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| bioorthogonal chemistry nobel prize: Peptide Conjugation Waleed M. Hussein, Rachel J. Stephenson, Istvan Toth, 2021-08-14 This volume explores diverse protocols for peptide conjugation, and provides thoroughly tested and scientifically valid techniques that allow researchers and scientists to prepare, purify, characterize, and use peptide conjugation methods for chemical, biochemical, and biological studies. Some of the topics discussed in this book are gold nanoparticles, proteins, pegylated lipids, and vitamins. Chapters also cover enzymatic ligation using sortase A, construction of a phage-displayed cyclic-peptide library, quantum dot-peptide conjugates, and preparation of lipopeptides by CLipPA chemistry. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and comprehensive, Peptide Conjugation: Methods and Protocols is a valuable resource for experienced researches and undergraduate students alike who are interested in learning more about this exciting and developing field. |
| bioorthogonal chemistry nobel prize: Cycloadditions in Bioorthogonal Chemistry Milan Vrabel, Thomas Carell, 2016-05-28 The series Topics in Current Chemistry Collections presents critical reviews from the journal Topics in Current Chemistry organized in topical volumes. The scope of coverage is all areas of chemical science including the interfaces with related disciplines such as biology, medicine and materials science. The goal of each thematic volume is to give the non-specialist reader, whether in academia or industry, a comprehensive insight into an area where new research is emerging which is of interest to a larger scientific audience. Each review within the volume critically surveys one aspect of that topic and places it within the context of the volume as a whole. The most significant developments of the last 5 to 10 years are presented using selected examples to illustrate the principles discussed. The coverage is not intended to be an exhaustive summary of the field or include large quantities of data, but should rather be conceptual, concentrating on the methodological thinking that will allow the non-specialist reader to understand the information presented. Contributions also offer an outlook on potential future developments in the field. |
| bioorthogonal chemistry nobel prize: The Nobel Prize Winners Frank Northen Magill, 1990 |
| bioorthogonal chemistry nobel prize: Click Chemistry Vinod K. Tiwari, |
| bioorthogonal chemistry nobel prize: Chemical Glycobiology Randall Halcomb, American Chemical Society. Meeting, Peng George Wang, 2008 This ACS symposium book on Chemical Glycobiology summarizes the current status of the chemical techniques and tools developed to study the biological roles of carbohydrates and glycoconjugates. It is suitable for chemists and biochemists who are interested in synthesizing, understanding, and applying carbohydrate-related molecules or manipulating biological systems using carbohydrates. |
| bioorthogonal chemistry nobel prize: Organic Chemistry: 100 Must-Know Mechanisms Roman Valiulin, 2023-07-04 In chemistry, good problem-solving requires a balanced combination of scientific intuition and methodical analysis. Additionally, thoughtfully presented diagrams and infographics can convey a large amount of complex information in a more intuitive and accessible manner. 100 Must-Know Mechanisms (Second Edition) strives to be at the intersection of these two key principles. Its thorough visualizations enable experienced readers to use it as a quick reference for specific mechanisms of interest. At the same time, the book’s breadth of covered reactions, from classic to cutting-edge, make it a good study-aid for the developing chemist. A slow and consistent study of the entire series of mechanisms can help set the foundation for good scientific intuition, while its detailed infographics and careful navigation features encourage coming back to it frequently. This edition includes over 40 new illustrations, numerous new mechanistic schemes, enhanced original figures with a variety of real-case examples, and more |
| bioorthogonal chemistry nobel prize: Chemical Protein Synthesis Xuechen Li, 2022-06-29 This volume provides updated protocols for chemical protein synthesis. Chapters guide readers through development methods, strategies, and applications of protein chemical synthesis. Written in the format of the highly successful Methods in Molecular Biology series, each chapter includes an introduction to the topic, lists necessary materials and reagents, includes tips on troubleshooting and known pitfalls, and step-by-step, readily reproducible protocols. Authoritative and cutting-edge, Chemical Protein Synthesis aims to be a useful and practical guide to new researchers and experts looking to expand their knowledge. |
| bioorthogonal chemistry nobel prize: NMR with Biological Macromolecules in Solution Kurt Wüthrich, 2021 The book provides insights into the research of the Kurt Wüthrich laboratories from 1996-2020. During this time period, the technique of nuclear magnetic resonance (NMR) spectroscopy in solution went through several breakthroughs, while maturing into a standard method of structural biology. With the introduction of TROSY (transverse relaxation-optimized spectroscopy), the range of accessible molecular sizes was extended about thirty-fold, and efficient protein structure determination resulted from the demands of the structural genomics initiative. Applications in fundamental biology and biomedicine include studies of prion proteins and prion diseases (TSEs), the SARS-Corona virus proteome, trans-membrane signalling by G protein-coupled receptors (GPCRs), and signal transfer by pheromones.Key publications from the Kurt Wüthrich laboratories are placed in perspective, providing insights into new aspects of NMR spectroscopy in structural biology. In addition to methods development, this includes applications in diverse areas of biological research, such as prion proteins and their role in transmissible spongiform encephalopathies (TSEs), trans-membrane signal transfer by G protein-coupled receptors (GPCRs), structural characterization of the SARS-Corona virus proteome, metabolic-flux profiling in bacterial cultures, and signal transfers by pheromones. |
