| chemistry of natural products: Chemistry of Natural Products Sujata V. Bhat, B.A. Nagasampagi, Meenakshi Sivakumar, 2005-01-04 During the last few decades, research into natural products has advanced tremendously thanks to contributions from the fields of chemistry, life sciences, food science and material sciences. Comparisons of natural products from microorganisms, lower eukaryotes, animals, higher plants and marine organisms are now well documented. This book provides an easy-to-read overview of natural products. It includes twelve chapters covering most of the aspects of natural products chemistry. Each chapter covers general introduction, nomenclature, occurrence, isolation, detection, structure elucidation both by degradation and spectroscopic techniques, biosynthesis, synthesis, biological activity and commercial applications, if any, of the compounds mentioned in each topic. Therefore it will be useful for students, other researchers and industry. The introduction to each chapter is brief and attempts only to supply general knowledge in the particular field. Furthermore, at the end of each chapter there is a list of recommended books for additional study and a list of relevant questions for practice. |
| chemistry of natural products: Chemistry of Natural Products N. R. Krishnaswamy, 1999 This book is a comprehensive account of the essential features of the chemistry of organic compounds of natural origin. The objective has been to condense the encyclopedic range of the subject into a medium-sized book by taking a radically different approach. |
| chemistry of natural products: Introduction to Natural Products Chemistry Rensheng Xu, Yang Ye, Weimin Zhao, 2011-07-20 Natural products chemistry-the chemistry of metabolite products of plants, animals and microorganisms-is involved in the investigation of biological phenomena ranging from drug mechanisms to gametophytes and receptors and drug metabolism in the human body to protein and enzyme chemistry. Introduction to Natural Products Chemistry has collected the |
| chemistry of natural products: Comprehensive Natural Products III , 2020-07-22 Comprehensive Natural Products III, Third Edition, Seven Volume Set updates and complements the previous two editions, including recent advances in cofactor chemistry, structural diversity of natural products and secondary metabolites, enzymes and enzyme mechanisms and new bioinformatics tools. Natural products research is a dynamic discipline at the intersection of chemistry and biology concerned with isolation, identification, structure elucidation, and chemical characteristics of naturally occurring compounds such as pheromones, carbohydrates, nucleic acids and enzymes. This book reviews the accumulated efforts of chemical and biological research to understand living organisms and their distinctive effects on health and medicine and to stimulate new ideas among the established natural products community. Provides readers with an in-depth review of current natural products research and a critical insight into the future direction of the field Bridges the gap in knowledge by covering developments in the field since the second edition published in 2010 Split into 7 sections on key topics to allow students, researchers and professionals to find relevant information quickly and easily Ensures that the knowledge within is easily understood by and applicable to a large audience |
| chemistry of natural products: Studies in Natural Products Chemistry Atta-ur- Rahman, 2012-12-06 Natural products play an integral and ongoing role in promoting numerous aspects of scientific advancement, and many aspects of basic research programs are intimately related to natural products. With articles written by leading authorities in their respective fields of research, Studies in Natural Products Chemistry, Volume 37 presents current frontiers and future guidelines for research based on important discoveries made in the field of bioactive natural products. It is a valuable source for researchers and engineers working in natural products and medicinal chemistry. - Describes the chemistry of bioactive natural products - Contains contributions by leading authorities in the field - A valuable source for researchers and engineers working in natural product and medicinal chemistry |
