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| chelation therapy parkinson's disease: Chelation Therapy in the Treatment of Metal Intoxication Jan Aaseth, Guido Crisponi, Ole Anderson, 2016-04-18 Chelation Therapy in the Treatment of Metal Intoxication presents a practical guide to the use of chelation therapy, from its basic chemistry, to available chelating antidotes, and the application of chelating agents. Several metals have long been known to be toxic to humans, and continue to pose great difficulty to treat. These challenges pose particular problems in industrial settings, with lead smelting known to be associated with hemopoietic alterations and paralyses, and the inhalation of mercury vapor in mercury mining being extremely detrimental to the central nervous system. Clinical experience has demonstrated that acute and chronic human intoxications with a range of metals can be treated efficiently by administration of chelating agents. Chelation Therapy in the Treatment of Metal Intoxication describes the chemical and biological principles of chelation in the treatment of these toxic metal compounds, including new chelators such as meso-2,3-dimercaptosuccinic acid (DMSA) and D,L-2,3-dimercapto-1-propanesulfonic acid (DMPS). - Presents all the current findings on the potential for chelation as a therapy for metal intoxication - Presents practical guidelines for selecting the most appropriate chelating agent - Includes coverage on radionuclide exposure and metal storage diseases - Describes the chemical and biological principles of chelation in the treatment of toxic metal compounds |
| chelation therapy parkinson's disease: Iron Chelation Therapy Chaim Hershko, 2002 Within the last few years, iron research has yielded exciting new insights into the understanding of normal iron homeostasis. Such development, and the evolution of improved strategies of Iron Chelating Therapy require better understanding of the pathophysiology of iron toxicity and the mechanism of action of iron chelating drugs. The timeliness of the present volume is underlined by several significant developments in recent years. New insights have been gained into the molecular basis of aberrant iron handling in hereditary disorders and the pathophysiology of iron overload. This volume highlights the impact of long term Iron Celating Therapy using deferoxamine or the new, but controversial oral iron chelator deferiprone based on experience gained by multicenter trails, with special emphasis on survival, morbidity and drug toxicity; it reviews the development of the new and improved orally effective chelators suitable for clinical use in the near future and examines novel strategies of iron chelating treatment for the control of cell proliferation in malignant disease or malaria. |
| chelation therapy parkinson's disease: Essential Metals in Medicine: Therapeutic Use and Toxicity of Metal Ions in the Clinic Peggy L. Carver, 2019-01-14 Volume 19, entitled Essential Metals in Medicine: Therapeutic Use and Toxicity of Metal Ions in the Clinic of the series Metal Ions in Life Sciences centers on the role of metal ions in clinical medicine. Metal ions are tightly regulated in human health: while essential to life, they can be toxic as well. Following an introductory chapter briefly discussing several important metal-related drugs and diseases and a chapter about drug development, the focus is fi rst on iron: its essentiality for pathogens and humans as well as its toxicity. Chelation therapy is addressed in the context of thalassemia, its relationship to neurodegenerative diseases and also the risks connected with iron administration are pointed out. A subject of intense debate is the essentiality of chromium and vanadium. For example, chromium(III) compounds are taken as a nutritional supplement by athletes and bodybuilders; in contrast, chromate, Cr(VI), is toxic and a carcinogen for humans. The benefi cial and toxic effects of manganese, cobalt, and copper on humans are discussed. The need for antiparasitic agents is emphasized as well as the clinical aspects of metal-containing antidotes for cyanide poisoning. In addition to the essential and possibly essential ones, also other metal ions play important roles in human health, causing harm (like the metalloid arsenic, lead or cadmium) or being used in diagnosis or treatment of human diseases, like gadolinium, gallium, lithium, gold, silver or platinum. The impact of this vibrant research area on metals in the clinic is provided in 14 stimulating chapters, written by internationally recognized experts from the Americas, Europe and China, and is manifested by approximately 2000 references, and about 90 illustrations and tables. Essential Metals in Medicine: Therapeutic Use and Toxicity of Metal Ions in the Clinic is an essential resource for scientists working in the wide range from pharmacology, enzymology, material sciences, analytical, organic, and inorganic biochemistry all the way through to medicine ... not forgetting that it also provides excellent information for teaching. |
| chelation therapy parkinson's disease: Cardiovascular Magnetic Resonance Warren J. Manning, Dudley J. Pennell, 2018-04-26 - Provides state-of-the-art coverage of CMR technologies and guidelines, including basic principles, imaging techniques, ischemic heart disease, right ventricular and congenital heart disease, vascular and pericardium conditions, and functional cardiovascular disease. - Includes new chapters on non-cardiac pathology, pacemaker safety, economics of CMR, and guidelines as well as new coverage of myocarditis and its diagnosis and assessment of prognosis by cardiovascular magnetic resonance, and the use of PET/CMR imaging of the heart, especially in sarcoidosis. - Features more than 1,100 high-quality images representing today's CMR imaging. - Covers T1, T2 and ECV mapping, as well as T2* imaging in iron overload, which has been shown to save lives in patients with thalassaemia major - Discusses the