| bioorthogonal chemistry nobel prize: Optimization of Solid-Phase Combinatorial Synthesis Bing Yan, Anthony W. Czarnik, 2001-12-04 Addresses the key topic in combinatorial synthesis--how to optimize the quality of a combinatorial library--by determining the usefulness of synthesized compunds, the reliability of biological assay results, and analyzing acadmic and industrial applications, real-world examples, and case studies of successful and unsuccessful technologies. |
| bioorthogonal chemistry nobel prize: Optochemical Biology , 2019-07-30 Optochemical Biology, Volume 624, the latest release in the Methods in Enzymology series, continues the legacy of this premier serial with quality chapters on a variety of topics, including Cell Lineage Tracing in Zebrafish Embryos with an Expanded Genetic Code, Optical Control of Tumor Induction in the Zebrafish, Optogenetic Control by Pulsed Illumination, Optimizing the Photocontrol of bZIP Coiled Coils with Azobenzene Crosslinkers: Role of the Crosslinking Site, Site-Directed RNA Editing in Vivo Can Be Triggered by the Light-Driven Assembly of an Artificial Riboprotein, In Situ Formation of an Azo Bridge on Proteins Controllable by Visible Light, and much more. - Provides the authority and expertise of leading contributors from an international board of authors - Presents the latest release in the Methods in Enzymology series - Includes the latest information on optochemical biology |
| bioorthogonal chemistry nobel prize: Theranostics Elisabeth Eppard, 2021-09-29 In recent years, due to advancing technology and diagnostic and therapeutic techniques, medicine and health care have become more patient-oriented. This concept of personalized medicine or theranostics can be traced back to the beginnings of nuclear medicine when radioisotopes were uncovered as diagnostic and therapeutic tools. Nowadays, the field of theranostics is in flux, as new techniques and materials allow a growing range of applications beneficial for patients. This book examines new developments in theranostics and provides a comprehensive overview of the state of the art in this exciting discipline. |
| bioorthogonal chemistry nobel prize: Organic Nanochemistry Yuming Zhao, 2024-01-18 ORGANIC NANOCHEMISTRY How-to guide for entry-level practitioners to quickly learn the cutting-edge research concepts and methodologies of modern organic nanochemistry Organic Nanochemistry describes the fundamentals of organic nanochemistry research, encompassing modern synthetic reactions, supramolecular strategies, nanostructure and property characterization techniques, and state-of-the-art data analysis and processing methods, along with synthetic chemistry as applied to organic nanomaterials and molecular devices. Accompanying each of these principles are case studies (from basic design to detailed experimental implementation) to help the reader fully comprehend the concepts and methods involved. Various theories suitable for nanoscale simulations, including quantum mechanics, semi-empirical quantum mechanics, and molecular dynamics theories, are discussed at an introductory level. Computational examples are provided, allowing interested readers to grasp essential modelling techniques for better understanding of organic nanochemistry. The content is paired with online supplementary material that includes instructional materials and guides to using common scientific software for computational modelling and simulations. Written by a highly qualified professor, Organic Nanochemistry includes discussion on: Key concepts and theories of organic chemistry, which are essential to understand the fundamental properties of organic molecular and supramolecular systems Useful synthetic methodologies for the synthesis and functionalization of organic nanomaterials, and the chemistry and application of exotic carbon nanomaterials Supramolecular aspects in organic nanochemistry, especially the well-developed disciplines of host-guest chemistry and organic self-assembly chemistry Construction and testing of molecular devices and molecular machines and state-of-the-art computational modelling methods for properties of nanoscale organic systems Guiding the reader on a journey from familiar chemical concepts and principles to cutting-edge research of nano-science and technology, Organic Nanochemistry serves as an excellent textbook learning resource for advanced and graduate students, as well as a self-study guide or how-to reference for practicing chemists. |
| bioorthogonal chemistry nobel prize: Modern Applications of Cycloaddition Chemistry Paolo Quadrelli, 2019-03-20 Modern Applications of Cycloaddition Chemistry examines this area of organic chemistry, with special attention paid to cycloadditions in synthetic and mechanistic applications in modern organic chemistry. While many books dedicated to cycloaddition reactions deal with the synthesis of heterocycles, general applications, specific applications in natural product synthesis, and the use of a class of organic compounds, this work sheds new light on pericyclic reactions by demonstrating how these valuable tools elegantly solve synthetic and mechanistic problems. The work examines how pericyclic reactions have been extensively applied to different chemistry areas, such as chemical biology, biological processes, catalyzed cycloaddition reactions, and more. This work will be useful for organic chemists who deal with organic chemistry, medicinal chemistry, agrochemistry and material chemistry. - Provides details on the synthesis of antiviral and anticancer compounds, marking the key role of unconventional catalyzed cycloaddition reactions for preparing new derivatives in a unique reaction pathway that is scalable in industrial processes - Contains the most up-to-date review of the use of pericyclic reactions in drug delivery - Includes the enzyme-catalyzed processes involving cycloaddition reactions for different targets, demonstrating that cycloaddition is more common in nature than expected - Features new applications for cycloadditions in material chemistry and provides a general view of the most recent results in the area |
| bioorthogonal chemistry nobel prize: Knowledge Trove-TB-07 Ashok Kumar Tangri, Knowledge Trove is a carefully graded general knowledge series for classes 1 to 8. The series has been designed to make general knowledge learning more interesting and interactive and to ensure that the child is tuned in to the latest developments around the world. This series has been revised keeping in mind the competencies mentioned in the NCF 2023. This book also prepares the students for the various competitive examinations they might take in future. |
