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| blood thinners for mechanical heart valves: The Patient's Guide to Heart Valve Surgery Adam Pick, 2007 Each year, over 250,000 heart valve repair and heart valve replacement operations are performed for conditions including stenosis, prolapse, insufficiency, aneurysm, Tetralogy of Fallot and regurgitation. However, most patients and caregivers surveyed felt their expectations were mismanaged - both before and after surgery. The Patient's Guide to Heart Valve Surgery was written by Adam Pick, a double heart valve surgery patient, to address this troubling issue and prepare the patient and caregiver for the challenges and opportunities of valve surgery - from diagnosis through recovery. |
| blood thinners for mechanical heart valves: The Obstetric Hematology Manual Sue Pavord, Beverley Hunt, 2010-04-15 Obstetric hematology is a fast-growing area of medicine covering the diagnosis and management of hematological problems of pregnancy. Comprehensive in approach, The Obstetric Hematology Manual addresses the many hematological conditions that can cause serious problems in pregnancy, delivery and the post-partum period for both mother and baby. Written by a team of international authorities, this text provides up-to-date, evidence-based guidelines on best care, as well as sound advice based on the experience and opinion of experts. Where appropriate, basic principles are discussed to clarify the rationale for management, and systems and procedures for disease prevention are highlighted. Many conditions and cases are discussed, including venous thromboembolism, pre-eclampsia, anemia, thrombocytopenia and inherited disorders. This book will appeal to both trainees and practitioners in obstetrics, obstetric medicine, obstetric anesthesia and hematology. It is also an accessible text for midwives, nurses, and laboratory staff. |
| blood thinners for mechanical heart valves: Cardiac Problems in Pregnancy Uri Elkayam, 2019-09-02 Cardiac Problems in Pregnancy offers clinicians the most detailed and comprehensive guide to diagnosing and managing pregnancy-associated cardiovascular diseases currently available. Covering a wide spectrum of congenital and acquired cardiovascular conditions, its extensive contents examine diseases of the heart with an expert awareness of the implications of pregnancy and the attendant physiological changes it brings. Such guidance is vitally required in an age in which congenital and acquired heart diseases are the leading causes of non-obstetrical maternal morbidity and mortality. Featuring 36 new or extensively revised chapters, this fourth edition of the book complements coverage of the latest research and clinical advances with a complete and up-to-date bibliography of literature on pregnancy in women with cardiovascular conditions. It also serves as a practical, step-by-step companion for those caring for heart disease patients during pregnancy, labor, and the post-partum period. Contents include: Coverage of all elements of maternal cardiology Newly written chapters featuring fresh research and data Guidance on performing risk assessments and interventions both prior to and during gestation Explanations of a range of diagnostic and therapeutic approaches to cardiovascular disease in pregnant patients Drawing on expertise from across the fields of cardiovascular medicine, obstetrics, anesthesiology, cardiac surgery, pharmacology, and clinical science, Cardiac Problems in Pregnancy is designed to give invaluable support to all medical professionals involved in maximizing the safety and success of cardiologically complex pregnancies. |
| blood thinners for mechanical heart valves: Design Disrupted Dawn Stafford, 2021-12 Design Disrupted's primary goal is to equip the homeowner, fashionista, fashion, and interior designer with simple guidelines to effectively create an exquisitely designed interior space inspired by your body and personal fashion design decisions. The human body is broken down into sections equating to interior space to further understand the correlation. This book was conceived for a broad readership to be used as an action tool, reference manual to explore and experiment with your own fashion and interior design themes. Design principles and themes are illustrated with beautiful curated examples to explain the theory of how the body style and interior design intertwine-a compilation of design combinations and variations which will ignite the imagination and spawn ideas. The aim of successful interior design is to construct well-formed spaces through the masterful use of the body abd personalized fashion design as a guideline. Design Disrupted connects your body and your space removing the interior design process's abstruseness. |
| blood thinners for mechanical heart valves: Learning Cardiac Auscultation Allen J. Taylor, 2015-10-13 The book contains a series of core auscultation “lessons”. All are case based and describe auscultation as it relates to a patient and in terms of the gold standard for interpretation of heart sounds. Auscultation is the term for listening to the internal sounds of the body, usually using a stethoscope. It is performed for the purposes of examining the circulatory system and respiratory system (heart sounds and breath sounds). As a topic it is one of the oldest in cardiology but its utility should never be underestimated. In this era of hugely expensive imaging tests, auscultation is a cornerstone of efficient diagnosis and therefore needs a fresh look. The core content of this book describes the search for diagnostic clues within patients’ heart sounds and as such this book provides superb practical advice in the form of a series of clinical pearls reflecting what accurate diagnosis with auscultation can mean to patient prognosis and outcome. This often subtle but ultimately simple subject often produces complex results and these must be considered in light of modern next-level diagnostic methods and patient management. |
| blood thinners for mechanical heart valves: Cardiac Valve Prostheses Edward A. Lefrak, Albert Starr, 1979 |
| blood thinners for mechanical heart valves: Direct Oral Anticoagulants Riccardo Proietti, Ahmed AlTurki, Nicola Ferri, Vincenzo Russo, T. Jared Bunch, 2021-06-28 This book concisely covers the latest developments in the application of direct oral anticoagulants (DOACs) within cardiovascular medicine. It details the pharmacodynamics and pharmacokinetic mechanisms of DOACs and their application in treating patients with conditions ranging from coronary heart disease through kidney disease and cancer, including their perioperative management. Direct Oral Anticoagulants: From Pharmacology to Clinical Practice systematically describes the underlying mechanisms associated with DOACs and their use to treat a range of conditions and is an indispensable resource for all trainee and practicing physicians in a range of disciplines seeking a concise up-to-date resource on the topic. |
