience has demonstrated that acute and chronic human intoxications with a range of metals can be treated efficiently by administration of chelating agents. Chelation Therapy in the Treatment of Metal Intoxication describes the chemical and biological principles of chelation in the treatment of these toxic metal compounds, including new chelators such as meso-2,3-dimercaptosuccinic acid (DMSA) and D,L-2,3-dimercapto-1-propanesulfonic acid (DMPS). - Presents all the current findings on the potential for chelation as a therapy for metal intoxication - Presents practical guidelines for selecting the most appropriate chelating agent - Includes coverage on radionuclide exposure and metal storage diseases - Describes the chemical and biological principles of chelation in the treatment of toxic metal compounds |
| chelation therapy for thalassemia: Liver Pathology Linda D. Ferrell, MD, Sanjay Kakar, MD, 2011-03-28 This unique book provides detailed insight into a wealth of expert experience in liver pathology, with an in-depth review of the expertÌs analysis and diagnostic process supported by high-quality color photomicrographs and discussion of the diagnostic principles involved in evaluating these lesions. The diagnostic problems and cases selected show the wide range of specimens seen in liver pathology and address the difficult issues in diagnosis encountered in these lesions. Chapters and cases are authored by many of the leading experts and educators in liver pathology today. Liver Pathology will be essential reading for every pathologist who evaluates liver pathology specimens. In addition it will be a valuable resource for pathology residents and fellows. All Consultant Pathology Titles Provide: Actual consultation cases and expert analysis Expert analysis provides a detailed discussion of the reasoning behind the diagnosis of each case Comprehensive coverage of challenging diagnoses The cases are richly illustrated with high-quality photomicrographs |
| chelation therapy for thalassemia: Cardiovascular Magnetic Resonance Warren J. Manning, Dudley J. Pennell, 2018-04-26 - Provides state-of-the-art coverage of CMR technologies and guidelines, including basic principles, imaging techniques, ischemic heart disease, right ventricular and congenital heart disease, vascular and pericardium conditions, and functional cardiovascular disease. - Includes new chapters on non-cardiac pathology, pacemaker safety, economics of CMR, and guidelines as well as new coverage of myocarditis and its diagnosis and assessment of prognosis by cardiovascular magnetic resonance, and the use of PET/CMR imaging of the heart, especially in sarcoidosis. - Features more than 1,100 high-quality images representing today's CMR imaging. - Covers T1, T2 and ECV mapping, as well as T2* imaging in iron overload, which has been shown to save lives in patients with thalassaemia major - Discusses the cost-effectiveness of CMR. - Provides state-of-the-art coverage of CMR technologies and guidelines, including basic principles, imaging techniques, ischemic heart disease, right ventricular and congenital heart disease, vascular and pericardium conditions, and functional cardiovascular disease. - Includes new chapters on non-cardiac pathology, pacemaker safety, economics of CMR, and guidelines as well as new coverage of myocarditis and its diagnosis and assessment of prognosis by cardiovascular magnetic resonance, and the use of PET/CMR imaging of the heart, especially in sarcoidosis. - Features more than 1,100 high-quality images representing today's CMR imaging. - Covers T1, T2 and ECV mapping, as well as T2* imaging in iron overload, which has been shown to save lives in patients with thalassaemia major. - Discusses the cost-effectiveness of CMR. - Expert ConsultTM eBook version included with purchase. This enhanced eBook experience allows you to search all of the text, figures, and references from the book on a variety of devices. |
| chelation therapy for thalassemia: Thalassemia and Other Hemolytic Anemias Isam Jaber Al-Zwaini, 2018-07-11 Thalassemia is a very common disease first described by pediatrician Thomas Benton Cooley in 1925 who described it in a patient of Italian origin. At that time, it was designated as Cooley's anemia. George Hoyt Whipple, a Nobel prize winner, and W. L. Bradford, a professor of pediatrics at the University of Rochester, coined the term thalassemia in 1936, which in Greek means anemia of the sea (Thalassa means sea, and emia means blood), due to the fact that it is very common in the area of the Mediterranean Sea. This name is actually misleading because it can occur everywhere in the world. Thalassemia is not a single disease; it is rather a group of hereditary disorders of the production of globulin chain of the hemoglobin. Throughout the world, thalassemia affects approximately 4.4 of every 10,000 live births. It represents a major social and emotional impact on the patient and his family and a major burden on health services where the prevalence is high. |