| bioorthogonal chemistry nobel prize: Introduction to Molecular Magnetism Cristiano Benelli, Dante Gatteschi, 2015-06-22 This first introduction to the rapidly growing field of molecular magnetism is written with Masters and PhD students in mind, while postdocs and other newcomers will also find it an extremely useful guide. Adopting a clear didactic approach, the authors cover the fundamental concepts, providing many examples and give an overview of the most important techniques and key applications. Although the focus is one lanthanide ions, thus reflecting the current research in the field, the principles and the methods equally apply to other systems. The result is an excellent textbook from both a scientific and pedagogic point of view. |
| bioorthogonal chemistry nobel prize: Chemoselective and Bioorthogonal Ligation Reactions W. Russ Algar, Philip Dawson, Igor L. Medintz, 2017-03-17 This timely, one-stop reference is the first on an emerging and interdisciplinary topic. Covering both established and recently developed ligation chemistries, the book is divided into two didactic parts: a section that focuses on the details of bioorthogonal and chemoselective ligation reactions at the level of fundamental organic chemistry, and a section that focuses on applications, particularly in the areas of chemical biology, biomaterials, and bioanalysis, highlighting the capabilities and benefits of the ligation reactions. With chapters authored by outstanding scientists who range from trailblazers in the field to young and emerging leaders, this book on a highly interdisciplinary topic will be of great interest for biochemists, biologists, materials scientists, pharmaceutical chemists, organic chemists, and many others. |
| bioorthogonal chemistry nobel prize: The Molecular Basis of Evolution Christian Boehmer Anfinsen, 1965 |
| bioorthogonal chemistry nobel prize: Life During a Golden Age of Peptide Chemistry Bruce Merrifield, 1993 Thirteenth in a series of autobiographies of 22 eminent organic chemists, the present volume chronicles the life and contributions to the field of Bruce Merrifield, winner of the 1984 Nobel Prize for chemistry. Subtitled The Concept and Development of Solid-Phase Peptide Synthesis. Highly illustrated with diagrams, tables, graphs and (bandw) photographs. Annotation copyright by Book News, Inc., Portland, OR |
| bioorthogonal chemistry nobel prize: Na-ion Batteries , 2021-05-11 This book covers both the fundamental and applied aspects of advanced Na-ion batteries (NIB) which have proven to be a potential challenger to Li-ion batteries. Both the chemistry and design of positive and negative electrode materials are examined. In NIB, the electrolyte is also a crucial part of the batteries and the recent research, showing a possible alternative to classical electrolytes – with the development of ionic liquid-based electrolytes – is also explored. Cycling performance in NIB is also strongly associated with the quality of the electrode-electrolyte interface, where electrolyte degradation takes place; thus, Na-ion Batteries details the recent achievements in furthering knowledge of this interface. Finally, as the ultimate goal is commercialization of this new electrical storage technology, the last chapters are dedicated to the industrial point of view, given by two startup companies, who developed two different NIB chemistries for complementary applications and markets. |
| bioorthogonal chemistry nobel prize: Worlds in the making: The evolution of the universe Svante Arrhenius, 2023-07-10 Worlds in the making: The evolution of the universe by Svante Arrhenius (translated by H. Borns). Published by Good Press. Good Press publishes a wide range of titles that encompasses every genre. From well-known classics & literary fiction and non-fiction to forgotten−or yet undiscovered gems−of world literature, we issue the books that need to be read. Each Good Press edition has been meticulously edited and formatted to boost readability for all e-readers and devices. Our goal is to produce eBooks that are user-friendly and accessible to everyone in a high-quality digital format. |
| bioorthogonal chemistry nobel prize: Historic Documents of 2022 Heather Kerrigan, River Horse Communications, LLC, 2023-09-24 Published annually since 1972, the Historic Documents series has made primary source research easy by presenting excerpts from documents on the important events of each year for the United States and the World. Each volume pairs 60 to 70 original background narratives with well over 100 documents to chronicle the major events of the year, from official reports and surveys to speeches from leaders and opinion makers, to court cases, legislation, testimony, and much more. |
| bioorthogonal chemistry nobel prize: Chemical Epigenetics Antonello Mai, 2020-03-31 This book presents an authoritative review of the most significant findings about all the epigenetic targets (writers, readers, and erasers) and their implication in physiology and pathology. The book also covers the design, synthesis and biological validation of epigenetic chemical modulators, which can be useful as novel chemotherapeutic agents. Particular attention is given to the chemical mechanisms of action of these molecules and to the drug discovery prose which allows their identification. This book will appeal to students who want to know the extensive progresses made by epigenetics (targets and modulators) in the last years from the beginning, and to specialized scientists who need an instrument to quickly search and check historical and/or updated notices about epigenetics. |
| bioorthogonal chemistry nobel prize: Copper-Mediated Cross-Coupling Reactions Gwilherm Evano, Nicolas Blanchard, 2013-11-11 Providing comprehensive insight into the use of copper in cross-coupling reactions, Copper-Mediated Cross-Coupling Reactions provides a complete up-to-date collection of the available reactions and catalytic systems for the formation of carbon-heteroatom and carbon-carbon bonds. This essential reference covers a broad scope of copper-mediated reactions, their variations, key advances, improvements, and an array of academic and industrial applications that have revolutionized the field of organic synthesis. The text also discusses the mechanism of these transformations, the use of copper as cost-efficient alternative to palladium, as well as recently developed methods for conducting copper-mediated reactions with supported catalysts. |