| blood thinners for mechanical heart valves: Animals and Medicine Jack Botting, 2015-05-04 Animals and Medicine: The Contribution of Animal Experiments to the Control of Disease offers a detailed, scholarly historical review of the critical role animal experiments have played in advancing medical knowledge. Laboratory animals have been essential to this progress, and the knowledge gained has saved countless lives—both human and animal. Unfortunately, those opposed to using animals in research have often employed doctored evidence to suggest that the practice has impeded medical progress. This volume presents the articles Jack Botting wrote for the Research Defence Society News from 1991 to 1996, papers which provided scientists with the information needed to rebut such claims. Collected, they can now reach a wider readership interested in understanding the part of animal experiments in the history of medicine—from the discovery of key vaccines to the advancement of research on a range of diseases, among them hypertension, kidney failure and cancer.This book is essential reading for anyone curious about the role of animal experimentation in the history of science from the nineteenth century to the present. |
| blood thinners for mechanical heart valves: Anticoagulation Therapy Ozcan Basaran, Murat Biteker, 2016-09-08 The available parenteral and oral anticoagulants have a large clinical use. Understanding biochemistry of anticoagulants may help to improve therapeutic strategies. Resistance to vitamin K antagonist drugs might be a problem for rodent populations. Patients who have thrombogenic risk factors should be anticoagulated. The need for cardiac implantable electronic devices is increasing, and there is a substantial number of patients who are on oral anticoagulant therapy. Prothrombin complex concentrate and other plasma concentrates are useful to deal with over-coagulated situations. The efficacy and safety of non-vitamin K antagonist oral anticoagulants have been proven in large phase III trials. The real-world data suggest even better outcomes with these agents compared to vitamin K antagonists. |
| blood thinners for mechanical heart valves: Emergency Management of the Hi-Tech Patient in Acute and Critical Care Ioannis Koutroulis, Nicholas Tsarouhas, 2021-06-28 EMERGENCY MANAGEMENT OF THE HI-TECH PATIENT IN ACUTE AND CRITICAL CARE Emergency Management of the Hi-Tech Patient in Acute and Critical Care helps practitioners stabilize and care for pediatric and adult patients who have specialized medical devices such as prosthetic valves, cochlear transplants, insulin pumps, orthopedic hardware, and ventriculoperitoneal (VP) shunts. Using a step-by-step approach to acute presentations of patients with clinical hardware, this concise yet comprehensive guide provides specific instructions for the initial evaluation and management of numerous clinical scenarios including device malfunctions, infections, trauma, surgical complications, and more. Encompassing management of both the patient and the device, the guide enables emergency and critical care clinicians to rapidly make appropriate treatment decisions without the immediate need for extensive research, extended discussions with subspecialists, or recalling complex diagnostic and therapeutic algorithms. Clear, concise, and easy-to-follow chapters—written by a panel of highly experienced experts across specialties—include numerous algorithms, figures, tables, diagrams, and color illustrations and clinical images. An invaluable resource for improving the quality of care for the unique hi-tech patient population, this advanced practical manual: Provides algorithms for the most common clinical scenarios of device malfunction and related complications Covers management of patients who have undergone major operations such as organ transplantation or complex congenital heart disease repair Presents detailed management plans for a wide range of hardware types and medical conditions Offers expert guidance to practitioners in settings where not all specialties are readily available, such as rural and remote areas or community hospitals Features contributions from a team of experts in various areas of adult and pediatric emergency and critical care medicine Emergency Management of the Hi-Tech Patient in Acute and Critical Care is a must-have clinical reference and guide for pediatric and adult emergency medicine physicians, general pediatricians, internists, general practitioners, critical care specialists, and allied health practitioners. |
| blood thinners for mechanical heart valves: Essential Clinical Anesthesia Charles Vacanti, Scott Segal, Pankaj Sikka, Richard Urman, 2011-07-11 The clinical practice of anesthesia has undergone many advances in the past few years, making this the perfect time for a new state-of-the-art anesthesia textbook for practitioners and trainees. The goal of this book is to provide a modern, clinically focused textbook giving rapid access to comprehensive, succinct knowledge from experts in the field. All clinical topics of relevance to anesthesiology are organized into 29 sections consisting of more than 180 chapters. The print version contains 166 chapters that cover all of the essential clinical topics, while an additional 17 chapters on subjects of interest to the more advanced practitioner can be freely accessed at www.cambridge.org/vacanti. Newer techniques such as ultrasound nerve blocks, robotic surgery and transesophageal echocardiography are included, and numerous illustrations and tables assist the reader in rapidly assimilating key information. This authoritative text is edited by distinguished Harvard Medical School faculty, with contributors from many of the leading academic anesthesiology departments in the United States and an introduction from Dr S. R. Mallampati. This book is your essential companion when preparing for board review and recertification exams and in your daily clinical practice. |
| blood thinners for mechanical heart valves: Calcific Aortic Valve Disease Elena Aikawa, 2013-06-12 Due to population aging, calcific aortic valve disease (CAVD) has become the most common heart valve disease in Western countries. No therapies exist to slow this disease progression, and surgical valve replacement is the only effective treatment. Calcific Aortic Valve Disease covers the contemporary understanding of basic valve biology and the mechanisms of CAVD, provides novel insights into the genetics, proteomics, and metabolomics of CAVD, depicts new strategies in heart valve tissue engineering and regenerative medicine, and explores current treatment approaches. As we are on the verge of understanding the mechanisms of CAVD, we hope that this book will enable readers to comprehend our current knowledge and focus on the possibility of preventing disease progression in the future. |