| chemistry of natural products: Selected Topics in the Chemistry of Natural Products Raphael Ikan, 2008 A New York Times Notable Book for 2011 A Globe and Mail Best Books of the Year 2011 Title A Kirkus Reviews Best Nonfiction of 2011 title Virtually all human societies were once organized tribally, yet over time most developed new political institutions which included a central state that could keep the peace and uniform laws that applied to all citizens. Some went on to create governments that were accountable to their constituents. We take these institutions for granted, but they are absent or are unable to perform in many of today’s developing countries—with often disastrous consequences for the rest of the world. Francis Fukuyama, author of the bestselling The End of History and the Last Man and one of our most important political thinkers, provides a sweeping account of how today’s basic political institutions developed. The first of a major two-volume work, The Origins of Political Order begins with politics among our primate ancestors and follows the story through the emergence of tribal societies, the growth of the first modern state in China, the beginning of the rule of law in India and the Middle East, and the development of political accountability in Europe up until the eve of the French Revolution. Drawing on a vast body of knowledge—history, evolutionary biology, archaeology, and economics—Fukuyama has produced a brilliant, provocative work that offers fresh insights on the origins of democratic societies and raises essential questions about the nature of politics and its discontents. |
| chemistry of natural products: Chemistry of Natural Products V.K. Ahluwalia, Lalita S. Kumar, Sanjiv Kumar, 2022-11-30 This book is designed to serve as a textbook for core as well as elective courses offered to undergraduate and advanced undergraduate students enrolled in chemistry. This textbook comprehensively deals various topics of organic chemistry such as amino acids, peptides, proteins and enzymes. The text is divided into four chapters: a chapter each dedicated to amino acids, peptides, proteins and enzymes, respectively. The important reactions have been explained with the help of the mechanisms involved. It gives a detailed account of the solution phase and solid phase synthesis of peptides as well as discussing the structure and function of some biologically important peptides. It also covers the classification, nomenclature and mode of action of enzymes, and a detailed account of the structure and function of different co-enzymes. The book also includes pedagogical features like end-of-chapter exercises to aid in self learning. Given the scope, this textbook will be useful for graduate and advanced graduate students pursuing the course of chemistry, especially organic chemistry. |
| chemistry of natural products: Natural Products O. P. Agarwal, 2006 |
| chemistry of natural products: Total Synthesis of Natural Products Jie Jack Li, E.J. Corey, 2013-03-14 'Total Synthesis of Natural Products' is written and edited by some of today's leaders in organic chemistry. Eleven chapters cover a range of natural products, from steroids to alkaloids. Each chapter contains an introduction to the natural product in question, descriptions of its biological and pharmacological properties and outlines of total synthesis procedures already carried out. Particular emphasis is placed on novel methodologies developed by the respective authors and their research groups. This text is ideal for graduate and advanced undergraduate students, as well as organic chemists in academia and industry. |
| chemistry of natural products: Natural Products in Medicinal Chemistry Stephen Hanessian, 2013-12-18 The inspiration provided by biologically active natural products to conceive of hybrids, congeners, analogs and unnatural variants is discussed by experts in the field in 16 highly informative chapters. Using well-documented studies over the past decade, this timely monograph demonstrates the current importance and future potential of natural products as starting points for the development of new drugs with improved properties over their progenitors. The examples are chosen so as to represent a wide range of natural products with therapeutic relevance among others, as anticancer agents, antimicrobials, antifungals, antisense nucleosides, antidiabetics, and analgesics. From the content: * Part I: Natural Products as Sources of Potential Drugs and Systematic Compound Collections * Part II: From Marketed Drugs to Designed Analogs and Clinical Candidates * Part III: Natural Products as an Incentive for Enabling Technologies * Part IV: Natural Products as Pharmacological Tools * Part V: Nature: The Provider, the Enticer, and the Healer |
| chemistry of natural products: Natural Products Chemistry Raymond Cooper, George Nicola, 2014-07-29 Notoriously cumbersome to isolate and challenging to synthesize, the path of natural products to viable drugs is an arduous journey. Yet compounds isolated from nature may possess fascinating structures, biological profiles and pharmaceutical potential far greater than anything made by man. Natural Products Chemistry: Sources, Separations and Structures presents a practical guide to sourcing, isolating, and discovering new compounds from nature many of which become pharmaceutical drugs. This book emphasizes the challenges and advantages of products acquired from nature, compared to those obtained from combinatorial chemistry. A basic introduction, the book describes the whole cycle from farm to final compound, backed up by case studies