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| biobuilder synthetic biology in the lab: BioBuilder Natalie Kuldell PhD., Rachel Bernstein, Karen Ingram, Kathryn M Hart, 2015-06-22 [P]rovides open-access, modular, hands-on lessons in synthetic biology for secondary and post-secondary classrooms and laboratories--Page [4] of book cover |
| biobuilder synthetic biology in the lab: Synthetic Biology - a Primer (revised Edition) Paul S. FREEMONT, Richard I. KITNEY, 2015-08-24 Synthetic Biology -- A Primer (Revised Edition) presents an updated overview of the field of synthetic biology and the foundational concepts on which it is built. This revised edition includes new literature references, working and updated URL links, plus some new figures and text where progress in the field has been made.The book introduces readers to fundamental concepts in molecular biology and engineering and then explores the two major themes for synthetic biology, namely 'bottom-up' and 'top-down' engineering approaches. 'Top-down' engineering uses a conceptual framework of systematic design and engineering principles focused around the Design-Build-Test cycle and mathematical modelling. The 'bottom-up' approach involves the design and building of synthetic protocells using basic chemical and biochemical building blocks from scratch exploring the fundamental basis of living systems.Examples of cutting-edge applications designed using synthetic biology principles are presented, including: The book also describes the Internationally Genetically Engineered Machine (iGEM) competition, which brings together students and young researchers from around the world to carry out summer projects in synthetic biology. Finally, the primer includes a chapter on the ethical, legal and societal issues surrounding synthetic biology, illustrating the integration of social sciences into synthetic biology research.Final year undergraduates, postgraduates and established researchers interested in learning about the interdisciplinary field of synthetic biology will benefit from this up-to-date primer on synthetic biology. |
| biobuilder synthetic biology in the lab: Biopunk Marcus Wohlsen, 2012-07-31 Bill Gates recently told Wired that if he were a teenager today, he would be hacking biology. If you want to change the world in some big way, he says, that's where you should start-biological molecules. The most disruptive force on the planet resides in DNA. Biotech companies and academic researchers are just beginning to unlock the potential of piecing together life from scratch. Champions of synthetic biology believe that turning genetic code into Lego-like blocks to build never-before-seen organisms could solve the thorniest challenges in medicine, energy, and environmental protection. But as the hackers who cracked open the potential of the personal computer and the Internet proved, the most revolutionary discoveries often emerge from out-of-the-way places, forged by brilliant outsiders with few resources besides boundless energy and great ideas. In Biopunk, Marcus Wohlsen chronicles a growing community of DIY scientists working outside the walls of corporations and universities who are committed to democratizing DNA the way the Internet did information. The biohacking movement, now in its early, heady days, aims to unleash an outbreak of genetically modified innovation by making the tools and techniques of biotechnology accessible to everyone. Borrowing their idealism from the worlds of open-source software, artisinal food, Internet startups, and the Peace Corps, biopunks are devoted advocates for open-sourcing the basic code of life. They believe in the power of individuals with access to DNA to solve the world's biggest problems. You'll meet a new breed of hackers who aren't afraid to get their hands wet, from entrepreneurs who aim to bring DNA-based medical tools to the poorest of the poor to a curious tinkerer who believes a tub of yogurt and a jellyfish gene could protect the world's food supply. These biohackers include: -A duo who started a cancer drug company in their kitchen -A team who built an open-source DNA copy machine -A woman who developed a genetic test in her apartment for a deadly disease that had stricken her family Along with the potential of citizen science to bring about disruptive change, Wohlsen explores the risks of DIY bioterrorism, the possibility of genetic engineering experiments gone awry, and whether the ability to design life from scratch on a laptop might come sooner than we think. |
| biobuilder synthetic biology in the lab: Synthetic Biology: A Lab Manual Josefine Liljeruhm, Erik Gullberg, Anthony C Forster, 2014-04-16 Synthetic Biology: A Lab Manual is the first manual for laboratory work in the new and rapidly expanding field of synthetic biology. Aimed at non-specialists, it details protocols central to synthetic biology in both education and research. In addition, it provides all the information that teachers and students from high schools and tertiary institutions need for a colorful lab course in bacterial synthetic biology using chromoproteins and designer antisense RNAs. As a bonus, practical material is provided for students of the annual international Genetically Engineered Machine (iGEM) competition. The manual is based upon a highly successful course at Sweden's Uppsala University and is coauthored by one of the pioneers of synthetic biology and two bioengineering postgraduate students.An inspiring foreword is written by another pioneer in the field, Harvard's George Church: “Synthetic biology is to early recombinant DNA as a genome is to a gene. Is there anything that SynBio will not impact? There was no doubt that the field of SynBio needed ‘A Lab Manual’ such as the one that you now hold in your hands.” |
