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| bioorganic and medicinal chemistry impact factor 2022: Bioorganic and Medicinal Chemistry (Chemistry) (English Edition) Dr. Neeraj Kumar Tripathi, Dr. Rajesh Chandra Verma , 2022-01-01 Thakur Publication proudly presents the Bioorganic and Medicinal Chemistry e-Book, designed specifically for B.Sc 2nd Year students at U.P. State Universities. This comprehensive e-Book serves as an essential resource for students studying the intriguing field of bioorganic and medicinal chemistry. Written by knowledgeable experts in the field, this English edition e-Book covers the common syllabus prescribed by U.P. State Universities. It provides a detailed exploration of the principles and applications of bioorganic and medicinal chemistry, offering students a deeper understanding of the interdisciplinary nature of this subject. |
| bioorganic and medicinal chemistry impact factor 2022: Fragment-Based Drug Discovery Steven Howard, Chris Abell, 2015-06-17 Fragment-based drug discovery is a rapidly evolving area of research, which has recently seen new applications in areas such as epigenetics, GPCRs and the identification of novel allosteric binding pockets. The first fragment-derived drug was recently approved for the treatment of melanoma. It is hoped that this approval is just the beginning of the many drugs yet to be discovered using this fascinating technique. This book is written from a Chemist's perspective and comprehensively assesses the impact of fragment-based drug discovery on a wide variety of areas of medicinal chemistry. It will prove to be an invaluable resource for medicinal chemists working in academia and industry, as well as anyone interested in novel drug discovery techniques. |
| bioorganic and medicinal chemistry impact factor 2022: Targeted Protein Degradation Angela M. Cacace, Christopher M. Hickey, Miklós Békés, 2021-08-26 This volume contains a collection of innovative techniques for studying targeted protein degradation. Chapters guide readers through heterobifunctional proteolysis-targeting chimeras (PROTACs) approaches, E3 ligase, E3 ligase-induced ubiquitylation, proteomic approaches, novel degrader molecules, molecular glue, and stabilize binding interaction between a target and E3 ubiquitin ligase. Written in the format of the highly successful Methods in Molecular Biology series, each chapter includes an introduction to the topic, lists necessary materials and reagents, includes tips on troubleshooting and known pitfalls, and step-by-step, readily reproducible protocols. Authoritative and cutting-edge, Targeted Protein Degradation: Methods and Protocols aims to ensure successful results in this emerging field of drug discovery. |
| bioorganic and medicinal chemistry impact factor 2022: Current Molecular Targets of Heterocyclic Compounds for Cancer Therapy Vivek Asati, Ankur Vaidya, 2024-04-10 Current Molecular Targets of Heterocyclic Compounds for Cancer Therapy discusses recently developed treatments based on molecular targets which are genetically altered in cancer cells and are essential for tumor development and survival. Considerable research effort has been devoted to the development of targeted drugs that inhibit the action of pathogenic kinases, and clinical studies performed so far have validated the positive effects of kinase inhibitors for cancer treatment. Each chapter discusses a molecular target, such as ALK2, ATR, CK, Src-Abl, EGFR, Fyn-Blk-Lyn, IGFs, and PAK1. The book's chapters are written by experts who actively work on the targets to help readers fully understand how they can be used. This is a valuable resource for cancer researchers, oncologists, graduate students and members of the biomedical field who are interested in the potential of novel cancer therapies based on molecular targets. - Discusses recently discovered molecular targets for cancer therapy - Brings updated literature of heterocyclic compounds, an important construction motif for the development of new anticancer drugs - Encompasses comprehensive compilation of recently introduced anticancer drugs in the market and their health outcomes and pharmacoeconomics |
| bioorganic and medicinal chemistry impact factor 2022: Handbook of Oncobiology: From Basic to Clinical Sciences R. C. Sobti, |
| bioorganic and medicinal chemistry impact factor 2022: Drug Formulation Design Rahul Shukla, Aleksey Kuznetsov, Akbar Ali, 2023-06-07 This book discusses the theoretical and practical aspects required to formulate conventional drug dosage forms and advanced technology-based therapeutics. It is organized into four sections: “Preformulation”, “Formulation Design and Approaches”, “Characterization and Analysis”, and “Cocrystal Engineering”. The approaches discussed enhance the overall quality of treatment and overcome the side effects of available therapies. The book is a collection of scholarly literature relevant to pharmaceutical technology and existing pharmaceutical technologies. It is a useful reference for industrial personnel working on developing novel pharmaceutical dosage forms. |
| bioorganic and medicinal chemistry impact factor 2022: Radical SAM Enzymes , 2018-08-09 Radical SAM Enzymes, Volume 606, the latest release in the Methods in Enzymology series, highlights new advances in the field, with this new volume presenting interesting chapters on the Characterization of the glycyl radical enzyme choline trimethylamine-lyase and its radical S-adenosylmethionine activating enzyme, Diphathimide biosynthesis, Radical SAM glycyl radical activating enzymes, Radical SAM enzyme BioB in the biosynthesis of biotin, Biogenesis of the PQQ cofactor, Role of MoaAC in the biogenesis of the molybdenum cofactor, Biosynthesis of the nitrogenase cofactor, Bioinformatics of the radical SAM superfamily, The involvement of SAM radical enzymes in the biosynthesis of methanogenic coenzymes, methanopterin and coenzyme F420, and more. |