drawn from industry and research applications. It broadens the scope of applications and draws upon examples from various sources. Natural products chemistry, as taught today, draws its examples mainly from marine chemistry or plant chemistry; however, there is also a fascinating and rich world of fermented (microbial and algal) products leading to complex structures. Thus, the book draws upon examples from the microbial world and from insects too. Therefore, this is a source of bioactive metabolites, not traditionally available in academic settings, more the mainstay of the pharmaceutical industry. Providing a roadmap of the process of collecting a compound from nature, isolating the active ingredient, and determining the chemical structure, this book provides a unique approach to the world of natural products. |
| chemistry of natural products: Selected Topics in the Chemistry of Natural Products Raphael Ikan, 2008 Labor is the most important of the three traditional factors of production (land, labor and capital), accounting for some 75 per cent of the GDP. It is therefore important to focus on issues of labor economics. In this book the approach taken will be that of the free market philosophy of libertarianism, the perspective that allows the maximum of freedom, consistent with the responsibility of all to respect the equal rights of all others. The position of this book on unions is unique outside of the libertarian movement, and this is indicative of its analysis of several other issues, such as minimum wages. For scholars on the left, it is almost true that unions can do no wrong (for Marxists, they do not do enough, but that is another story). Their role is to raise wages for the workingman, and this task is almost unstintingly applauded. Conservatives, on the other hand, oppose unions root and branch (except for their support of foreign wars, which is also another story). To this end they support a welter of regulations, designed to reduce their power: limitations of check offs, forced secret ballots, etc. For libertarians, the analysis depends, intimately, on whether or not these are voluntary organizations. If they are, there is no more justification for imposing secret ballots on them than to do so for the chess or garden club. If they are not, they should not be weakened by restrictions, but, rather, banned, and their leaders imprisoned. |
| chemistry of natural products: Natural Products in Chemical Biology Natanya Civjan, 2012-07-03 Based on the award winning Wiley Encyclopedia of Chemical Biology, this book provides a general overview of the unique features of the small molecules referred to as natural products, explores how this traditionally organic chemistry-based field was transformed by insights from genetics and biochemistry, and highlights some promising future directions. The book begins by introducing natural products from different origins, moves on to presenting and discussing biosynthesis of various classes of natural products, and then looks at natural products as models and the possibilities of using them in medicine. |
| chemistry of natural products: The Chemistry of Natural Products - VIII T. R. Govindachari, 1973 |
| chemistry of natural products: Natural Products Chemistry Koji Nakanishi, Toshio Goto, Shô Itô, 2013-10-22 Natural Products Chemistry, Volume 1 covers the introductory survey, history, structure, synthesis, reactions, and biosynthesis of natural products. The book discusses the classification of natural products; physico-chemical data on natural products; and the mono- and sesquiterpenes. The text also describes the structure and biosynthesis of sester-, tri- and higher terpenoids, as well as of the steroids. Chemists, biochemists, and microbiologists will find the book invaluable. |
| chemistry of natural products: Natural Product Chemistry at a Glance Stephen P. Stanforth, 2006-08-11 Natural products have been a fertile area of chemical investigation for many years, driving the development of both analytical chemistry and of new synthetic reactions and methodologies. Many of the most important synthetic reactions in chemistry have been developed in the quest to characterise and synthesise these materials. Natural Product Chemistry at a Glance provides a concise overview of the main principles and reactions of natural product chemistry, for students studying chemistry and related courses at undergraduate level. Based on the highly successful and student friendly at a glance approach, the material developed in this book has been chosen to reinforce the principles of elementary organic reactions and to highlight the similarity between many organic reactions and biological processes. It will also serve as an initial platform for more advanced excursions into the origin of natural products. Students using Natural Product Chemistry at a Glance will find they have a resource with which they can quickly, economically and confidently acquire, regularly review and revise the basic facts that underpin the biosynthesis and chemistry of natural products. |