| biobuilder synthetic biology in the lab: Radiobiology for the Radiologist Eric J. Hall, Amato J. Giaccia, 2012-03-28 In print since 1972, this seventh edition of Radiobiology for the Radiologist is the most extensively revised to date. It consists of two sections, one for those studying or practicing diagnostic radiolo, nuclear medicine and radiation oncology; the other for those engaged in the study or clinical practice of radiation oncology--a new chapter, on radiologic terrorism, is specifically for those in the radiation sciences who would manage exposed individuals in the event of a terrorist event. The 17 chapters in Section I represent a general introduction to radiation biology and a complete, self-contained course especially for residents in diagnostic radiology and nuclear medicine that follows the Syllabus in Radiation Biology of the RSNA. The 11 chapters in Section II address more in-depth topics in radiation oncology, such as cancer biology, retreatment after radiotherapy, chemotherapeutic agents and hyperthermia. Now in full color, this lavishly illustrated new edition is replete with tables and figures that underscore essential concepts. Each chapter concludes with a summary of pertinent conclusions to facilitate quick review and help readers retain important information. |
| biobuilder synthetic biology in the lab: BioBuilder Natalie Kuldell, Rachel Bernstein, Karen Ingram, Kathryn M. Hart, 2015 Today's synthetic biologists are in the early stages of engineering living cells to help treat diseases, sense toxic compounds in the environment, and produce valuable drugs. With this manual, you can be part of it. Based on the BioBuilder curriculum, this valuable book provides open-access, modular, hands-on lessons in synthetic biology for secondary and post-secondary classrooms and laboratories. It also serves as an introduction to the field for science and engineering enthusiasts. Developed at MIT in collaboration with award-winning high school teachers, BioBuilder teaches the foundational ideas of the emerging synthetic biology field, as well as key aspects of biological engineering that researchers are exploring in labs throughout the world. These lessons will empower teachers and students to explore and be part of solving persistent real-world challenges. |
| biobuilder synthetic biology in the lab: Zero to Genetic Engineering Hero Justin Pahara, Julie Legault, 2021-08-19 Zero to Genetic Engineering Hero is made to provide you with a first glimpse of the inner-workings of a cell. It further focuses on skill-building for genetic engineering and the Biology-as-a-Technology mindset (BAAT). This book is designed and written for hands-on learners who have little knowledge of biology or genetic engineering. This book focuses on the reader mastering the necessary skills of genetic engineering while learning about cells and how they function. The goal of this book is to take you from no prior biology and genetic engineering knowledge toward a basic understanding of how a cell functions, and how they are engineered, all while building the skills needed to do so. |
| biobuilder synthetic biology in the lab: Regenesis George M Church, Edward Regis, 2014-04-08 A Harvard biologist and master inventor explores how new biotechnologies will enable us to bring species back from the dead, unlock vast supplies of renewable energy, and extend human life. In Regenesis, George Church and science writer Ed Regis explore the possibilities of the emerging field of synthetic biology. Synthetic biology, in which living organisms are selectively altered by modifying substantial portions of their genomes, allows for the creation of entirely new species of organisms. These technologies-far from the out-of-control nightmare depicted in science fiction-have the power to improve human and animal health, increase our intelligence, enhance our memory, and even extend our life span. A breathtaking look at the potential of this world-changing technology, Regenesis is nothing less than a guide to the future of life. |
| biobuilder synthetic biology in the lab: Building Microservices Sam Newman, 2015-02-02 Annotation Over the past 10 years, distributed systems have become more fine-grained. From the large multi-million line long monolithic applications, we are now seeing the benefits of smaller self-contained services. Rather than heavy-weight, hard to change Service Oriented Architectures, we are now seeing systems consisting of collaborating microservices. Easier to change, deploy, and if required retire, organizations which are in the right position to take advantage of them are yielding significant benefits. This book takes an holistic view of the things you need to be cognizant of in order to pull this off. It covers just enough understanding of technology, architecture, operations and organization to show you how to move towards finer-grained systems. |
| biobuilder synthetic biology in the lab: Zinc Finger Proteins Shiro Iuchi, Natalie Kuldell, 2007-03-06 In the early 1980s, a few scientists started working on a Xenopus transcription factor, TFIIIA. They soon discovered a novel domain associated with zinc, and named this domain zinc finger. Th e number of proteins with similar zinc fingers grew quickly and these proteins are now called C2H2, Cys2His2 or classical zinc finger proteins. To date, about 24,000 C2H2 zinc finger proteins have been recognized. Approximately 700 human genes, or more than 2% of the genome, have been estimated to encode C2H2 finger proteins. From the beginning these proteins were thought to be numerous, but no one could have predicted such a huge number. Perhaps thousands of scientists are now working on C2H2 zinc finger proteins fi-om variou s viewpoints. This field is a good example of how a new science begins with the insight of a few scientists and how it develops by efforts of numerous independent scientists, in contrast to a policy-driven scientific project, such as the Human Genome Project, with goals clearly set at its inception and with work performed by a huge collaboration throughout the world. As more zinc finger proteins were discovered, several subfamilies, such as C2C2, CCHC, CCCH, LIM, RING, TAZ, and FYVE emerged, increasing our understanding of zinc fingers. The knowledge was overwhelming. Moreover, scientists began defining the term zinc finger differently and using various names for identical zinc fingers. These complications may explain why no single comprehensive resource of zinc finger proteins was available before this publication. |