cost-effectiveness of CMR. - Provides state-of-the-art coverage of CMR technologies and guidelines, including basic principles, imaging techniques, ischemic heart disease, right ventricular and congenital heart disease, vascular and pericardium conditions, and functional cardiovascular disease. - Includes new chapters on non-cardiac pathology, pacemaker safety, economics of CMR, and guidelines as well as new coverage of myocarditis and its diagnosis and assessment of prognosis by cardiovascular magnetic resonance, and the use of PET/CMR imaging of the heart, especially in sarcoidosis. - Features more than 1,100 high-quality images representing today's CMR imaging. - Covers T1, T2 and ECV mapping, as well as T2* imaging in iron overload, which has been shown to save lives in patients with thalassaemia major. - Discusses the cost-effectiveness of CMR. - Expert ConsultTM eBook version included with purchase. This enhanced eBook experience allows you to search all of the text, figures, and references from the book on a variety of devices. |
| chelation therapy parkinson's disease: Oxidative Stress and Neurodegenerative Disorders G. Ali Qureshi, S. Hasan Parvez, 2007-03-22 Oxidative stress is the result of an imbalance in pro-oxidant/antioxidant homeostasis that leads to the generation of toxic reactive oxygen species. Brain cells are continuously exposed to reactive oxygen species generated by oxidative metabolism, and in certain pathological conditions defense mechanisms against oxygen radicals may be weakened and/or overwhelmed. DNA is a potential target for oxidative damage, and genomic damage can contribute to neuropathogenesis. It is important therefore to identify tools for the quantitative analysis of DNA damage in models on neurological disorders. This book presents detailed information on various neurodegenerative disorders and their connection with oxidative stress. This information will provide clinicians with directions to treat these disorders with appropriate therapy and is also of vital importance for the drug industries for the design of new drugs for treatment of degenerative disorders.* Contains the latest information on the subject of neurodegenerative disorders* Reflects on various factors involved in degeneration and gives suggestions for how to tackle these problems |
| chelation therapy parkinson's disease: Ageing Vulnerability Gregory R. Bock, Jamie A. Goode, 2001-03-30 Ageing at individual and population levels presents one of the greatest challenges to humankind as we begin the 21st century. Throughout the world, older adults are the fasts growing population group. Ageing is associated with an increased risk for development of chronic diseases that contribute to morbidity and mortality. |
| chelation therapy parkinson's disease: Mucuna versus Parkinson: treatment with natural levodopa Rafael González Maldonado, 2014-08-19 “Mucuna pruriens” is a bean that grows in the tropics. It is very rich in natural levodopa that is better tolerated and more potent than the synthetic levodopa in Sinemet or Stalevo. Two prestigious neurologists have patented extracts of mucuna seeds as a treatment for Parkinson's. Meanwhile, patients have recorded their positive experiences with mucuna; they buy it online (no prescription needed) and use it in secrecy without consulting their neurologist. Neither the patients nor the doctors (most of them) have clear ideas about this plant, its ingredients (not only levodopa), the proportions in which it is absorbed, or how to manage it. Mucuna versus Parkinson: Natural Levodopa Treatment is so far the most complete and up-to-date monograph on the subject, it describes the theoretical and practical approaches to the use of this plant as a treatment option for Parkinson's disease. Also included are more than one hundred of references. |
| chelation therapy parkinson's disease: Trace Elements and Minerals in Health and Longevity Marco Malavolta, Eugenio Mocchegiani, 2018-11-13 This book describes the role of trace elements in health and longevity, pursuing a biogerontological approach. It offers essential information on the impact of trace elements on molecular and physiological processes of aging, and on their impact on health in connection with aging. The major topics covered in its 11 chapters, each dedicated to a specific trace element or mineral, are: a) Role of the element in species longevity, b) Recommended intake for longevity in animal species and in the elderly, c) Deficiency and age-related disease, d) Excess/toxicity and age-related disease, and e) Interactions with drugs prescribed in the elderly. Clinical, animal and other laboratory models of interest in aging are included, which enable a more in-depth analysis to be made. The respective chapters are a mixture of overviews and more in-depth reviews in which the mechanisms of aging are described from the point of view of their specific interactions with trace elements and minerals. |
| chelation therapy parkinson's disease: Principles and Practice of Movement Disorders E-Book Joseph Jankovic, Mark Hallett, Stanley Fahn, 2011-08-09 Principles and Practice of Movement Disorders provides the complete, expert guidance you need to diagnose and manage these challenging conditions. Drs. Stanley Fahn, Joseph Jankovic and Mark Hallett explore all facets of these disorders, including the latest rating scales for clinical research, neurochemistry, clinical pharmacology, genetics, clinical trials, and experimental therapeutics. This edition features many new full-color images, additional coverage of pediatric disorders, updated Parkinson information, and many other valuable updates. An accompanying Expert Consult website makes the content fully searchable and contains several hundred video clips that illustrate the manifestations of all the movement disorders in the book along with their differential diagnoses. Get just the information you need for a clinical approach to diagnosis and management, with minimal emphasis on basic science. Find the answers you need quickly and easily thanks to a reader-friendly full-color format, with plentiful diagrams, photographs, and tables. Apply the latest advances to diagnosis and treatment of pediatric movement disorders, Parkinson disease, and much more. View the characteristic presentation of each disorder with a complete collection of professional-quality, narrated videos online. Better visualize every concept with new full-color illustrations throughout. Search the complete text online, follow links to PubMed abstracts, and download all of the illustrations, at www.expertconsult.com. |