| chelation therapy for thalassemia: Hepatotoxicity Hyman J. Zimmerman, 1999 Written by the foremost authority in the field, this volume is a comprehensive review of the multifaceted phenomenon of hepatotoxicity. Dr. Zimmerman examines the interface between chemicals and the liver; the latest research in experimental hepatotoxicology; the hepatotoxic risks of household, industrial, and environmental chemicals; and the adverse effects of drugs on the liver. This thoroughly revised, updated Second Edition features a greatly expanded section on the wide variety of drugs that can cause liver injury. For quick reference, an appendix lists these medications and their associated hepatic injuries. Also included are in-depth discussions of drug metabolism and factors affecting susceptibility to liver injury. |
| chelation therapy for thalassemia: Clinical Manual of Blood and Bone Marrow Transplantation Syed A. Abutalib, Parameswaran Hari, 2017-04-19 Providing the practicing and trainee hematologist with a practical and immediately applicable compendium of answers the Clinical Manual of Blood and Bone Marrow Transplantation covers the spectrum of the hematopoietic cell transplant specialty, in particular practical issues in transplant patient care, and the set up and functioning of a transplant program. Supplies the practicing and trainee hematologist with a practical and immediately applicable compendium of answers to clinical questions Covers the spectrum of the hematopoietic cell transplant specialty, in particular practical issues in transplant patient care, and the set up and functioning of a transplant program Contains concise chapters written with a focus on tables, algorithms and figures to aid rapid referral Benefits from expert contributions from an international authorship |
| chelation therapy for thalassemia: The Thalassemias D. J. Weatherall, 1983 |
| chelation therapy for thalassemia: Emergency Management of Thalassaemia John Porter (Hematologist), Ali Taher, Afif Mufarrij, Manolis Gavalas, 2012 The multi-organ pathology of the thalassaemias means that the most successful patient treatment programmes involve a number of medical staff, led by paediatricians and haematologists, but including other specialists in a multidisciplinary approach. However, this means that medical professionals not involved in such multidisciplinary groups, including primary care physicians and the staff of Accident and Emergency departments, rarely treat patients with thalassaemia. As a result, their knowledge of how to address acute complications in such patients is extremely limited. This handbook aims to provide a brief evaluation of the situations in which a thalassaemia patient may seek help beyond the specialized environment he/she is used to. The layout of the handbook is intended to enable the medical professional in a busy clinical setting to draw essential information at a glance, supporting rapid, accurate as possible, decisions on how to proceed. |
| chelation therapy for thalassemia: The Obstetric Hematology Manual Sue Pavord, Beverley Hunt, 2018-02-08 Understand the rapidly growing complexities of obstetric hematology and high-risk pregnancy management, with experts in the field. Now in its second edition, this comprehensive and essential guide focuses on providing the best support for patients and clinical staff, to prevent serious complications in pregnancy and the post-partum period for both mother and baby. Wide-ranging and detailed, the guide offers discussions on basic principles of best care, through to tackling lesser-known hematological conditions, such as cytopenias and hemoglobinopathies. Updated with color illustrations, cutting-edge research, accurate blood film reproductions, and practical case studies, the revised edition places invaluable advice into everyday context. This unique resource is essential reading for trainees and practitioners in obstetrics, anesthesia, and hematology, as well as midwives, nurses, and laboratory staff. Clarifying difficult procedures for disease prevention, the guide ensures safety when the stakes are high. Reflecting current evidence-based guidelines, the updated volume is key to improving pregnancy outcomes worldwide. |
| chelation therapy for thalassemia: Pediatric Hematology Robert Wynn, Rukhmi Bhat, Paul Monagle, 2017-02-16 A succinct summary of the key principles and facts that guide the everyday practice of modern, clinical paediatric hematology. Covering all the information necessary for examinations in the topic, this book is ideal for postgraduates studying paediatric hematology, as well as for junior doctors in training. |
| chelation therapy for thalassemia: Inherited Hemoglobin Disorders Anjana Munshi, 2015-11-11 The book, Inherited Hemoglobin Disorders, describes the genetic defects of hemoglobins, disease complications, and therapeutic strategies. This book has two distinct sections. The first theme includes seven chapters devoted to the types of hemoglobinopathies, mutation spectrum, diagnostic methods, and disease complications, and the second theme includes three chapters focusing on various treatment strategies. The content of the chapters presented in the book is guided by the knowledge and experience of the contributing authors. This book serves as an important resource and review to the researchers in the field of hemoglobinopathies. |
