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| biologic therapies for crohn's disease: Advances in Inflammatory Bowel Diseases P. Rutgeerts, J-F. Colombel, S.B. Hanauer, J. Schölmerich, Guido Tytgat, A. van Gossum, 1998-12-31 Ulcerative colitis and Crohn's disease remain a great therapeutic challenge to the medical community. In recent years knowledge about the pathogenesis of these diseases has progressed rapidly but the cause of the diseases remains completely unknown. It has become clear that dysregulation of the mucosal immune system is the basis for the chronic evolution of the diseases in a genetically susceptible population. Exciting new therapeutic approaches have been attempted in the last couple of years and cytokine and anti-cytokine treatments in particular seem very promising, especially in intractable disease. The format of the Falk Symposium 106 on `Advances in Inflammatory Bowel Diseases', held in Brussels, Belgium, June 18-20, 1998, was somewhat innovative as each session attempted to link the new insights into pathogenetic mechanisms with new therapeutic approaches, resulting in optimal information transfer. The classic therapeutic schemes were updated with a special focus on step-wise build-up of therapy. |
| biologic therapies for crohn's disease: Biologics in Inflammatory Bowel Disease Scott Plevy Associate Professor of Medicine Division of Gastroenterology, 2010 SERIES OVERVIEW: The Oxford American Pocket Notes are a series of ultra-concise, small-format books for healthcare professionals on topics related to the diagnosis, treatment and management of various medical conditions. Each title typically features an outline of key points, guidelines and tools such as patient assessments and treatment algorithms, for a specific area of medical diagnosis and/or management. Highly practical in format, content and style, the Pocket Notes serve as a quick, easily accessible point-of-care reference for busy practitioners. In effect, they are miniature versions of the Oxford American Medical Library and Oxford American Handbooks in Medicine, capturing the key essentials needed for appropriate assessment and treatment. Inflammatory bowel disease (IBD) is a gastrointestinal condition which causes inflammation of the lining of the digestive tract. This disease affects an estimated one million Americans, usually in the forms of ulcerative colitis (UC) and Crohn's disease (CD). These two diseases have similar symptoms and are often confused for one another. Crohn's disease can occur anywhere in the digestive tract, often spreading deep into the layers of affected tissues, but ulcerative colitis usually affects only the innermost lining (mucosa) of the large intestine and rectum. IBD patients suffer from severe diarrhea and abdominal pain, and may experience other complications, such as arthritis and kidney stones, that affect the body beyond the intestinal tract. The Oxford American Pocket Notes: Biologics in Inflammatory Bowel Disease is a practical guide to the safe administration of biological agents to treat inflammatory gastrointestinal illnesses. This ultra-concise and practical volume focuses on tumor necrosis factor (TNF) blocking therapy (TNF blocker), an important new class of biologic therapy indicated for the treatment of several rheumatic and other auto-immune disorders, including Crohn's disease and ulcerative colitis. This uniquely compact and affordable book features evidence-based discussion and guidelines on the mechanism of action, dosing, administration and safety considerations for the biologic agents approved to treat CD and UC, thus providing practicing physicians with easily accessible tools and insights on the use of these drugs in a daily practice setting. Culled from the pages of Handbook of Biological Therapy, this portable guide is a valuable resource for gastroenterologists, primary care physicians and other healthcare providers involved in the management of these chronic but treatable diseases. |
| biologic therapies for crohn's disease: Treatment of Inflammatory Bowel Disease with Biologics Adam S. Cheifetz, Joseph D. Feuerstein, 2017-11-09 This book is a concise yet comprehensive overview of the use of biologics for the treatment of Crohn’s disease and ulcerative colitis. The volume details how best to utilize these medications in order to optimize their efficacy and safety, as well as how to understand, recognize, and treat complications that may arise from using biologics to treat IBD. The text also focuses on new data, novel biologics, and biosimilars of this rapidly expanding field. Written by experts in the field, Treatment of Inflammatory Bowel Disease with Biologics is a valuable resource for gastroenterologists, allied health professionals, fellows, and trainees who treat patients with inflammatory bowel disease. |
| biologic therapies for crohn's disease: Safe and Effective Medicines for Children Institute of Medicine, Board on Health Sciences Policy, Committee on Pediatric Studies Conducted Under the Best Pharmaceuticals for Children Act (BPCA) and the Pediatric Research Equity Act (PREA), 2012-10-13 The Best Pharmaceuticals for Children Act (BPCA) and the Pediatric Research Equity Act (PREA) were designed to encourage more pediatric studies of drugs used for children. The FDA asked the IOM to review aspects of pediatric studies and changes in product labeling that resulted from BPCA and PREA and their predecessor policies, as well as assess the incentives for pediatric studies of biologics and the extent to which biologics have been studied in children. The IOM committee concludes that these policies have helped provide clinicians who care for children with better information about the efficacy, safety, and appropriate prescribing of drugs. The IOM suggests that more can be done to increase knowledge about drugs used by children and thereby improve the clinical care, health, and well-being of the nation's children. |
| biologic therapies for crohn's disease: Biologics, Biosimilars, and Biobetters Iqbal Ramzan, 2021-02-03 A comprehensive primer and reference, this book provides pharmacists and health practitioners the relevant science and policy concepts behind biologics, biosimilars, and biobetters from a practical and clinical perspective. Explains what pharmacists need to discuss the equivalence, efficacy, safety, and risks of biosimilars with physicians, health practitioners, and patients about Guides regulators on pragmatic approaches to dealing with these drugs in the context of rapidly evolving scientific and clinical evidence Balances scientific information on complex drugs with practical information, such as a checklist for pharmacists |
