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| brain stem cell therapy: Jasper's Basic Mechanisms of the Epilepsies Jeffrey Noebels, 2012-06-29 Jasper's Basic Mechanisms, Fourth Edition, is the newest most ambitious and now clinically relevant publishing project to build on the four-decade legacy of the Jasper's series. In keeping with the original goal of searching for a better understanding of the epilepsies and rational methods of prevention and treatment., the book represents an encyclopedic compendium neurobiological mechanisms of seizures, epileptogenesis, epilepsy genetics and comordid conditions. Of practical importance to the clinician, and new to this edition are disease mechanisms of genetic epilepsies and therapeutic approaches, ranging from novel antiepileptic drug targets to cell and gene therapies. |
| brain stem cell therapy: Stem Cells and the Future of Regenerative Medicine Institute of Medicine, Board on Neuroscience and Behavioral Health, National Research Council, Division on Earth and Life Studies, Board on Life Sciences, Committee on the Biological and Biomedical Applications of Stem Cell Research, 2002-01-25 Recent scientific breakthroughs, celebrity patient advocates, and conflicting religious beliefs have come together to bring the state of stem cell researchâ€specifically embryonic stem cell researchâ€into the political crosshairs. President Bush's watershed policy statement allows federal funding for embryonic stem cell research but only on a limited number of stem cell lines. Millions of Americans could be affected by the continuing political debate among policymakers and the public. Stem Cells and the Future of Regenerative Medicine provides a deeper exploration of the biological, ethical, and funding questions prompted by the therapeutic potential of undifferentiated human cells. In terms accessible to lay readers, the book summarizes what we know about adult and embryonic stem cells and discusses how to go about the transition from mouse studies to research that has therapeutic implications for people. Perhaps most important, Stem Cells and the Future of Regenerative Medicine also provides an overview of the moral and ethical problems that arise from the use of embryonic stem cells. This timely book compares the impact of public and private research funding and discusses approaches to appropriate research oversight. Based on the insights of leading scientists, ethicists, and other authorities, the book offers authoritative recommendations regarding the use of existing stem cell lines versus new lines in research, the important role of the federal government in this field of research, and other fundamental issues. |
| brain stem cell therapy: Brain Neurotrauma Firas H. Kobeissy, 2015-02-25 With the contribution from more than one hundred CNS neurotrauma experts, this book provides a comprehensive and up-to-date account on the latest developments in the area of neurotrauma including biomarker studies, experimental models, diagnostic methods, and neurotherapeutic intervention strategies in brain injury research. It discusses neurotrauma mechanisms, biomarker discovery, and neurocognitive and neurobehavioral deficits. Also included are medical interventions and recent neurotherapeutics used in the area of brain injury that have been translated to the area of rehabilitation research. In addition, a section is devoted to models of milder CNS injury, including sports injuries. |
| brain stem cell therapy: Cell Therapy Against Cerebral Stroke Kiyohiro Houkin, Koji Abe, Satoshi Kuroda, 2017-03-05 This book presents comprehensive reviews for both translational research and clinical trials on cell therapy for stroke. Cerebral stroke is still a leading cause of death and disability. However, despite intensive research, few treatment options are available. The therapeutic potential of cell transplantation has been studied for various pathological conditions of the central nervous system (CNS) including traumatic brain injury, traumatic spinal cord injury, degenerative disease, demyelinating disease and ischemic stroke, as the injured neural tissue in the CNS has only a limited regenerative capacity. Recently, a growing body of evidence in this field suggests that cell transplantation holds great potential as a form of stroke therapy. The authors, who are experts in the field of neurosurgery, review and discuss optimal cell sources and various issues involved in translational research; further, they outline ongoing clinical trials in Japan. |
| brain stem cell therapy: Autoimmune Neurology , 2016-03-11 Autoimmune Neurology presents the latest information on autoimmune neurologic disease, the immune response to the body where organs run wild, causing the immune system to attack itself. Autoimmunity is a main element in numerous nervous system diseases and can target any structure within the central or peripheral nervous system. Over the past 20 years, significant advances in our understanding of the pathophysiology of autoimmune disorders, including the use of biomarkers has led to new diagnosis and treatment options. Neurologic conditions associated with autoimmune reactions include dementia, neuromuscular disease, epilepsy, sleep disorders, diabetes, and other common neurologic disorders and disease. This current tutorial-reference will be a must-have title for clinical neurologists, research neurologists, neuroscientists, and any medical professional working with autoimmune disease and disorders. - Includes comprehensive coverage of autoimmune neurology - Details the latest techniques for the study, diagnosis, and treatment of diseases and disorders, including dementia, neuromuscular disease, epilepsy, and sleep disorders - Presents a focused reference for clinical practitioners and the clinical neurology and neurology research communities |