| chelation therapy for thalassemia: Metal Related Neurodegenerative Disease , 2013-11-07 This issue reviews the role of metals in neurodegenerative diseases; including Parkinson's and Huntington's disease; restless leg syndrome and NBIA disorders; and Wilson's disease and manganese and calcium accumulation disorders. An update on advances in neuroimaging and pathology of metal related disease is also presented. - This volume of International Review of Neurobiology brings together cutting-edge research on metal related neurodegenerative disease - It reviews the role of metals in neurodegenerative diseases, including Parkinson's and Huntington's disease; restless leg syndrome and NBIA disorders; and Wilson's disease and manganese and calcium accumulation disorders - An update on advances in neuroimaging and pathology of metal related disease is also presented |
| chelation therapy for thalassemia: Textbook of Clinical Pediatrics H. A. Harfi, H. Nazer, William Oh, F. B. Stapleton, R. J. Whitley, 2012-01-10 The new edition of this classic reference offers a problem-based approach to pediatric diseases. It encompasses almost all pediatric subspecialties and covers every pediatric disease and organ system. It includes case studies and over 750 lavish illustrations. |
| chelation therapy for thalassemia: Experimental Protocols for Reactive Oxygen and Nitrogen Species Naoyuki Taniguchi, John M. C. Gutteridge, 2023 This cook book of experiments for the biochemistry, molecular and cellular biology and clinical aspects of free radical research is for any laboratory researcher who works on free radicals and their physiological effect. |
| chelation therapy for thalassemia: Spirulina in Human Nutrition and Health M. E. Gershwin, Amha Belay, 2007-10-08 Astonishingly rich in nutrients, Spirulina is one of the most popular and well researched functional foods in the multi-billion dollar global food supplement market. This ancient species provides readily bioavailable protein along with carotenoids, essential fatty acids, vitamins, and minerals and has therapeutic applications in non-communicable di |
| chelation therapy for thalassemia: Williams Hematology, 9E Kenneth Kaushansky, Marshall A. Lichtman, Josef Prchal, Marcel M. Levi, Oliver W. Press, Linda J. Burns, Michael Caligiuri, 2015-12-23 Publisher's Note: Products purchased from Third Party sellers are not guaranteed by the publisher for quality, authenticity, or access to any online entitlements included with the product. The world's most highly regarded reference text on the mechanisms and clinical management of blood diseases A Doody's Core Title for 2020! Edition after edition, Williams Hematology has guided generations of clinicians, biomedical researchers, and trainees in many disciplines through the origins, pathophysiological mechanisms, and management of benign and malignant disorders of blood cells and coagulation proteins. It is acknowledged worldwide as the leading hematology resource, with editors who are internationally regarded for their research and clinical achievements and authors who are luminaries in their fields. The Ninth Edition of Williams Hematology is extensively revised to reflect the latest advancements in basic science, translational pathophysiology, and clinical practice. In addition to completely new chapters, it features a full-color presentation that includes 700 photographs, 300 of which are new to this edition, and 475 illustrations. Recognizing that blood and marrow cell morphology is at the heart of diagnostic hematology, informative color images of the relevant disease topics are conveniently integrated into each chapter, allowing easy access to illustrations of cell morphology important to diagnosis. Comprehensive in its depth and breath, this go-to textbook begins with the evaluation of the patient and progresses to the molecular and cellular underpinnings of normal and pathological hematology. Subsequent sections present disorders of the erythrocyte, granulocytes and monocytes, lymphocytes and plasma cells, malignant myeloid and lymphoid diseases, hemostasis and thrombosis, and transfusion medicine. |
| chelation therapy for thalassemia: Newborn Screening for Sickle Cell Disease and other Haemoglobinopathies Stephan Lobitz, Jacques Elion, Raffaella Colombatti, Elena Cela, 2019-10-07 Newborn Screening for Sickle Cell Disease and other Haemoglobinopathies is a Special Issue of the International Journal of Neonatal Screening. Sickle cell disease is one of the most common inherited blood disorders, with a huge impact on health care systems due to high morbidity and high mortality associated with the undiagnosed disease. Newborn screening helps to make the diagnosis early and to prevent fatal complications and diagnostic odysseys. This book gives an overview of diagnostic standards in newborn screening for sickle cell disease and examples of existing newborn screening programs. |
| chelation therapy for thalassemia: Haploidentical Transplantation Stefan O. Ciurea, Rupert Handgretinger, 2018-05-03 In this book, world-renowned experts in the field express well-reasoned opinions on a range of issues and controversies relating to haploidentical transplantation with the aim of providing practicing hematologists with clinically relevant and readily applicable information. Among the areas covered are graft manipulation and methods to control T-cell alloreactivity, the nature of the ideal graft and donor, haploidentical transplantation in pediatric and adult patients with malignant and nonmalignant diseases, immunologic reconstitution following transplantation, complications, and the prevention and treatment of relapse post transplantation. Attention is drawn to the implications of high-impact clinical trials whenever such trials are available. The readily intelligible text is complemented by numerous helpful tables, algorithms, and figures. The book will provide practical support for hematologists and transplant physicians as they attempt to provide optimal care in this exciting but increasingly complex medical specialty. |