| biologic therapies for crohn's disease: Harrison's Principles of Internal Medicine Tinsley Randolph Harrison, 1998 Classic text for practitioners, residents, and students. |
| biologic therapies for crohn's disease: The ASCRS Manual of Colon and Rectal Surgery David E. Beck, John L. Rombeau, Michael J. Stamos, Steven D. Wexner, 2009-06-12 The ASCRS Textbook of Surgery of the Colon and Rectum offers a comprehensive textbook designed to provide state of the art information to residents in training and fully trained surgeons seeking recertification. The textbook also supports the mission of the ASCRS to be the world’s authority on colon and rectal disease. The combination of junior and senior authors selected from the membership of the ASCRS for each chapter will provide a comprehensive summary of each topic and allow the touch of experience to focus and temper the material. This approach should provide the reader with a very open minded, evidence based approach to all aspects of colorectal disease. Derived from the textbook, The ASCRS Manual of Surgery of the Colon and Rectum offers a “hands on” version of the textbook, written with the same comprehensive, evidence-based approach but distilled to the clinical essentials. In a handy pocket format, readers will find the bread and butter information for the broad spectrum of practice. In a consistent style, each chapter outlines the condition or procedure being discussed in a concise outline format – easy to read, appropriately illustrated and referenced. |
| biologic therapies for crohn's disease: Pediatric Inflammatory Bowel Disease Petar Mamula, Jonathan E. Markowitz, Robert N. Baldassano, 2012-12-14 Pediatric Inflammatory Bowel Disease, Second Edition provides an essential reference with an emphasis on the unique pediatric issues of IBD. Chapters focus on complications of IBD specific to children and adolescents. Treatment recommendations are based on the latest clinical research available. The textbook also presents sections dedicated to the aspects of participation in clinical research unique to children and adolescents and the complicated yet vital process of successfully transitioning a patient from a pediatric to adult specialist. Controversies in pediatric IBD care such as the off-label use of medications are also covered. The format incorporates multiple tables, graphs, and figures to improve readability and make for an efficient reference for clinicians to use. Thoroughly revised and updated from the first edition, the volumes includes new therapies that are currently being used or tested for treatment of IBD, important areas regarding incidence and prevalence, immunization and response to vaccine administration as well as advancements in our understanding of growth and development with particular to the use of growth hormone therapy. Other new areas covered include important topics of complementary and alternative medicine use in IBD, immunization, and liver disease in IBD. Pediatric Inflammatory Bowel Disease, Second Edition is a valuable resource for pediatric gastroenterologists as well as adult gastroenterologists. |
| biologic therapies for crohn's disease: Crohn's Disease and Ulcerative Colitis Daniel C. Baumgart, 2017-03-01 This new edition is a unique combined resource for physicians and scientists addressing the needs of both groups. In addition to stimulating exchange and collaboration and shortening the path between discovery and application of new knowledge, the book helps clinicians understand new therapeutic concepts from their origins. The volume serves as a comprehensive guide to the current diagnostic modalities, including enhanced imaging techniques such as MRI and CT enterography, virtual colonoscopy, ultrasound, and endomicroscopy, as well as conventional and complex immunomodulatory principles. The latest edition also includes revised chapters from the previous edition, as well as new chapters reflecting current developments in the field. Written by experts in their field, Crohn’s Disease and Ulcerative Colitis: From Epidemiology and Immunobiology to a Rational Diagnostic and Therapeutic Approach, Second Edition is of great value to gastroenterologists, surgeons, internists, pediatricians and gynecologists trainees, as well as all those involved in Crohn’s disease, ulcerative colitis, and related autoimmune disorders. |
| biologic therapies for crohn's disease: Safety of Biologics Therapy Brian A. Baldo, 2016-08-12 This long overdue title provides a comprehensive, up-to-date, state-of-the art review of approved biologic therapies, with coverage of mechanisms of action, Indications for therapy, immunogenicity and a detailed examination of adverse effects and safety of the many and diverse therapeutic agents presented in a total of 13 chapters. It is predicted that by 2016, biologics will make up half of the world's 20 top-selling drugs and by 2018, biologic medicine sales will account for almost half of the world's 100 biggest selling drugs. Recombinant proteins dominate the growing list of the more than 200 approved biotherapeutic agents with targeted antibodies, fusion proteins and receptors; cytokines; hormones; enzymes; proteins involved in blood-clotting, homeostasis and thrombosis; vaccines; botulinum neurotoxins; and, more recently, biosimilar preparations, comprising the majority of approved biologics. Written with clinicians, other health care professionals, and researchers in mind, Safety of Biologics Therapy examines, in a single volume, the full range of issues surrounding the safety of approved biologic therapies. A good understanding of the risks and safety issues of modern biologics therapy is increasingly being demanded of all those connected with their development, handling, prescribing, administration and subsequent patient management. In addition to being of great value to clinicians in all branches of medicine, and to nurses, pharmacists and researchers, this book will prove invaluable for students taking undergraduate and graduate courses in the above disciplines and in the biomedical sciences. |