| brain stem cell therapy: Regenerative Rehabilitation Sarah M. Greising, Jarrod A. Call, 2022-06-01 This contributed volume presents the current state of research on regenerative rehabilitation across a broad range of neuro- and musculoskeletal tissues. At its core, the primary goal of regenerative rehabilitation is to restore function after damage to bones, skeletal muscles, cartilage, ligaments/tendons, or tissues of the central and peripheral nervous systems. The authors describe the physiology of these neuro- and musculoskeletal tissue types and their inherent plasticity. The latter quality is what enables these tissues to adapt to mechanical and/or chemical cues to improve functional capacity. As a result, readers will learn how regenerative rehabilitation exploits that quality, to trigger positive changes in tissue function. Combining basic, translational, and clinical aspects of the topic, the book offers a valuable resource for both scientists and clinicians in the regenerative rehabilitation field. |
| brain stem cell therapy: Perinatal Stem Cells Anthony Atala, Kyle J. Cetrulo, Rouzbeh R. Taghizadeh, Curtis L Cetrulo, Sean Murphy, 2018-06-14 Perinatal Stem Cells provides researchers and clinicians with a comprehensive description of the current clinical and pre-clinical applications of stem cells derived from perinatal sources, such as amniotic fluid, placenta and placental membranes, the umbilical cord and Wharton's jelly. It's compiled by leading experts in the field, offering readers detailed insights into sources of perinatal stem cells and their potential for disease treatment. Therapeutic applications of perinatal stem cells include the treatment of in utero and pregnancy related diseases, cardiac disease, liver disease, pulmonary disease, inflammatory diseases, for hematopoietic regeneration, and for neural protection after stroke or traumatic brain injury. In addition, the rapid advance in clinical translation and commercialization of perinatal stem cell therapies is highlighted in a section on Clinical and Industry Perspective which provides insight into the new opportunities and challenges involved in this novel and exciting industry. - Explores current clinical and pre-clinical application of stem cells derived from perinatal sources - Offers detailed insight into sources of perinatal stem cells and their potential for disease treatment - Discusses progress in the manufacturing, banking and clinical translation of perinatal stem cells - Edited by a world-renowned team to present a complete story of the development and promise of perinatal stem cells |
| brain stem cell therapy: Mesenchymal Stem Cell Therapy Lucas G. Chase, Mohan C Vemuri, 2012-12-12 Over the past decade, significant efforts have been made to develop stem cell-based therapies for difficult to treat diseases. Multipotent mesenchymal stromal cells, also referred to as mesenchymal stem cells (MSCs), appear to hold great promise in regards to a regenerative cell-based therapy for the treatment of these diseases. Currently, more than 200 clinical trials are underway worldwide exploring the use of MSCs for the treatment of a wide range of disorders including bone, cartilage and tendon damage, myocardial infarction, graft-versus-host disease, Crohn’s disease, diabetes, multiple sclerosis, critical limb ischemia and many others. MSCs were first identified by Friendenstein and colleagues as an adherent stromal cell population within the bone marrow with the ability to form clonogenic colonies in vitro. In regards to the basic biology associated with MSCs, there has been tremendous progress towards understanding this cell population’s phenotype and function from a range of tissue sources. Despite enormous progress and an overall increased understanding of MSCs at the molecular and cellular level, several critical questions remain to be answered in regards to the use of these cells in therapeutic applications. Clinically, both autologous and allogenic approaches for the transplantation of MSCs are being explored. Several of the processing steps needed for the clinical application of MSCs, including isolation from various tissues, scalable in vitro expansion, cell banking, dose preparation, quality control parameters, delivery methods and numerous others are being extensively studied. Despite a significant number of ongoing clinical trials, none of the current therapeutic approaches have, at this point, become a standard of care treatment. Although exceptionally promising, the clinical translation of MSC-based therapies is still a work in progress. The extensive number of ongoing clinical trials is expected to provide a clearer path forward for the realization and implementation of MSCs in regenerative medicine. Towards this end, reviews of current clinical trial results and discussions of relevant topics association with the clinical application of MSCs are compiled in this book from some of the leading researchers in this exciting and rapidly advancing field. Although not absolutely all-inclusive, we hope the chapters within this book can promote and enable a better understanding of the translation of MSCs from bench-to-bedside and inspire researchers to further explore this promising and quickly evolving field. |