| chemistry of natural products: Chemistry of Plant Natural Products Sunil Kumar Talapatra, Bani Talapatra, 2015-03-05 Aimed at advanced undergraduate and graduate students and researchers working with natural products, Professors Sunil and Bani Talapatra provide a highly accessible compilation describing all aspects of plant natural products. Beginning with a general introduction to set the context, the authors then go on to carefully detail nomenclature, occurrence, isolation, detection, structure elucidation (by both degradation and spectroscopic techniques) stereochemistry, conformation, synthesis, biosynthesis, biological activity and commercial applications of the most important natural products of plant origin. Each chapter also includes detailed references (with titles) and a list of recommended books for additional study making this outstanding treatise a useful resource for teachers of chemistry and researchers working in universities, research institutes and industry. |
| chemistry of natural products: Medicinal Chemistry of Bioactive Natural Products Xiao-Tian Liang, Wei-Shuo Fang, 2006-03-17 Current discoveries and research into bioactive natural products Medicinal Chemistry of Bioactive Natural Products provides a much-needed survey of bioactive natural products and their applications in medicinal chemistry. This comprehensive reference features articles by some of the world's leading scientists in the field on discovery, structure elucidation, and elegant synthetic strategies--developed for natural products--with an emphasis on the structure activity relationship of bioactive natural products. The topics have been carefully chosen on the basis of relevance to current research and to importance as clinicially useful agents. Rather than attempting to be a comprehensive encyclopedia of bioactive natural products, Medicinal Chemistry of Bioactive Natural Products guides the reader to the key developments in the field. By providing not only practical detail but a historical perspective on the chemistry and biology of the compounds under consideration, the book serves as a handy resource for researchers in their own work developing pharmaceuticals, and as an inspiring introduction for young scientists to the dynamic field of bioactive natural products research. Enhanced by examples with updated research results, the discussion covers such topics as: * The chemistry and biology of epothilones * Vancomycin and other glycopeptide antibiotic derivates * Antitumor and other related activities of Taxol and its analogs * The antimalarial properties of the traditional Chinese medicine, Quinghaosu (artemisinin) * Huperzine A: A natural drug for the treatment of Alzheimer's disease * The medicinal chemistry of ginkgolides from Ginkgo biloba * Recent progress in Calophyllum coumarins as potent anti-HIV agents * Plant-derived anti-HIV agents and analogs * Chemical synthesis of annonaceous acetogenins and their structurally modified mimics |
| chemistry of natural products: Comprehensive Natural Products Chemistry Derek Barton, O. Meth-Cohn, 1999-02-18 Comprehensive Natural Products Chemistry |
| chemistry of natural products: Natural Products Dieter Sicker, Klaus-Peter Zeller, Hans-Ullrich Siehl, Stefan Berger, 2019-03-25 Written by experienced authors, this book presents numerous natural everyday products with a high range of structural diversity. Twenty natural products have been arranged in five sections, describing three alkaloids, five colored compounds, three carbohydrates and glycosides, seven terpenoids, and two aromatic compounds. Adopting a highly didactical approach, each chapter features a uniform structure: Background, in-depth information about isolation processes and structural characterization as well as a Q&A section at the end. Alongside the theoretical information many practical hints for the laboratory work are also included. A comprehensive overview of UV-, IR- and NMR-spectroscopy as well as mass-spectrometry for every exemplified compound is provided and the understanding of these methods is supported by concluding questions and exercises. Educating and entertaining, this full-color textbook turns the learning process into a real pleasure, not only for students in natural products chemistry but also experienced professionals. |
| chemistry of natural products: Medicinal Natural Products Paul M. Dewick, 2002-01-03 This guide covers classes of natural products in medicine, whether derived from plants, micro-organisms or animals. Structured according to biosynthetic pathway, it is written from a chemistry-based approach. |