| chelation therapy parkinson's disease: Parkinson's Disease William J. Weiner, Lisa M. Shulman, Anthony E. Lang, 2013-12-01 The third edition incorporates findings from years of intensive research. Recent innovations, including deep brain stimulation and new medications, have significantly improved the lives of people who have Parkinson's disease. Nevertheless, patients and families continue to face many challenges. They have long relied on this book for reliable advice about medical, emotional, and physical issues. Bringing this trusted guide up to date, three expert neurologists describe • New understandings gained by five years of additional research on Parkinson's disease • New focus on the importance of exercise • New information about imaging techniques such as SPECT Scan and DATScan that are aiding in the diagnosis • New findings about the genetics of the disease • Promising uses of new technologies such as tablet devices for people who have trouble communicating • Information about impulse control disorders caused by some drugs used to address the symptoms of the disease • A complete update on treatments such as medications, surgery, and more |
| chelation therapy parkinson's disease: Food and Free Radicals Midori Hiramatsu, 1997-04-30 Proceedings of the First Symposium held in Yamagata, Japan, June 16, 1994 |
| chelation therapy parkinson's disease: Handbook of Neurological Therapy Carlo Colosimo, Antonio Gil-Nagel, Nils Erik Gilhus, Alan M. Rapoport, Olajide Williams, 2015 This is a practical book on neurological therapy. It is aimed at giving concise and updated answers to busy practicing clinicians in the clinic, ward, or emergency department. An evidence-based approach is used, but when there is no evidence or the data are inconclusive, an expert opinion is always given in order to meet the expectations of the reader. All neurological conditions, common and less common, are discussed; each chapter has a similar format, and contains an initial brief introduction on the epidemiology and clinical features of each disease. The therapy is then discussed, including pharmacological and non-pharmacological, with wide use of Tables & Figures. Flowcharts are also included in most of the chapters. |
| chelation therapy parkinson's disease: A Textbook on EDTA Chelation Therapy Elmer M. Cranton, 2001-04-01 Chelation therapy, based on the intravenous infusion of EDTA, is a highly effective treatment for atherosclerotic cardiovasular disease. Saftey and effectivenss are well documented in clinical studies, all of which to date are supportive of this therapy, and there are no studies showing lack of effectiveness. A strong case is made for the use of this safe, efficacious, and inexpensive therapy before resorting to surgery and other risky and invasive treatments. In this newly revised and extensively updated edition of what has come to be regarded as the definitive textbook on the subject, renowned chelation expert Elmer M. Cranton, M.D., presents the work of the world's leading experts in chelation therapy. This therapy has been proven effective over and over again in clinical practice, says Dr. Cranton. More than one million patients have recieved more than twenty million infusions with no serious or lasting adverse effects. In his foreword, Nobel Prize winner Dr. Linus Pauling states, EDTA chelation therapy makes good sense to me as a chemist and medical researcher. It has a rational scientific basis, and the evidence for clinical benefit seems to be quite strong. Here in a single volume you will learn everything you need to know to responsibly administer and advocate chelation therapy. You will find a coherent scientific rationale, clinical trials demonstating effectiveness, guidelines for saftey, detailed protocols for administration, and techniques for pre- and post-treatment laboratory evalutaion. |
| chelation therapy parkinson's disease: Biological Inorganic Chemistry Ivano Bertini, 2007 Part A.: Overviews of biological inorganic chemistry : 1. Bioinorganic chemistry and the biogeochemical cycles -- 2. Metal ions and proteins: binding, stability, and folding -- 3. Special cofactors and metal clusters -- 4. Transport and storage of metal ions in biology -- 5. Biominerals and biomineralization -- 6. Metals in medicine. -- Part B.: Metal ion containing biological systems : 1. Metal ion transport and storage -- 2. Hydrolytic chemistry -- 3. Electron transfer, respiration, and photosynthesis -- 4. Oxygen metabolism -- 5. Hydrogen, carbon, and sulfur metabolism -- 6. Metalloenzymes with radical intermediates -- 7. Metal ion receptors and signaling. -- Cell biology, biochemistry, and evolution: Tutorial I. -- Fundamentals of coordination chemistry: Tutorial II. |
| chelation therapy parkinson's disease: Chelation Can Cure Edward W. McDonagh, 1987 |
| chelation therapy parkinson's disease: Brain Drug Targeting William M. Pardridge, 2001-05-31 This challenging 2001 book reviews modern neurotherapeutics from the point of view of drug targeting. |