| brain stem cell therapy: Induced Pluripotent Stem Cells in Brain Diseases Vivi M. Heine, Stephanie Dooves, Dwayne Holmes, Judith Wagner, 2011-11-23 Brain diseases can have a large impact on patients and society, and treatment is often not available. A new approach in which somatic cells are reprogrammed into induced pluripotent cells (iPS cells) is a significant breakthrough for regenerative medicine. This promises patient-specific tissue for replacement therapies, as well as disease-specific cells for developmental modeling and drug treatment screening. However, this method faces issues of low reprogramming efficiency, and poorly defined criteria for determining the conversion of one cell type to another. Cells contain epigenetic “memories” of what they were that can affect reprogramming. This book discusses the various methods to reprogram cells, the control and determination of cell identity, the epigenetic models that have emerged and the application of iPS cell therapy for brain diseases, in particular Parkinson’s disease and Vanishing White Matter (VWM). |
| brain stem cell therapy: Stem Cells Mariusz Z. Ratajczak, 2020-01-02 Since different types of stem cells for therapeutic applications have recently been proposed, this timely volume explores various sources of stem cells for tissue and organ regeneration and discusses their advantages and limitations. Also discussed are pros and cons for using embryonic stem cells, induced pluripotent stem cells, and adult stem cells isolated from postnatal tissues. Different types of adult stem cells for therapeutic applications are also reviewed, including hematopoietic stem cells, epidermal stem cells, endothelial progenitors, neural stem cells, mesenchymal stem cells, and very small embryonic-like stem cells. This book also addresses paracrine effects of stem cells in regenerative medicine that are mediated by extracellular microvesicles and soluble secretome. Finally, potential applications of stem cells in cardiology, gastroenterology, neurology, immunotherapy, and aging are presented. This is an ideal book for students and researchers working in the stem cell research field. |
| brain stem cell therapy: Neural Crest Stem Cells Maya Sieber-Blum, 2012 Offers readers an understanding of the development of neural crest cells, which is crucial as many birth defects and tumours are of neural crest origin. Delving into stem cells from different locations of the body, this book explores the best possible source of such cells for the use in medical applications. |
| brain stem cell therapy: Translational Research in Traumatic Brain Injury Daniel Laskowitz, Gerald Grant, 2016-04-21 Traumatic brain injury (TBI) remains a significant source of death and permanent disability, contributing to nearly one-third of all injury related deaths in the United States and exacting a profound personal and economic toll. Despite the increased resources that have recently been brought to bear to improve our understanding of TBI, the developme |
| brain stem cell therapy: Cardiac Regeneration Masaki Ieda, Wolfram-Hubertus Zimmermann, 2017-10-27 This Volume of the series Cardiac and Vascular Biology offers a comprehensive and exciting, state-of-the-art work on the current options and potentials of cardiac regeneration and repair. Several techniques and approaches have been developed for heart failure repair: direct injection of cells, programming of scar tissue into functional myocardium, and tissue-engineered heart muscle support. The book introduces the rationale for these different approaches in cell-based heart regeneration and discusses the most important considerations for clinical translation. Expert authors discuss when, why, and how heart muscle can be salvaged. The book represents a valuable resource for stem cell researchers, cardiologists, bioengineers, and biomedical scientists studying cardiac function and regeneration. |
| brain stem cell therapy: Umbilical Cord Stem Cell Therapy David A. Steenblock, Anthony G. Payne, 2006 Examines the potential for stem cells gleaned from umbilical cords to generate a wealth of new therapy and healing medicines for neurological conditions and blood problems. |
| brain stem cell therapy: Molecular, Genetic, And Cellular Advances In Cerebrovascular Diseases Hua Su, Michael T Lawton, 2017-12-26 This book will cover recent advances in genetics and molecular biology of cerebrovascular diseases, including ischemic stroke, brain arteriovenous malformation, brain aneurysms, and cavernous malformation. Developments in diagnostics, imaging and treatment will also be discussed.Much progress has been made in recent years in these fields, but not been summarized in one comprehensive text. This volume fills the gap in the literature by compiling them in one convenient, handy volume for neuroscience researchers and medical professionals. |
| brain stem cell therapy: Cell Therapy for Brain Injury David C. Hess, 2015-05-15 Cell Therapy for Brain Injury is a thorough examination of using state-of-the-art cell therapy in the treatment of strokes and other traumatic brain injuries. This invaluable book covers this niche topic in depth from basic stem cell biology and principles of cell therapy through proposed mechanisms of action of cell therapy in stroke, pre-clinical data in stroke models, ongoing clinical trials, imaging and tracking of cells with MRI, neural stem cells in stroke and the big pharma perspective of cell therapy. Each chapter is written by well-known leaders in each field, thus providing a wealth of expertise. The breadth of this book makes it essential reading for neuroscientists, stem cell biologists, researchers or clinical trialists at pharmaceutical or biotechnology companies. It also serves as a thorough introduction for graduate students or post-doctoral fellows who hope to work in these fields. |