| chemistry of natural products: Natural Products Isolation Satya D. Sarker, 2008-02-05 The term “natural products” spans an extremely large and diverse range of chemical compounds derived and isolated from biological sources. Our interest in natural products can be traced back thousands of years for their usefulness to humankind, and this continues to the present day. Compounds and extracts derived from the biosphere have found uses in medicine, agriculture, cosmetics, and food in ancient and modern societies around the world. Therefore, the ability to access natural products, understand their usefulness, and derive applications has been a major driving force in the field of natural product research. The first edition of Natural Products Isolation provided readers for the first time with some practical guidance in the process of extraction and isolation of natural products and was the result of Richard Cannell’s unique vision and tireless efforts. Unfortunately, Richard Cannell died in 1999 soon after completing the first edition. We are indebted to him and hope this new edition pays adequate tribute to his excellent work. The first edition laid down the “ground rules” and established the techniques available at the time. Since its publication in 1998, there have been significant developments in some areas in natural product isolation. To capture these developments, publication of a second edition is long overdue, and we believe it brings the work up to date while still covering many basic techniques known to save time and effort, and capable of results equivalent to those from more recent and expensive techniques. |
| chemistry of natural products: Natural Products Chemistry Tatiana G. Volova, Debarshi Kar Mahapatra, Sonia Khanna, A. K. Haghi, 2020-11-17 Natural Products Chemistry: Biomedical and Pharmaceutical Phytochemistry focuses on the development of biochemical, biomedical and their applications. It highlights the importance of accomplishing an integration of engineering with biology and medicine to understand and manage the scientific, industrial, and clinical aspects. It also explains both the basic science and the applications of biotechnology-derived pharmaceuticals, with special emphasis on their clinical use. The biological background provided enables readers to comprehend the major problems in biochemical engineering and formulate effective solutions. This title also expands upon current concepts with the latest research and applications, providing both the breadth and depth researchers need. The book also introduces the topic of natural products chemistry with an overview of key concepts. This book is aimed at professionals from industry, academicians engaged in chemical science or natural product chemistry research, and graduate-level students. |
| chemistry of natural products: Natural Products J. Mann, 1994 An account of the structure, chemistry, biosynthesis, and biological activity of most types of organic compounds, with each chapter devoted to classes of compounds, such as carbohydrates, nucleotides and polynucleotides, fatty acids, terpenoids, phenolics, and alkaloids. Includes numerous bandw diagrams. An excellent complement to a standard text on basic organic chemistry. For senior undergraduates and graduate students of organic and medicinal chemistry, biochemistry, pharmacy, and pharmacology. Annotation copyright by Book News, Inc., Portland, OR |
| chemistry of natural products: Frontiers in Natural Product Chemistry: Volume 7 Atta-ur-Rahman, 2021-11-27 Frontiers in Natural Product Chemistry is a book series devoted to publishing monographs that highlight important advances in natural product chemistry. The series covers all aspects of research in the chemistry and biochemistry of naturally occurring compounds, including research on natural substances derived from plants, microbes and animals. Reviews of structure elucidation, biological activity, organic and experimental synthesis of natural products as well as developments of new methods are also included in the series. Volume seven of the series brings seven reviews covering these topics: - Plant-Derived Anticancer Compounds Used in Cancer Therapies - Pradimicin and Benanomicin Antibiotics - The Chemical Compositions of Bixa orellana and their Pharmacological Activities - Overview of Phytochemistry and Pharmacology of Nilakanthi (Ajuga bracteosa Wall. ex Benth.) - Tetracyclic benzocarbazoles and derivatives - Chalcones as Antiinflammatory, Antidiabetic, and Antidepressant Agents - Bioactive Steroids from Marine Organisms |
| chemistry of natural products: Recent Advances in Natural Products Analysis Seyed Mohammad Nabavi, Mina Saeedi, Seyed Fazel Nabavi, Ana Teresa Sanches Silva, 2020-03-07 Recent Advances in Natural Products Analysis is a thorough guide to the latest analytical methods used for identifying and studying bioactive phytochemicals and other natural products. Chemical compounds, such as flavonoids, alkaloids, carotenoids and saponins are examined, highlighting the many techniques for studying their properties. Each chapter is devoted to a compound category, beginning with the underlying chemical properties of the main components followed by techniques of extraction, purification and fractionation, and then techniques of identification and quantification. Biological activities, possible interactions, levels found in plants, the effects of processing, and current and potential industrial applications are also included. - Focuses on the latest analytical techniques used for studying phytochemical and other biological compounds - Authored and edited by the top worldwide experts in their field - Discusses the current and potential applications and predicts future trends of each compound group |