| biobuilder synthetic biology in the lab: Mammalian Synthetic Biology Jamie A. Davies, Paul S. Freemont, 2020 This primer introduces the challenges and opportunities of applying synthetic biological techniques to mammalian cells, tissues, and organisms. It covers the special features that make engineering mammalian systems different from engineering bacteria, fungi, and plants, and provides an overview of current techniques. A variety of cutting-edge examples illustrate the different purposes of mammalian synthetic biology, including pure biomedical research, drug production, tissue engineering, and regenerative medicine. |
| biobuilder synthetic biology in the lab: Genome Refactoring Natalie Kuldell, Neal Lerner, 2022-06-01 The science of biology celebrates the discovery and understanding of biological systems that already exist in nature. In parallel, the engineering of biology must learn how to make use of our understanding of the natural world to design and build new useful biological systems. Synthetic biology represents one example of recent work to engineer biological systems. This emerging field aims to replace the ad hoc process of assembling biological systems by primarily developing tools to assemble reliable-but-complex living organisms from standard components that can later be reused in new combination. The focus of this book is genome refactoring, one of several approaches to manage the complexity of a biological system in which the goal is to redesign the genetic elements that encode a living form--preserving the function of that form but encoding it with a genome far easier to study and extend. This book presents genome refactoring in two ways: as an important aspect of the emerging field of synthetic biology and as a powerful teaching tool to train would be professionals in the subject. Chapters focus on the overarching goals of synthetic biology and their alignment with the motivations and achievements in genome engineering; the engineering frameworks of refactoring, including genome synthesis, standardization of biological parts, and abstraction; a detailed description of the bacteriophages that have been refactored up to this point; and the methods of refactoring and contexts for that work drawn from the bacteriophage M13. Overall, these examples offer readers the potential for synthetic biology and the areas in need of further research. If successful, synthetic biology and genome refactoring could address any number of persistent societal needs, including sustainable energy, affordable and effective medicine, and green manufacturing practices. Table of Contents: Tools for Genome Engineering and Synthetic Biology / Bacteriophage as Templates for Refactoring / Methods/Teaching Protocols for M13 Reengineering / Writing and Speaking as Biological Engineers / Summary and Future Directions / Appendix A / Appendix B / Appendix C |
| biobuilder synthetic biology in the lab: What's Your Bio Strategy Karl Schmieder, John Cumbers, 2017-10 |
| biobuilder synthetic biology in the lab: Essential Bioinformatics Jin Xiong, 2006-03-13 Essential Bioinformatics is a concise yet comprehensive textbook of bioinformatics, which provides a broad introduction to the entire field. Written specifically for a life science audience, the basics of bioinformatics are explained, followed by discussions of the state-of-the-art computational tools available to solve biological research problems. All key areas of bioinformatics are covered including biological databases, sequence alignment, genes and promoter prediction, molecular phylogenetics, structural bioinformatics, genomics and proteomics. The book emphasizes how computational methods work and compares the strengths and weaknesses of different methods. This balanced yet easily accessible text will be invaluable to students who do not have sophisticated computational backgrounds. Technical details of computational algorithms are explained with a minimum use of mathematical formulae; graphical illustrations are used in their place to aid understanding. The effective synthesis of existing literature as well as in-depth and up-to-date coverage of all key topics in bioinformatics make this an ideal textbook for all bioinformatics courses taken by life science students and for researchers wishing to develop their knowledge of bioinformatics to facilitate their own research. |
| biobuilder synthetic biology in the lab: Concepts of Genetics, Global Edition William S Klug, Michael Cummings, Charlotte A. Spencer, Michael A Palladino, Darrell Killian, 2019-02-26 For all introductory genetics courses. Concepts of Genetics emphasises the fundamental ideas of genetics, while exploring modern techniques and applications of genetic analysis. This best-selling text continues to provide understandable explanations of complex, analytical topics and recognises the importance of teaching students how to become effective problem solvers. The 12th Edition has been extensively updated to provide comprehensive coverage of important, emerging topics such as CRISPR-Cas and the study of posttranscriptional gene regulation in eukaryotes. An expanded emphasis on ethical considerations that genetics is bringing into everyday life is addressed in Genetics, Ethics, and Society and Case Study features. The full text downloaded to your computer With eBooks you can: search for key concepts, words and phrases make highlights and notes as you study share your notes with friends eBooks are downloaded to your computer and accessible either offline through the Bookshelf (available as a free download), available online and also via the iPad and Android apps. Upon purchase, you will receive via email the code and instructions on how to access this product. Time limit The eBooks products do not have an expiry date. You will continue to access your digital ebook products whilst you have your Bookshelf installed. |