| chelation therapy for thalassemia: Hematopoietic Stem Cell Transplantation in Clinical Practice Jennifer G. Treleaven, A. John Barrett, 2008-09-02 A guide to the practice of stem cell transplantation, its status in the treatment of various disorders and the problems that arise after transplantation, aimed at the whole transplant team. - An up to date guide to best practice in the use of stem cell transplantation, covering current status in the treatment of malignant and non-malignant conditions, practical aspects and problems such as infection and graft versus host disease. - Has a practical, accessible approach with free use of algorithms, list tables. - Aimed at the whole transplant team - this is an interdisciplinary field. - International contributor team with editors in the UK and USA. - Illustrated in colour throughout. |
| chelation therapy for thalassemia: Principles and Practice of Movement Disorders E-Book Joseph Jankovic, Mark Hallett, Stanley Fahn, 2011-08-09 Principles and Practice of Movement Disorders provides the complete, expert guidance you need to diagnose and manage these challenging conditions. Drs. Stanley Fahn, Joseph Jankovic and Mark Hallett explore all facets of these disorders, including the latest rating scales for clinical research, neurochemistry, clinical pharmacology, genetics, clinical trials, and experimental therapeutics. This edition features many new full-color images, additional coverage of pediatric disorders, updated Parkinson information, and many other valuable updates. An accompanying Expert Consult website makes the content fully searchable and contains several hundred video clips that illustrate the manifestations of all the movement disorders in the book along with their differential diagnoses. Get just the information you need for a clinical approach to diagnosis and management, with minimal emphasis on basic science. Find the answers you need quickly and easily thanks to a reader-friendly full-color format, with plentiful diagrams, photographs, and tables. Apply the latest advances to diagnosis and treatment of pediatric movement disorders, Parkinson disease, and much more. View the characteristic presentation of each disorder with a complete collection of professional-quality, narrated videos online. Better visualize every concept with new full-color illustrations throughout. Search the complete text online, follow links to PubMed abstracts, and download all of the illustrations, at www.expertconsult.com. |
| chelation therapy for thalassemia: Encyclopedia of Metalloproteins Robert H. Kretsinger, Vladimir N. Uversky, Eugene A. Permyakov, 2013-05-01 In biochemistry, a metalloprotein is a generic term for a protein that contains a metal cofactor. The metal may be an isolated ion or may be coordinated with a nonprotein organic compound, such as the porphyrin found in hemoproteins. In some cases, the metal is co-coordinated with a side chain of the protein and an inorganic nonmetallic ion. This kind of protein-metal-nonmetal structure is seen in iron-sulfur clusters Metalloproteins deals with all aspects related to the intracellular and extracellular metal-binding proteins, including their structures, properties and functions. The biological roles of metal cations and metal-binding proteins are endless. They are involved in all crucial cellular activities. Many pathological conditions are related to the problematic metal metabolism. Research in metalloprotein-related topics is therefore rapidly growing, and different aspects of metal-binding proteins progressively enter curricula at Universities and even at the High School level on occasion. However, no key resource providing basic, but comprehensible knowledge on this rapidly expanding field exists. The Encyclopedia of Metalloproteins aims to bridge this gap, and will attempt to cover various aspects of metalloprotein/metalloproteomics and will deal with the different issues related to the intracellular and extracellular metal-binding proteins, including their structures, properties and functions. The goal is to cover exhaustively all catalytically and biologically crucial metal ions and to find at least one interacting protein for other metal ions. The Encyclopedia of Metalloproteins will provide a key resource for advanced undergraduate and graduate students, researchers, instructors, and professors interested in protein science, biochemistry, cell biology, and genetics. |
| chelation therapy for thalassemia: Red Cell Metabolism Ernest Beutler, 1975 |