| bioorganic and medicinal chemistry impact factor 2022: The Role of Chromenes in Drug Discovery and Development Ashutosh Kumar Dash, Deepak Kumar, 2023-08-08 Chromene is a naturally abundant heterocyclic compound found in alkaloids, tocopherols, terpenes and other compounds. Its derivatives can be used as a scaffold that exhibits pharmacological activity in the human body. Chromene drugs and related bioactive molecules are the prime focus of this reference. It presents 13 thoroughly researched chapters that comprehensively cover all aspects about the molecule. Starting with a detailed introduction to its role and importance in drug discovery, the book goes into the details of chromene structure, synthesis and pharmacology. Readers can gain knowledge of different commercial medicines based on chromene and its pharmacological activity against different diseases. The elaborate topics in the book will help researchers working on chromene based drugs. Key highlights of the book include: - Complete coverage of chromene’s role in nature and drug development with references to historical background and current developments - References to commercial and preclinical drugs and patents of interest - Explanation of chromene bioacivity in different diseases (antioxidant, antidiabetic, antinflammatory, antibacterial and antifungal activities, antitumour, immunomodulatory activity) - Explanation of chromene activity against SARS-Cov2 |
| bioorganic and medicinal chemistry impact factor 2022: Encyclopedia of Polymeric Nanomaterials Shiro Kobayashi, Klaus Müllen, 2015-06-12 Over the last few years, nanoscience and nanotechnology have been the focus of significant research attention, both from academia and industry. This sustained focus has in-turn driven the interdisciplinary field of material science research to the forefront of scientific inquiry through the creation and study of nanomaterials. Nanomaterials play an important role in the development of new materials as they can be used to influence and control physical properties and specific characteristics of other materials. Nanostructured materials that have been created include nanoparticles, nanocapsules, nanoporous materials, polymer multi-layers to name a few. These are increasingly used across applications as diverse as automotive, environment, energy, catalysis, biomedical, pharmaceutical, and polymer industries. The Encyclopedia of Polymeric Nanomaterials (EPN) intends to be a comprehensive reference work on this dynamic field studying nanomaterials within the context of the relationship between molecular structure and the properties of polymeric materials. Alphabetically organized as an encyclopedic Major Reference Work, EPN will cover the subject along multiple classification axes represented by name, source, properties, function, and structures or even processes, applications and usage. The underlying themes of the encyclopedia has been carefully identified to be based not just on material-based and function-based representation but also on structure- and process-based representation. The encyclopedia will have an exclusive focus on polymeric nanomaterials (for e.g., nanoceramics, nanocomposites, quantum dots, thin films) and will be a first of its kind work to have such an organization providing an overview to the concepts, practices and applications in the field. The encyclopedia intends to cover research and development work ranging from the fundamental mechanisms used for the fabrication of polymeric nanomaterials to their advanced application across multiple industries. |
| bioorganic and medicinal chemistry impact factor 2022: Deep Eutectic Solvents Diego J. Ramón, Gabriela Guillena, 2020-01-13 A useful guide to the fundamentals and applications of deep eutectic solvents Deep Eutectic Solvents contains a comprehensive review of the use of deep eutectic solvents (DESs) as an environmentally benign alternative reaction media for chemical transformations and processes. The contributors cover a range of topics including synthesis, structure, properties, toxicity and biodegradability of DESs. The book also explores myriad applications in various disciplines, such as organic synthesis and (bio)catalysis, electrochemistry, extraction, analytical chemistry, polymerizations, (nano)materials preparation, biomass processing, and gas adsorption. The book is aimed at organic chemists, catalytic chemists, pharmaceutical chemists, biochemists, electrochemists, and others involved in the design of eco-friendly reactions and processes. This important book: -Explores the promise of DESs as an environmentally benign alternative to hazardous organic solvents -Covers the synthesis, structure, properties (incl. toxicity) as well as a wide range of applications -Offers a springboard for stimulating critical discussion and encouraging further advances in the field Deep Eutectic Solvents is an interdisciplinary resource for researchers in academia and industry interested in the many uses of DESs as an environmentally benign alternative reaction media. |
| bioorganic and medicinal chemistry impact factor 2022: Applications of Machine Learning Prashant Johri, Jitendra Kumar Verma, Sudip Paul, 2020-05-04 This book covers applications of machine learning in artificial intelligence. The specific topics covered include human language, heterogeneous and streaming data, unmanned systems, neural information processing, marketing and the social sciences, bioinformatics and robotics, etc. It also provides a broad range of techniques that can be successfully applied and adopted in different areas. Accordingly, the book offers an interesting and insightful read for scholars in the areas of computer vision, speech recognition, healthcare, business, marketing, and bioinformatics. |