| chelation therapy parkinson's disease: The Importance Of Iron In Pathophysiologic Conditions Raffaella Gozzelino, Paolo Arosio, 2015-06-09 The iron element (Fe) is strictly required for the survival of most forms of life, including bacteria, plants and humans. Fine-tuned regulatory mechanisms for Fe absorption, mobilization and recycling operate to maintain Fe homeostasis, the disruption of which leads to Fe overload or Fe depletion. Whereas the deleterious effect of Fe deficiency relies on reduced oxygen transport and diminished activity of Fe-dependent enzymes, the cytotoxicity induced by Fe overload is due to the ability of this metal to act as a pro-oxidant and catalyze the formation of highly reactive hydroxyl radicals via the Fenton chemistry. This results in unfettered oxidative stress generation that, by inducing protein, lipid and DNA oxidation, leads to Fe-mediated programmed cell death and organ dysfunction. Major and systemic Fe overloads occurring in hemochromatosis and Fe-loading anemias have been extensively studied. However, localized tissue Fe overload was recently associated to a variety of pathologies, such as infection, inflammation, cancer, cardiovascular and neurodegenerative disorders. In keeping with the existence of cross-regulatory interactions between Fe homeostasis and the pathophysiology of these diseases, further investigations on the mechanisms that provide cellular and systemic adaptation to tissue Fe overload are instrumental for future therapeutic approaches. Thus, we encourage our colleagues to submit original research papers, reviews, perspectives, methods and technology reports to contribute their findings to a current state of the art on a comprehensive overview of the importance of iron metabolism in pathophysiologic conditions. |
| chelation therapy parkinson's disease: Amalgam Illness Andrew Hall Cutler, 1999 |
| chelation therapy parkinson's disease: Etiology of Parkinson's Disease Jonas H. Ellenberg, William C. Koller, James William Langston, 1995-03-01 This comprehensive reference provides a detailed overview of current concepts regarding the cause of Parkinson's disease-emphasizing the issues involved in the design, implementation, and analysis of epidemiological studies of parkinsonism. |
| chelation therapy parkinson's disease: The Encyclopedia of Parkinson's Disease Anthony D. Mosley, 2009 Explains the complex issues and topics related to Parkinson's, including etiology, surgeries, research, medical terms, and much more. |
| chelation therapy parkinson's disease: Parkinson's Disease and Movement Disorders Joseph Jankovic, Eduardo Tolosa, 2007 Written by an international group of renowned experts, the Fifth Edition of this premier reference provides comprehensive, current information on the genetics, pathophysiology, diagnosis, medical and surgical treatment, and behavioral and psychologic concomitants of all common and uncommon movement disorders. Coverage includes Parkinson's disease, other neurodegenerative diseases, tremors, dystonia, Tourette's syndrome, Huntington's disease, and ataxias. This edition features extensive updates on genetics, imaging, and therapeutics of Parkinson's disease, other parkinsonian disorders, and all hyperkinetic movement disorders. A bound-in CD-ROM, Video Atlas of Movement Disorders, demonstrates the movement and posture abnormalities and other disturbances associated with Parkinson's disease and other neurologic disorders. |
| chelation therapy parkinson's disease: Natural Iron Chelator. Chemistry, Biology, and Therapeutic Applications Farid Badria, 2020-02-20 Master's Thesis from the year 2019 in the subject Chemistry - General, grade: 4.0, Mansoura University, language: English, abstract: Iron-overload disorder (hemochromatosis) is one of the major reasons of morbidity, caused by genetic disorder of protein involved in regulation of iron absorption or due to multiple transfusion of iron in chronic anemia for example thalassemia. Resulting in initiation and propagation reactive oxygen species which attacking macromolecules of cells such as proteins, lipids, RNA and DNA and ultimately cells death. Leading to a state of oxidative stress associated with many of health problems such as heart failure, liver cirrhosis, fibrosis, gallbladder disorders, diabetes, arthritis, infertility, and cancer. The available chelators drugs can forming soluble, stable complexes with excessive iron andexcreted it in the feces and/or urine. But due to, their high cost, severe side effects, poor oralbioavailability or short plasma half-life make them suboptimal. Sixteen plant leaves were collected, authenticated and subjected to exhausted extraction by 70% methanol. The obtained leaves extracts were screened for their iron chelation activity using 2,2`- bipyridyl assay. Among the screened extracts, the Mangiferaindica leaves showed the highest iron chelation activity(69.71 ± 0.27%)comparable to positive control, EDTA(70.30 ± 0.08%). The total extract of theM. indica leaves was partitioned with different solvents (petroleum ether, methylene chloride, ethyl acetate and n-butanol). The resultingfractions were screened for their iron chelation activity using 2, 2`- bipyridyl assay.EtOAcfractionhad the significant chelating activity (123 ± 2.75%),more potent than EDTA(64.12 ± 1.48%) and total extract of M. indica leaves (69.71 ± 0.27%). The mangiferin compound was subjected to comparison with desferal® to assurance the quality of its chelating activity throughdetermine the active sites responsible of its chelating property and evaluation the effect of its iron-stable complex on its antioxidant activity. According to introduced results, through different biological analysis. We found that, the iron-overloaded rats treated with ethyl acetate fraction had significant decreases in iron accumulation within liver and spleen (the major organs affected by iron overload). We assume that, the mangiferin may protect from reactive oxygenspecies-stimulatedseveral of disordersby its iron chelatingactivity which promotes its antioxidant property. |
| chelation therapy parkinson's disease: Antioxidants in Nutrition, Health, and Disease John M. C. Gutteridge, Barry Halliwell, 1994 A critical and informed look at the merits and limitations of nutritional antioxidant supplementation in the general population. |