| blood thinners for mechanical heart valves: Principles of Heart Valve Engineering Arash Kheradvar, 2019-08-28 Principles of Heart Valve Engineering is the first comprehensive resource for heart valve engineering that covers a wide range of topics, including biology, epidemiology, imaging and cardiovascular medicine. It focuses on valves, therapies, and how to develop safer and more durable artificial valves. The book is suitable for an interdisciplinary audience, with contributions from bioengineers and cardiologists that includes coverage of valvular and potential future developments. This book provides an opportunity for bioengineers to study all topics relating to heart valve engineering in a single book as written by subject matter experts. - Covers the depth and breadth of this interdisciplinary area of research - Encompasses a wide range of topics, from basic science, to the translational applications of heart valve engineering - Contains contributions from leading experts in the field that are heavily illustrated |
| blood thinners for mechanical heart valves: Thrombosis, Embolism and Bleeding Eric G. Butchart, Endre Bodnar, 1992 |
| blood thinners for mechanical heart valves: New Approaches to Aortic Diseases from Valve to Abdominal Bifurcation Ion C. Tintoiu, John A. Elefteriades, Adrian Ursulescu, Malcolm John Underwood, Ionel Droc, 2017-11-15 New Approaches to Aortic Disease from Valve to Abdominal Bifurcation provides a complete look at aortic valve diseases from all points of view, including etiology, physiopathology, prevention, diagnosis and treatment. The book offers new insights into the aortic valve and pathology based on evidence of current diagnostic methods, treatments and post-surgery evolution. Content is split into three distinct parts for ease of reference, including an overview of aortic pathology, diagnostic evaluations methods, and treatments. Also included are guidelines and future research directions, making this a must-have volume for all cardiologists and cardiovascular surgeons who address significant issues in this topic area. - Present pathophysiological sequences that are shown in correlation with histological details - Includes detailed clinical examinations and the value of the initial assessment using chest X-ray, echocardiography, angiography, CT angiography and magnetic resonance, etc. - Provides conventional descriptions of surgical techniques that are entirely detailed, along with long-term results and possible complications |
| blood thinners for mechanical heart valves: Case-Based Textbook of Echocardiography Anita Sadeghpour, Azin Alizadehasl, 2018-10-24 This volume is a step-by-step educational echocardiography textbook from basic principles to advanced concepts. It is designed to rationalise and instruct readers on the rapid development in echocardiographic techniques, including real-time three-dimensional echocardiography, strain/strain rate imaging, and speckle tracking, which have greatly expanded the capabilities of cardiac imaging while overshadowing the importance of the basics of echocardiography. Case-Based Textbook of Echocardiography offers a comprehensive review of echocardiography from basic skills to advanced techniques, including practical information from recently published ASE/EACVI guidelines and explanatory movies and figures. Providing balance between the science and clinical pearls, it is of great interest for all trainee cardiologists and echocardiographers and helpful to all clinicians in cardiology, internal medicine, cardiac surgery, interventio nal cardiology and paediatric cardiology. |
| blood thinners for mechanical heart valves: Cardiac Surgery Shahzad G. Raja, 2020-02-11 This textbook provides a succinct overview of cardiac surgery, with key concepts being emphasized throughout. An abundance of illustrations, intra-operative photographs, tables as well as information boxes, aids the reader to visualise, grasp and retain difficult concepts. The inclusion of evidence-based approaches to the management of a range of cardiac surgical conditions equips the reader with an understanding of how to overcome a variety of potentially tough clinical challenges. Concise Cardiac Surgery: A Complete Guide comprehensively covers a range of techniques used in cardiac surgery. It is therefore, an ideal resource for the trainee and practising cardiac surgeon seeking a practically focused text detailing how to apply the latest techniques and evidence-based approaches in their day-to-day practice. |
| blood thinners for mechanical heart valves: Cardiovascular Clinical Trials Marcus Flather, Deepak Bhatt, Tobias Geisler, 2012-12-03 The pace of therapeutic advances in the treatment of cardiovascular diseases is rapid, and new clinically-relevant information appears with such frequency that it can be extremely challenging for clinicians to keep up. Still, knowledge and interpretation of major clinical trials is crucial for the range of clinicians who manage cardiovascular patients, especially since important trial evidence often needs to be implemented soon after it is published. Confidently apply gold standard treatment for 10 of the most critical areas of cardiology Written by an international team of experts, Cardiovascular Clinical Trials: Putting the Evidence into Practice: Provides a succinct overview of recent major clinical trials - the gold standard for all medical treatment - across all the major cardiovascular subspecialties, to ensure you’re up-to-date on the most critical findings Guides cardiology trainees and clinicians on how cardiovascular clinical trials are designed and conducted, including statistical methodology, so you can conduct and/or appraise future trials yourself Addresses methodology as well as clinical effectiveness Offers evidence-based assessments on the most effective treatments and authoritative clinical information on management of the conditions so you can confidently apply what you learn Physicians, surgeons, specialist nurses – any clinician seeking an accessible resource for designing and conducting cardiovascular trials and then translating their results into practice will appreciate this book’s clear guidance and succinct and practical approach. |