| bioorthogonal chemistry nobel prize: Caller Number Nine Debbie Duncan, 2011-08-22 Thirteen-year-old Laura Hill wins a trip for two to Hawaii with L.A.'s coolest D.J. in the spring of 1967, when times are changing and girls are beginning to discover their power. |
| bioorthogonal chemistry nobel prize: Acids and Bases Brian G. Cox, 2013-01-31 This book seeks to enhance our understanding of acids and bases by reviewing and analysing their behaviour in non-aqueous solvents. The behaviour is related where possible to that in water, but correlations and contrasts between solvents are also presented. |
| bioorthogonal chemistry nobel prize: Click Chemistry Ram K. Gupta, 2024-09-06 Click chemistry involves highly efficient, reliable, and stereoselective reactions that can synthesize new materials cost-effectively. The first volume entitled “Click Chemistry: Fundamentals and Synthesis” covers the fundamentals, mechanisms, kinetics, and various approaches to synthesizing new materials making it suitable for synthetic chemists and researchers working in nanoscience and technology. The main objective of this book is to provide information about current, state-of-the-art development in click chemistry as well as challenges. Experts from around the world have contributed towards this book, making this a suitable textbook for students and providing new guidelines to researchers and industries working in these areas. |
| bioorthogonal chemistry nobel prize: Inorganic Chemical Biology Gilles Gasser, 2014-06-23 Understanding, identifying and influencing the biological systems are the primary objectives of chemical biology. From this perspective, metal complexes have always been of great assistance to chemical biologists, for example, in structural identification and purification of essential biomolecules, for visualizing cellular organelles or to inhibit specific enzymes. This inorganic side of chemical biology, which continues to receive considerable attention, is referred to as inorganic chemical biology. Inorganic Chemical Biology: Principles, Techniques and Applications provides a comprehensive overview of the current and emerging role of metal complexes in chemical biology. Throughout all of the chapters there is a strong emphasis on fundamental theoretical chemistry and experiments that have been carried out in living cells or organisms. Outlooks for the future applications of metal complexes in chemical biology are also discussed. Topics covered include: • Metal complexes as tools for structural biology • IMAC, AAS, XRF and MS as detection techniques for metals in chemical biology • Cell and organism imaging and probing DNA using metal and metal carbonyl complexes • Detection of metal ions, anions and small molecules using metal complexes • Photo-release of metal ions in living cells • Metal complexes as enzyme inhibitors and catalysts in living cells Written by a team of international experts, Inorganic Chemical Biology: Principles, Techniques and Applications is a must-have for bioinorganic, bioorganometallic and medicinal chemists as well as chemical biologists working in both academia and industry. |
| bioorthogonal chemistry nobel prize: Nanotechnologies in Preventive and Regenerative Medicine Vuk Uskokovic, 2017-10-30 Nanotechnologies in Preventative and Regenerative Medicine demonstrates how control at the nanoscale can help achieve earlier diagnoses and create more effective treatments. Chapters take a logical approach, arranging materials by their area of application. Biomaterials are, by convention, divided according to the area of their application, with each chapter outlining current challenges before discussing how nanotechnology and nanomaterials can help solve these challenges This applications-orientated book is a valuable resource for researchers in biomedical science who want to gain a greater understanding on how nanotechnology can help create more effective vaccines and treatments, and to nanomaterials researchers seeking to gain a greater understanding of how these materials are applied in medicine. - Demonstrates how nanotechnology can help achieve more successful diagnoses at an earlier stage - Explains how nanomaterials can be manipulated to create more effective drug treatments - Offers suggestions on how the use of nanotechnology might have future applications to create even more effective treatments |
| bioorthogonal chemistry nobel prize: Stereoelectronic Effects Igor V. Alabugin, 2016-10-17 Stereoelectronic Effects illustrates the utility of stereoelectronic concepts using structure and reactivity of organic molecules An advanced textbook that provides an up-to-date overview of the field, starting from the fundamental principles Presents a large selection of modern examples of stereoelectronic effects in organic reactivity Shows practical applications of stereoelectronic effects in asymmetric catalysis, photochemical processes, bioorganic chemistry and biochemistry, inorganic and organometallic reactivity, supramolecular chemistry and materials science |
| bioorthogonal chemistry nobel prize: The Cyclic Peptide Toxins of Amanita and Other Poisonous Mushrooms Jonathan Walton, 2018-05-09 Poisonous mushrooms have fascinated scientists and laypersons alike for thousands of years. Almost all mushroom fatalities are due to the genus Amanita, whose poetic common names (death cap, destroying angel) attest to their lethality. In his classic 1986 book, Theodor Wieland covered the state of our knowledge about the chemistry and biochemistry of the toxins of Amanita mushrooms up until that time, with a particular focus on the decades of chemical research by him and the Wieland dynasty (including his father, brother, brother-in-law, and cousin). Wieland’s book is now mainly of historical interest, with its exhaustive overview of the early chemical studies done without benefit of methods taken for granted by modern chemists. This book is a complete top-to-bottom revision of Wieland’s 1986 book. The material covers history, chemistry, and biology with equal thoroughness. It should be of interest to natural products chemists and biologists, professional and amateur mycologists, and toxicologists. The three scientific fields that are most relevant to the book are natural products chemistry, mycology, and fungal molecular genetics. Dr. Walton is an expert in all three. To maximize the broad utility and appeal of the book, care has been taken to define all technical terms specific to a particular discipline, so that, for example, mycologists will be able to understand the relevant chemistry, and chemists will be able to understand the relevant fungal biology. |