| chelation therapy parkinson's disease: Parkinson's Disease Paul Tuite, MD, Cathi Thomas, RN, MS, Laura Ruekert, PharmD, RPh, Hubert H. Fernandez, MD, 2009-03-23 As a quick, user-friendly reference, this book covers all aspects of effectively managing patients with Parkinson's disease, with discussions of symptoms, causes, patient evaluation, and home care adviceÖ.Nurses, physicians, and associated healthcare professions from rehabilitation specialists to social workers will find this an excellent source of information on the many aspects of care of Parkinson's disease patients. --Doody's This book serves as a practical compendium on the management issues related to Parkinson's disease (PD). As a quick, user-friendly reference, the book covers all aspects of effectively managing PD, with discussions of symptoms, causes of PD, patient evaluation, and home care advice. Conveniently organized in bullet-point, encyclopedic format, Parkinson's Disease is the comprehensive, one-stop reference for health professionals treating patients with PD. Four key sections: Problems presents guidelines on addressing complications that occur during the disease process, including anxiety, hallucinations, depression, vision problems, and more Evaluation discusses the numerous patient evaluations required throughout the duration of the illness, such as genetic testing, brain imaging, speech and swallowing evaluation, and more Treatment presents both pharmacological and non-pharmacological treatment approaches for patients with PD Appendices include supplemental reading, medication tools and assessment scales, rating scales, and additional notes Nurses, primary care doctors, and associated health care professionals--from rehabilitation specialists to social workers--will find Parkinson's Disease the one reference they cannot do without. |
| chelation therapy parkinson's disease: Forty Something Forever Harold Brecher, Arline Brecher, 1992-01-01 |
| chelation therapy parkinson's disease: Mineral and Metal Neurotoxicology Masayuki Yasui, M. Anthony Verity, 1996-09-26 Trace minerals and metals such as zinc, copper, and magnesium are accepted as a natural part of the human system. Interactions of some elements and/or disturbances in trace-metal or mineral homeostasis can, however, be toxic to the central nervous system (CNS). Mineral and Metal Neurotoxicology describes a wide range of basic and clinical issues |
| chelation therapy parkinson's disease: Iron Chelators David G. Badman, Raymond J. Bergeron, Gary M. Brittenham, 2000 |
| chelation therapy parkinson's disease: The Diagnosis of Psychosis Rudolf N. Cardinal, Edward T. Bullmore, 2011-03-31 Psychosis has many causes. Psychiatrists typically receive the most thorough training in its diagnosis, but the diagnosis of psychosis secondary to nonpsychiatric conditions is not often emphasized. An understanding of the underlying cause of psychosis is important for effective management. The Diagnosis of Psychosis bridges the gap between psychiatry and medicine, providing a comprehensive review of primary and secondary causes of psychosis. It covers both common and rare causes in a clinically focused guide. Useful both for teaching and reference, the text covers physical and mental state examination, describes key investigations, and summarizes the non-psychiatric features of medical conditions causing psychosis. Particularly relevant for psychiatrists and trainees in psychiatry, this volume will also assist neurologists and general physicians who encounter psychosis in their practice. |
| chelation therapy parkinson's disease: Parkinson's Disease Donald Grosset, Hubert Fernandez, Katherine Grosset, Michael Okun, 2009-06-26 This books’ coverage ranges from incidence, diagnosis, investigation, drug treatments, non-motor features of Parkinson’s Disease, assessment scales and surgical intervention, to the role of nurses, physio– and occupational therapists, speech/language pathologists, dieticians, and to the use of complementary medicine. |
| chelation therapy parkinson's disease: Metal Chelation in Medicine Robert R Crichton, Roberta J Ward, Robert C Hider, 2016-10-18 Metal chelators are emerging as versatile tool with many medical applications. Their versatility allows them to be used in chelation therapy for treating diseases caused by toxic and heavy metal poisoning, chelating agents are capable of binding to toxic metal ions to form complex structures which are easily excreted from the body removing them from intracellular or extracellular spaces. In addition, metal chelators can also be applied as contrast agents in MRI scanning. Metal Chelation in Medicine provides a clear and timely perspective on the role of chelating agents in the management of metal intoxications and storage diseases. Written by leaders in the field of chelators, this publication is at the cutting-edge of the subject. It covers a broad range of topics such as the use of metal chelators in non-invasive assessment of brain iron overload, and the treatment of systemic iron overload and neurodegenerative diseases. As such it is particularly valuable to clinicians treating metal poisonings and metal storage diseases. However, it is also a useful text for researchers, industry professionals and university students with a specific interest in medicinal chemistry, chelation, metal ions, imaging and non-invasive techniques. |