| brain stem cell therapy: Brain Repair Donald G. Stein, Simón Brailowsky, Bruno Will, 1997 Over a half million people each year suffer brain-damaging injuries and diseases--but the outlook for their eventual recovery is far more hopeful than it was just a short while ago. In Brain Repair, three internationally renowned neuroscientists team up to offer an intriguing and up-to-the-minute introduction to the explosive advances being made in the research, technology, and treatment of brain damage. The key to neuroscience's most exciting discoveries to date is a theory that is rapidly gaining adherents in the scientific community--the theory of neuroplasticity. Neuroplasticity stresses that cells throughout the brain can not only regenerate, but can adapt their function to assume critical roles once performed by damaged tissue. In clear, accessible language, the authors show us that the brain manufactures a host of complex chemicals that actually foster growth in damaged brain cells. We visit the laboratories where researchers are untangling the mystery of Parkinson's disease and trying to understand what goes wrong in stroke victims, and why some, thought permanently impaired, show remarkable improvements. In addition, they discuss how even today misguided ideas can adversely affect how physicians treat patients. And, along the way, they detail the fascinating history of how brain structure and functioning has been understood and studied, from prehistoric times to the present. A best-selling volume in France and Mexico, Brain Repair provides a vividly written, wide-ranging look at the leading edge of one of science's most exciting frontiers. |
| brain stem cell therapy: Cell Therapy, Stem Cells and Brain Repair Cyndy D. Davis, Paul R. Sanberg, 2007-11-09 As our world continues to evolve, the field of regenerative medicine f- lows suit. Although many modern day therapies focus on synthetic and na- ral medicinal treatments for brain repair, many of these treatments and prescriptions lack adequate results or only have the ability to slow the p- gression of neurological disease or injury. Cell therapy, however, remains the most compelling treatment for neurodegenerative diseases, disorders, and injuries, including Parkinson’s disease, Huntington’s disease, traumatic brain injury, and stroke, which is expanded upon in more detail in Chapter 1 by Snyder and colleagues. Cell therapy is also unique in that it is the only therapeutic strategy that strives to replace lost, damaged, or dysfunctional cells with healthy ones. This repair and replacement may be due to an administration of exogenous cells itself or the activation of the body’s own endogenous reparative cells by a trophic, immune, or inflammatory response to cell transplantation. However, the precise mechanism of how cell therapy works remains elusive and is c- tinuing to be investigated in terms of molecular and cellular responses, in particular. Moreover, Chapter 11 by Emerich and associates, discusses some of the possibilities of cell immunoisolation and the potential for treating central nervous system diseases. |
| brain stem cell therapy: Stem Cell Biology and Gene Therapy Peter J. Quesenberry, Gary S. Stein, Bernard G. Forget, Sherman M. Weissman, 1998-09-10 STEM CELL BIOLOGY AND GENE THERAPY Edited by Peter J. Quesenberry, Gary S. Stein, Bernard Forget, and Sherman Weissman Advances in molecular genetics and recombinant DNA technology have ushered in a new era in medical therapeutic research. New insights into the molecular basis of human disease and the role played by biological regulatory mechanisms have precipitated tremendous drug development efforts backed by intensive research into human gene therapy worldwide. Stem Cell Biology and Gene Therapy is the first book to thoroughly cover major advances in the field and their applications to novel molecular therapies. This self-contained volume integrates biological and clinical components of stem cell biology, examines some of the most difficult aspects of gene therapy, and provides a systematic review of advanced gene modification techniques. Twenty essays by leading researchers address some of the most compelling topics in contemporary medical research, including: * Fundamental regulatory mechanisms that operate in stem cells * Stem cells from a therapeutic perspective, including preparations of stem cells and their therapeutic potential as vehicles for gene therapy * Delivery systems for therapeutic genes, including an overview of the most promising vectors * Clinical applications for gene therapy, covering a broad range of diseases such as hemophilia, cancers, neurological disease, and more Complete with illustrations and real-world examples of a variety of disorders, Stem Cell Biology and Gene Therapy is essential for researchers in gene therapy and members of the biotechnology industry who are developing human molecular therapies for commercial use. It is also an important reference for molecular biologists, cell biologists, immunologists, molecular geneticists, hematologists, cancer researchers, biochemists, and anyone working in internal medicine. |