| blood thinners for mechanical heart valves: Core Topics in Cardiac Anesthesia Jonathan H. Mackay, Joseph E. Arrowsmith, 2012-03-15 Since the publication of the first edition of Core Topics in Cardiac Anaesthesia, the clinical landscape has undergone significant change. Recent developments include the increased use of electrophysiology, the resurgence of primary percutaneous intervention in acute coronary syndromes, the use of percutaneous devices in patients previously considered inoperable, and the withdrawal of aprotinin. Against this landscape, this invaluable resource has been fully updated. New chapters are dedicated to right heart valves, pulmonary vascular disease, cardiac tumours and cardiac trauma. All other chapters have been updated according to the latest international guidelines. Written and edited by an international author team with a wealth of expertise in all aspects of the perioperative care of cardiac patients, topics are presented in an easy to digest and a readily accessible manner. Core Topics in Cardiac Anaesthesia, Second Edition is essential reading for residents and fellows in anaesthesia and cardiac surgery and clinical perfusionists. |
| blood thinners for mechanical heart valves: Cardiology Explained Euan A. Ashley, Euan Ashley, Josef Niebauer, 2004 One of the most time-consuming tasks in clinical medicine is seeking the opinions of specialist colleagues. There is a pressure not only to make referrals appropriate but also to summarize the case in the language of the specialist. This book explains basic physiologic and pathophysiologic mechanisms of cardiovascular disease in a straightforward manner, gives guidelines as to when referral is appropriate, and, uniquely, explains what the specialist is likely to do. It is ideal for any hospital doctor, generalist, or even senior medical student who may need a cardiology opinion, or for that ma. |
| blood thinners for mechanical heart valves: Heart Valve Disease Jose Zamorano, Patrizio Lancellotti, Luc Pierard, Philippe Pibarot, 2019-11-12 This book provides a state-of-the-art description of the pathophysiology, diagnosis and management of valvular heart disease (VHD). With an aging population, the incidence and complexity of VHD has markedly increased and the introduction of transcatheter valve therapies have revolutionized the management of these frequent and serious cardiovascular diseases. The development of percutaneous valve interventions has revolutionized the management of VHD (or has dramatically changed its management) Heart Valve Disease: State of the Art is dedicated to provide up-to-date knowledge to clinical and interventional cardiologists, cardiovascular imagers and cardiac surgeons. It provides state-of-the-art information for the health-care professional working in heart valve clinics, heart teams, and centers of excellence that specialize in managing patients with heart valve disease. |
| blood thinners for mechanical heart valves: Heart and Neurologic Disease , 2021-02-23 The Handbook of Clinical Neurology series volumes provide comprehensive summaries of recent research on the brain and nervous system as they relate to clinical neurology. Cardiac disorders and diseases may often co-occur with, or cause, subsequent neurological disorders. Heart and Neurologic Disease identifies the top cardiac diseases and disorders most likely to have neurological disorders, how they will present, and how they are best treated. It identifies the mechanisms of action explaining why the conditions co-occur, and what clinicians should look for symptom wise, and how risk may be assessed. Coverage includes genetic cardiac disorders, cardiac trauma, surgery, infection, disease, and arrhythmia. - Identifies the top cardiac diseases and disorders most likely to have neurological complications - Specifies how the neurological complication will present and advance and how it should be treated - Discusses the mechanism of action—why the two conditions co-occur - Includes genetic conditions, trauma, surgery, infection, disease, arrythmias, and more - Covers prevention and risk assessment |
| blood thinners for mechanical heart valves: Acute Rheumatic Fever and Rheumatic Heart Disease Dr. Scott Dougherty, Jonathan Carapetis, Liesl Zuhlke, Nigel Wilson, 2020-02-22 Acute Rheumatic Fever and Rheumatic Heart Disease is a concise, yet comprehensive, clinical resource highlighting must-know information on rheumatic heart disease and acute rheumatic fever from a global perspective. Covering the major issues dominating the field, this practical resource presents sufficient detail for a deep and thorough understanding of the latest treatment options, potential complications, and disease management strategies to improve patient outcomes. - Divided into four distinct sections for ease of navigation: Acute Rheumatic Fever, Rheumatic Heart Disease, Population-Based Strategies for Disease Control, and Acute and Emergency Presentations. - International editors and chapter authors ensure a truly global perspective. - Covers all clinical aspects, including epidemiology, pathophysiology, clinical features, diagnosis, management, and treatment. - Includes key topics on population-based measures for disease control for effective primary, secondary, and tertiary prevention. - Consolidates today's available information and guidance into a single, convenient resource. |
| blood thinners for mechanical heart valves: Anticoagulation Therapy Joe F. Lau, Geoffrey D. Barnes, Michael B. Streiff, 2018-04-16 This book presents the latest evidence and guidelines supporting the use of anticoagulant therapy for various clinical scenarios. The field of anticoagulation therapy is evolving rapidly, particularly since the arrival and widespread adoption of direct oral anticoagulants. Organized in two parts, this book reviews the pharmacologic properties of various anticoagulants and details the clinical applications of anticoagulant therapy. Drugs such as warfarin and unfractionated heparin, as well as parenteral and direct oral anticoagulants are discussed in terms of their pharmacokinetics, drug-disease interactions, dosing strategies, and risk considerations. Clinical applications of anticoagulant therapy in disorders such as acute coronary syndromes, atrial fibrillation, and thrombophilia and in special populations such as pregnant women, the elderly, and in the patient with cancer are highlighted. Clinical vignettes, algorithms, clinical pearls, and self-assessment questions are integrated throughout the book. Featuring contributions from authorities in the field, Anticoagulation Therapy is an essential resource for cardiologists, vascular medicine specialists, hematologists, internists, and all other healthcare professionals who prescribe anticoagulants. |