| chelation therapy parkinson's disease: Binding, Transport and Storage of Metal Ions in Biological Cells Wolfgang Maret, Anthony Wedd, 2014-07-09 Metal ions play key roles in biology. Many are essential for catalysis, for electron transfer and for the fixation, sensing, and metabolism of gases. Others compete with those essential metal ions or have toxic or pharmacological effects. This book is structured around the periodic table and focuses on the control of metal ions in cells. It addresses the molecular aspects of binding, transport and storage that ensure balanced levels of the essential elements. Organisms have also developed mechanisms to deal with the non-essential metal ions. However, through new uses and manufacturing processes, organisms are increasingly exposed to changing levels of both essential and non-essential ions in new chemical forms. They may not have developed defenses against some of these forms (such as nanoparticles). Many diseases such as cancer, diabetes and neurodegeneration are associated with metal ion imbalance. There may be a deficiency of the essential metals, overload of either essential or non-essential metals or perturbation of the overall natural balance. This book is the first to comprehensively survey the molecular nature of the overall natural balance of metal ions in nutrition, toxicology and pharmacology. It is written as an introduction to research for students and researchers in academia and industry and begins with a chapter by Professor R J P Williams FRS. |
| chelation therapy parkinson's disease: Ask the Doctor About Parkinson's Disease Michael Okun, MD, Dr. Hubert Fernandez, MD, 2009-09-17 Presents answers to common questions about Parkinson's disease, drawing on the content of the Ask the Doctor website column by the National Parkinson Foundation to address concerns related to heredity, treatments, and the future of stem-cell research |
| chelation therapy parkinson's disease: Parkinson's Disease and Related Disorders , 1977 |
| chelation therapy parkinson's disease: The Development of Iron Chelators for Clinical Use Raymond J. Bergeron, Gary M. Brittenham, 1993-12-06 Representing an integration of basic and clinical sciences, this book focuses on new concepts in the design, synthesis, and testing of iron chelators for clinical application. It provides an overview of the pathophysiology of iron metabolism as it relates to the origins of iron-mediated tissue damage, and it clearly outlines successes and shortcomings of current iron chelation therapy in preventing such damage. The book also describes a number of other exciting potential therapeutic applications of iron chelators, such as in the treatment of malaria. Other topics covered include iron coordination chemistry, recent advances in synthetic methods for accessing iron chelators, siderophore models, subcellular iron storage targets, and the possible application of biotechnology in the production of therapeutically useful iron chelators. The book also describes new animal models for evaluating chelators. |
| chelation therapy parkinson's disease: Iron Chelation Therapy Chaim Hershko, 2012-12-06 Within the last few years, iron research has yielded exciting new insights into the under standing of normal iron homeostasis. However, normal iron physiology offers little protec tion from the toxic effects of pathological iron accumulation, because nature did not equip us with effective mechanisms of iron excretion. Excess iron may be effectively removed by phlebotomy in hereditary hemochromatosis, but this method cannot be applied to chronic anemias associated with iron overload. In these diseases, iron chelating therapy is the only method available for preventing early death caused mainly by myocardial and hepatic iron toxicity. Iron chelating therapy has changed the quality of life and life expectancy of thalassemic patients. However, the high cost and rigorous requirements of deferoxamine therapy, and the significant toxicity of deferiprone underline the need for the continued development of new and improved orally effective iron chelators. Such development, and the evolution of improved strategies of iron chelating therapy require better understanding of the pathophysiology of iron toxicity and the mechanism of action of iron chelating drugs. The timeliness of the present volume is underlined by several significant develop ments in recent years. New insights have been gained into the molecular basis of aberrant iron handling in hereditary disorders and the pathophysiology of iron overload (Chapters 1-5). |
| chelation therapy parkinson's disease: Natural Therapies for Parkinson's Disease Laurie Mischley, 2009-10 Conventional management of Parkinson's disease (PD) is limited. The pharmaceutical and surgical options that are available have significant side effects and only correct symptoms for a limited period of time. Even with the best conventional treatment, the disease progresses and becomes severely disabling. No existing conventional therapies that the progress of the disease; available medicines only treat symptoms temporarily. Conventional medicine views the course of the disease as progressive and irreversible. Many patients, who are only partially satisfied with conventional medicine, seek alternative and complementary options in an attempt to slow, stop, or reverse the disease process. This book has several functions:- It is a science-based reference manual.- It is inspiring and empowering to patients.- It is educational for both patients and neurologists.- It is entertaining.- It fosters an understanding between conventional and complementary providers.Chapters on , Alpha-Lipoic Acid, Aluminum, Antioxidants, Beta-carotene, Calorie Restriction, Carnitine, Chelation, Cholesterol, Choline, Coenzyme Q-10, Constipation, Creatine, Curcumin (Turmeric), Dairy, DHA (fish oil), Fava Beans, Glutathione, H. pylori (Helicobacter pylori), Homocysteine, Iron, Manganese, Marijuana (Cannabis sativa), Mucuna pruriens, Velvet bean, Cowhage, Niacin, Tea, Vitamin B6, Vitamin D, and other topics. |
| chelation therapy parkinson's disease: Cognition in Parkinson's Disease , 2022-03-02 Cognition in Parkinson's Disease, Volume 269 in the Progress in Brain Research series, highlights new advances in the field, with this new volume presenting interesting chapters on a variety of timely topics, including Cognition in Prodromal Parkinson's disease, The epidemiology of cognitive function in Parkinson's disease, Real-life consequences of cognitive dysfunction in Parkinson's disease, Animal models of cognition in Parkinson's disease, Functional neuroanatomy of cognition in Parkinson's disease, Neuroimaging approaches to cognition in Parkinson's disease, Cognitive dysfunction and neuropsychiatric aspects of Parkinson's disease, Neuropsychology of Parkinson's disease, Cholinergic Systems, Attentional-Motor Integration, and Cognitive Control in Parkinson Disease, and much more. - Provides the authority and expertise of leading contributors from an international board of authors - Presents the latest release in Progress in Brain Research series - Updated release includes the latest information on Cognition in Parkinson's Disease |