| brain stem cell therapy: The Stem Cell Cure Gaurav K. Goswami, Kerry Johnson, 2020-03-31 The 150+ year lifespan of our ancient ancestors can be achieved once again by harnessing the power of our own cells with The Stem Cell Cure! Renowned regenerative and restorative sports medicine doctor Gaurav Goswami, M.D. provides advanced minimally invasive, non-surgical treatments to help his patients get back to peak performance levels – no matter their age. Harnessing the transformative power of stem cells is central to his expertise. In fact, stem cell therapy is proven to be effective in the treatment of many common conditions from arthritis and back pain to Alzheimer’s, Parkinson’s, and cancer. This book is an accessible and informative introduction to the amazing powers of Stem Cell Therapy – the biggest revolution in medicine since the discovery of penicillin, and a wave of the future. Co-authored by bestselling author and popular keynote speaker Kerry Johnson MBA PhD, The Stem Cell Cure provides specific ways for readers to boost their health and vitality for a lifetime by recovering, regenerating, and repairing injuries and disease. |
| brain stem cell therapy: Mesenchymal Stem Cells in Human Health and Diseases Ahmed El-Hashash, 2020-01-07 Mesenchymal Stem Cells in Human Health and Diseases provides a contemporary overview of the fast-moving field of MSC biology, regenerative medicine and therapeutics. MSCs offer the potential to dramatically reduce human suffering from disease. Numerous MSC-based studies are ongoing each year, each offering hope for novel treatments in human disease. This book provides information on MSC application in well-studied human diseases and tissue repair/regeneration and recent advances in their research and treatment. These discoveries are placed within the structural context of tissue and developmental biology in sections dealing with recent advances in our understanding of MSC biology. - Includes insights ranging from MSC biology and development through the derivation and identification and properties of MSCs - Helps to identify potential innovative solutions for restoring normal morphogenesis and/or regeneration of diseased organs - Discusses the fact-based promise of MSC therapeutics and regenerative medicine in the real world |
| brain stem cell therapy: The Incidence and Economic Burden of Injuries in the United States Eric Finkelstein, Phaedra S. Corso, Ted R. Miller, 2006 Injuries are one of the most serious public health problems facing the United States today. Through premature death, disability, medical cost and lost productivity, injuries impact the health and welfare of all Americans. Deaths only begin to tell the story. Although many injuries are minor, a large proportion result in fractures, amputations, burns, or other significant injuries that have far-reaching consequences. Now, for the first time in over 15 years, we have comprehensive estimates of the impact of these injuries in economic terms. This book updates a landmark Report to Congress from 1989. Since the report, no undertaking has addressed the incidence and economic burden of injuries with more timely data, despite major changes in the fields of prevention, reporting, and surveillance. Since the mid-eighties, new safety technologies have been developed to prevent injuries or to decrease the severity of injuries, and new policies and laws have been enacted to promote injury prevention. Chapter topics include incidence by detailed categorizations, lifetime medical costs and productivity losses as a result of injuries, and a discussion of recent trends. Lavishly illustrated with tables and graphs, this volume is a valuable reference for public health practitioners, researchers, and students alike. |
| brain stem cell therapy: Stem Cell Therapy for Vascular Diseases Tulio Pinho Navarro, Lara Lellis Navarro Minchillo Lopes, Alan Dardik, 2020-11-05 Vascular diseases are the leading cause of death worldwide. Distinguished clinical and surgical approaches have attempted to overcome its morbidity and mortality; still 17.9 million people die every year due to vascular affections. Stem cell therapy has emerged as a promising therapeutic strategy. Stem cells synthesize and secrete cytokines that promote cell recruitment, immunomodulation, extracellular matrix remodeling, angiogenesis, and neuroregeneration, all of which promote regeneration. Besides that, stem cells are also capable of differentiating in various cell types, being employed in tissue engineering. Preclinical and clinical investigations have reported efficacy of stem cell therapy for various vascular diseases. Even though results are encouraging, the studies demonstrate variation in stem cell type and origin, route and protocol for administration, and concomitant use of other treatment strategies, impairing easy interpretation of results and clinical application. The purpose of this book is to compile and comprise the current state of the evidence regarding stem cell therapy for each vascular disease, elucidating possible clinical applications. More than an objective guide for readers on the use of this novel treatment strategy, this publication will advocate for stem cell therapy use and development and will be of significant interest to physicians in a wide range of disciplines as well as researchers. |
| brain stem cell therapy: Human Embryonic Stem Cells Jon Odorico, Roger Pedersen, Su-Chun Zhang, 2004-02-01 Since the first successful isolation and cultivation of human embryonic stem cells at the University of Wisconsin, Madison in 1998, there has been high levels of both interest and controversy in this area of research. This book provides a concise overview of an exciting field, covering the characteristics of both human embryonic stem cells and pluripotent stem cells from other human cell lineages. The following chapters describe state-of-the-art differentiation and characterization of specific ectoderm, mesoderm and endoderm-derived lineages from human embryonic stem cells, emphasizing how these can be used to study human developmental mechanisms. A further chapter discusses genetic manipulation of human ES cells. The concluding section covers therapeutic applications of human ES cells, as well as addressing the ethical and legal issues that this research have raised. |