| biologic therapies for crohn's disease: Your Child with Inflammatory Bowel Disease North American Society for Pediatric Gastroenterology, Hepatology and Nutrition, 2010-06-10 When a child has inflammatory bowel disease, the family has many concerns: Why is my child sick? What can we do to help him get better? What does the future hold for her? In this book, an expert team of pediatric gastroenterologists explains the symptoms, diagnoses, and treatments associated with Crohn disease, ulcerative colitis, and indeterminate colitis to help parents and children cope with the challenges of IBD. The authors' empathy and experience are evident throughout as they answer such questions as: • What are inflammatory bowel disease, Crohn disease, and ulcerative colitis?• Is there a cure for IBD?• How is IBD going to affect my child's daily life?• Will my child's diet change?• Can my child still play sports?• Will my child need surgery?• What are the side effects of commonly prescribed medications? The book also provides parents with practical advice on how to tell their children about their IBD and discusses the challenges children may face at school and in their social lives, especially as they grow older. Additional information on IBD medications, complementary treatments, and further reading round out this comprehensive and reliable resource. |
| biologic therapies for crohn's disease: Evidence-Based Medicine Toolkit Carl Heneghan, Douglas Badenoch, 2013-05-06 This bestselling pocket guide to the skills of evidence-basedmedicine succeeds in demystifying the terminology and processes ina handy and easy-to-follow format, all within the space of 100pages. With an improved layout, this second edition ofEvidence-based Medicine Toolkit offers more up-to-dateguidance as well as new sections on important areas ofresearch. New features of this second edition include: A box for each major database showing how to search theevidence, and highlighting the differences between them Flow charts for different study types New critical appraisal sections on qualitative research andeconomic evaluation Expanded list of EBM resources on the net. With these added features to make the job easier, the newToolkit is now an even better companion for all health careprofessionals using evidence-based methodology in their researchand practice. |
| biologic therapies for crohn's disease: Inflammatory Bowel Diseases Ashwin N. Ananthakrishnan, Ramnik J. Xavier, Daniel K. Podolsky, 2017-04-24 Inflammatory Bowel Diseases: A Clinician’s Guide provides practical guidance for the diagnosis and management of those suspected or known to have one of the forms of these complex diseases. It is perfect both for gastroenterology trainees learning to care for these patients and the experienced physician as a concise and practical resource for day to day use. Written by the experts, Inflammatory Bowel Diseases: A Clinician’s Guide is an essential tool for all gastroenterologists managing patients with inflammatory bowel disease. |
| biologic therapies for crohn's disease: Endoscopy in Inflammatory Bowel Disease Richard Kozarek, Michael Chiorean, Michael Wallace, 2014-11-03 This book conjoins the latest advances on the use of endoscopy to diagnose, monitor, and treat patients with inflammatory bowel disease. Chapters include the historical use of rigid sigmoidoscopy, non-interventional imaging procedures, and the correlation of pathology and endoscopic visualization. This is the first book to include individual chapters in gastroenterology, colorectal surgery, and IBD texts, the preeminent role of endoscopic imaging in the management of chronic ulcerative colitis, and Crohn's disease. It also includes chapters on capsule endoscopy and balloon and overtube-assisted enteroscopy to define the presence and activity of Crohn's enteritis and additional chapters defining the use of random biopsies versus chromoendoscopy, and computer enhanced imaging to define possible dysplasia development. The book also includes access to online videos, making it the ultimate verbal and visual tool for all medical professionals interested in the advances in the field over the last several decades. Endoscopy in Inflammatory Bowel Disease is a concise text that is of great value to practicing endoscopists, gastroenterologists, general or colorectal surgeons, physicians in training, and all medical professionals caring for patients with inflammatory bowel disease. |
| biologic therapies for crohn's disease: Prognostic Factors in Cancer Paul Hermanek, 1995 |
| biologic therapies for crohn's disease: Current Medical Treatment Cyril William Holmes Havard, 1976 |
| biologic therapies for crohn's disease: WHO consolidated guidelines on tuberculosis. Module 2 World Health Organization, 2021-03-22 The WHO consolidated guidelines on tuberculosis. Module 2: screening – systematic screening for tuberculosis disease is an updated and consolidated summary of WHO recommendations on systematic screening for tuberculosis (TB) disease, containing 17 recommendations for populations in which TB screening should be conducted and tools to be used for TB screening. TB screening is strongly recommendations for household and close contacts of individuals with TB, people living with HIV, miners exposed to silica dust, and prisoners. In addition, screening is conditionally recommended for people with risk factors for TB attending health care, and for communities with risk factors for TB and limited access to care (e.g. homeless, urban poor, refugees, migrants). General population screening is recommended in high-burden settings (0.5% prevalence or higher). Symptoms, chest radiography (CXR), and molecular WHO-recommended rapid diagnostic tests for TB are recommended as screening tools for all adults eligible for screening. Computer-aided detection programmes are recommended as alternatives to human interpretation of CXR in settings where trained personnel are scarce. For people living with HIV, C-reactive protein is also a good screening tool. This guideline document is accompanied by an operational handbook, the WHO operational handbook on tuberculosis. Module 2: screening – systematic screening for tuberculosis disease, that presents principles of screening, steps in planning and implementing a screening programme, and algorithm options for screening different populations. |