| chelation therapy for thalassemia: Internal Medicine Jarrah Ali Al-Tubaikh, 2016-11-14 This very well-received book, now in its second edition, equips the radiologist with the information needed in order to diagnose internal medicine disorders and their complications from the radiological perspective. It offers an easy-to-consult tool that documents the most common and most important radiological signs of a wide range of diseases, across diverse specialties, with the aid of an excellent gallery of images and illustrations. Compared with the first edition, numerous additions and updates have been made, with coverage of additional disorders and inclusion of many new images. Entirely new chapters focus on occupational medicine and toxicology imaging, chiropractic medicine, and energy and quantum medicine. Internal Medicine – An Illustrated Radiological Guide puts the radiologist in the internal medicine physician’s shoes. It teaches radiologists how to think in terms of disease progression and complications, explains where to look for and to image these complications, and identifies the best modalities for reaching a diagnosis. It will also benefit internal medicine physicians by clarifying the help that radiology can offer them and assisting in the choice of investigation for diagnostic confirmation. |
| chelation therapy for thalassemia: Advanced Models of Cognition for Medical Training and Practice David A. Evans, Vimla L. Patel, 1992-11-10 Cognitive science is a multidisciplinary science concerned with understanding and utilizing models of cognition. It has spawned a great dealof research on applications such as expert systems and intelligent tutoring systems, and has interacted closely with psychological research. However, it is generally accepted that it is difficult to apply cognitive-scientific models to medical training and practice. This book is based on a NATO Advanced Research Workshop held in Italy in 1991, the purpose of which was to examine the impact ofmodels of cognition on medical training and practice and to outline future research programmes relating cognition and education, and in particular to consider the potential impact of cognitive science on medical training and practice. A major discovery presented in the book is that the research areas related to artificial intelligence, cognitive psychology, and medical decision making are considerably closer, both conceptually and theoretically, than many of the workshop participants originally thought. |
| chelation therapy for thalassemia: The Clinical Approach to Thalassaemia Bernadette Modell, Vasili Berdoukas, 1984 |
| chelation therapy for thalassemia: Iron Chelation Therapy Chaim Hershko, 2012-12-06 Within the last few years, iron research has yielded exciting new insights into the under standing of normal iron homeostasis. However, normal iron physiology offers little protec tion from the toxic effects of pathological iron accumulation, because nature did not equip us with effective mechanisms of iron excretion. Excess iron may be effectively removed by phlebotomy in hereditary hemochromatosis, but this method cannot be applied to chronic anemias associated with iron overload. In these diseases, iron chelating therapy is the only method available for preventing early death caused mainly by myocardial and hepatic iron toxicity. Iron chelating therapy has changed the quality of life and life expectancy of thalassemic patients. However, the high cost and rigorous requirements of deferoxamine therapy, and the significant toxicity of deferiprone underline the need for the continued development of new and improved orally effective iron chelators. Such development, and the evolution of improved strategies of iron chelating therapy require better understanding of the pathophysiology of iron toxicity and the mechanism of action of iron chelating drugs. The timeliness of the present volume is underlined by several significant develop ments in recent years. New insights have been gained into the molecular basis of aberrant iron handling in hereditary disorders and the pathophysiology of iron overload (Chapters 1-5). |
| chelation therapy for thalassemia: Quality of Life Assessment in Clinical Trials Maurice J. Staquet, Ron D. Hays, Peter M. Fayers, 1998 Researchers in all clinical fields are becoming increasingly aware of the importance of quality of life measurements in judging the efficacy of a given treatment, and it is becoming more common for psychological criteria to play an important role in the evaluation of therapies. In the past ten years a number of methods have been developed for carrying out such assessments. Quality of life research does however use special statistical methods which might well be unfamiliar to the clinician. Quality of life assessment in clinical trials: methods and practice explores these methods in a non-mathematical manner, comparing and contrasting the tools available to the clinician, and highlighting any potential pitfalls. It describes the methods used to collect and analyse quality of life data. The book will have widespread appeal to clinical trialists and researchers from a wide range of specialties. |