| brain stem cell therapy: Human Embryonic Stem Cells Arlene Chiu, Mahendra S. Rao, 2003-08 A discussion of all the key issues in the use of human pluripotent stem cells for treating degenerative diseases or for replacing tissues lost from trauma. On the practical side, the topics range from the problems of deriving human embryonic stem cells and driving their differentiation along specific lineages, regulating their development into mature cells, and bringing stem cell therapy to clinical trials. Regulatory issues are addressed in discussions of the ethical debate surrounding the derivation of human embryonic stem cells and the current policies governing their use in the United States and abroad, including the rules and conditions regulating federal funding and questions of intellectual property. |
| brain stem cell therapy: Stem Cell Therapies Adam C. Berger, Sarah H. Beachy, Board on Health Sciences Policy, Steve Olson, Board on Life Sciences, Division on Earth and Life Sciences, Institute of Medicine, National Academy of Sciences, 2014-06-18 Stem cells offer tremendous promise for advancing health and medicine. Whether being used to replace damaged cells and organs or else by supporting the body's intrinsic repair mechanisms, stem cells hold the potential to treat such debilitating conditions as Parkinson's disease, diabetes, and spinal cord injury. Clinical trials of stem cell treatments are under way in countries around the world, but the evidence base to support the medical use of stem cells remains limited. Despite this paucity of clinical evidence, consumer demand for treatments using stem cells has risen, driven in part by a lack of available treatment options for debilitating diseases as well as direct-to-consumer advertising and public portrayals of stem cell-based treatments. Clinics that offer stem cell therapies for a wide range of diseases and conditions have been established throughout the world, both in newly industrialized countries such as China, India, and Mexico and in developed countries such as the United States and various European nations. Though these therapies are often promoted as being established and effective, they generally have not received stringent regulatory oversight and have not been tested with rigorous trials designed to determine their safety and likely benefits. In the absence of substantiated claims, the potential for harm to patients - as well as to the field of stem cell research in general - may outweigh the potential benefits. To explore these issues, the Institute of Medicine, the National Academy of Sciences, and the International Society for Stem Cell Research held a workshop in November 2013. Stem Cell Therapies summarizes the workshop. Researchers, clinicians, patients, policy makers, and others from North America, Europe, and Asia met to examine the global pattern of treatments and products being offered, the range of patient experiences, and options to maximize the well-being of patients, either by protecting them from treatments that are dangerous or ineffective or by steering them toward treatments that are effective. This report discusses the current environment in which patients are receiving unregulated stem cell offerings, focusing on the treatments being offered and their risks and benefits. The report considers the evidence base for clinical application of stem cell technologies and ways to assure the quality of stem cell offerings. |
| brain stem cell therapy: Functional Neural Transplantation III , 2012-12-31 This issue of Progress in Brain Research is split over 2 volumes, bringing together cutting-edge research on Functional Neural Transplantation. The 2 volumes review current knowledge and understanding, provide a starting point for researchers and practitioners entering the field, and build a platform for further research and discovery. - Leading authors review the state-of-the-art in their field of investigation, and provide their views and perspectives for future research - Chapters are extensively referenced to provide readers with a comprehensive list of resources on the topics covered - All chapters include comprehensive background information and are written in a clear form that is also accessible to the non-specialist |
| brain stem cell therapy: The Future of Brain Repair Jack Price, 2020-03-24 A scientist assesses the potential of stem cell therapies for treating such brain disorders as stroke, Alzheimer's disease, and Parkinson's disease. Stem cell therapies are the subject of enormous hype, endowed by the media with almost magical qualities and imagined by the public to bring about miracle cures. Stem cells have the potential to generate new cells of different types, and have been shown to do so in certain cases. Could stem cell transplants repair the damaged brain? In this book, neurobiologist Jack Price assesses the potential of stem cell therapies to treat such brain disorders as stroke, Alzheimer's disease, Parkinson's disease, and spinal cord injuries. Certainly brain disorders are in need of effective treatments. These disorders don't just kill, they disable, and conventional drug therapies have not had much success in treating them. Price explains that repairing the human brain is difficult, largely because of its structural, functional, and developmental complexity. He examines the self-repairing capacity of blood and gut cells—and the lack of such capacity in the brain; describes the limitations of early brain stem cell therapies for neurodegenerative disorders; and discusses current clinical trials that may lead to the first licensed stem cell therapies for stroke, Parkinson's and macular degeneration. And he describes the real promise of pluripotential stem cells, which can make all the cell types that constitute the body. New technologies, Price reports, challenge the very notion of cell transplantation, instead seeking to convince the brain itself to manufacture the new cells it needs. Could this be the true future of brain repair? |