| bioorganic and medicinal chemistry impact factor 2022: Immunosuppression and Immunomodulation Rajeev K. Tyagi, Prakriti Sharma, Praveen Sharma, 2023-07-12 This book synthesizes the key concepts of immunosuppression and immunomodulation. A comprehensive understanding of these processes is necessary to develop vaccines and therapeutic interventions for diseases. This book examines the role of information molecules such as cytokines and chemokines and other proteins secreted by the host upon interacting with the pathogen(s) that modulate and suppress the immune system and assist the pathogen(s) in causing disease. Chapters discuss the modulation of inflammation, signaling pathways, the interaction of immune cells, and resulting immunity as well as its suppression. |
| bioorganic and medicinal chemistry impact factor 2022: Pharmaceutical Applications Ponnadurai Ramasami, 2021-10-25 Based on The Virtual Conference on Chemistry and its Applications (VCCA-2020) - Research and Innovations in Chemical Sciences: Paving the Way Forward held in August 2020 and organized by the Computational Chemistry Group of the University of Mauritius. The chapters reflect a wide range of fundamental and applied research in the chemical sciences and interdisciplinary subjects. |
| bioorganic and medicinal chemistry impact factor 2022: CPP, Cell-Penetrating Peptides Ülo Langel, 2023-10-18 In this book, a summary and update of the most important areas of cell-penetrating peptides (CPP) research are presented, while raising relevant questions for further development. The CPP sequences are presented and discussed throughout the book. The methods for testing CPP mechanisms are discussed in detail. Various approaches for the testing of endocytotic pathways of CPP uptake are also described. Different CPP uptake experiments are compared since it is becoming clear that it is often best to apply several methods in a complementary manner in order to most comprehensively evaluate CPP uptake mechanisms due to the complexity of these processes. A brief summary of functionality issues of CPPs, both in vitro and in vivo, is discussed. Therapeutic potential of CPPs and commercial developments are discussed. The present, second edition of this book is the updated and expanded version of the first edition, published in 2019. The development of the field of cell-penetrating peptides in these five years has been obvious and exciting. This second edition of the book has been partly reorganized and comprehensively expanded with the exciting research in 2019-2023. Around 2500 novel scientific articles have become available, most of them are reviewed in the second edition. Additional rapidly growing areas of high impact presented in this second edition are therapeutic developments (Chapter 16) and delivery of oligonucleotides and proteins/peptides (Chapters 5 and 6) including novel reports on genome editing with CPP assistance. Also, several additional examples are available now on clinical trials using CPPs (Chapter 15). The book is written for researchers and students in the field. |
| bioorganic and medicinal chemistry impact factor 2022: Successful Drug Discovery, Volume 5 Janos Fischer, Christian Klein, Wayne E. Childers, 2021-02-12 Filled with unique insights into current drugs that have made it to the marketplace In the fifth volume of Successful Drug Discovery, the inventors and primary developers of drugs that made it to the market tell the story of the drugs discovery and development. Case studies of drugs from different therapeutic fields reveal the all-too-often unpredictable path from the first drug candidate molecule to the successfully marketed drug. In addition, this new volume addresses overarching topics for drug discovery, such as drug discovery in academia, and discusses currently important classes of small molecule as well as biological drugs. Comprehensive in scope, the books nine chapters provide a representative cross-section of the present-day drug development effort. The authoritative fifth volume is filled with relevant data and chemical information, as well as the insight and experience of the best contemporary drug creators. This important volume: - Puts the focus on recently introduced drugs that have not yet made it into standard textbooks or general references - Contains information and insight that is new and often not even available from the primary literature - Reveals what it takes to successfully develop a drug molecule that has made it all the way to the market - Is endorsed and supported by the International Union of Pure and Applied Chemistry (IUPAC) Written for medicinal chemists, pharmaceutical chemists, organic chemists, Successful Drug Discovery, Volume Five reveals the most recent techniques used by drug innovators in the drug development process. |
| bioorganic and medicinal chemistry impact factor 2022: Chemoinformatics for Drug Discovery Jürgen Bajorath, 2013-09-25 Chemoinformatics strategies to improve drug discovery results With contributions from leading researchers in academia and the pharmaceutical industry as well as experts from the software industry, this book explains how chemoinformatics enhances drug discovery and pharmaceutical research efforts, describing what works and what doesn't. Strong emphasis is put on tested and proven practical applications, with plenty of case studies detailing the development and implementation of chemoinformatics methods to support successful drug discovery efforts. Many of these case studies depict groundbreaking collaborations between academia and the pharmaceutical industry. Chemoinformatics for Drug Discovery is logically organized, offering readers a solid base in methods and models and advancing to drug discovery applications and the design of chemoinformatics infrastructures. The book