| biologic therapies for crohn's disease: Mild to Moderate Psoriasis John Y. M. Koo, Ethan C. Levin, Argentina Leon, Jashin J. Wu, Mark G. Lebwohl, 2014-03-18 Using a practical and problem-focused approach, this updated, full-color Third Edition of Mild-to-Moderate Psoriasis equips dermatologists, internists, family practitioners, and residents with a state-of-the-art guide to the clinical management of mild-to-moderate psoriasis.Written by an international team of key opinion leaders, this resource explores new developments in treatments for the condition and provides clinicians with up-to-date strategies for optimal patient management. |
| biologic therapies for crohn's disease: CDC Yellow Book 2018: Health Information for International Travel Centers for Disease Control and Prevention CDC, 2017-04-17 THE ESSENTIAL WORK IN TRAVEL MEDICINE -- NOW COMPLETELY UPDATED FOR 2018 As unprecedented numbers of travelers cross international borders each day, the need for up-to-date, practical information about the health challenges posed by travel has never been greater. For both international travelers and the health professionals who care for them, the CDC Yellow Book 2018: Health Information for International Travel is the definitive guide to staying safe and healthy anywhere in the world. The fully revised and updated 2018 edition codifies the U.S. government's most current health guidelines and information for international travelers, including pretravel vaccine recommendations, destination-specific health advice, and easy-to-reference maps, tables, and charts. The 2018 Yellow Book also addresses the needs of specific types of travelers, with dedicated sections on: · Precautions for pregnant travelers, immunocompromised travelers, and travelers with disabilities · Special considerations for newly arrived adoptees, immigrants, and refugees · Practical tips for last-minute or resource-limited travelers · Advice for air crews, humanitarian workers, missionaries, and others who provide care and support overseas Authored by a team of the world's most esteemed travel medicine experts, the Yellow Book is an essential resource for travelers -- and the clinicians overseeing their care -- at home and abroad. |
| biologic therapies for crohn's disease: Nutrition Guide for Clinicians Neal D. Barnard, Rick Weissinger, MS, Brent J. Jaster, MD, 2009 Designed by medical professionals, this manual is a comprehensive, portable medical reference that covers nearly one hundred diseases and conditions, including risk factors, diagnoses, and typical treatments. Most importantly, it provides the latest evidence-based information on nutrition's role in prevention and treatment. |
| biologic therapies for crohn's disease: Personalizing Treatment In IBD: Hype or Reality In 2020? Fernando Gomollón, Edouard Louis, 2021-07-05 |
| biologic therapies for crohn's disease: Surgery for Crohn's Disease Stephen M. Kavic, 2015 Crohn's disease is a chronic illness that afflicts millions of patients worldwide. Despite its increasing recognition as a medical specialty within gastroenterology, there has been little attention devoted to Crohn's from a surgical perspective. This volume fills that void and acts as the first catalogue to address the surgical management of Crohn's disease. The goal of this work was to provide surgeons with the latest medical and surgical information to manage patients with Crohn's disease effectively.In this book, contributions from both gastroenterologists describe the history, diagnosis, nutrition, medical management, and surveillance of Crohn's disease. Chapters from general and colorectal surgeons detail common clinical techniques, minimally invasive surgical approach and management of perianal disease. In addition, surgical complications specific to Crohn's disease are also reviewed.This book provides all of the essential information needed in the surgical management of Crohn's disease in one simple volume. It aims to be a useful resource for practicing surgeons and surgical residents as well as gastroenterologists. The authors wish readers to understand the complex decision making and sophisticated surgical techniques that these patients often demand. |
| biologic therapies for crohn's disease: Beat Crohn's! Margaret A. Oppenheimer, 2009 Presents a dietary treatment for Crohn's disease and offers practical tips for implementing the regimen and a comparison of the benefits of this nutritional program as contrasted with the use of immunosuppressive drugs. |
| biologic therapies for crohn's disease: Curbside Consultation in IBD David T. Rubin, Sonia Friedman, Francis A. Farraye, 2009 Are you looking for concise, practical answers to questions that are often left unanswered by traditional IBD references? Are you seeking brief, evidence-based advice for complicated cases or complications? Curbside Consultation in IBD: 49 Clinical Questions provides quick and direct answers to the thorny questions commonly posed during a curbside consultation between colleagues. Dr. David Rubin, Dr. Sonia Friedman and Dr. Francis A. Farraye have designed this unique reference, which offers expert advice, preferences, and opinions on tough clinical questions commonly associated with IBD. The unique Q&A format provides quick access to current information related to IBD with the simplicity of a conversation between two colleagues. Numerous images, diagrams, and references are included to enhance the text and to illustrate IBD. Curbside Consultation in IBD: 49 Clinical Questions provides information that high-volume clinicians will appreciate, and yet is basic enough for residents. Gastroenterologists, fellows and residents in training, surgical attendings, and surgical residents will benefit from the user-friendly and casual format and the expert advice contained within. Some of the questions that are answered: - Which patients might be better for a top down approach (using anti-TNF therapy before steroids or proven failure of oral thiopurines)? What clinical behavior or serological markers might you use to identify these patients? - When is it appropriate to switch to another biologic therapy? - Should I be using chromoendoscopy in my surveillance colonoscopy in IBD? How and which agent? Would narrow band imaging be an alternative for this? - Can we follow flat low-grade dysplasia? Is any dysplasia really flat or just a spectrum of depth and size? - If women continue infliximab therapy during pregnancy, what are the implications for the baby? What should we be telling our patients about vaccinations? |