| brain stem cell therapy: Indwelling Neural Implants William M. Reichert, 2007-12-17 Despite enormous advances made in the development of external effector prosthetics over the last quarter century, significant questions remain, especially those concerning signal degradation that occurs with chronically implanted neuroelectrodes. Offering contributions from pioneering researchers in neuroprosthetics and tissue repair, Indwel |
| brain stem cell therapy: Human Neural Stem Cells Leonora Buzanska, 2018-09-12 This book summarizes early pioneering achievements in the field of human neural stem cell (hNSC) research and combines them with the latest advances in stem cell technology, including reprogramming and gene editing. The powerful potential of hNSC to generate and repair the developing and adult CNS has been confirmed by numerous experimental in vitro and in vivo studies. The book presents methods for hNSC derivation and discusses the mechanisms underlying NSC in vitro fate decisions and their in vivo therapeutic mode of action. The long-standing dogma that the human central nervous system (CNS) lacks the ability to regenerate was refuted at the end of the 20th century, when evidence of the presence of neurogenic zones in the adult human brain was found. These neurogenic zones are home to human neural stem cells (hNSCs), which are capable of self-renewing and differentiating into neurons, astrocytes and oligodendrocytes. NSCs isolated from human CNS have a number of clinical advantages, especially the innate potential to differentiate into functional neural cells. Nevertheless, their full clinical exploitation has been hindered by limited access to the tissue and low expansion potential. The search for an alternative to CNS sources of autologous, therapeutically competent hNSCs was the driving force for the many studies proving the in vitro plasticity of different somatic stem cells to generate NSCs and their functional progeny. Now the era of induced pluripotent stem cells has opened entirely new opportunities to achieve research and therapeutic goals with the aid of hNSCs. |
| brain stem cell therapy: Multiple Sclerosis Ian S. Zagon, Patricia J. McLaughlin, 2017 |
| brain stem cell therapy: The Behavior of the Laboratory Rat Ian Q. Whishaw, Bryan Kolb, 2004-09-02 Both seasoned and beginning investigators will be amazed at the range and complexity of rat behavior as described in the 43 chapters of this volume. The behavioral descriptions are closely tied to the laboratory methods from which they were derived, thus allowing the investigator to exploit both the behavior and the methods for their own research. It will also serve as an indispensable reference for other neuroscientists, psychologist, pharmacologists, geneticists, molecular biologists, zoologists, and their students and trainees. |
| brain stem cell therapy: Disease Control Priorities, Third Edition (Volume 5) Dorairaj Prabhakaran, Shuchi Anand, Thomas A. Gaziano, Jean-Claude Mbanya, Rachel Nugent, 2017-11-17 Cardiovascular, respiratory, and related conditions cause more than 40 percent of all deaths globally, and their substantial burden is rising, particularly in low- and middle-income countries (LMICs). Their burden extends well beyond health effects to include significant economic and societal consequences. Most of these conditions are related, share risk factors, and have common control measures at the clinical, population, and policy levels. Lives can be extended and improved when these diseases are prevented, detected, and managed. This volume summarizes current knowledge and presents evidence-based interventions that are effective, cost-effective, and scalable in LMICs. |
| brain stem cell therapy: Becoming Dr. Q Alfredo Quiñones-Hinojosa, 2011-10-01 Today he is known as Dr. Q, an internationally renowned neurosurgeon and neuroscientist who leads cutting-edge research to cure brain cancer. But not too long ago, he was Freddy, a nineteen-year-old undocumented migrant worker toiling in the tomato fields of central California. In this gripping memoir, Alfredo Quiñones-Hinojosa tells his amazing life story—from his impoverished childhood in the tiny village of Palaco, Mexico, to his harrowing border crossing and his transformation from illegal immigrant to American citizen and gifted student at the University of California at Berkeley and at Harvard Medical School. Packed with adventure and adversity—including a few terrifying brushes with death—Becoming Dr. Q is a testament to persistence, hard work, the power of hope and imagination, and the pursuit of excellence. It’s also a story about the importance of family, of mentors, and of giving people a chance. |
| brain stem cell therapy: Ocular Neuroprotection Leonard Levin, Leonard A. Levin, Adriana Di Polo, 2003-07 Ocular neuroprotection is aimed at protecting the death of photoreceptors, retinal ganglion, or other important neurons in cases of disease or trauma. Levin (ophthalmology and neurology, U. of Wisconsin at Madison, US) and Di Polo (pathology and cell biology, U. of Montreal, Canada) present 18 chapt. |