| biobuilder synthetic biology in the lab: Coviability of Social and Ecological Systems: Reconnecting Mankind to the Biosphere in an Era of Global Change Olivier Barrière, Mohamed Behnassi, Gilbert David, Vincent Douzal, Mireille Fargette, Thérèse Libourel, Maud Loireau, Laurence Pascal, Catherine Prost, Voyner Ravena-Cañete, Frédérique Seyler, Serge Morand, 2019-03-12 This second volume is the work of more than 55 authors from 15 different disciplines and includes complex systems science which studies the viability of components, and also the study of empirical situations. As readers will discover, the coviability of social and ecological systems is based on the contradiction between humanity, which adopts finalized objectives, and the biosphere, which refers to a ecological functions. We see how concrete situations shed light on the coviability’s determinants, and in this book the very nature of the coviability, presented as a concept-paradigm, is defined in a transversal and ontological ways. By adopting a systemic approach, without advocating any economic dogma (such as development) or dichotomizing between humans and nature, while emphasizing what is relevant to humans and what is not, this work neutrally contextualizes man’s place in the biosphere. It offers a new mode of thinking and positioning of the ecological imperative, and will appeal to all those working with social and ecological systems. |
| biobuilder synthetic biology in the lab: Monolith to Microservices Sam Newman, 2019-11-14 How do you detangle a monolithic system and migrate it to a microservice architecture? How do you do it while maintaining business-as-usual? As a companion to Sam Newman’s extremely popular Building Microservices, this new book details a proven method for transitioning an existing monolithic system to a microservice architecture. With many illustrative examples, insightful migration patterns, and a bevy of practical advice to transition your monolith enterprise into a microservice operation, this practical guide covers multiple scenarios and strategies for a successful migration, from initial planning all the way through application and database decomposition. You’ll learn several tried and tested patterns and techniques that you can use as you migrate your existing architecture. Ideal for organizations looking to transition to microservices, rather than rebuild Helps companies determine whether to migrate, when to migrate, and where to begin Addresses communication, integration, and the migration of legacy systems Discusses multiple migration patterns and where they apply Provides database migration examples, along with synchronization strategies Explores application decomposition, including several architectural refactoring patterns Delves into details of database decomposition, including the impact of breaking referential and transactional integrity, new failure modes, and more |
| biobuilder synthetic biology in the lab: Genentech Sally Smith Hughes, 2011-09-21 In the fall of 1980, Genentech, Inc., a little-known California genetic engineering company, became the overnight darling of Wall Street, raising over $38 million in its initial public stock offering. Lacking marketed products or substantial profit, the firm nonetheless saw its share price escalate from $35 to $89 in the first few minutes of trading, at that point the largest gain in stock market history. Coming at a time of economic recession and declining technological competitiveness in the United States, the event provoked banner headlines and ignited a period of speculative frenzy over biotechnology as a revolutionary means for creating new and better kinds of pharmaceuticals, untold profit, and a possible solution to national economic malaise. Drawing from an unparalleled collection of interviews with early biotech players, Sally Smith Hughes offers the first book-length history of this pioneering company, depicting Genentech’s improbable creation, precarious youth, and ascent to immense prosperity. Hughes provides intimate portraits of the people significant to Genentech’s science and business, including cofounders Herbert Boyer and Robert Swanson, and in doing so sheds new light on how personality affects the growth of science. By placing Genentech’s founders, followers, opponents, victims, and beneficiaries in context, Hughes also demonstrates how science interacts with commercial and legal interests and university research, and with government regulation, venture capital, and commercial profits. Integrating the scientific, the corporate, the contextual, and the personal, Genentech tells the story of biotechnology as it is not often told, as a risky and improbable entrepreneurial venture that had to overcome a number of powerful forces working against it. |
| biobuilder synthetic biology in the lab: Synthetic Biology (2nd Ed) LILJERUHM, 2025-04-03 |
| biobuilder synthetic biology in the lab: Lewin's GENES XII Jocelyn E. Krebs, Elliott S. Goldstein, Stephen T. Kilpatrick, 2017-03-02 Now in its twelfth edition, Lewin's GENES continues to lead with new information and cutting-edge developments, covering gene structure, sequencing, organization, and expression. Leading scientists provide revisions and updates in their individual field of study offering readers current data and information on the rapidly changing subjects in molecular biology. |
| biobuilder synthetic biology in the lab: Biotechnology Research in an Age of Terrorism National Research Council, Policy and Global Affairs, Development, Security, and Cooperation, Committee on Research Standards and Practices to Prevent the Destructive Application of Biotechnology, 2004-03-02 In recent years much has happened to justify an examination of biological research in light of national security concerns. The destructive application of biotechnology research includes activities such as spreading common pathogens or transforming them into even more lethal forms. Policymakers and the scientific community at large must put forth a vigorous and immediate response to this challenge. This new book by the National Research Council recommends that the government expand existing regulations and rely on self-governance by scientists rather than adopt intrusive new policies. One key recommendation of the report is that the government should not attempt to regulate scientific publishing but should trust scientists and journals to screen their papers for security risks, a task some journals have already taken up. With biological information and tools widely distributed, regulating only U.S. researchers would have little effect. A new International Forum on Biosecurity should encourage the adoption of similar measures around the world. Seven types of risky studies would require approval by the Institutional Biosafety Committees that already oversee recombinant DNA research at some 400 U.S. institutions. These experiments of concern include making an infectious agent more lethal and rendering vaccines powerless. |