| chelation therapy parkinson's disease: Oxidative Stress and Redox Signalling in Parkinson’s Disease Rodrigo Franco, Jonathan A Doorn, Jean-Christophe Rochet, 2017-07-21 Parkinson's Disease is the second most common neurodegenerative disorder affecting millions of people worldwide. In order to find neuroprotective strategies, a clear understanding of the mechanisms involved in the dopaminergic death of cells that progresses the disease is needed. Oxidative stress can be defined as an imbalance between the production of reactive species and the ability to detoxify them and their intermediates or by-products. Oxidative damage to lipids, proteins, and DNA has been detected in autopsies from individuals with Parkinson’s Disease and so links can be made between oxidative stress and Parkinson’s Disease pathogenesis. This book provides a thorough review of the mechanisms by which oxidative stress and redox signalling mediate Parkinson’s Disease. Opening chapters bring readers up to speed on basic knowledge regarding oxidative stress and redox signalling, Parkinson’s Disease, and neurodegeneration before the latest advances in this field are explored in detail. Topics covered in the following chapters include the role of mitochondria, dopamine metabolism, metal homeostasis, inflammation, DNA-damage and thiol-signalling. The role of genetics and gene-environment interactions are also explored before final chapters discuss the identification of potential biomarkers for diagnosis and disease progression and the future of redox/antioxidant based therapeutics. Written by recognized experts in the field, this book will be a valuable source of information for postgraduate students and academics, clinicians, toxicologists and risk assessment groups. Importantly, it presents the current research that might later lead to redox or antioxidant – based therapeutics for Parkinson’s disease. |
| chelation therapy parkinson's disease: Crime H. Thomas Milhorn, 2004-12 This book is an overview of the United States legal system, with a brief introduction to Islamic and International law. The book is divided into six parts. Part I (The Legal System and Crime) introduces the U.S. legal system and the classification of crime. Part II (White Collar Crime) covers cybercrime, crime the old fashioned way, and healthcare fraud. Part III (Homicide) deals with simple murder, serial murder, mass and spree murder; and assassination. Part IV (Special Groups) covers the mafia; the family; the medical, legal, and teaching professions; the religion profession; celebrities; and stupid criminals. Part V (On the Edge) deals with topics I consider to be a bit strange; that is, quackery, innovative defenses, and dangerous cults. And finally, Part VI (Residue) discusses what is left ... capital punishment and crimes against humanity, including terrorism. Throughout the book, to illustrate points, I have used over 300 cases of actual crimes. The names of the people and the facts of the cases used in the discussions of these crimes are taken directly from referenced news reports. The subtitle, Computer Viruses to Twin Towers, reflects the scope of the book; that is, from computer viruses, which cause only aggravation or loss of money, to the deadly terrorist attacks on the Twin Towers of the World Trade Center and the Pentagon on September 11, 2001 that snuffed out almost 3000 lives. |
| chelation therapy parkinson's disease: Iron as Therapeutic Targets in Human Diseases Paolo Arosio, Maura Poli, Raffaella Gozzelino, 2020-02-11 Iron is an essential element for almost all organisms, a cofactor playing a crucial role in a number of vital functions, including oxygen transport, DNA synthesis, and respiration. However, its ability to exchange electrons renders excess iron potentially toxic, since it is capable of catalyzing the formation of highly poisonous free radicals. As a consequence, iron homeostasis is tightly controlled by sophisticated mechanisms that have been partially elucidated. Because of its biological importance, numerous disorders have been recently linked to the deregulation of iron homeostasis, which include not only the typical disorders of iron overload and deficiency but also cancer and neurodegenerative diseases. This leads iron metabolism to become an interesting therapeutic target for novel pharmacological treatments against these diseases. Several therapies are currently under development for hematological disorders, while other are being considered for different pathologies. The therapeutic targeting under study includes the hepcidin/ferroportin axis for the regulation of systemic iron homeostasis, complex cytosolic machineries for the regulation of the intracellular iron status and its association with oxidative damage, and reagents exploiting proteins of iron metabolism such as ferritin and transferrin receptor. A promising potential target is a recently described form of programmed cell death named ferroptosis, in which the role of iron is essential but not completely clarified. This Special Issue has the aim to summarize the state-of-the-art, and the latest findings published in the iron field, as well as to elucidate future directions. |
Chelation therapy for heart disease: Does it work? - Mayo Clinic
Mar 18, 2025 · Chelation therapy doesn't seem to be an effective treatment for heart disease. Chelation therapy has long been used as a treatment for mercury and lead poisoning. And in …
Terapia de quelación para las enfermedades del corazón: ¿funciona?