| chemistry of natural products: Bioactive Natural Products Goutam Brahmachari, 2015-03-23 Ein multidisziplinärer Überblick über die aktuellen Themen und Zukunftstrends in der Erforschung von Naturstoffen mit Schwerpunkt auf pharmazeutischen und medizinischen Anwendungen. |
| chemistry of natural products: Molecular and Supramolecular Chemistry of Natural Products and Their Model Compounds Jurgen-Hinrich Fuhrhop, Claus Endisch, 2000-01-03 An assessment of the known properties of natural products and their model compounds to determine their usefulness in biological and medical experimentation, as well as in synkinetics - the reversible synthesis of noncovalent compounds. It explores new techniques such as cryoelectron and scanning force microscopy and solid-state NMR spectroscopy of membrane systems. There are 500 figures and reaction schemes. |
| chemistry of natural products: Bioactive Natural Products Goutam Brahmachari, 2012 Bioactive natural products are a rich source of novel therapeutics. Thus, the search for bioactive molecules from nature continues to play an important role in fashioning new medicinal agents. This volume, which comprises sixteen chapters written by active researchers and leading experts in natural products chemistry, brings together an overview of current discoveries in this remarkable field. It also provides information on the industrial application of natural products for medicinal purposes. This book will serve as a valuable resource for researchers to predict promising leads for developing pharmaceuticals to treat various ailments and disease manifestations. |
| chemistry of natural products: Chemistry of Natural Products Mayuri Napagoda, Lalith Jayasinghe, 2022-04-19 Plants produce secondary metabolites that humans harness for their own benefit. About half of drugs currently in clinical use are based on these chemicals found in nature. Chemistry of Natural Products covers secondary metabolites present in medicinal plants and their biosynthesis, biological activities, and isolation and separation techniques. This book is ideal for researchers in the areas of biochemistry, medicine, and pharmacology. |
| chemistry of natural products: Natural Product Extraction Mauricio A Rostagno, Juliana M Prado, 2015-10-09 Natural products are sought after by the food, pharmaceutical and cosmetics industries, and research continues into their potential for new applications. Extraction of natural products in an economic and environmentally-friendly way is of high importance to all industries involved. This book presents a holistic and in-depth view of the techniques available for extracting natural products, with modern and more environmentally-benign methods, such as ultrasound and supercritical fluids discussed alongside conventional methods. Examples and case studies are presented, along with the decision-making process needed to determine the most appropriate method. Where appropriate, scale-up and process integration is discussed. Relevant to researchers in academia and industry, and students aiming for either career path, Natural Product Extraction presents a handy digest of the current trends and latest developments in the field with concepts of Green Chemistry in mind. |
| chemistry of natural products: Progress in the Chemistry of Organic Natural Products , 2011-10-01 The volumes of this classic series, now referred to simply as Zechmeister after its founder, L. Zechmeister, have appeared under the Springer imprint ever since the series was founded in 1938. The volumes contain contributions on various topics related to the origin, distribution, chemistry, synthesis, biochemistry, function or use of various classes of naturally occurring substances ranging from small molecules to biopolymers. Each contribution is written by a recognized authority in his field and provides a comprehensive and up-to-date review of the topic in question. Addressed to biologists, technologists and chemists alike, the series can be used by the expert as a source of information and literature citations and by the non-expert as a means of orientation in a rapidly developing discipline. |