features 15 chapters, including: What are our models really telling us? A practical tutorial on avoiding common mistakes when building predictive models Exploration of structure-activity relationships and transfer of key elements in lead optimization Collaborations between academia and pharma Applications of chemoinformatics in pharmaceutical research experiences at large international pharmaceutical companies Lessons learned from 30 years of developing successful integrated chemoinformatic systems Throughout the book, the authors present chemoinformatics strategies and methods that have been proven to work in pharmaceutical research, offering insights culled from their own investigations. Each chapter is extensively referenced with citations to original research reports and reviews. Integrating chemistry, computer science, and drug discovery, Chemoinformatics for Drug Discovery encapsulates the field as it stands today and opens the door to further advances. |
| bioorganic and medicinal chemistry impact factor 2022: Na-ion Batteries , 2021-05-11 This book covers both the fundamental and applied aspects of advanced Na-ion batteries (NIB) which have proven to be a potential challenger to Li-ion batteries. Both the chemistry and design of positive and negative electrode materials are examined. In NIB, the electrolyte is also a crucial part of the batteries and the recent research, showing a possible alternative to classical electrolytes – with the development of ionic liquid-based electrolytes – is also explored. Cycling performance in NIB is also strongly associated with the quality of the electrode-electrolyte interface, where electrolyte degradation takes place; thus, Na-ion Batteries details the recent achievements in furthering knowledge of this interface. Finally, as the ultimate goal is commercialization of this new electrical storage technology, the last chapters are dedicated to the industrial point of view, given by two startup companies, who developed two different NIB chemistries for complementary applications and markets. |
| bioorganic and medicinal chemistry impact factor 2022: N-Heterocycles Keshav Lalit Ameta, Ravi Kant, Andrea Penoni, Angelo Maspero, Luca Scapinello, 2022-04-23 This book presents an overview of the recent advancements for the synthesis of small- and medium-sized azaheterocycles, including pyrroles, indoles, pyrimidines, pyridines, pyrrolidines, imidazoles, pyrazoles, pyrazolines, lactams, and 1,2,3-triazoles, which are significant scaffolds for compounds with pharmaceutical uses. The book also discusses various properties and performance attributes of azaheterocycles including their bioactivity and synthetic strategies. Given the contents, the book will be a valuable reference for students, researchers, and professionals interested in organic synthesis and medicinal chemistry. |
| bioorganic and medicinal chemistry impact factor 2022: Advanced Healthcare Materials Ashutosh Tiwari, 2014-05-09 Offers a comprehensive and interdisciplinary view of cutting-edge research on advanced materials for healthcare technology and applications Advanced healthcare materials are attracting strong interest in fundamental as well as applied medical science and technology. This book summarizes the current state of knowledge in the field of advanced materials for functional therapeutics, point-of-care diagnostics, translational materials, and up-and-coming bioengineering devices. Advanced Healthcare Materials highlights the key features that enable the design of stimuli-responsive smart nanoparticles, novel biomaterials, and nano/micro devices for either diagnosis or therapy, or both, called theranostics. It also presents the latest advancements in healthcare materials and medical technology. The senior researchers from global knowledge centers have written topics including: State-of-the-art of biomaterials for human health Micro- and nanoparticles and their application in biosensors The role of immunoassays Stimuli-responsive smart nanoparticles Diagnosis and treatment of cancer Advanced materials for biomedical application and drug delivery Nanoparticles for diagnosis and/or treatment of Alzheimers disease Hierarchical modelling of elastic behavior of human dental tissue Biodegradable porous hydrogels Hydrogels in tissue engineering, drug delivery, and wound care Modified natural zeolites Supramolecular hydrogels based on cyclodextrin poly(pseudo)rotaxane Polyhydroxyalkanoate-based biomaterials Biomimetic molecularly imprinted polymers |
| bioorganic and medicinal chemistry impact factor 2022: Advances in Extraction and Applications of Bioactive Phytochemicals Mihir Kumar Purkait, Dibyajyoti Haldar, Prangan Duarah, 2022-11-30 Advances in Extraction and Applications of Bioactive Phytochemicals presents comprehensive and systematic coverage of extraction techniques for bioactive phytochemical compounds and their delivery and therapeutic effectiveness. Sections focus on the pharmaceutical industry's perspective, aiming at compiling recent advances of natural products in the field of drug delivery, including a brief overview of plant-based bioactive molecules, utilization of different plant elements for the extraction of phytochemicals, a compilation of conventional extraction approaches, advanced extraction methods, including Supercritical carbon-dioxide extraction, computational methods to improve production, drug delivery aspects of bioactive phytochemicals, their therapeutic effectiveness, and more. This book is a complete reference targeted at pharma researchers in academic and corporate environments and those willing to apply the most current extraction methods and health applications. Researchers in medicinal chemistry and chemical engineering will also benefit from this comprehensive resource. - Offers a consistent compilation of the most current phytochemical extraction techniques - Includes detailed protocols for extraction - Covers the main classes of naturally occurring bioactive phytochemical compounds |