| blood thinners for mechanical heart valves: Mitral Valve Surgery Robert S. Bonser, Domenico Pagano, Axel Haverich, 2010-12-25 Part of the Monographs in Cardiac Surgery Series – Introducing ‘basic science into the cardiac operating room’. Fast systematic review of small areas of cardiac surgery including up-to-date information. This will allow more rapid publication than the alternative cardiac surgery ‘tomes’. This entry into the series will provide readers with a complete review of the current understanding in mitral valve surgery and include extensive details on the diagnosis and surgical management of patients with mitral valve disease. |
| blood thinners for mechanical heart valves: Cardiovascular Thrombus On Topaz, 2018-08-18 Cardiovascular Thrombus: From Pathology and Clinical Presentations to Imaging, Pharmacotherapy and Interventions provides a comprehensive, up-to-date presentation of the research and clinical practices as related to the contemporary aspects of the diagnosis and management of cardiovascular thrombosis. The formation, identification and management of cardiovascular thrombus is of paramount importance for researchers and practicing physicians, yet it remains one of the most challenging diagnostic and clinical scenarios. This important reference connects between research, up-to-date clinical knowledge, and the technological tools available for diagnosis and management of thrombus in cardiovascular medicine. The book includes comprehensive descriptions and review of pathology, clinical presentations, diagnosis, pharmacotherapy, interventions and future trends. It is the perfect reference for basic science students and researchers in general and interventional cardiology, general and interventional radiology, vascular medicine specialists, and vascular, general and cardiac surgeons. Provides comprehensive presentation of the pathophysiology, clinical presentations and diagnosis of cardiovascular thrombosis Includes the most up-to-date information on the practical management of patients with thrombus related conditions Written by the leading experts in the field Describes the current and upcoming pharmacotherapy and technology available for thrombus research and treatment |
| blood thinners for mechanical heart valves: The ESC Textbook of Cardiovascular Medicine A. John Camm, 2019 |
| blood thinners for mechanical heart valves: Atlas of Cardiac Surgical Techniques E-Book Frank W. Sellke, Marc Ruel, 2018-01-31 Get expert, step-by-step guidance on a wide variety of both open and interventional cardiac surgical techniques. Atlas of Cardiac Surgical Techniques, 2nd Edition, helps you expand your surgical repertoire and hone your skills with a vividly illustrated, easy-to-navigate text and pearls and pitfalls throughout. This revised atlas covers the surgical procedures you need to master, including minimally invasive techniques, robotic surgery, aortic dissection, and much more. - Seven brand-new chapters cover Hybrid Coronary Revascularization, Aortic Valve Repair Techniques, Transcatheter Aortic Valve Replacement, Robotic Mitral Valve Surgery, Surgery for Hypertrophic Cardiomyopathy, Approaches and Techniques to Extra-Corporeal Membrane Oxygenation, and Pulmonary Endarterectomy. - Multiple new contributing authors offer a fresh perspective in their areas of expertise. - A consistent chapter format guides you quickly from surgical anatomy and preoperative considerations through operative steps and postoperative care. - Online videos highlight key stages of surgical procedures. - More than 400 full-color images, line drawings, and intraoperative photographs clearly depict the step-by-step progression of procedures. - Expert ConsultTM eBook version included with purchase. This enhanced eBook experience allows you to search all of the text, figures, and references from the book on a variety of devices. |
| blood thinners for mechanical heart valves: Haschek and Rousseaux's Handbook of Toxicologic Pathology Wanda M Haschek, Colin G. Rousseaux, Matthew A. Wallig, Brad Bolon, Ricardo Ochoa, 2013-05-01 Haschek and Rousseaux's Handbook of Toxicologic Pathology is a key reference on the integration of structure and functional changes in tissues associated with the response to pharmaceuticals, chemicals and biologics. The 3e has been expanded by a full volume, and covers aspects of safety assessment not discussed in the 2e. Completely revised with many new chapters, it remains the most authoritative reference on toxicologic pathology for scientists and researchers studying and making decisions on drugs, biologics, medical devices and other chemicals, including agrochemicals and environmental contaminants. New topics include safety assessment, the drug life cycle, risk assessment, communication and management, carcinogenicity assessment, pharmacology and pharmacokinetics, biomarkers in toxicologic pathology, quality assurance, peer review, agrochemicals, nanotechnology, food and toxicologic pathology, the environment and toxicologic pathology and more. - Provides new chapters and in-depth discussion of timely topics in the area of toxicologic pathology and broadens the scope of the audience to include toxicologists and pathologists working in a variety of settings - Offers high-quality and trusted content in a multi-contributed work written by leading international authorities in all areas of toxicologic pathology - Features hundreds of full color images in both the print and electronic versions of the book to highlight difficult concepts with clear illustrations |
| blood thinners for mechanical heart valves: Office Practice of Neurology Martin A. Samuels, Steven K. Feske, 2003 This comprehensive text is the perfect clinical resource, offering quick access to all of the information needed to provide out-patient neurologic care. It focuses on the common and chronic problems that require long-term management, and provides step-by-step guidance on the decision-making process. Readers will find an expanded section on multiple sclerosis as well as updated and revised information in every section, including all of the latest studies and their results. Plus, a table at the beginning of each chapter summarizes the authors' approaches to diagnosis and management. Features contributions from more than 200 authors, representing a wide spectrum of specialists in neurology and related fields. Covers the major problems that any practicing neurologist might encounter, including those that may be rare. Presents a wealth of useful clinical information with enough comprehensive coverage on the difficult, long-term, and complicated disorders. Features an expanded section on multiple sclerosis, with in-depth discussions on the clinical issues surrounding the disease. Discusses the latest molecular genetic studies, including new information on the progressive ataxias · Alzheimer's disease · Huntington's disease · mitochondrial disorders · and familial stroke and headache syndromes. Reports on the results of recent clinical studies on asymptomatic carotid atherosclerosis and symptomatic carotid endarterectomy. Includes the latest methods for treating stroke · seizures · multiple sclerosis · migraine · Parkinson's disease · amyotrophic lateral sclerosis · and Alzheimer's disease. Presents a summary table at the beginning of each chapter, highlighting the authors' approaches to various problems of diagnosis and management. |