| biologic therapies for crohn's disease: Therapy for Severe Psoriasis E-Book Jashin J. Wu, Steven R. Feldman, Mark Lebwohl, 2016-12-02 A brand-new title in the field of dermatology, Therapy for Severe Psoriasis provides the ultimate coverage of the treatment options available for today's most serious cases, including biologics and oral therapies. It features discussions of the newest drug therapies, recent FDA-approved biosimilars, and combination approaches to care, while an overview chapter was designed to aid those new to the field in understanding the nuances of difficult-to-treat subtypes of psoriasis. Comprehensive and focused, Therapy for Severe Psoriasis will be a welcome addition to the library of any dermatologist seeking in-depth information on the challenges of this condition. - Each of the 16 chapters includes either an in-depth focus on a single therapy or an overview of a unique aspect of psoriasis, including: UVB therapy, methotrexate, acitretin, cyclosporine, apremilast, etanercept, infliximab, adalimumab, ustekinumab, secukinumab, and ixekizumab. - Takes an evidence-based approach to hard-to-treat severe psoriasis. - Discusses the newest drug therapies (such as ixekizumab), plus recent FDA-approved biosimilars, a topic unique to this particular psoriasis text. - Presents combination approaches for instances when standard treatments are not successful. - Includes an overview chapter to help beginners understand the nuances of the disorder. |
| biologic therapies for crohn's disease: Breastfeeding and Medication Wendy Jones, 2018-05-11 Sadly, women often feel they have no alternative but to give up breastfeeding, having been prescribed or purchased medication. In many cases, however, this is unnecessary. This book outlines the evidence base for the use of medication during breastfeeding. Breastfeeding and Medication presents a comprehensive A to Z guide to the most frequently prescribed drugs and their safety for breastfeeding mothers. Evaluating the evidence for interventions and using a simple format for quickly identifying medications that are safe or unsafe to use, it also highlights those drugs where there is inconclusive evidence. Additional contextual information makes this the most complete text for those practitioners who support and treat breastfeeding women. It: provides an overview of the anatomy and physiology of the breast together with hormonal influences to better understand how complications, such as mastitis, arise and inform the approach to their treatment; includes a section on conditions that affect women specifically when they are lactating where prescription of medication may be necessary; discusses the importance of breastfeeding and its advantages, as well as its disadvantages; and explores how to support breastfeeding mothers, and presents a counselling model approach. This new edition contains information on more drugs and a chapter on the management of some chronic conditions which may affect breastfeeding mothers. In most cases there are options to support the mother’s optimal care whilst allowing her to continue to breastfeed her baby as long as she wishes. This is a topic which raises many questions on social media, which informed the choice of conditions to consider. This is an invaluable reference for all health practitioners and volunteers who work with, support and treat breastfeeding women, including lactation consultants, breastfeeding support workers, health visitors, GPs, practice nurses, pharmacists and midwives. |
| biologic therapies for crohn's disease: Living with Crohn's & Colitis Jessica Black, N.D., Dede Cummings, 2010-06-29 A wellness plan for those with inflammatory bowel diseases like Crohn’s and ulcerative colitis—with expert guidance on creating a gut-healthy diet, finding the right treatments for you, and much more Approximately 1.5 million people in the United States alone are afflicted with inflammatory bowel disease (IBD), a category of illnesses that includes Crohn’s disease and ulcerative colitis, and that number is steadily growing. Although there is not yet a cure for Crohn’s or ulcerative colitis, patients can help reduce their symptoms and improve their overall wellbeing by following a comprehensive wellness plan such as those outlined in Living with Crohn’s & Colitis. Living with Crohn’s & Colitis offers patient-focused, expert guidance on everything from the latest medical treatments, how to cope with a diagnosis, and tips for balancing diet with a busy lifestyle so you can form a personalized wellness plan. Also included: • Easy to understand information on the role of inflammation and the immune system on gut health • Traditional and alternative treatment options for a broad, full-body approach to wellness • A three-month wellness plan adjustable to each individual’s health needs • Over 25 delicious recipes designed for those with IBD Learning to live with the myriad aspects of Crohn’s and ulcerative colitis treatment, including dietary restrictions and medications, can seem overwhelming. Written by a naturopathic doctor and a Crohn’s patient, Living with Crohn’s & Colitis is a thoughtful, balanced resource to help you on your journey to wellness. |
| biologic therapies for crohn's disease: Management of Psoriasis Nikhil Yawalkar, 2009 Treatments for psoriasis, besides affecting the skin, may be associated with various comorbidities (for instance, depression, psoriatic arthritis, Crohn's disease and, in severe psoriasis, metabolic syndrome and cardiovascular diseases), which often presents a therapeutic challenge to physicians.Written by renowned experts, this volume gives a comprehensive overview of psoriasis and its various comorbidities. It describes the treatment modalities for mild and moderate-to-severe psoriasis, including topical, phototherapeutic and conventional systemic treatments (e.g. acitretine, methotrexate and cyclosporine), as well as biological therapies (e.g. alefacept, efalizumab, etanercept, adalimumab and infliximab). The chapters on biological therapies focus on key safety issues. Further chapters focus on such topics as the management of childhood psoriasis and psoriasis in distinctive locations, such as the scalp, face, flexures, palm/soles and nails. Finally, future therapeutic modalities, with the focus on small molecules and potential biological therapies, are discussed.This publication will make significant reading to dermatologists and all physicians dealing with psoriasis, such as general practitioners, psychiatrists, rheumatologists, cardiologists and diabetologists. |