| bioorthogonal chemistry nobel prize: Enzymes for Solving Humankind's Problems José J. G. Moura, Isabel Moura, Luisa B. Maia, 2020-12-01 This book presents specific key natural and artificial systems that are promising biocatalysts in the areas of health, agriculture, environment and energy. It provides a comprehensive account of the state of the art of these systems and outlines the significant progress made in the last decade using these systems to develop innovative, sustainable and environmentally friendly solutions. Chapters from expert contributors explore how natural enzymes and artificial systems tackle specific targets such as: climate change, carbon footprint and economy and carbon dioxide utilisation; nitrogen footprint and fixation and nitrous oxide mitigation; hydrogen production, fuel cells and energy from bacteria; biomass transformation and production of added-value compounds, as well as biosensors development. This book provides an important and inspiring account for the designing of new natural and artificial systems with enhanced properties, and it appeals not only to students and researchers working in the fields of energy, health, food and environment, but also to a wider audience of educated readers that are interested in these up-to-date and exciting subjects. Chapter “Carbon Dioxide Utilisation—The Formate Route” is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com. |
| bioorthogonal chemistry nobel prize: The Chemistry of Metal-Organic Frameworks Stefan Kaskel, 2016-06-14 Providing vital knowledge on the design and synthesis of specific metal-organic framework (MOF) classes as well as their properties, this ready reference summarizes the state of the art in chemistry. Divided into four parts, the first begins with a basic introduction to typical cluster units or coordination geometries and provides examples of recent and advanced MOF structures and applications typical for the respective class. Part II covers recent progress in linker chemistries, while special MOF classes and morphology design are described in Part III. The fourth part deals with advanced characterization techniques, such as NMR, in situ studies, and modelling. A final unique feature is the inclusion of data sheets of commercially available MOFs in the appendix, enabling experts and newcomers to the field to select the appropriate MOF for a desired application. A must-have reference for chemists, materials scientists, and engineers in academia and industry working in the field of catalysis, gas and water purification, energy storage, separation, and sensors. |
| bioorthogonal chemistry nobel prize: Nobel Prize Laureates , 1979 |
| bioorthogonal chemistry nobel prize: The Nature of the Chemical Bond and the Structure of Molecules and Crystals Linus Pauling, 2023 |
| bioorthogonal chemistry nobel prize: Cycloadditions in Bioorthogonal Chemistry Milan Vrabel, Thomas Carell, 2016-06-03 The series Topics in Current Chemistry Collections presents critical reviews from the journal Topics in Current Chemistry organized in topical volumes. The scope of coverage is all areas of chemical science including the interfaces with related disciplines such as biology, medicine and materials science. The goal of each thematic volume is to give the non-specialist reader, whether in academia or industry, a comprehensive insight into an area where new research is emerging which is of interest to a larger scientific audience. Each review within the volume critically surveys one aspect of that topic and places it within the context of the volume as a whole. The most significant developments of the last 5 to 10 years are presented using selected examples to illustrate the principles discussed. The coverage is not intended to be an exhaustive summary of the field or include large quantities of data, but should rather be conceptual, concentrating on the methodological thinking that will allow the non-specialist reader to understand the information presented. Contributions also offer an outlook on potential future developments in the field. |
| bioorthogonal chemistry nobel prize: Bio-inspired Polymers Nico Bruns, Andreas F M Kilbinger, 2016-10-14 Many key aspects of life are based on naturally occurring polymers, such as polysaccharides, proteins and DNA. Unsurprisingly, their molecular functionalities, macromolecular structures and material properties are providing inspiration for designing new polymeric materials with specific functions, for example, responsive, adaptive and self-healing materials. Bio-inspired Polymers covers all aspects of the subject, ranging from the synthesis of novel polymers, to structure-property relationships, materials with advanced properties and applications of bio-inspired polymers in such diverse fields as drug delivery, tissue engineering, optical materials and lightweight structural materials. Written and edited by leading experts on the topic, the book provides a comprehensive review and essential graduate level text on bio-inspired polymers for biochemists, materials scientists and chemists working in both industry and academia. |