| blood thinners for mechanical heart valves: Antithrombotic Therapy Richard C. Becker, Dan J. Fintel, David Green, 2004 Clinical application of antithrombotic therapy in both arterial disease (acute coronary syndromes, acute MI, peripheral arterial disease, valvular heart disease, atrial fibrillation) and venous disease (venous thromboembolic disease and pulmonary embolism). Results of major clinical trials and their implications for clinical practice are reviewed. |
| blood thinners for mechanical heart valves: Cancer-Associated Thrombosis Alok A. Khorana, Charles W. Francis, 2007-09-26 Showcasing the expertise of top-tier specialists who contributed to the newly released guidelines for the care of thrombosis in cancer patients, this exciting guide was written and edited by members of the American Society of Clinical Oncology panel, (ASCO), on the prevention and treatment of cancer-associated thrombosis, among others, and provides |
| blood thinners for mechanical heart valves: The Artificial Heart Institute of Medicine, Division of Health Care Services, Committee to Evaluate the Artificial Heart Program of the National Heart, Lung, and Blood Institute, 1991-02-01 A significant medical event is expected in 1992: the first human use of a fully implantable, long-term cardiac assist device. This timely volume reviews the artificial heart program-and in particular, the National Institutes of Health's major investment-raising important questions. The volume includes: Consideration of the artificial heart versus heart transplantation and other approaches to treating end-stage heart disease, keeping in mind the different outcomes and costs of these treatments. A look at human issues, including the number of people who may require the artificial heart, patient quality of life, and other ethical and societal questions. Examination of how this technology's use can be targeted most appropriately. Attention to achieving access to this technology for all those who can benefit from it. The committee also offers three mechanisms to aid in allocating research and development funds. |
| blood thinners for mechanical heart valves: Oral Anticoagulants L. Poller, Jack Hirsh, 1996-08-02 Warfarin and related drugs have been used for over half a century in prevention and treatment of thrombotic disorders. Only recently however has their clinical role been firmly established by randomised studies and their benefit/risk ratio improved by lower dose therapy with improvements in laboratory monitoring. 'Oral Anticoagulants' is the first comprehensive, practical survey of the subject available. An international team of recognised experts provide detailed coverage on the mode of action; clinical pharmodynamics; magnitude and sources of variability in individuals response to oral anticoagulant; methods of individualising dosing regimens; laboratory monitoring; and comparison between the different currently prescribed oral anticoagulants. |
| blood thinners for mechanical heart valves: Principles of Regenerative Medicine Anthony Atala, Robert Lanza, James A. Thomson, Robert Nerem, 2010-12-16 Virtually any disease that results from malfunctioning, damaged, or failing tissues may be potentially cured through regenerative medicine therapies, by either regenerating the damaged tissues in vivo, or by growing the tissues and organs in vitro and implanting them into the patient. Principles of Regenerative Medicine discusses the latest advances in technology and medicine for replacing tissues and organs damaged by disease and of developing therapies for previously untreatable conditions, such as diabetes, heart disease, liver disease, and renal failure. - Key for all researchers and instituions in Stem Cell Biology, Bioengineering, and Developmental Biology - The first of its kind to offer an advanced understanding of the latest technologies in regenerative medicine - New discoveries from leading researchers on restoration of diseased tissues and organs |
| blood thinners for mechanical heart valves: Tissue Heart Valves Marian I. Ionescu, 1979 |
| blood thinners for mechanical heart valves: Percutaneous Balloon Valvuloplasty Tsung O. Cheng, 1992 |
| blood thinners for mechanical heart valves: Stentless Bioprostheses Tirone E David, Hans A Huysmans, Stephen Westaby, 2004-11-23 This text is divided into seven sections covering the applications, uses, effects and designs of stentless bioprostheses. The three opening chapters describe the paediatric applications of stentless bioprostheses, with reference to aortic valve replacement and right ventricular outflow tract reconstruction Chapters in the second section discuss the use of stentless bioprostheses in the mitral position. The following two sections discuss different aspects of the clinical outcomes of stentless bioprostheses and the fifth section has seven chapters on haemodynamics and left ventricular function. The final sections cover the topics of implantation techniques and the design and construction of stentless bioprostheses. The second edition is updated and enhanced and is Illustrated in full colour. |
| blood thinners for mechanical heart valves: Gastroenterological Endoscopy Michael B. Wallace, Paul Fockens, Joseph Jao-Yiu Sung, 2018-01-24 Praise for the previous edition: Extraordinary achievement … this volume stands on its own as a marvelous feat in bringing such a vast array of clear and coherent instruction to endoscopists at all skill levels.—Gastroenterology Written and edited by internationally renowned specialists, the third edition of Gastroenterological Endoscopy covers the entire spectrum of diagnostic and therapeutic procedures for the upper and lower GI tract while providing the latest overview of GI disorders. A great wealth of high-resolution photographs provides the visual information needed to confidently assess and diagnose mucosal lesions of the entire digestive tract. Significant advances in the field—both medical and technical—since the last edition are covered in comprehensive detail. Key Features: New panel of top international editors, continuing the tradition of excellence, depth, and breadth as originated by founding editors Classen, Tytgat, and Lightdale; list of contributing authors is a who's who of GI endoscopy Coverage of newest, advanced tools and techniques: gastric-POEMS, submucosal tunnel endoscopic resection (STER), lumen-apposing metal stents, over-the-scope clips, and much more More than 1,500 exquisite images Gastroenterological Endoscopy, third edition, surely deserves a prominent place in any complete endoscopy reference collection. Michael B. Wallace, MD, is Professor of Medicine at the Division of Gastroenterology and Hepatology, Mayo Clinic, Jacksonville, Florida, USA Paul Fockens, MD, is Professor and Chair of the Dept. of Gastroenterology and Hepatology at the Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands Joseph Jao-Yiu Sung, MD, PhD, is Mok Hing Yiu Professor of Medicine and Director of the Institute of Digestive Diseases of The Chinese University of Hong Kong, Shatin, Hong Kong An award-winning international medical and scientific publisher, Thieme has demonstrated its commitment to the highest standard of quality in the state-of-the-art content and presentation of all its products. Founded in 1886, the Thieme name has become synonymous with high quality and excellence in online and print publishing. |