| bioorganic and medicinal chemistry impact factor 2022: Organometallic Reactions Ernest I. Becker, Minoru Tsutsui, 1971 |
| bioorganic and medicinal chemistry impact factor 2022: Strategies and Solutions to Advanced Organic Reaction Mechanisms Andrei Hent, John Andraos, 2019-06-26 Strategies and Solutions to Advanced Organic Reaction Mechanisms: A New Perspective on McKillop's Problems builds upon Alexander (Sandy) McKillop's popular text, Solutions to McKillop's Advanced Problems in Organic Reaction Mechanisms, providing a unified methodological approach to dealing with problems of organic reaction mechanism. This unique book outlines the logic, experimental insight and problem-solving strategy approaches available when dealing with problems of organic reaction mechanism. These valuable methods emphasize a structured and widely applicable approach relevant for both students and experts in the field. By using the methods described, advanced students and researchers alike will be able to tackle problems in organic reaction mechanism, from the simple and straight forward to the advanced. |
| bioorganic and medicinal chemistry impact factor 2022: Flow Chemistry in Drug Discovery Jesus Alcazar, Antonio de la Hoz, Angel Díaz-Ortiz, 2021-12-08 This book reviews the challenges and opportunities posed by flow chemistry in drug discovery, and offers a handy reference tool for medicinal chemists interested in the synthesis of biologically active compounds. Prepared by expert contributors, the respective chapters cover not only fundamental methodologies and reactions, such as the application of catalysis, especially biocatalysis and organocatalysis; and non-conventional activation techniques, from photochemistry to electrochemistry; but also the development of new process windows, processes and reactions in drug synthesis. Particular attention is given to automatization and library synthesis, which are of great importance in the pharmaceutical industry. Readers will also find coverage on selected topics of general interest, such as how flow chemistry is contributing to drug discovery R&D in developing countries, and the green character of this enabling technology, for example in the production of raw materials for the pharmaceutical industry from waste. Given its scope, the book appeals to medicinal chemistry researchers working in academia and industry alike, as well as professionals involved in scale-up and drug development. |
| bioorganic and medicinal chemistry impact factor 2022: Phytochemicals Venketeshwer Rao, Leticia Rao, 2015-09-30 Global dietary recommendations emphasize the consumption of plant-based foods for the prevention and management of chronic diseases. Plants contain many biologically active compounds referred to as phytochemicals or functional ingredients. These compounds play an important role in human health. Prior to establishing the safety and health benefits of these compounds, they must first be isolated, purified, and their physico-chemical properties established. Once identified, their mechanisms of actions are studied. The chapters are arranged in the order from isolation, purification and identification to in vivo and clinical studies, there by covering not only the analytical procedures used but also their nutraceutical and therapeutic properties. |
| bioorganic and medicinal chemistry impact factor 2022: Advances in Food and Nutrition Research Fidel Toldra, 2022-09-03 Advances in Food and Nutrition Research, Volume 102 provides the latest advances on the identification and characterization of emerging bioactive compounds with putative health benefits, along with up-to-date information on food science. Chapters in this new release include Stability of polyphenols in food processing, Contribution of polysaccharides from crustacean on fermented food products, Food application of pigments from extremophile microorganisms, Recent advances in the development of healthier meat products, Food proteins in blood glucose control, Milk biomarker metabolomics and its application in milk origin, safety and quality control, Food Authenticity through protein and metabolic markers, and more. - Contains contributions that have been carefully selected based on their vast experience and expertise on the subject - Includes updated, in-depth and critical discussions of available information, thus presenting the reader with a unique opportunity to learn - Encompasses a broad view of the topics at hand |
| bioorganic and medicinal chemistry impact factor 2022: Catalytic Hydrogenation L. Cervený, 1986-08-01 The collection of contributions in this volume presents the most up-to-date findings in catalytic hydrogenation. The individual chapters have been written by 36 top specialists each of whom has achieved a remarkable depth of coverage when dealing with his particular topic. In addition to detailed treatment of the most recent problems connected with catalytic hydrogenations, the book also contains a number of previously unpublished results obtained either by the authors themselves or within the organizations to which they are affiliated.Because of its topical and original character, the book provides a wealth of information which will be invaluable not only to researchers and technicians dealing with hydrogenation, but also to all those concerned with homogeneous and heterogeneous catalysis, organic technology, petrochemistry and chemical engineering. |