| bioorthogonal chemistry nobel prize: Catalytic Cascade Reactions Peng-Fei Xu, Wei Wang, 2013-11-11 Demonstrates the advantages of catalytic cascade reactions for synthesizing natural products and pharmaceuticals Riding the wave of green chemistry, catalytic cascade reactions have become one of the most active research areas in organic synthesis. During a cascade reaction, just one reaction solvent, one workup procedure, and one purification step are needed, thus significantly increasing synthetic efficiency. Featuring contributions from an international team of pioneers in the field, Catalytic Cascade Reactions demonstrates the versatility and application of these reactions for synthesizing valuable compounds. The book examines both organocatalysis and transition-metal catalysis reactions, bringing readers up to date with the latest discoveries and activities in all major areas of catalytic cascade reaction research. Catalytic Cascade Reactions begins with three chapters dedicated to organocatalytic cascade reactions, exploring amines, Brønsted acids, and the application of organocatalytic cascade reactions in natural product synthesis and drug discovery. Next, the book covers: Gold-catalyzed cascade reactions Cascade reactions catalyzed by ruthenium, iron, iridium, rhodium, and copper Palladium-catalyzed cascade reactions of alkenes, alkynes, and allenes Application of transition-metal catalyzed cascade reactions in natural product synthesis and drug discovery Engineering mono- and multifunctional nanocatalysts for cascade reactions Multiple-catalyst-promoted cascade reactions All chapters are thoroughly referenced, providing quick access to important original research findings and reviews so that readers can explore individual topics in greater depth. Drawing together and analyzing published findings scattered across the literature, this book provides a single source that encapsulates our current understanding of catalytic cascade processes. Moreover, it sets the stage for the development of new catalytic cascade reactions and their applications. |
| bioorthogonal chemistry nobel prize: Measuring the Value of Invention Benjamin M. Miller, David Metz, Jon Schmid, Paige M. Rudin, Marjory S. Blumenthal, 2021-02-11 Inventions, such as new tools, devices, processes, and medicines, have provided significant benefits to society. Inventions help people around the world live longer, healthier, and more-productive lives and provide new ways to build, move, communicate, heal, learn, and play. Understanding and clearly communicating the value of invention can help policymakers appreciate the benefits of supporting the development of inventions and of addressing inequities that suppress the development of female and minority inventors. In this report, researchers use the inventions of Lemelson-MIT Prize winners as examples to illustrate the scientific, technological, economic, and social impacts that inventions can have on society. The impacts of this group's inventions are considered through evaluation of all prize winners in aggregate and through individual case studies of the prize winners from three particular years. Researchers highlight the substantial benefits to society, both nationally and globally, that have been provided by these inventors' works. The inventions discussed in this report have spawned new products, companies, and, in some cases, entirely new industries. Research also demonstrates that there are many different paths to the successful development and commercialization of inventions, with the success or failure of new inventions not always being entirely under the inventor's control. |
| bioorthogonal chemistry nobel prize: STEM Gems Stephanie Espy, 2016-06-06 Tired of seeing the same careers foisted upon women in TV, movies and magazines? Chemical engineer Stephanie Espy, a graduate of MIT, UC Berkeley and Emory University, tells the stories of 44 inspiring women in STEM to show girls and young women around the world a new set of women heroes to look up to.The statistics for women in Science, Technology, Engineering and Mathematics (STEM) careers are just plain sad. In recent years, fewer than 20% of college graduates in engineering and computer science were women. While stereotypes pervade about women in these fields, the truth is that most girls have never even heard of these careers and are not aware of the wide range of options that exist.In STEM Gems, you and your daughter, niece, neighbor, friend or student will discover: The stories of 44 inspiring women in diverse STEM fields and how they made it; The challenges these incredible women faced in pursuit of their dreams; The tremendous accomplishments these Gems have achieved in their respective STEM fields; Advice on how to pursue science, technology, engineering and mathematics careers; Actionable steps girls and young women can take right now to set themselves up for success; What girls and young women can expect in a promising STEM career, and much, much more!Through the powerful stories of the STEM Gems in this book, girls and young women will have their pick of current role models of various ages, ethnicities and job types. And through the eight chapters that outline actionable steps, girls and young women will learn what they can do right now, today, to set themselves up for success and to create their own unique paths. STEM Gems is relatable, encouraging and inspiring, demonstrating the limitless possibilities for the next generation of women. |
| bioorthogonal chemistry nobel prize: Synthesis And Applications In Chemistry And Materials (In 4 Volumes) Armando J L Pombeiro, Kamran T Mahmudov, Maria De Fatima Costa Guedes Da Silva, 2024-01-16 Chemistry and Material Sciences naturally depend greatly on Synthesis as the initial stage for the existence of compounds and materials with desired behaviors, within the overall streamline of Design/Synthesis — Properties — Application/Function, and their relations. Such a general approach is of a too wide scope to be properly treated in a single set of publications, but this one on 'Synthesis and Applications in Chemistry and Materials' restricts itself by aiming to show the strength and international character of the current research in synthetic chemistry that is being developed in Portugal or abroad by teams that cooperate with this country. Hence, it gathers representative contributions of main Portuguese research groups and foreign collaborating ones. Nevertheless, the topic should be understood in a wide sense, being open to types of studies with significance on sustainable synthesis and applications in chemistry, materials and/or related sciences. |
CLICK CHEMISTRY AND BIOORTHOGONAL CHEMISTRY
The Royal Swedish Academy of Sciences has decided to award Carolyn R. Bertozzi, Morten Meldal, and K. Barry Sharpless the Nobel Prize in Chemistry 2022, for the development of …
Bioorthogonal chemistry: Bridging chemistry, biology, and …
Given that bioorthogonal chemistry was a recipient of the 2022 Nobel Prize, we expect this field to be even more energized. Here, we highlight some of the most recent studies in this sphere …
2022 NOBEL PRIZE IN CHEMISTRY - Compound Interest
The 2022 Nobel Prize in Chemistry was awarded jointly to Carolyn R. Bertozzi, Morten Meldal and K. Barry Sharpless for their development of click chemistry and bioorthogonal chemistry.