May 24, 2025 · El Trial to Assess Chelation Therapy (Ensayo para evaluar la terapia de quelación) (TACT, por sus siglas en inglés) no proporcionó pruebas suficientes para apoyar el …
Wilson's disease - Diagnosis and treatment - Mayo Clinic
Dec 2, 2023 · Another copper chelation agent called trientine works much like penicillamine, but it tends to cause fewer side effects. Still, nervous system symptoms can get worse when taking …
心脏病的螯合疗法：是否有效？ - 妙佑医疗国际
目前尚不清楚螯合疗法是否能治疗心脏病。 长期以来，螯合疗法一直被用于治疗汞和铅中毒，但尚未证明可以治疗心脏病。当用于治疗心脏病时，此疗法可能引发严重副作用。即便如此，仍有 …
Lead poisoning - Diagnosis & treatment - Mayo Clinic
Jan 21, 2022 · Chelation therapy. In this treatment, a medication given by mouth binds with the lead so that it's excreted in urine. Chelation therapy might be recommended for children with a …
العلاج بالخلب لمرض القلب: هل هو مفيد؟ - Mayo Clinic (مايو كلينك)
Learn more about services at Mayo Clinic. يتضمن العلاج بالخَلْب جلسات أسبوعية للعلاج بثنائي أمين الإيثيلين رباعي حمض الأسيتيك (EDTA) عن طريق الحقن في الوريد.
Terapia de quelación para las enfermedades del corazón: …
Aug 10, 2023 · Learn more about services at Mayo Clinic.
Autism spectrum disorder - Symptoms and causes - Mayo Clinic
May 22, 2025 · Autism spectrum disorder is a condition related to brain development that affects how people see others and socialize with them. This causes problems in communication and …
Hemochromatosis - Diagnosis and treatment - Mayo Clinic
Jan 9, 2025 · Instead, a healthcare professional may recommend a medicine to remove excess iron. The medicine can be injected into the body, or it can be taken as a pill. The medicine …
Polypill: Does it treat heart disease? - Mayo Clinic
Apr 12, 2024 · The term "polypill" describes a pill that contains a combination of medicines. The medicines are commonly used to treat heart disease and high blood pressure. Healthcare …
Chelation therapy for heart disease: Does it work? - Mayo Clinic
Mar 18, 2025 · Chelation therapy doesn't seem to be an effective treatment for heart disease. Chelation therapy has long been used as a treatment for mercury and lead poisoning. And in …
Terapia de quelación para las enfermedades del corazón: ¿funciona?
May 24, 2025 · El Trial to Assess Chelation Therapy (Ensayo para evaluar la terapia de quelación) (TACT, por sus siglas en inglés) no proporcionó pruebas suficientes para apoyar el …
Wilson's disease - Diagnosis and treatment - Mayo Clinic
Dec 2, 2023 · Another copper chelation agent called trientine works much like penicillamine, but it tends to cause fewer side effects. Still, nervous system symptoms can get worse when taking …
心脏病的螯合疗法：是否有效？ - 妙佑医疗国际
目前尚不清楚螯合疗法是否能治疗心脏病。 长期以来，螯合疗法一直被用于治疗汞和铅中毒，但尚未证明可以治疗心脏病。当用于治疗心脏病时，此疗法可能引发严重副作用。即便如此，仍有 …
Lead poisoning - Diagnosis & treatment - Mayo Clinic
Jan 21, 2022 · Chelation therapy. In this treatment, a medication given by mouth binds with the lead so that it's excreted in urine. Chelation therapy might be recommended for children with a …
العلاج بالخلب لمرض القلب: هل هو مفيد؟ - Mayo Clinic (مايو كلينك)
Learn more about services at Mayo Clinic. يتضمن العلاج بالخَلْب جلسات أسبوعية للعلاج بثنائي أمين الإيثيلين رباعي حمض الأسيتيك (EDTA) عن طريق الحقن في الوريد.
Terapia de quelación para las enfermedades del corazón: …
Aug 10, 2023 · Learn more about services at Mayo Clinic.
Autism spectrum disorder - Symptoms and causes - Mayo Clinic
May 22, 2025 · Autism spectrum disorder is a condition related to brain development that affects how people see others and socialize with them. This causes problems in communication and …
Hemochromatosis - Diagnosis and treatment - Mayo Clinic
Jan 9, 2025 · Instead, a healthcare professional may recommend a medicine to remove excess iron. The medicine can be injected into the body, or it can be taken as a pill. The medicine …
Polypill: Does it treat heart disease? - Mayo Clinic
Apr 12, 2024 · The term "polypill" describes a pill that contains a combination of medicines. The medicines are commonly used to treat heart disease and high blood pressure. Healthcare …