| chemistry of natural products: Natural Products and Drug Discovery Subhash C. Mandal, Vivekananda Mandal, Tetsuya Konishi, 2018-02-16 Natural Products and Drug Discovery: An Integrated Approach provides an applied overview of the field, from traditional medicinal targets, to cutting-edge molecular techniques. Natural products have always been of key importance to drug discovery, but as modern techniques and technologies have allowed researchers to identify, isolate, extract and synthesize their active compounds in new ways, they are once again coming to the forefront of drug discovery. Combining the potential of traditional medicine with the refinement of modern chemical technology, the use of natural products as the basis for drugs can help in the development of more environmentally sound, economical, and effective drug discovery processes. Natural Products & Drug Discovery: An Integrated Approach reflects on the current changes in this field, giving context to the current shift and using supportive case studies to highlight the challenges and successes faced by researchers in integrating traditional medicinal sources with modern chemical technologies. It therefore acts as a useful reference to medicinal chemists, phytochemists, biochemists, pharma R&D professionals, and drug discovery students and researchers. - Reviews the changing role of natural products in drug discovery, integrating traditional knowledge with modern molecular technologies - Highlights the potential future role of natural products in preventative medicine - Supported by real world case studies throughout |
| chemistry of natural products: Comprehensive Natural Products II , 2010-03-05 This work presents a definitive interpretation of the current status of and future trends in natural products—a dynamic field at the intersection of chemistry and biology concerned with isolation, identification, structure elucidation, and chemical characteristics of naturally occurring compounds such as pheromones, carbohydrates, nucleic acids, and enzymes. With more than 1,800 color figures, Comprehensive Natural Products II features 100% new material and complements rather than replaces the original work (©1999). Reviews the accumulated efforts of chemical and biological research to understand living organisms and their distinctive effects on health and medicine Stimulates new ideas among the established natural products research community—which includes chemists, biochemists, biologists, botanists, and pharmacologists Informs and inspires students and newcomers to the field with accessible content in a range of delivery formats Includes 100% new content, with more than 6,000 figures (1/3 of these in color) and 40,000 references to the primary literature, for a thorough examination of the field Highlights new research and innovations concerning living organisms and their distinctive role in our understanding and improvement of human health, genomics, ecology/environment, and more Adds to the rich body of work that is the first edition, which will be available for the first time in a convenient online format giving researchers complete access to authoritative Natural Products content |
| chemistry of natural products: Natural Product Chemistry for Drug Discovery Antony D Buss, Mark S Butler, 2009-10-21 Natural Product Chemistry for Drug Discovery provides a comprehensive summary of where natural product chemistry is today in drug discovery. The book covers emerging technologies and case studies and is a source of up-to-date information on the topical subject of natural products. Natural products are once again considered important tools in the drug discovery toolbox. The authors are all experts in their respective fields of natural product chemistry. The book will appeal across the board from scientists to professionals, postgraduates and industrial chemists. The case studies selected for inclusion highlight recently marketed drugs and development candidates that have been derived from natural products. These 'real-life' examples show how new technologies, such as advances in screening, isolation, dereplication and prefractionation, have significantly enhanced the discovery process. |
| chemistry of natural products: Progress in the Chemistry of Organic Natural Products / Fortschritte der Chemie Organischer Naturstoffe / Progrès dans la Chimie des Substances Organiques Naturelles P. R. Ashurst, F. Bohlmann, L. Farkas, Y. Gaoni, H. Kling, R. Mechoulam, G. A. Morrison, L. Pallos, J. Romo, A. Romo De Vivar, J. K. Sutherland, E. Waldschmidt-Leitz, Th. Wieland, 2012-12-06 Mit Beiträgen zahlreicher Fachwissenschaftler |
| chemistry of natural products: Natural Product Chemistry Kurt Torssell, 1997-07-01 This book will be of interest to senior undergraduate and postgraduate students of organic chemistry, biochemistry, biology and pharmacology, medical chemistry and research laboratories. |