| biobuilder synthetic biology in the lab: Elements of Biotechnology P. K. Gupta, 1994 |
| biobuilder synthetic biology in the lab: AI and Machine Learning for Coders Laurence Moroney, 2020-10-01 If you're looking to make a career move from programmer to AI specialist, this is the ideal place to start. Based on Laurence Moroney's extremely successful AI courses, this introductory book provides a hands-on, code-first approach to help you build confidence while you learn key topics. You'll understand how to implement the most common scenarios in machine learning, such as computer vision, natural language processing (NLP), and sequence modeling for web, mobile, cloud, and embedded runtimes. Most books on machine learning begin with a daunting amount of advanced math. This guide is built on practical lessons that let you work directly with the code. You'll learn: How to build models with TensorFlow using skills that employers desire The basics of machine learning by working with code samples How to implement computer vision, including feature detection in images How to use NLP to tokenize and sequence words and sentences Methods for embedding models in Android and iOS How to serve models over the web and in the cloud with TensorFlow Serving |
| biobuilder synthetic biology in the lab: Designing Constructionist Futures Nathan Holbert, Matthew Berland, Yasmin B. Kafai, 2020-10-27 A diverse group of scholars redefine constructionism--introduced by Seymour Papert in 1980--in light of new technologies and theories. Constructionism, first introduced by Seymour Papert in 1980, is a framework for learning to understand something by making an artifact for and with other people. A core goal of constructionists is to respect learners as creators, to enable them to engage in making meaning for themselves through construction, and to do this by democratizing access to the world's most creative and powerful tools. In this volume, an international and diverse group of scholars examine, reconstruct, and evolve the constructionist paradigm in light of new technologies and theories. |
| biobuilder synthetic biology in the lab: Synthetic Biology Jamie A. Davies, 2018-06-14 Synthetic biology is one of the 21st century's fastest growing fields of research, as important for technology as for basic science. Building on traditional genetic engineering, which was restricted to changing one or two genes, synthetic biology uses multi-gene modules and pathways to make very significant changes to what cells can do. Synthetic biologists aim to have an impact in fields as diverse as drug manufacture, biofuel production, tackling pollution, and medical diagnostics. Further ahead, synthetic biology may even make possible the long-standing goal of creating new life from non-living starting materials. This Very Short Introduction provides a concise explanation of what synthetic biology is, and how it is beginning to affect many fields of technology. Jamie Davies also discusses the considerable controversies surrounding synthetic biology, from questions over the assumption that engineering concepts can be applied to living systems easily, to scepticism over the claims for commercial promise, fears that the dangers of engineering life are worse than its benefits, and concerns over whether humans should be designing living systems at all. ABOUT THE SERIES: The Very Short Introductions series from Oxford University Press contains hundreds of titles in almost every subject area. These pocket-sized books are the perfect way to get ahead in a new subject quickly. Our expert authors combine facts, analysis, perspective, new ideas, and enthusiasm to make interesting and challenging topics highly readable. |
| biobuilder synthetic biology in the lab: Makeology Kylie Peppler, Erica Halverson, Yasmin B. Kafai, 2016-05-20 Makeology introduces the emerging landscape of the Maker Movement and its connection to interest-driven learning. While the movement is fueled in part by new tools, technologies, and online communities available to today’s makers, its simultaneous emphasis on engaging the world through design and sharing with others harkens back to early educational predecessors including Froebel, Dewey, Montessori, and Papert. Makerspaces as Learning Environments (Volume 1) focuses on making in a variety of educational ecosystems, spanning nursery schools, K-12 environments, higher education, museums, and after-school spaces. Each chapter closes with a set of practical takeaways for educators, researchers, and parents. |
| biobuilder synthetic biology in the lab: Biological Database Modeling Jake Chen, Amandeep S. Sidhu, 2008 Modern biological research in areas like drug discovery produces a staggering volume of data, and the right modeling tools can help scientists apply it in ways never before imaginable. This collection of next-generation biodata modeling techniques combines innovative concepts, methods, and applications with case studies in genome, microarray, proteomics, and drug discovery projects to help bioinformatics professionals develop ever-more powerful data management systems in any domain. Breaking new ground at the intersection of life sciences and data management, the book introduces practitioners to core biodata modeling techniques, biological database resources, and ontology concepts. It explains the latest envelope-pushing methods and software applications for processing, integrating, and managing biodata. |
| biobuilder synthetic biology in the lab: Synthetic Aesthetics Alexandra Daisy Ginsberg, Jane Calvert, Pablo Schyfter, Alistair Elfick, Drew Endy, 2014-02-28 As synthetic biology transforms living matter into a medium for making, what is the role of design and its associated values? |