| biologic therapies for crohn's disease: Therapeutic Immunosuppression Angus W. Thomson, 2001 This work has broad applications in clinical medicine, ranging from prevention and treatment of organ and bone marrow transplant rejection, management of various autoimmune disorders (for example, rheumatoid arthritis), skin disease and asthma. Whereas traditionally only a small repertoire of immunosuppressive agents was available for clinical use, recent discoveries have significantly increased the number of approved agents, resulting in numerous trials to further evaluate their potential. There is also considerable interest in the potential of cell-based therapies (particularly hematopoietic stem and dendritic cell therapy) of allo- and autoimmunity. Important recent advances in the immunotherapy of allergic diseases are also covered in this book. This volume is intended both for practising physicians and surgeons and for biomedical scientists at the graduate/postdoctoral levels, and is designed to provide the theory behind these various approaches to immunosuppression, and to provide state-of-the-art reviews of current developments in each area. |
| biologic therapies for crohn's disease: Moderate to Severe Psoriasis John Koo, Jashin Wu, Alice Gottlieb, Ethan Levin, Argentina Leon, 2014-03-18 Written by experts in the dermatology field, this new fourth edition of Moderate-to-Severe Psoriasis discusses the current use of biologics and other pharmacologic and phototherapy treatments for moderate-to-severe psoriasis. Illustrated with high quality color figures, this standalone text emphasizes safe and effective treatments for the psoriasis |
| biologic therapies for crohn's disease: Mechanisms of Intestinal Inflammation R. Duchmann, 2004-04-30 In recent years considerable progress has been achieved in regard to our understanding of the induction and modulation of the immune response in the intestinal mucosa. It is clear that this mucosal immune reaction is predominantly steered by certain T-cell populations, which are characterized by their cytokine secretion profile. Less well known are the conditions under which the uptake and processing of a specific antigen leads to a certain immune response, whether it be protective, tolerant or inflammatory. However, here again distinct progress has been made in our understanding. Equally significant for immune regulation in the gut appears to be so-called innate immunity. Every shift of equilibrium in the highly regulated mucosal immune reaction is accompanied by an inflammatory reaction and destruction of the mucosa. In nearly all cases, this inflammatory response is dependent on the presence of bacterial intestinal flora. This book, the proceedings of Falk Symposium 133 on Mechanisms of Intestinal Inflammation: Implications for Therapeutic Intervention in IBD', held in Berlin, Germany, on 10-11 June 2003, summarizes present knowledge in the area of unspecific and specific immune reactions in the gut, recording the gaps in our knowledge and, in particular, presenting the possibilities of targeted intervention. The link to inflammatory bowel diseases - Crohn's disease and ulcerative colitis - is always in focus. Chapters by an international panel of basic scientists, clinical researchers and clinicians also record the problems which can originate through today's possible modulation of the immune reaction, setting the basis for review of clinical problems. This book is valuable readings for all scientists and physicians, who, from different perspectives, have an interest in research on IBD and in the clinical management of these diseases. |
| biologic therapies for crohn's disease: Obstetric Medicine Catherine Nelson-Piercy, Joanna Girling, 2007-05-26 Recognition of the importance of maternal medicine is now reflected in the content of the MRCOG exam, core training and higher training in both obstetrics and medicine. This book approaches obstetric medicine from the point of view of real patients and clinical scenarios as well as model answers to exam questions. The book will be invaluable for trainees and consultants who want to ‘test themselves’. |
| biologic therapies for crohn's disease: Adverse Reactions to Biologics L. Puig, W. Gulliver, 2017-11-07 In many areas of medicine physicians still face the great challenge of finding therapies that will meet the patients’ needs. In dermatology the challenge has arisen on multiple fronts through advances in the understanding of the immunopathogenesis of many inflammatory and malignant cutaneous disorders. Breakthroughs, combined with significant developments in targeted immunotherapy, have resulted in improved outcomes as these newer therapies are being used for both approved indications and as off-label therapies for various chronic inflammatory skin disorders and many forms of skin cancer. In the expectation that by truly understanding the safety profile of these targeted therapies patients’ outcomes will be significantly improved, this book offers insights into topics such as adverse reactions, infectious complications and the perioperative use of biologics in psoriasis, immunogenicity of biologic therapies, paradoxical reactions, safety of biologics used to treat autoimmune bullous diseases and primary cutaneous lymphomas, adverse reactions and skin manifestations of therapies targeting melanoma and non-melanoma skin cancer and other neoplastic diseases. Eminent researchers with extensive clinical experience have contributed to this publication, providing an in-depth overview of the latest knowledge in this field. |
| biologic therapies for crohn's disease: Drug-Induced Liver Injury , 2019-07-13 Drug-Induced Liver Injury, Volume 85, the newest volume in the Advances in Pharmacology series, presents a variety of chapters from the best authors in the field. Chapters in this new release include Cell death mechanisms in DILI, Mitochondria in DILI, Primary hepatocytes and their cultures for the testing of drug-induced liver injury, MetaHeps an alternate approach to identify IDILI, Autophagy and DILI, Biomarkers and DILI, Regeneration and DILI, Drug-induced liver injury in obesity and nonalcoholic fatty liver disease, Mechanisms of Idiosyncratic Drug-Induced Liver Injury, the Evaluation and Treatment of Acetaminophen Toxicity, and much more. - Includes the authority and expertise of leading contributors in pharmacology - Presents the latest release in the Advances in Pharmacology series |