| blood thinners for mechanical heart valves: Handbook of Toxicologic Pathology Wanda M. Haschek, Colin George Rousseaux, Matthew A. Wallig, 2002 In volume I, the book covers toxicologic pathology in its basic aspects, including its definition, the basic biochemical and morphologic mechanisms underlying the discipline, the basic practice of toxicologic pathology (including special techniques) and issues essential to the understanding of toxicologic pathology such as risk assessment, experimental design, and statistical analysis. Next, the book moves to specific issues affecting the practice toxicologic pathology, including issues such as knowledge management, regulatory affairs and writing pathology reports. Finally, Volume I closes with several chapters that deal with specific classes of environmental toxicants such as endocrine disruptors and heavy metals. Volume II addresses the toxicologic pathology in a thoroughly standardized systems manner, addressing the basic structure and function of a particular organ system, its response to toxic injury, mechanisms of injury and methods of evaluation of such injury.- |
Blood - Wikipedia
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Blood: Function, What It Is & Why We Need It - Cleveland Clinic
Blood is mostly fluid but contains cells and proteins. Blood has four parts: Red blood cells (bottom right), white blood cells, platelets (middle right) and plasma (top right). What is blood? Blood is …
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May 29, 2025 · Blood, fluid that transports oxygen and nutrients to cells and carries away carbon dioxide and other waste products. Blood contains specialized cells that serve particular …
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Detailed information on blood, including components of blood, functions of blood cells and common blood tests.
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Blood is a specialized body fluid. It has four main components: plasma, red blood cells, white blood cells, and platelets. The blood that runs through the veins, arteries, and capillaries is …
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Jan 16, 2024 · Blood supplies essential substances, such as sugars and oxygen, to cells and organs, and removes waste from cells. Hematologists work to identify and prevent blood and …
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Jun 2, 2024 · Blood is a fluid that contains plasma, white blood cells, and red blood cells. It is responsible for transporting oxygen, nutrients, and hormones throughout the body. For the …
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Jul 26, 2017 · Blood is the body fluid in humans and other animals that delivers the essential materials for life to the body’s cells. It has sometimes been called a fluid “tissue,” because like …
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Blood is a mixture of two components: cells and plasma. The heart pumps blood through the arteries, capillaries and veins to provide oxygen and nutrients to every cell of the body. The …
Blood Thinners For Mechanical Heart Valves (Download Only)
Blood Thinners For Mechanical Heart Valves: The Patient's Guide to Heart Valve Surgery Adam Pick,2007 Each year over 250 000 heart valve repair and heart valve replacement operations …
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If you are currently taking blood thinners (for irregular heartbeat, atrial fibrillation, heart disease, stents, stroke, mini-stroke, mechanical heart valves, blood clots in the legs or lungs, or other …
ABBREVIATIONS: - American Heart Association
Prosthetic Heart Valves Annual Thrombotic Risk Characteristics 2017 AHA/ACC Focused Update-Valvular Heart Disease3 High Any mitral valve prosthesis Older generation (caged-ball or …
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If you are currently taking blood thinners (for irregular heartbeat, atrial fibrillation, heart disease, stents, stroke, mini-stroke, mechanical heart valves, blood clots in the legs or lungs, or other …
Reducing the risk of blood clots in artificial heart valves
Jan 13, 2020 · People with mechanical heart valves need blood thinners on a daily basis, because they have a higher risk of blood clots and stroke. Researchers at the ARTORG Center of the …
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If you are currently taking blood thinners (for irregular heartbeat, atrial fibrillation, heart disease, stents, stroke, mini-stroke, mechanical heart valves, blood clots in the legs or lungs, or other …
Warfarin Versus Novel Oral Anticoagulants - AHA/ASA Journals
Nov 25, 2014 · NOACs and Mechanical Heart Valves Mechanical heart valves increase the risk of blood clots, including stroke. Patients with mechanical heart valves are prescribed …
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Blood Thinners For Mechanical Heart Valves B Lingard. Blood Thinners For Mechanical Heart Valves: The Patient's Guide to Heart Valve Surgery Adam Pick,2007 Each year over 250 000 …
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that the heart must pump extra hard. People whose heart valves are replaced with a mechanical valve must take blood thinners (e.g., warfarin or Coumadin®) for the rest of their lives. • Repair …
LIVING WITH YOUR NEW HEART VALVE
heart valves. Mechanical heart valves are constructed with strong, manmade materials and designs. The most important benefit of mechanical valves is that they are the most durable of …
Fabrication and In Vitro Characterization of a Tissue …
erefore, patients with mechanical heart valves require blood thinners throughout the rest of their life. Besides, both the bioprosthetic and mechanical valves are unable to grow with
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impede veins prompting stroke. Individuals with mechanical valves need to take anticoagulants (blood thinners), like warfarin, for the remainder of their life. Mechanical heart valves can …