| biobuilder synthetic biology in the lab: Connected Code Yasmin B. Kafai, Quinn Burke, 2016-09-02 Why every child needs to learn to code: the shift from “computational thinking” to computational participation. Coding, once considered an arcane craft practiced by solitary techies, is now recognized by educators and theorists as a crucial skill, even a new literacy, for all children. Programming is often promoted in K-12 schools as a way to encourage “computational thinking”—which has now become the umbrella term for understanding what computer science has to contribute to reasoning and communicating in an ever-increasingly digital world. In Connected Code, Yasmin Kafai and Quinn Burke argue that although computational thinking represents an excellent starting point, the broader conception of “computational participation” better captures the twenty-first-century reality. Computational participation moves beyond the individual to focus on wider social networks and a DIY culture of digital “making.” Kafai and Burke describe contemporary examples of computational participation: students who code not for the sake of coding but to create games, stories, and animations to share; the emergence of youth programming communities; the practices and ethical challenges of remixing (rather than starting from scratch); and the move beyond stationary screens to programmable toys, tools, and textiles. |
| biobuilder synthetic biology in the lab: Synthetic Biology Markus Schmidt, Alexander Kelle, Agomoni Ganguli-Mitra, Huib de Vriend, 2009-09-16 Synthetic biology is becoming one of the most dynamic new fields of biology, with the potential to revolutionize the way we do biotechnology today. By applying the toolbox of engineering disciplines to biology, a whole set of potential applications become possible ranging very widely across scientific and engineering disciplines. Some of the potential benefits of synthetic biology, such as the development of low-cost drugs or the production of chemicals and energy by engineered bacteria are enormous. There are, however, also potential and perceived risks due to deliberate or accidental damage. Also, ethical issues of synthetic biology just start being explored, with hardly any ethicists specifically focusing on the area of synthetic biology. This book will be the first of its kind focusing particularly on the safety, security and ethical concerns and other relevant societal aspects of this new emerging field. The foreseen impact of this book will be to stimulate a debate on these societal issues at an early stage. Past experiences, especially in the field of GM-crops and stem cells, have shown the importance of an early societal debate. The community and informed stakeholders recognize this need, but up to now discussions are fragmentary. This book will be the first comprehensive overview on relevant societal issues of synthetic biology, setting the scene for further important discussions within the scientific community and with civil society. |
| biobuilder synthetic biology in the lab: Synthetic Biology Manuel Porcar, Juli Peretó, 2014-09-09 Synthetic Biology (SB) is a revolutionary discipline with a vast range of practical applications, but is SB research really based on engineering principles? Does it contributing to the artificial synthesis of life or does it utilise approaches sufficiently advanced to fall outside the scope of biotechnology or metabolic engineering? This volume reviews the development of SB and includes the major milestones of the discipline, the ‘top-down’ and ‘bottom-up’ approaches towards the construction of an artificial cell and the development of the “iGEM” competition. We conclude that SB is an emerging field with extraordinary technological potential, but that most research projects actually are an extension of metabolic engineering since the complexity of living organisms, their tight dependence on evolution and our limited knowledge of the interactions between the molecules, actually make life difficult to engineer. |
| biobuilder synthetic biology in the lab: Chance in Evolution Grant Ramsey, Charles H. Pence, 2016-10-25 This illuminating volume explores the effects of chance on evolution, covering diverse perspectives from scientists, philosophers, and historians. The evolution of species, from single-celled organisms to multicellular animals and plants, is the result of a long and highly chancy history. But how profoundly has chance shaped life on earth? And what, precisely, do we mean by chance? Bringing together biologists, philosophers of science, and historians of science, Chance in Evolution is the first book to untangle the far-reaching effects of chance, contingency, and randomness on the evolution of life. The book begins by placing chance in historical context, starting with the ancients and moving through Darwin to contemporary biology. It documents the shifts in our understanding of chance as Darwin’s theory of evolution developed into the modern synthesis, and how the acceptance of chance in Darwinian theory affected theological resistance to it. Other chapters discuss how chance relates to the concepts of genetic drift, mutation, and parallel evolution—as well as recent work in paleobiology and the experimental evolution of microbes. By engaging in collaboration across biology, history, philosophy, and theology, this book offers a comprehensive overview both of the history of chance in evolution and of our current understanding of the impact of chance on life. |