| biologic therapies for crohn's disease: Gutbliss Robynne Chutkan, MD, 2013-10-03 A renowned physician shares her complete 10-day digestive tune-up for women, with important revelations about good gastrointestinal health. Many so-called cures for women’s bloating and indigestion, from juice cleanses to specialty diets, are based on junk science. For women seeking true relief from that overall feeling of discomfort in any size jeans, Dr. Robynne Chutkan has the perfect plan for feeling light, tight, and bright in ten days. Gutbliss offers: A primer on the real reasons for gastrointestinal distress, and why it’s much more common in women A look at the debilitating side effects of supposedly healthy habits—from Greek yogurt to bloat-inducing aspirin An expert analysis of symptoms that could indicate a serious underlying condition An indispensable checklist to pinpoint the exact cause of your bloating Just a few small changes in diet, lifestyle, and exercise can make a huge difference in a woman’s digestive health, but the changes have to be the right ones. Going beyond the basics of top sellers such as Wheat Belly, Dr. Chutkan’s Gutbliss empowers women to take control of their gastrointestinal wellness. |
| biologic therapies for crohn's disease: Neurorheumatology Tracey A. Cho, Shamik Bhattacharyya, Simon Helfgott, 2019-06-29 This detailed, practical textbook focuses on immune mediated disorders of the nervous system with particular focus on systemic autoimmune disorders. Divided into three sections, the first discusses the neuroanatomical and pathophysiologic basis of immune mediated disorders of the nervous system. Following this are 25 chapters devoted to individual clinical conditions. To conclude, the final section explains what is known about the mechanisms of immunomodulatory treatments and practical points about monitoring patients on these treatments. Neurorheumatology: A Comprehensive Guide to Immune Mediated Disorders of the Nervous System bridges the gaps among different branches of medicine and is an indispensable resource for rheumatologists and neurologists looking to develop a firm understanding of these dynamic disorders |
| biologic therapies for crohn's disease: The Essential RBRVS Ingenix, 2009 |
| biologic therapies for crohn's disease: Lectures on Pathological Anatomy Sir Samuel Wilks, Walter Moxon, 1875 |
| biologic therapies for crohn's disease: Biological Drugs Amit Sengupta, 2018 |
| biologic therapies for crohn's disease: Advanced Therapy of Inflammatory Bowel Disease, Volume 2 Theodore M. Bayless, Stephen B. Hanauer, 2014-05-14 Now published in two volumes to accommodate new chapters on the many advances in understanding and treatment options, this set of volumes represents the definitive reference on inflammatory bowel disease, a spectrum of diseases that is receiving increasing attention as our understanding of the etiological factors increases and diagnostic tools are refined. Basic research accelerated at the beginning of this decade and is now yielding new, more targeted treatments than were available just a few years ago. Volume 1 is on IBD and Ulcerative Colitis, and Volume 2 is on IBD and Crohn's Disease. All areas that were covered in the 2nd edition have been expanded and updated. New sections include the rapidly expanding knowledge of genetics and the role of the intestinal flora and environmental factors in etiology and pathogenesis. Among the 168 chapters, there are 20 on biologic therapies and 30 on surgical management. The consultant/authors clearly state their approach to important issues, such as the duration of immunomodulator and of anti-TNF-a use and the options for managing isolated low-grade dysplasia. A strong focus on the individual patient is woven throughout both volumes, including the benefits and risks of potentially life-altering therapies and surgeries. Entire sections detail concerns about the well-being of each person. This book provides information for health professionals who help both pediatric and adult patients navigate through the lifelong shadow of a chronic, probably genetically determined ordeal. |
BIOLOGIC AND BIOSIMILAR MEDICATIONS - Crohn’s and …
Biologic medications currently approved for treatment of Crohn’s disease and ulcerative colitis in Canada have been developed to target specific molecules within the inflammatory processes …
Inflammatory Bowel Disease Biologic Pathway
Vedolizumab: Can use 300mg IV dose at week 10 in Crohn’s disease and also 4 weekly maintenance dosing in both Crohn’s disease and UC when using the IV preparation. If loss of …
Positioning Therapies in the Management of Crohn's Disease
In the past decade, several new therapies with different mechanisms of action have been approved for the man-agement of moderate to severe Crohn’s disease. However, there is …
Comparative efficacy and safety of biologic therapies for …
We aimed to assess the comparative eficacy and safety of biologics in patients with Crohn’s disease.
Comparative Effectiveness of Immunosuppressants and …
We identified randomized controlled trials (N 39) comparing methotrexate, azathioprine/6-mercaptopurine, in iximab, adalimumab, certolizumab, vedolizumab, or combined thera-pies …
Comparative Safety and Effectiveness of Biologic Therapy for …
With a paucity of head-to-head trials, real-world evidence can inform the comparative effectiveness and safety of biologic therapies for the management of Crohn’s disease (CD).
Biologic Therapies for Crohn’s Disease: Update from the …
Review the current role of biologic therapies in the treatment of moderatetosevere Crohn’s disease. Outline emerging data on the use of biologics as they relate to use in clinical practice. …
Optimal use of biologics in the management of Crohn’s disease
In order to achieve short-term and long-term goals with these new agents, it is important to review how these therapies may be optimized for the best results.
CROHN’S DISEASE: BIOLOGIC THERAPY - Crohn’s and …
Biologic medications for IBD target specific activity in the immune system to treat inflammation, which is the body’s normal response to things like injury, infection, stress and pain.