| chelation therapy for thalassemia: Metal-based Anticancer Agents Angela Casini, Anne Vessières, Samuel M Meier-Menches, 2019-04-05 Metal-based anticancer drugs are among the most successful therapeutic agents, as evidenced by the frequent prescription of selected platinum and arsenic compounds to patients. Metal-based Anticancer Agents covers the interdisciplinary world of inorganic drug discovery and development by introducing the most prominent compound classes based on different transition metals, discussing emerging concepts and enabling methods, as well as presenting key pre-clinical and clinical aspects. Recent progress on the unique features of next-generation targeted metal-based anticancer agents, including supramolecular coordination complexes used for both therapy and drug delivery, promise a bright future beyond the benefits of pure cytotoxic activity. With contributions from global leaders in the field, this book will serve as a useful reference to established researchers as well as a practical guide to those new to metallodrugs, and postgraduate students of medicinal chemistry and metallobiology. |
| chelation therapy for thalassemia: Textbook of Pediatric Hematology & Hemato-Oncology MR Lokeshwar, 2015-08-31 Textbook of Pediatric Hematology & Hemato-Oncology is a highly illustrated, comprehensive guide to diseases and cancers of the blood in paediatrics. Fifty chapters by internationally recognised paediatric haematologists and haemato-oncologists are grouped into seven sections, covering physiology, neonatal haematology, red blood cell and white blood cell disorders, bleeding disorders, transfusion medicine, haemato-oncology and other general topics. The haemato-oncology section covers cancers of the blood and includes lymphoblastic leukaemia, myeloid leukaemia (chronic and acute), juvenile myelomonocytic leukaemia, and bone marrow transplantation. The final ‘general’ section features discussion on gene therapy, monoclonal antibodies and biological response modifiers. Each chapter is peer-reviewed, with a list of references ensuring authoritative content, and the book is further enhanced by nearly 200 images and illustrations. Textbook of Pediatric Hematology & Hemato-Oncology is an indispensable resource for paediatricians, practitioners and trainees. Key Points Comprehensive guide to paediatric diseases and cancers of the blood 50 peer reviewed chapters with references 198 images and illustrations |
| chelation therapy for thalassemia: Iron Overload and Chelation in Thalassaemia Christos Kattamis, 1989 |
| chelation therapy for thalassemia: Sex-Specific Analysis of Cardiovascular Function Peter L. M. Kerkhof, Virginia M. Miller, 2018-07-26 This book gathers together contributions from internationally renowned authors in the field of cardiovascular systems and provides crucial insight into the importance of sex- and gender-concepts during the analysis of patient data. This innovative title is the first to offer the elements necessary to consider sex-related properties in both clinical and basic studies regarding the heart and circulation on multiscale levels (i.e. molecular, cellular, electrophysiologically, neuroendocrine, immunoregulatory, organ, allometric, and modeling). Observed differences at (ultra)cellular and organ level are quantified, with focus on clinical relevance and implications for diagnosis and patient management. Since the cardiovascular system is of vital importance for all tissues, Sex-Specific Analysis of Cardiovascular Function is an essential source of information for clinicians, biologists, and biomedical investigators. The wide spectrum of differences described in this book will also act as an eye-opener and serve as a handbook for students, teachers, scientists and practitioners. |
| chelation therapy for thalassemia: The Thalassaemia Syndromes David J. Weatherall, J. B. Clegg, 2008-04-30 In the new edition of this successful and authoritative book, the thalassaemias are reviewed in detail with respect to their clinical features, cellular pathology, molecular genetics, prevention and treatment. It is aimed at specialists in haematology in the laboratory or clinical setting, particularly in areas where thalassaemia is common either in the native population or in immigrant communities. The fourth edition has been both updated and re-organized. Three new chapters have been added on the link between alpha-thalassaemia and mental retardation, on avoidance and population control and on global epidemiology. Considerable emphasis is placed on molecular pathology reflecting the huge burst of information to have come out of this field in the last few years. |
| chelation therapy for thalassemia: Radiology of Thalassemia Constantin Papavasiliou, Theophanis Cambouris, Phaedon Fessas, 2011-12-10 Estimates reveal that there are some 200 million heterozygous carriers of abnormal hemoglobins genes worldwide, and tens of thousands of severely affected patients. Effective application of imaging techniques is essential to combat the continuing development of the disease and to ensure risk-free follow-up of the chronically ill. This is the first book to offer complete coverage of such radiologic applications with both conventional and the most modern imaging modalities. Interventional radiology, marrow transplantation, prenatal diagnosis by ultrasonography, and radiotherapy for bone marrow heterotopia are also featured. |