| biobuilder synthetic biology in the lab: Biomolecular Feedback Systems Domitilla Del Vecchio, Richard Murray, 2014-10-26 This book provides an accessible introduction to the principles and tools for modeling, analyzing, and synthesizing biomolecular systems. It begins with modeling tools such as reaction-rate equations, reduced-order models, stochastic models, and specific models of important core processes. It then describes in detail the control and dynamical systems tools used to analyze these models. These include tools for analyzing stability of equilibria, limit cycles, robustness, and parameter uncertainty. Modeling and analysis techniques are then applied to design examples from both natural systems and synthetic biomolecular circuits. In addition, this comprehensive book addresses the problem of modular composition of synthetic circuits, the tools for analyzing the extent of modularity, and the design techniques for ensuring modular behavior. It also looks at design trade-offs, focusing on perturbations due to noise and competition for shared cellular resources. Featuring numerous exercises and illustrations throughout, Biomolecular Feedback Systems is the ideal textbook for advanced undergraduates and graduate students. For researchers, it can also serve as a self-contained reference on the feedback control techniques that can be applied to biomolecular systems. Provides a user-friendly introduction to essential concepts, tools, and applications Covers the most commonly used modeling methods Addresses the modular design problem for biomolecular systems Uses design examples from both natural systems and synthetic circuits Solutions manual (available only to professors at press.princeton.edu) An online illustration package is available to professors at press.princeton.edu |
| biobuilder synthetic biology in the lab: Living Construction Martyn Dade-Robertson, 2020-10-28 Modern biotechnologies give us unprecedented control of the fundamental building blocks of life. For designers, across a range of disciplines, emerging fields such as synthetic biology offer the promise of new sustainable materials and structures which may be grown, are self-assembling, self-healing and adaptable to change. While there is a thriving speculative discourse on the future of design in the age of biotechnology, there are few realized design applications. This book, the first in the Bio Design series, acts as a bridge between design speculation and scientific reality and between contemporary design thinking, in areas such as architecture, product design and fashion design, and the traditional engineering approaches which currently dominate biotechnologies. Filled with real examples, Living Construction reveals how living cells construct and transform materials through methods of fabrication and assembly at multiple scales and how designers can utilize these processes. |
| biobuilder synthetic biology in the lab: Programmable Planet Ted Anton, 2023-07-25 Honorable Mention, 2024 Richard Frisbie Award for Adult Nonfiction, Society of Midland Authors A new science is reengineering the fabric of life. Synthetic biology offers bold new ways of manufacturing medicines, clothing, foods, fragrances, and fuels, often using microbe fermentation, much like brewing beer. The technology can help confront climate change, break down industrial pollutants, and fight novel viruses. Today, researchers are manipulating life forms and automating evolution to create vegetarian “meat,” renewable construction materials, and cancer treatments. In the process, they are changing our concept of what life science can achieve. Is this a new industrial and information revolution—or dangerous tinkering that could unleash unintended consequences? Programmable Planet is a grand tour through the world of synthetic biology, telling the stories of the colorful visionaries whose ideas are shaping discoveries. Ted Anton explores the field from its beginning in fighting malaria in Africa to the COVID vaccines and beyond. Covering medical and agricultural triumphs and blunders, he examines successes in energy production, plant gene editing, and chemical manufacturing, as well as the most controversial attempts at human gene enhancement. This book reports from the front lines of research, showing policy makers’ struggle to stay abreast of the technologies they aim to regulate. Even-handed, lively, and informative, Programmable Planet gives a glimpse of the promise and problems of a new biology-based industry. |
| biobuilder synthetic biology in the lab: Non-Conventional Copyright Enrico Bonadio, Nicola Lucchi, 2018-10-26 'Copyright law has always somehow managed to adapt to new technological and social developments as well as to new artistic and creative practices. However, every time such a development occurs, the legitimate question arises if the system is adaptable or if the breakthrough is so gigantic that a new system needs to be elaborated. In any case, new scholarly reflections are needed in regular intervals and that is exactly the purpose of this fascinating edited collection by Enrico Bonadio and Nicola Lucchi on non-conventional copyright, exploring from various angles the copyright issues of all sorts of creations ranging from unconventional art forms, new music and atypical cultural practices to new advances in technology, not forgetting to investigate the delicate issues around copyright on illegal and immoral works.' - Christophe Geiger, University of Strasbourg, France Copyright law constantly evolves to keep up with societal changes and technological advances. Contemporary forms of creativity can threaten the comfortable conceptions of copyright law as creative people continually find new ways of expressing themselves. In this context, Non-Conventional Copyrightidentifies possible new spaces for copyright protection. With current copyright law in mind, the contributions explore if the law should be more flexible as to whether new or unconventional forms of expression - including graffiti, tattoos, land art, conceptual art and bio art, engineered DNA, sport movements, jokes, magic tricks, DJ sets, perfume making, typefaces, or illegal and immoral works - deserve protection. Vitally, the contributors suggest that it may be time to challenge some of the basic tenets of copyright laws by embracing more flexible ways to identify protectable works and interpret the current requirements for protection. Additionally, some contributors cast doubts about whether copyright is the right instrument to address and regulate these forms of expression. Contemporary in topic, this thought-provoking book will be essential reading for intellectual property law scholars, practitioners and policymakers. Creative people and those involved in the creative industries will also find this book an engaging read. Contributors include: E. Bonadio, S. Burke, C. Cronin, T. Dagne, T.W. Dornis, F.J. Dougherty, T.M. Gates, M.P. George, E. Haber, S. Karapapa, Y.M. King, T. Iverson, N. Lucchi, G. Mazziotti, J. McCutcheon, L. McDonagh, M. Maggiore, P. Mezei, M. Mimler, A.G. Scaria, C.Y.N. Smith, X. Tang |