Mitral Valve Surgery - Food and Drug Administration
blood through your heart. The valves open to allow blood to move forward , but close to ... Mechanical valves usually last for the rest of the patient’s life but require daily treatment with …
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replacement: mechanical and tissue. Mechanical valves have long-term durability, but patients must take blood-thinning medication (anticoagulation therapy) to prevent the formation of …
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These are often people with mechanical heart valves and therefore require a greater level of blood thinning than other people using anticoagulant therapies, such as VKA with an INR target …
ABBREVIATIONS: - American Heart Association
Prosthetic Heart Valves Annual Thrombotic Risk Characteristics 2017 AHA/ACC Focused Update-Valvular Heart Disease3 High Any mitral valve prosthesis Older generation (caged-ball or …
Blood Thinners For Mechanical Heart Valves (Download Only)
Blood Thinners For Mechanical Heart Valves: The Patient's Guide to Heart Valve Surgery Adam Pick,2007 Each year over 250 000 heart valve repair and heart valve replacement operations …
Foldax Advances the Next Big Thing in Heart Valves: Robotic …
Sep 8, 2022 · alternative: mechanical heart valves, which are durable, but come with the lifestyle consequences of forever being on blood thinners. In 2013 Charhut founded Foldax with three …
ABBREVIATIONS: - American Heart Association
Prosthetic Heart Valves Annual Thrombotic Risk Characteristics 2017 AHA/ACC Focused Update-Valvular Heart Disease3 High Any mitral valve prosthesis Older generation (caged-ball or …
Okanagan Valve: The Next Generation of Mechanical Heart …
Mechanical heart valves (MHV) can be surgically implanted to replace a failing valve but require life-long consumption of blood thinners, such as Warfarin, to prevent blood clotting issues. …
Important Information and Treatment Options
The heart has four chambers; the upper two chambers are called the left atrium and right atrium, and the lower two are called the left ventricle and right ventricle. Heart valves are the …
LIVING WITH YOUR NEW HEART VALVE
bioprosthetic or tissue heart valves. Mechanical heart valves are constructed with strong, manmade materials and designs. The most important benefit of mechanical valves is that they …
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All indications for anticoagulation are considered, including atrial fibrillation, venous thromboembolism, prosthetic cardiac valves, and intracardiac thrombus. Mechanical …
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Patients requiring a replacement valve have the option of either mechanical heart valves or bioprosthetic heart valves . These valves have significantly extended the lifespans of …
Mitral Valve Replacement Surgery
Comparison of Tissue and Mechanical Valves: Long-term blood thinner required No Yes – Daily blood thinner medication and regular blood tests for rest of life Tissue Valves Mechanical …
A guide for patients - St. Elizabeth Healthcare
are less likely to require anticoagulants (blood thinners) after surgery. Biological valves may begin to wear out over time and therefore are generally not recommended for younger patients. …
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on the valve surface and embolism10. ˜erefore, patients with mechanical heart valves require blood thinners throughout the rest of their life. Besides, both the bioprosthetic and mechanical ...
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anticoagulants (blood thinners), e.g. warfarin, which requires monthly blood tests to monitor. This process of thinning the blood is called anticoagulation. Tissue heart valves, in contrast, do not …
Q&A: Mechanical or tissue heart valve replacements
Q&A: Mechanical or tissue heart valve replacements March 2 2021, by Mayo Clinic News Network ... mechanical valves require the blood thinner warfarin to keep them from clotting and aspirin ...
AORTIC STENOSIS - Henry Ford Health
BIOLOGICAL VS. MECHANICAL VALVES • Biological valves: These are made of cow, pig or human heart tissue that has been specially treated to reduce the chances of rejection or …
Experimental investigation of flow through a bileaflet …
problem [1, 5]. However, biological prosthetic heart valves do not require the use of blood thinners to be administered to the patient, making them an attractive alternative to MHVs. A number of …
Aortic Stenosis: Considerations for Replacing Your Aortic Valve
Are you able and willing to take a blood thinner? Tissue Valve . Age <50 . SAVR Mechanical or Ross Procedure . Age 50–65 . SAVR Mechanical or Tissue Valve . Age 65–80 . SAVR or TAVI …
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body. The right side of the heart pumps blood through the lungs, where the blood picks up oxygen. The blood with oxygen goes to the left side of the heart, and the left side of the heart …
Perioperative Anticoagulation Algorithm - St. Charles Health …
Mechanical Heart Valves All mitral valve prosthesis Older mechanical aortic valve prosthesis (caged ball/tilting disk) Stroke/TIA Bi-leaflet aortic valve prosthesis and history of stroke Two or …
Stroke preventers, not blood thinners! - psa.org.au
Stroke preventers, not blood thinners! Evaluate clinical, patient, and practical factors to ensure the most appropriate oral anticoagulant (OAC) is prescribed for each person ... mechanical heart …
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through thick and thin - South Denver Cardiology
• Coagulation = blood clotting • An anticoagulant is a medication that reduces the bloods potential to clot • Anticoagulants are often called “blood-thinners” 2 3 ... • INR = 2.5-3.5, for mechanical …
through thick and thin - South Denver Cardiology
• Coagulation = blood clotting • An anticoagulant is a medication that reduces the bloods potential to clot • Anticoagulants are often called “blood-thinners” 2 3 ... • INR = 2.5-3.5, for mechanical …
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to keep blood moving through your body. The right side of the heart pumps blood through the lungs, where the blood picks up oxygen. The blood with oxygen goes to the left side of the …
PERI-OPERATIVE MANAGEMENT OF ANTICOAGULATION …
mechanical heart valves (MHV), need separate consideration. For patients with acute VTE the risk of recurrence without anticoagulation is very high in the first three months (Kearon and Hirsh …
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Jun 11, 2024 · consistent with long-established standards for heart valves. The results were presented last week at the New York Valves: The Structural Heart Summit 2024 by Isaac …