| chelation therapy for thalassemia: Transfusion Medicine for Pathologists Brian Castillo, Amitava Dasgupta, Kimberly Klein, Hlaing Tint, Amer Wahed, 2018-06-29 Transfusion Medicine for Pathologists: A Comprehensive Review for Board Preparation, Certification, and Clinical Practice is a concise study guide designed to complement standard textbooks in the field of clinical pathology. Pathology residents and fellows of transfusion medicine will find this book useful as a preparation tool for their exams. In addition, the book is a valuable timesaver for busy residents looking for a focused and compact study guide on transfusion medicine that will also be ideal for practicing pathologists who cross-cover transfusion medicine in their clinical practice. - Incorporates key words at the end of each chapter for quick review before an exam - Includes concise and easy-to-digest chapters ranging from Donor Selection and Testing, to Blood Bank Testing, Transfusion Reactions, Apheresis, Hemotherapy, Special Transfusion Situations, and more - Focuses on key topics to study for board examinations, saving time during busy residency programs |
| chelation therapy for thalassemia: The Development of Iron Chelators for Clinical Use Raymond J. Bergeron, Gary M. Brittenham, 1993-12-06 Representing an integration of basic and clinical sciences, this book focuses on new concepts in the design, synthesis, and testing of iron chelators for clinical application. It provides an overview of the pathophysiology of iron metabolism as it relates to the origins of iron-mediated tissue damage, and it clearly outlines successes and shortcomings of current iron chelation therapy in preventing such damage. The book also describes a number of other exciting potential therapeutic applications of iron chelators, such as in the treatment of malaria. Other topics covered include iron coordination chemistry, recent advances in synthetic methods for accessing iron chelators, siderophore models, subcellular iron storage targets, and the possible application of biotechnology in the production of therapeutically useful iron chelators. The book also describes new animal models for evaluating chelators. |
| chelation therapy for thalassemia: The Drug Trial Miriam Shuchman, 2005 Winner of the Writers' Trust of Canada's Shaughnessy Cohen Prize for Political Writing and the Canadian Science Writers' Association's Science in Society Book Award. Poison-pen letters, possible medical misconduct and a swirl of competing accusations that led to two inquiries – the Olivieri affair ended careers and shook the international research establishment. A riveting anatomy of Canada’s most controversial drug trial, by the medical journalist who helped break the story. In August 1998, a medical scandal erupted in the national and international media whose consequences still reverberate. A charismatic young doctor named Nancy Olivieri, working with young people who suffered from a rare blood disorder, stated that she had discovered serious problems with an experimental drug manufactured by Canada’s largest drug company, Apotex. Though her research contract required her to remain silent, she decided she had no choice but to warn the patients enrolled in her trials. Apotex retaliated by cancelling her research and slamming her reputation. In the aftermath, Olivieri became a whistleblower applauded in academia and the media for standing up to powerful corporate interests. The Olivieri affair spawned two inquiries and multiple lawsuits, but the full story of Canada’s biggest science scandal has never been told – until now. In the hands of psychiatrist and medical journalist Miriam Shuchman, the debacle over the pill called L1 is revealed as a modern morality play in which every crack in the system of scientific research, corporate financing and peer review stands out in stark relief. By talking with the people whom both Olivieri and Apotex wanted to heal – the young men and women struggling to have normal lives despite debilitating treatment – Shuchman also brings us the moving story of the toll on patients’ health when battles break out among the physicians and researchers aiming to heal them. |
| chelation therapy for thalassemia: Disorders of Hemoglobin Martin H. Steinberg, 2009-08-17 Completely revised new edition of the definitive reference on disorders of hemoglobin. |
| chelation therapy for thalassemia: The Politics of Sickle Cell and Thalassaemia Elizabeth N. Anionwu, Karl Atkin, 2001 Sickle cell disorder (SCD) and thalassaemia are inherited blood disorders which have only recently gained serious attention among health professionals and policy makers. In this text, Anionwu (nursing, Thames Valley U.) and Atkin (U. of Leeds) explore issues regarding these disorders in the UK, and the broader problems faced by minority ethnic communities in acquiring adequate health care and support. Coverage includes a clinical introduction to haemoglobinopathies; screening and diagnosing within the context of the new genetics, including associated ethical dilemmas and problems; general problems faced by patients and their families, and their daily coping strategies; current shortfalls in providing care; examples of existing good practice; strategies and struggles from the historical development of haemoglobinopathy services in the UK; and opportunities and threats for the future. c. Book News Inc. |
Chelation therapy for heart disease: Does it work? - Mayo Clinic
Mar 18, 2025 · Chelation therapy doesn't seem to be an effective treatment for heart disease. Chelation therapy has long been used as a treatment for mercury and lead poisoning. And in …
Terapia de quelación para las enfermedades del corazón: ¿funciona?