| biobuilder synthetic biology in the lab: Engineered Living Materials Wil V. Srubar III, 2022-02-16 This book will serve as a primer for readers to understand recent advances, applications, and current challenges in the field of Engineered Living Materials. The chapters cover core science and engineering research areas, including (1) advances in synthetic biology and genetic programmability for Engineered Living Materials, (2) functional Engineered Living Material for application in energy, electronics, and construction, and (3) novel manufacturing approaches for Engineered Living Materials at multiple scales. The emerging field of Engineered Living Materials represents a significant paradigm shift in materials design and synthesis, in which living cells are used to impart biologically active functionalities to manmade materials. The result is a genetically programmable augmentation of non-living matter to exhibit unprecedented life-like (i.e., living) capabilities. At the intersection of synthetic biology and materials science, the field of Engineered Living Materials exhibits unprecedented promise and potential to alter the way we synthesize new materials and design medical devices, fabrics, robotics, commodity polymers, and construction materials. Materials with attributes of living systems can be engineered with an ability to respond to their environment and designed to self-repair in response to physical or other stresses or detect the presence of specific stimuli, such as light, heat, pressure, or hazardous chemical compounds. Although nascent, scientists and researchers in the field of Engineered Living Materials have made marked advances in demonstrating a potential to revolutionize a multitude of science and engineering disciplines. This volume will define the current state of the art of Engineered Living Materials, and highlight grand opportunities and challenges that abound at the nexus of synthetic biology and materials science and engineering. |
| biobuilder synthetic biology in the lab: Makeology Kylie Peppler, Erica Rosenfeld Halverson, Yasmin B. Kafai, 2016-05-20 Makeology introduces the emerging landscape of the Maker Movement and its connection to interest-driven learning. While the movement is fueled in part by new tools, technologies, and online communities available to today’s makers, its simultaneous emphasis on engaging the world through design and sharing with others harkens back to early educational predecessors including Froebel, Dewey, Montessori, and Papert. Makers as Learners (Volume 2) highlights leading researchers and practitioners as they discuss and share current perspectives on the Maker movement and research on educational outcomes in makerspaces. Each chapter closes with a set of practical takeaways for educators, researchers, and parents. |
| biobuilder synthetic biology in the lab: Intellectual Property Issues in Microbiology Harikesh Bahadur Singh, Chetan Keswani, Surya Pratap Singh, 2019-07-27 In the current era current era of significant innovations, science and technology are powerful tools improving human welfare through prosperity and sustainable development. The development of microbiology based industries in any given country is shaped by the characteristics of its technology—particularly its close relation to scientific knowledge, and by country-specific factors such as the level and nature of the scientific knowledge base, the institutional set-up, and the role assumed by the government, all of which influence the country's ability to exploit the new opportunities. This unique book presents an integrated approach for sustained innovation in various areas of microbiology. Focusing on the industrial and socio-legal implications of IPR in microbiological advances, it offers a comprehensive overview not only of the implications of IPR in omics-based research but also of the ethical and intellectual standards and how these can be developed for sustained innovation. The book is divided into three sections discussing current advances in microbiological innovations, recent intellectual property issues in agricultural, and pharmaceutical microbiology respectively. Integrating science and business, it offers a glimpse behind the scenes of the microbiology industry, and provides a detailed analysis of the foundations of the present day industry for students and professionals alike. |
| biobuilder synthetic biology in the lab: The Science of Soft Robots Koichi Suzumori, Kenjiro Fukuda, Ryuma Niiyama, Kohei Nakajima, 2023-10-14 The goal of this textbook is to equip readers with as structured knowledge of soft robotics as possible. Seeking to overcome the limitations of conventional robots by making them more flexible, gentle and adaptable, soft robotics has become one of the most active fields over the last decade. Soft robotics is also highly interdisciplinary, bringing together robotics, computer science, material science, biology, etc. After the introduction, the content is divided into three parts: Design of Soft Robots; Soft Materials; and Autonomous Soft Robots. Part I addresses soft mechanisms, biological mechanisms, and soft manipulation & locomotion. In Part II, the basics of polymer, biological materials, flexible & stretchable sensors, and soft actuators are discussed from a materials science standpoint. In turn, Part III focuses on modeling & control of continuum bodies, material intelligence, and information processing using soft body dynamics. In addition, the latest research results and cutting-edge research are highlighted throughout the book. Written by a team of researchers from highly diverse fields, the work offers a valuable textbook or technical guide for all students, engineers and researchers who are interested in soft robotics. |
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