| bioorganic and medicinal chemistry impact factor 2022: Surface Water Photochemistry Paola Calza, Davide Vione, 2015-11-20 Borne out of the current widespread interest in the pollution of water bodies, this book explores the latest research concerning the photochemical fate of organic pollutants in surface water. The main objective is to give insight into both the functioning of ecosystems and the behaviour of emerging pollutants in those ecosystems. Particular importance is dedicated to techniques that can be used in the field and in the laboratory for the detection of pollutants and of their transformation intermediates. The inclusion of photochemical processes that have not gained previous coverage will afford the reader novel insights, whilst the focus on modelling and transformation intermediates will ensure the title's relevance to academics, the chemical manufacturing industries and environmental assessment experts alike. |
| bioorganic and medicinal chemistry impact factor 2022: Bioorganic and Medicinal Chemistry , 1997 |
| bioorganic and medicinal chemistry impact factor 2022: Proteinkinase Inhibitors Stefan Laufer, 2021-03-23 This book reviews the principles of design and examples of successful implementation of proteinkinase inhibitors (PKI), and offers a comprehensive and authoritative overview of the history and latest developments in the field. Chapters written by experts from industry and academia cover the function, structure and topology of Proteinkinases, molecular modelling, disclose how to achieve high level of selectivity for kinase inhibitors, and exploit kinase inhibitors for cancer treatment. Particular attention is given to Inhibitors of c-Jun N-terminal kinase 3, and to covalent Janus Kinase 3 Inhibitors. A case study on Receptor Tyrosine Kinases EGFR, VEGFR, PDGFR is also presented in this book. Given its breath, this book will appeal to medicinal chemists, students, researchers and professionals alike. |
| bioorganic and medicinal chemistry impact factor 2022: Advances in Medicinal Chemistry B.E. Maryanoff, A.B. Reitz, 1999-04-01 Volume 4 of Advances in Medicinal Chemistry is comprised of six chapters on a wide range of topics in medicinal chemistry, including molecular modeling, structure-based drug design, organic synthesis, peptide conformational analysis, biological assessment, structure-activity correlation, and lead optimization. Chapter 1 presents an account about amino acid-based peptide mimetics corresponding to b-turn, loop, helical motifs in proteins as a probe of ligand-receptor and ligand-enzyme molecular interactions. Chapter 2 addresses new facets of the medicinal chemistry of the important anticancer drug Taxol® (paclitaxel). Chapter 3 relates an account of the search for new drugs for the treatment of malaria based on the natural product artemisinin. Chapter 4 applies computational chemistry to the evaluation of compound libraries for biological testing. Chapter 5 describes the construction of a 3-dimensional molecular model of the human thrombin receptor, the first protease-activated G-protein coupled receptor (PAR-1), as a means to explore the intermolecular contacts involved in agonist peptide recognition. Finally, Chapter 6 describes the research conducted at Merck on inhibitors of farnesyl transferase as a potential treatment for human cancers. |
| bioorganic and medicinal chemistry impact factor 2022: Bioassay Techniques for Drug Development Atta-ur-Rahman, M. Iqbal Choudhary, William J. Thomsen, 2001-10-04 The goal of an activity-directed isolation process is to isolate bioactive compounds which may provide structural leads of therapeutic importance. Whereas the traditional process of drug development is long and expensive, simple and rapid bioassays can serve as the starting point for drug discovery. This book presents a range of bench top bioassa |
| bioorganic and medicinal chemistry impact factor 2022: Development of New MDR-tuberculosis Drugs Jarmila Vinšová, 2010 The emergence of resistance to anti-tuberculosis drugs, particularly of MDR-TB and newly XDR-TB, has become a major public health problem. The current treatment regiment has several disadvantages, i.e. long treatment period (DOTS takes minimum 6 months) during which tubercle bacilli mutant become resistant to one or more drugs; side effects of the used drugs; co-infection of HIV/AIDS. The emergence of MDR-TB has made many currently available anti-TB drugs ineffective. Sleeping latent forms of mutant bacilli resistant against common anti-TB drugs pose the risk of epidemic for the new generation. This book outlines the recent advances in the development of new multi-drug-resistant tuberculosis (MDR-TB) drugs. |
| bioorganic and medicinal chemistry impact factor 2022: Preparative Carbohydrate Chemistry Stephen Hanessian, 1997-01-02 Detailing commonly used methods and procedures, this reference discusses the reactions and derivative forms of carbohydrates. Preparative Carbohydrate Chemistry covers the formation, cleavage, and reactions of derivatives and illustrates bond-forming reactions of SN2 types, free radicals, chain extensions, and branching. The contents include: sugar derivatives; selected reactions in carbohydrate chemistry; chemical synthesis of oligosaccharides and O-and N -glycosyl compounds; enzymatic synthesis of sialic acid, KDO, and related deoxyulosonic acids, and of oligosaccharides; synthesis of -glycosyl compounds; carbocycles from carbohydrates; and total synthesis of sugars from non-sugars. This authoritative reference offers relevant chapters on reactions and derivative forms of carbohydrates, including commonly used methods as well as new experimental procedures. It also contains insightful chapter commentaries and succinct topic histories. |