QnAs with Carolyn R. Bertozzi
Dec 30, 2022 · The 2022 Nobel Prize in Chemistry (1) was awarded to three scientists for the development of click chemistry and bioorthogonal chemistry, two innovations that have had a …
Click does the trick: understanding the 2022 Nobel Prize in …
Tamaryin Godinho This year, the Nobel Prize in Chemistry was awarded for click chemistry. Learn about the stunning methodological advance behind this simple-sounding name yn R. Bertozzi, …
Simple connections take the prize - Nature
Click chemistry and bioorthogonal chemistry have finally been recognized with the Nobel Prize in Chemistry. 2022 Nobel Prize in Chemistry was awarded to Carolyn Bertozzi, Morten Meldal...
The 2022 nobel prize in chemistry for the development of click ...
The 2022 Nobel Prize in Chemistry recognized the development of biorthogonal chemical ligation reactions known as click chemistry in biomedicine. This concept has catalyzed signicant …
Their functional chemistry - Kungl. Vetenskapsakademien
g a straightforward route. The chemical reactions being recognised are so unique they can be used in living organisms; they are bioorthogonal, which means they do not disturb the o. her …
Their functional chemistry works wonders - NobelPrize.org
Carolyn Bertozzi developed click reactions that can be used inside living organisms. Her bioorthogo-nal reactions – which occur without disturbing the normal chemistry of the cell – …
Click and bioorthogonal chemistry win 2022 Nobel Prize in …
T hree scientists have won the 2022 Nobel Prize in Chemistry: Carolyn R. Bertozzi of Stanford University, Morten Meldal of the University of Copenhagen, and K. Barry Sharpless of Scripps …
ShortCommunication Click Chemistry and Bioorthogonal …
overies, conceptualization plays a significant role in this year’s nobel prize in chemistry. The azide-alkyn cycloaddition, also referred to as the “click” reaction was first developed by …
5 October 2022 The Nobel Prize in Chemistry 2022
out disrupting the normal chemistry of the cell. These reactions are now used globally to explore cells and track biological processes. Using bioorthogonal reactions, researchers have …
Nobel Prizes in Chemistry (2022) for the Development of Click …
Abstract emistry and biorthogonal chemistry. The chemistry was developed by Sharpless, Meldal, and Bertozzi. Click chemistry has been ex ensively utilized in catalysis, solid-state peptide …
Voices: Challenges and opportunities for bioorthogonal …
Bioorthogonal chemistry was deservedly recognized with the 2022 Nobel Prize in Chemistry, having trans-formed the way chemists and biologists interrogate biological systems in the past …
Click Chemistry and Bioorthogonal Chemistry: General …
Jan 3, 2024 · The protocol has garnered the highest recognition with the awarding of the ‘Nobel Prize in Chemistry for the year 2022’ to Profes-sors Carolyn R. Bertozzi, Morten Meldal, and …
A Special Virtual Issue Celebrating the 2022 Nobel Prize in …
In recognition of the impact of click and bioorthogonal chemistries, the Chemistry Nobel Committee of the Royal Swedish Academy of Sciences awarded the Nobel Prize in Chemistry …
Click Chemistry and Bioorthogonal Chemistry - NobelPrize.org
The Royal Swedish Academy of Sciences has decided to award David Baker, Demis Hassabis and John Jumper the Nobel Prize in Chemistry 2024, for computational protein design and …
Bioorthogonal chemistry for biological insights - Cell Press
With remarkable therapeutic potential, bioorthogonal chemistry has transformed the way chemists and biologists interrogate biological systems and was rightfully recognized with the 2022 Nobel …
Slideshow Chemistry prize 2022 - Nobel Prize Lessons
Bioorthogonal chemistry illuminates the cell Carolyn Bertozzi refined the method further so that it can be used in living organisms too. By attaching one of the click molecules to a fluorescent …
Assignment Chemistry prize 2022 - Nobel Prize lessons
Barry Sharpless, Morten Meldal and Carolyn Bertozzi have been awarded the 2022 Nobel Prize in Chemistry “for the development of click chemistry and bioorthogonal chemistry”.