Head-to-head biologic therapy in Crohn's disease - The Lancet
top-down therapy, with early use of biologic therapy increasingly favoured over conventional therapy (corticosteroids and immunomodulators). Three classes of biologic therapy are …
Fact Sheet - Crohn's & Colitis Foundation
Medical treatment for Crohn’s disease and ulcerative colitis has two main goals: achieving remission and then maintaining remission. Biologics are antibodies created in the laboratory …
Crohn's Disease: Use of Biologic Agents to Treat Adult …
Treatment with biologic agents should be initiated and reviewed by specialist clinicians with experience of biologic therapy and of managing CD.
Biologic Therapies inCrohn’s Disease
In patients with moderate to severe Crohn’s, resistant to therapy with steroids, mesalamine and azathioprine, 65% of infliximab-treated patients showed a clinical response, as compared to 17%
Comparative Effectiveness of Biologic Therapies in …
Comparative effectiveness of biologics in preventing penetrating disease (PD) in Crohn’s dis-ease (CD) is not well established. We compared the risk of developing luminal and perianal PD …
Treatment Pathways Leading to Biologic Therapies for …
Biologic therapies have been available for inflammatory bowel disease for >20 years, but patient outcomes have not changed appreciably over this time period.
A step towards informed positioning of advanced therapies …
Since the approval of infliximab for moderate-to-severe Crohn’s disease in 1998, newer biologic therapies have emerged, leading to ongoing questions about their optimal positioning, both as …
Newer Biologic and Small-Molecule Therapies for …
In this review, we discuss how to initiate, switch, combine, and terminate such therapies.
Fact Sheet - Crohn's & Colitis Foundation
Over the last several years, new treatments called biologics have been available for the treatment of inflammatory bowel disease (IBD) and other inflammatory diseases. These treatments are …
INFORMATION SHEET BIOLOGIC MEDICINES - Crohn's and …
Whether you’ve been prescribed a biologic for Crohn’s or Colitis or you’re considering it as an option, this information sheet is for you. It looks at: • the different biologics available for …
BIOLOGIC AND BIOSIMILAR MEDICATIONS - Crohn’s and …
Biologic medications currently approved for treatment of Crohn’s disease and ulcerative colitis in Canada have been developed to target specific molecules within the inflammatory processes …
Inflammatory Bowel Disease Biologic Pathway
Vedolizumab: Can use 300mg IV dose at week 10 in Crohn’s disease and also 4 weekly maintenance dosing in both Crohn’s disease and UC when using the IV preparation. If loss of …
Positioning Therapies in the Management of Crohn's Disease
In the past decade, several new therapies with different mechanisms of action have been approved for the man-agement of moderate to severe Crohn’s disease. However, there is …
Comparative efficacy and safety of biologic therapies for …
We aimed to assess the comparative eficacy and safety of biologics in patients with Crohn’s disease.
Comparative Effectiveness of Immunosuppressants and …
We identified randomized controlled trials (N 39) comparing methotrexate, azathioprine/6-mercaptopurine, in iximab, adalimumab, certolizumab, vedolizumab, or combined thera-pies …
Comparative Safety and Effectiveness of Biologic Therapy for …
With a paucity of head-to-head trials, real-world evidence can inform the comparative effectiveness and safety of biologic therapies for the management of Crohn’s disease (CD).
Biologic Therapies for Crohn’s Disease: Update from the …
Review the current role of biologic therapies in the treatment of moderatetosevere Crohn’s disease. Outline emerging data on the use of biologics as they relate to use in clinical practice. …
Optimal use of biologics in the management of Crohn’s disease
In order to achieve short-term and long-term goals with these new agents, it is important to review how these therapies may be optimized for the best results.
CROHN’S DISEASE: BIOLOGIC THERAPY - Crohn’s and Colitis
Biologic medications for IBD target specific activity in the immune system to treat inflammation, which is the body’s normal response to things like injury, infection, stress and pain.
Head-to-head biologic therapy in Crohn's disease - The …
top-down therapy, with early use of biologic therapy increasingly favoured over conventional therapy (corticosteroids and immunomodulators). Three classes of biologic therapy are …
Fact Sheet - Crohn's & Colitis Foundation
Medical treatment for Crohn’s disease and ulcerative colitis has two main goals: achieving remission and then maintaining remission. Biologics are antibodies created in the laboratory …
Crohn's Disease: Use of Biologic Agents to Treat Adult …
Treatment with biologic agents should be initiated and reviewed by specialist clinicians with experience of biologic therapy and of managing CD.
Biologic Therapies inCrohn’s Disease
In patients with moderate to severe Crohn’s, resistant to therapy with steroids, mesalamine and azathioprine, 65% of infliximab-treated patients showed a clinical response, as compared to 17%
Comparative Effectiveness of Biologic Therapies in …
Comparative effectiveness of biologics in preventing penetrating disease (PD) in Crohn’s dis-ease (CD) is not well established. We compared the risk of developing luminal and perianal PD …
Treatment Pathways Leading to Biologic Therapies for …
Biologic therapies have been available for inflammatory bowel disease for >20 years, but patient outcomes have not changed appreciably over this time period.
A step towards informed positioning of advanced therapies …
Since the approval of infliximab for moderate-to-severe Crohn’s disease in 1998, newer biologic therapies have emerged, leading to ongoing questions about their optimal positioning, both as …
Newer Biologic and Small-Molecule Therapies for …
In this review, we discuss how to initiate, switch, combine, and terminate such therapies.