May 24, 2025 · El Trial to Assess Chelation Therapy (Ensayo para evaluar la terapia de quelación) (TACT, por sus siglas en inglés) no proporcionó pruebas suficientes para apoyar el …
Wilson's disease - Diagnosis and treatment - Mayo Clinic
Dec 2, 2023 · Another copper chelation agent called trientine works much like penicillamine, but it tends to cause fewer side effects. Still, nervous system symptoms can get worse when taking …
心脏病的螯合疗法：是否有效？ - 妙佑医疗国际
目前尚不清楚螯合疗法是否能治疗心脏病。 长期以来，螯合疗法一直被用于治疗汞和铅中毒，但尚未证明可以治疗心脏病。当用于治疗心脏病时，此疗法可能引发严重副作用。即便如此，仍有 …
Lead poisoning - Diagnosis & treatment - Mayo Clinic
Jan 21, 2022 · Chelation therapy. In this treatment, a medication given by mouth binds with the lead so that it's excreted in urine. Chelation therapy might be recommended for children with a …
العلاج بالخلب لمرض القلب: هل هو مفيد؟ - Mayo Clinic (مايو كلينك)
Learn more about services at Mayo Clinic. يتضمن العلاج بالخَلْب جلسات أسبوعية للعلاج بثنائي أمين الإيثيلين رباعي حمض الأسيتيك (EDTA) عن طريق الحقن في الوريد.
Terapia de quelación para las enfermedades del corazón: …
Aug 10, 2023 · Learn more about services at Mayo Clinic.
Autism spectrum disorder - Symptoms and causes - Mayo Clinic
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Hemochromatosis - Diagnosis and treatment - Mayo Clinic
Jan 9, 2025 · Instead, a healthcare professional may recommend a medicine to remove excess iron. The medicine can be injected into the body, or it can be taken as a pill. The medicine …
Polypill: Does it treat heart disease? - Mayo Clinic
Apr 12, 2024 · The term "polypill" describes a pill that contains a combination of medicines. The medicines are commonly used to treat heart disease and high blood pressure. Healthcare …
Chelation therapy for heart disease: Does it work? - Mayo Clinic
Mar 18, 2025 · Chelation therapy doesn't seem to be an effective treatment for heart disease. Chelation therapy has long been used as a treatment for mercury and lead poisoning. And in …
Terapia de quelación para las enfermedades del corazón: ¿funciona?
May 24, 2025 · El Trial to Assess Chelation Therapy (Ensayo para evaluar la terapia de quelación) (TACT, por sus siglas en inglés) no proporcionó pruebas suficientes para apoyar el …
Wilson's disease - Diagnosis and treatment - Mayo Clinic
Dec 2, 2023 · Another copper chelation agent called trientine works much like penicillamine, but it tends to cause fewer side effects. Still, nervous system symptoms can get worse when taking …
心脏病的螯合疗法：是否有效？ - 妙佑医疗国际
目前尚不清楚螯合疗法是否能治疗心脏病。 长期以来，螯合疗法一直被用于治疗汞和铅中毒，但尚未证明可以治疗心脏病。当用于治疗心脏病时，此疗法可能引发严重副作用。即便如此，仍有 …
Lead poisoning - Diagnosis & treatment - Mayo Clinic
Jan 21, 2022 · Chelation therapy. In this treatment, a medication given by mouth binds with the lead so that it's excreted in urine. Chelation therapy might be recommended for children with a …
العلاج بالخلب لمرض القلب: هل هو مفيد؟ - Mayo Clinic (مايو كلينك)
Learn more about services at Mayo Clinic. يتضمن العلاج بالخَلْب جلسات أسبوعية للعلاج بثنائي أمين الإيثيلين رباعي حمض الأسيتيك (EDTA) عن طريق الحقن في الوريد.
Terapia de quelación para las enfermedades del corazón: …
Aug 10, 2023 · Learn more about services at Mayo Clinic.
Autism spectrum disorder - Symptoms and causes - Mayo Clinic
May 22, 2025 · Autism spectrum disorder is a condition related to brain development that affects how people see others and socialize with them. This causes problems in communication and …
Hemochromatosis - Diagnosis and treatment - Mayo Clinic
Jan 9, 2025 · Instead, a healthcare professional may recommend a medicine to remove excess iron. The medicine can be injected into the body, or it can be taken as a pill. The medicine …
Polypill: Does it treat heart disease? - Mayo Clinic
Apr 12, 2024 · The term "polypill" describes a pill that contains a combination of medicines. The medicines are commonly used to treat heart disease and high blood pressure. Healthcare …