| chemistry of natural products: Studies in Natural Products Chemistry Elfie Stocker-Wörgötter, Lucimara Mach Cortes Cordeiro, Marcello Iacomini, 2013-03-15 Lichens are fascinating symbiotic organisms, biosynthesizing a broad spectrum of interesting secondary metabolites and polysaccharides. A considerable number of them have been found to exert biological activities, such as antibiotic, antimycobacterial, antiviral, anti-inflammatory, analgesic, antipyretic, antiproliferative, and cytotoxic effects. Only a very low percentage of “lichen substances” have been actually screened for their biological activities and their potential therapeutic applications in medicine. This is due to difficulties to obtain large quantities of lichens from nature, isolated lichen fungi and algae from cultures for extractions. Ten years ago, we have started to bypass these problems by introducing first traditional and then by exploring novel microbiological techniques and advanced molecular tools for our culture experiments. “Case studies” with selected cultured mycobionts and photobionts, accumulating considerable quantities of a focused compound, have been performed as tests for large-scale culturing, to be able to utilize facilities like phytotrons and bioreactors (small-scale bioreactors) for future approaches. Further studies have focused on the chemical identification of the metabolites from cultures and the genetic characterization of lichen PKS genes (Polyketide synthase genes). Another interesting group of lichen metabolites is cell wall polysaccharides. All lichen species investigated so far produce these polymers in considerable amounts and many of them have been shown to exhibit antitumor, immunostimulating, antiviral as well as other types of biological activity. Lichens polysaccharides are mainly of the following structural types: α-glucans (isolichenan, nigeran, pseudonigeran, and pullulan), β-glucans (lichenan, pustulan, laminaran, and lentinan-type glucan), galactomannans, and complex heteroglycans (galactoglucomannan, galactomannoglucan, rhamnopyranosylgalactofuranan, and glucomannan). Investigations on lichen polysaccharides were carried out using material extracted from the entire thallus with no mention of the origin of component polymers (fungal partner or photobiont). In order to understand the contribution of the symbiotic partners to the polysaccharide present in the lichen thallus, the carbohydrates produced by some aposymbiotically cultured mycobionts and photobionts (Trebouxia, Asterochloris, and Coccomyxa) were analyzed. The studies demonstrated that most of the polysaccharides previously found in the symbiotic thalli were also produced by the aposymbiotically cultivated fungal partner, while there were no similarities between the polysaccharides extracted from the photobiont with those from the respective lichen. Surprisingly, the photobionts synthesized very interesting polysaccharides, such as β-galactofuranan, mannogalactofuranan, rhamnopyranosylgalactofuranan, and an O-methylated mannogalactan. One of them was biologically active, having in vitro activity on murine peritoneal macrophages. |
| chemistry of natural products: Natural Products of Woody Plants John W. Rowe, 2012-12-06 Wood as found in trees and bushes was of primary importance to ancient humans in their struggle to control their environment. Subsequent evolution through the Bronze and Iron Ages up to our present technologically advanced society has hardly diminished the importance of wood. Today, its role as a source of paper products, furniture, building materials, and fuel is still of major significance. Wood consists of a mixture of polymers, often referred to as lignocellulose. The cellulose micro fibrils consist of an immensely strong, linear polymer of glucose. They are associated with smaller, more complex polymers composed of various sugars called hemicelluloses. These polysaccharides are embedded in an amorphous phenylpropane polymer, lignin, creating a remarkably strong com posite structure, the lignocellulosic cell wall. Wood also contains materials that are largely extraneous to this lignocellulosic cell wall. These extracellular substances can range from less than 1070 to about 35% of the dry weight of the wood, but the usual range is 2% -10%. Among these components are the mineral constituents, salts of calcium, potassium, sodium, and other metals, particularly those present in the soil where the tree is growing. Some of the extraneous components of wood are too insoluble to be ex tracted by inert solvents and remain to give extractive-free wood its color; very often these are high-molecular-weight polyphenolics. |
| chemistry of natural products: Natural Product Biosynthesis Christopher T. Walsh, Yi Tang, 2017-04-28 This textbook describes the types of natural products, the biosynthetic pathways that enable the production of these molecules, and an update on the discovery of novel products in the post-genomic era. |
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Main Topics in Chemistry - ThoughtCo
What Is the Importance of Chemistry? - ThoughtCo
What Is the Importance of Chemistry? - ThoughtCo
The 5 Main Branches of Chemistry - ThoughtCo
The 5 Main Branches of Chemistry - ThoughtCo
A to Z Chemistry Dictionary - ThoughtCo
A to Z Chemistry Dictionary - ThoughtCo