| bioorganic and medicinal chemistry impact factor 2022: Peptide Synthesis Waleed M. Hussein, Mariusz Skwarczynski, Istvan Toth, 2019-12-27 This book provides a variety of procedures for synthetically producing peptides and their derivatives, ensuring the kind of precision that is of paramount importance for successful synthesis. Numerous techniques relevant to drugs and vaccines are explored, such as conjugation and condensation methodologies. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Peptide Synthesis: Methods and Protocols serves as an essential guide to the many crucial processes that will allow researchers to efficiently prepare, purify, characterize, and use peptides for chemical, biochemical, and biological studies. |
| bioorganic and medicinal chemistry impact factor 2022: Pharmaceutical Chemistry Chris Rostron, Chris (Honorary Research Fellow Rostron, Honorary Research Fellow Liverpool John Moores), Jill (Reader Barber, Reader The University of Manchester), 2021-03 Pharmaceutical Chemistry provides a wide-ranging overview of organic chemistry as applied to the study and practice of pharmacy. Drugs are simply chemicals, so to fully understand their manufacture, formulation, and the way they work in our bodies, a knowledge of organic compounds and their reactions is essential. |
| bioorganic and medicinal chemistry impact factor 2022: Re-emergence of Natural Products for Drug Discovery in Honor of Prof. Dr. M. Iqbal Choudhary Hidayat Hussain, Hina Siddiqui, Ioannis P. Gerothanassis, 2024-02-29 This Research Topic will honor Prof. M. Iqbal Choudhary for his pioneering contribution in the field of Bioorganic, Synthetic, and Natural Product Chemistry. Prof. M. Iqbal Choudhary is Director and Professor of Bioorganic and Natural Product Chemistry at the International Center for Chemical and Biological Sciences (H. E. J. Research Institute of Chemistry and Dr. Panjwani Center for Molecular Medicine and Drug Research), Pakistan and Coordinator General COMSTECH. Since 1990, Prof. Choudhary has been among the world leaders in the field of natural product chemistry, and has made pioneering contributions in the discovery of novel natural products. Prof. Choudhary has 1,212 publications (cumulative impact of > 2500) with 33,550 citations (h index 76) in the fields of organic and bioorganic chemistry. He also published 94 patents (64 US Patents), 90 books and 40 chapters in books, published by major U.S. and European presses. He discovered many potent anti-epileptic and anti-leishmanial compounds from indigenous medicinal plants that are under clinical trials. His contributions to reverse bacterial resistance to antibiotics represent seminal contributions in this important field. He has trained hundreds of young researchers, especially women, from across the Afro-Asian region in natural product chemistry and established several research centers in Pakistan, and helped to setup research units in Africa, and South and Central Asia. His scientific contributions have been recognized by prestigious national and international awards and honors, and fellowships of several academies of science. |
| bioorganic and medicinal chemistry impact factor 2022: Theory, Techniques and Applications of Nanotechnology in Gene Silencing Surendra Nimesh, Ramesh Chandra, 2022-09-01 This book focuses on various aspects of nanotechnology based gene silencing. The initial chapters detail the techniques available for in vitro and in vivo characterization of nanoparticles. In the later chapters, exhaustive details about various polymeric systems employed for gene silencing has been accounted. |
| bioorganic and medicinal chemistry impact factor 2022: Basic 1H- and 13C-NMR Spectroscopy Metin Balci, 2005-01-19 Nuclear Magnetic Resonance (NMR) spectroscopy is a powerful and theoretically complex analytical tool. Basic 1H- and 13C-NMR Spectroscopy provides an introduction to the principles and applications of NMR spectroscopy. Whilst looking at the problems students encounter when using NMR spectroscopy, the author avoids the complicated mathematics that are applied within the field. Providing a rational description of the NMR phenomenon, this book is easy to read and is suitable for the undergraduate and graduate student in chemistry. - Describes the fundamental principles of the pulse NMR experiment and 2D NMR spectra - Easy to read and written with the undergraduate and graduate chemistry student in mind - Provides a rational description of NMR spectroscopy without complicated mathematics |
| bioorganic and medicinal chemistry impact factor 2022: Forensic Science Advances and Their Application in the Judiciary System Danielle Sapse, Lawrence Kobilinsky, 2011-08-01 This volume examines how new cutting edge forensic techniques are currently being applied or have the potential to be applied in judicial proceedings. Examples include new applications of Raman spectroscopy, quantum chemistry, lithium in DNA analysis, and the burgeoning area of toxicogenetics. In each case legal issues are addressed, including the |
| bioorganic and medicinal chemistry impact factor 2022: HPLC for Pharmaceutical Scientists Yuri V. Kazakevich, Rosario LoBrutto, 2007-02-16 HPLC for Pharmaceutical Scientists is an excellent book for both novice and experienced pharmaceutical chemists who regularly use HPLC as an analytical tool to solve challenging problems in the pharmaceutical industry. It provides a unified approach to HPLC with an equal and balanced treatment of the theory and practice of HPLC in the pharmaceutical industry. In-depth discussion of retention processes, modern HPLC separation theory, properties of stationary phases and columns are well blended with the practical aspects of fast and effective method development and method validation. Practical and pragmatic approaches and actual examples of effective development of selective and rugged HPLC methods from a physico-chemical point of view are provided. This book elucidates the role of HPLC throughout the entire drug development process from drug candidate inception to marketed drug product and gives detailed specifics of HPLC application in each stage of drug development. The latest advancements and trends in hyphenated and specialized HPLC techniques (LC-MS, LC-NMR, Preparative HPLC, High temperature HPLC, high pressure liquid chromatography) are also discussed. |