CLICK CHEMISTRY AND BIOORTHOGONAL CHEMISTRY
The Royal Swedish Academy of Sciences has decided to award Carolyn R. Bertozzi, Morten Meldal, and K. Barry Sharpless the Nobel Prize in Chemistry 2022, for the development of click …
Bioorthogonal chemistry: Bridging chemistry, biology, and …
Given that bioorthogonal chemistry was a recipient of the 2022 Nobel Prize, we expect this field to be even more energized. Here, we highlight some of the most recent studies in this sphere and …
2022 NOBEL PRIZE IN CHEMISTRY - Compound Interest
The 2022 Nobel Prize in Chemistry was awarded jointly to Carolyn R. Bertozzi, Morten Meldal and K. Barry Sharpless for their development of click chemistry and bioorthogonal chemistry.
QnAs with Carolyn R. Bertozzi
Dec 30, 2022 · The 2022 Nobel Prize in Chemistry (1) was awarded to three scientists for the development of click chemistry and bioorthogonal chemistry, two innovations that have had a …
Click does the trick: understanding the 2022 Nobel Prize in …
Tamaryin Godinho This year, the Nobel Prize in Chemistry was awarded for click chemistry. Learn about the stunning methodological advance behind this simple-sounding name yn R. Bertozzi, …
Simple connections take the prize - Nature
Click chemistry and bioorthogonal chemistry have finally been recognized with the Nobel Prize in Chemistry. 2022 Nobel Prize in Chemistry was awarded to Carolyn Bertozzi, Morten Meldal...
The 2022 nobel prize in chemistry for the development of …
The 2022 Nobel Prize in Chemistry recognized the development of biorthogonal chemical ligation reactions known as click chemistry in biomedicine. This concept has catalyzed signicant …
Their functional chemistry - Kungl. Vetenskapsakademien
g a straightforward route. The chemical reactions being recognised are so unique they can be used in living organisms; they are bioorthogonal, which means they do not disturb the o. her …
Their functional chemistry works wonders - NobelPrize.org
Carolyn Bertozzi developed click reactions that can be used inside living organisms. Her bioorthogo-nal reactions – which occur without disturbing the normal chemistry of the cell – are …
Click and bioorthogonal chemistry win 2022 Nobel Prize in …
T hree scientists have won the 2022 Nobel Prize in Chemistry: Carolyn R. Bertozzi of Stanford University, Morten Meldal of the University of Copenhagen, and K. Barry Sharpless of Scripps …
ShortCommunication Click Chemistry and Bioorthogonal …
overies, conceptualization plays a significant role in this year’s nobel prize in chemistry. The azide-alkyn cycloaddition, also referred to as the “click” reaction was first developed by …
5 October 2022 The Nobel Prize in Chemistry 2022
out disrupting the normal chemistry of the cell. These reactions are now used globally to explore cells and track biological processes. Using bioorthogonal reactions, researchers have …
Nobel Prizes in Chemistry (2022) for the Development of …
Abstract emistry and biorthogonal chemistry. The chemistry was developed by Sharpless, Meldal, and Bertozzi. Click chemistry has been ex ensively utilized in catalysis, solid-state peptide …
Voices: Challenges and opportunities for bioorthogonal …
Bioorthogonal chemistry was deservedly recognized with the 2022 Nobel Prize in Chemistry, having trans-formed the way chemists and biologists interrogate biological systems in the past …
Click Chemistry and Bioorthogonal Chemistry: General …
Jan 3, 2024 · The protocol has garnered the highest recognition with the awarding of the ‘Nobel Prize in Chemistry for the year 2022’ to Profes-sors Carolyn R. Bertozzi, Morten Meldal, and …
A Special Virtual Issue Celebrating the 2022 Nobel Prize in …
In recognition of the impact of click and bioorthogonal chemistries, the Chemistry Nobel Committee of the Royal Swedish Academy of Sciences awarded the Nobel Prize in Chemistry …
Click Chemistry and Bioorthogonal Chemistry
The Royal Swedish Academy of Sciences has decided to award David Baker, Demis Hassabis and John Jumper the Nobel Prize in Chemistry 2024, for computational protein design and …
Bioorthogonal chemistry for biological insights - Cell Press
With remarkable therapeutic potential, bioorthogonal chemistry has transformed the way chemists and biologists interrogate biological systems and was rightfully recognized with the 2022 Nobel …
Slideshow Chemistry prize 2022 - Nobel Prize Lessons
Bioorthogonal chemistry illuminates the cell Carolyn Bertozzi refined the method further so that it can be used in living organisms too. By attaching one of the click molecules to a fluorescent …
Assignment Chemistry prize 2022 - Nobel Prize lessons
Barry Sharpless, Morten Meldal and Carolyn Bertozzi have been awarded the 2022 Nobel Prize in Chemistry “for the development of click chemistry and bioorthogonal chemistry”.