Bioorganic And Medicinal Chemistry Impact Factor 2022
bioorganic chemistry, high-throughput screening, combinatorial chemistry, drug targets, and natural product research and structure-activity relationship studies. The series presents highly …
Bioorganic & Medicinal Chemistry Letters - file1.lookchem.com
able due to its electronic properties, which have an impact on the pK a value, and therefore the protonation state of the c-phosphate/ phosphonate. Reaction of the fluorescent-labeled …
APPROVED LIST OF JOURNALS - bitmesra.ac.in
6 Bioorganic Medicinal Chemistry Elsevier 0968-0896 Impact factor 2 -5 3.073 Q2 7 Bioorganic Chemistry Elsevier 0045-2068 Impact factor 2 -5 4.831 Q1 8 Chemical Biology & Drug Design …
Bioorganic And Medicinal Chemistry Impact Factor 2022(1)
bioorganic and medicinal chemistry offering students a deeper understanding of the interdisciplinary nature of this subject Fragment-Based Drug Discovery Steven Howard,Chris …
Bioorganic And Medicinal Chemistry Impact Factor 2022 Copy
Enter the realm of "Bioorganic And Medicinal Chemistry Impact Factor 2022," a mesmerizing literary masterpiece penned with a distinguished author, guiding readers on a profound …
Bioorganic And Medicinal Chemistry Letters Impact Factor …
For researchers in bioorganic and medicinal chemistry, understanding the impact factor of Bioorganic & Medicinal Chemistry Letters (BMCL) is paramount for strategic publication …
Bioorganic And Medicinal Chemistry Impact Factor
Volume 1 covers leading-edge research and recent developments in rational drug design, synthetic chemistry, bioorganic chemistry, high-throughput screening, combinatorial chemistry, …
Research publications S. M. Basavarajaiah S. M. Basavarajaiah
Bioorganic and Medicinal Chemistry, 32 (2021) 115973. https://doi.org/10.1016/j.bmc.2020.115973 Impact Factor - 3.641; Citations - 49 2. N. J. Basha, S. M. Basavarajaiah, K. Shyamsunder, …
Bioorganic And Medicinal Chemistry Impact Factor - Viralstyle
This book is written from a Chemist's perspective and comprehensively assesses the impact of fragment-based drug discovery on a wide variety of areas of medicinal chemistry. It will prove …
Curriculum Vitae Kunal Roy PhD, - jadavpuruniversity.in
[Impact Factor 3.8 (2022)] Associate Editor, Computational and Structural Biotechnology Journal (Elsevier) (https://www.sciencedirect.com/journal/computational-and-structural-biotechnology-
Bioorganic And Medicinal Chemistry Impact Factor 2022 …
Bioorganic And Medicinal Chemistry Impact Factor 2022: Fragment-Based Drug Discovery Steven Howard,Chris Abell,2015-06-17 Fragment based drug discovery is a rapidly evolving …
Prof. Dr. M. Iqbal Choudhary-A lifetime career dedicated to …
Notably, the cumulative impact factor of his publications is over 2,550 (calculated in Dec. 2022) and his citations exceeding 36,700 (h-Index: 80). Under his direct supervision, over 100 Ph. D....
Bioorganic And Medicinal Chemistry Impact Factor [PDF]
interdisciplinary subjects The Kappa Opioid Receptor Lee-Yuan Liu-Chen,Saadet Inan,2022 This book covers the latest knowledge in structure signaling and biochemical pharmacology of KOR …
Bioorganic And Medicinal Chemistry Impact Factor 2022 (2024)
Bioorganic And Medicinal Chemistry Impact Factor 2022: Fragment-Based Drug Discovery Steven Howard,Chris Abell,2015-06-17 Fragment based drug discovery is a rapidly evolving …
Bioorganic & Medicinal Chemistry Letters - file1.lookchem.com
Platelet-derived growth factor (PDGF), connective tissue growth factor (CTGF) and transforming growth factor-b (TGF-b) are cyto- kines that have been implicated in the progression of renal …
Bioorganic And Medicinal Chemistry Impact Factor 2022
Bioorganic And Medicinal Chemistry Impact Factor 2022 is available in our digital library an online access to it is set as public so you can download it instantly. Our digital library hosts in multiple …
Dr.Nuzhat Arshad Chairperson NED University of …
JOURNALS) : ( IMPACT FACTOR 2022 = 35) 2022 1. Nuzhat Arshad,Shumaila Jawaid, Jamshed Hashim, Irfan Ullah, Somia Gul, Aisha Aziz Abdul Wadood, Alamzeb Khan, Highly potent anti …
Bioorganic & Medicinal Chemistry Letters - lookchem
Compound 20 (called Pro-XylaneTM) was identified as the best activator of GAGs biosynthesis. Pro-XylaneTM was developed using environmentally friendly conditions relevant to ‘Green …
Bioorganic And Medicinal Chemistry Impact Factor (2024)
Liu-Chen,Saadet Inan,2022 This book covers the latest knowledge in structure signaling and biochemical pharmacology of KOR as well as preclinical research and clinical applications …
List of Journals S.No. Name ISSN No. Publisher Impact Indexed i…
4 Future Medicinal Chemistry 2320-5148 Future Group 3.31 EMBASE/Excerpta Medica, Journal Citation ... 15 Bioorganic and Medicinal Chemistry Letters 0960-894X …
Bioorganic And Medicinal Chemistry Impact Factor 2022
bioorganic chemistry, high-throughput screening, combinatorial chemistry, drug targets, and natural product research and structure-activity relationship studies. The …
Bioorganic & Medicinal Chemistry Letters - file1.lookch…
able due to its electronic properties, which have an impact on the pK a value, and therefore the protonation state of the c-phosphate/ phosphonate. Reaction of the …
APPROVED LIST OF JOURNALS - bitmesra.ac.in
6 Bioorganic Medicinal Chemistry Elsevier 0968-0896 Impact factor 2 -5 3.073 Q2 7 Bioorganic Chemistry Elsevier 0045-2068 Impact factor 2 -5 4.831 Q1 8 Chemical …
Bioorganic And Medicinal Chemistry Impact Factor 2022(1)
bioorganic and medicinal chemistry offering students a deeper understanding of the interdisciplinary nature of this subject Fragment-Based Drug Discovery Steven …