| brain stem cell therapy: The Stem Cell Activation Diet Dana Elia, 2020-03-24 Unleash your body’s natural healing and rejuvenation process with this science-backed nutrition guide and fasting program. Every day, your stem cells work to generate and renew the cells of your body, from your lungs and skeleton to your skin and blood. With the right diet and lifestyle choices, you can activate your own stem cells and harness your body’s natural ability to heal. The Stem Cell Activation Diet will guide you through a scientifically researched program that will jump-start these miracle worker cells to: · Prevent chronic issues like diabetes and heart disease · Relieve inflammation and pain · Support healthy cognitive function · Heal from injury or surgery Written by a registered dietician nutritionist, The Stem Cell Activation Diet makes it easy to understand how stem cell activation can benefit your specific needs and how to make the best choices for your body. |
| brain stem cell therapy: Neural Stem Cells and Therapy Tao Sun, 2012-02-15 This book is a collective work of international experts in the neural stem cell field. The book incorporates the characterization of embryonic and adult neural stem cells in both invertebrates and vertebrates. It highlights the history and the most advanced discoveries in neural stem cells, and summarizes the mechanisms of neural stem cell development. In particular, this book provides strategies and discusses the challenges of utilizing neural stem cells for therapy of neurological disorders and brain and spinal cord injuries. It is suitable for general readers, students, doctors and researchers who are interested in understanding the principles of and new discoveries in neural stem cells and therapy. |
| brain stem cell therapy: Neural Progenitor Cells Loic P. Deleyrolle, 2021-09-24 This updated edition collects cutting-edge techniques used to study neural stem and progenitor cells as well as the brain microenvironment. Featuring a wide range of technological advances in the study of neural stem cells, the volume highlights the promises of stem cell-based therapeutic applications for central nervous system ailments. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Neural Progenitor Cells: Methods and Protocols, Second Edition serves as an invaluable resource for the next generation of neuroscientists as they develop innovative experimental paradigms and progress toward therapeutic applications in the field of neurobiology. |
| brain stem cell therapy: Physical Disabilities Uner Tan, 2017 |
| brain stem cell therapy: The Future of Brain Repair Jack Price, 2020-03-24 A scientist assesses the potential of stem cell therapies for treating such brain disorders as stroke, Alzheimer's disease, and Parkinson's disease. Stem cell therapies are the subject of enormous hype, endowed by the media with almost magical qualities and imagined by the public to bring about miracle cures. Stem cells have the potential to generate new cells of different types, and have been shown to do so in certain cases. Could stem cell transplants repair the damaged brain? In this book, neurobiologist Jack Price assesses the potential of stem cell therapies to treat such brain disorders as stroke, Alzheimer's disease, Parkinson's disease, and spinal cord injuries. Certainly brain disorders are in need of effective treatments. These disorders don't just kill, they disable, and conventional drug therapies have not had much success in treating them. Price explains that repairing the human brain is difficult, largely because of its structural, functional, and developmental complexity. He examines the self-repairing capacity of blood and gut cells—and the lack of such capacity in the brain; describes the limitations of early brain stem cell therapies for neurodegenerative disorders; and discusses current clinical trials that may lead to the first licensed stem cell therapies for stroke, Parkinson's and macular degeneration. And he describes the real promise of pluripotential stem cells, which can make all the cell types that constitute the body. New technologies, Price reports, challenge the very notion of cell transplantation, instead seeking to convince the brain itself to manufacture the new cells it needs. Could this be the true future of brain repair? |
Current State of Stem Cell Treatments for Cerebral Palsy: A …
Regenerative therapies using stem cells often seek to replace dead cells and support the remaining cells. Differentiate — The ability to transform into specialized cell types found in the …
Restoring Neurological Function Using Stem Cells
stem cells actually work by pumping out various types of proteins and other molecules, including very powerful growth factors, that enhance the brain’s natural ability to repair itself. These …
Stem Cell Repor ts - Cell Press
Stem cell-based therapies have emerged as promising strategies to enhance post-stroke recovery. Building on a large body of preclinical evidence, clinical trials are currently ongoing to …
Advancements in Brain Stem Cell Therapy: Unlocking the …
Stem cells used in brain stem cell therapy can be broadly categorized into two types: Embryonic Stem Cells (ESCs) and induced Pluripotent Stem Cells (iPSCs). ESCs are obtained from early …
Wrapping stem cells with wireless electrical - Nature
In this work, to overcome this hurdle, we propose to use the graphene nanosheets as nanopatches to wrap the membrane of NSCs to in situ generate electric signals to stimulate …
Stem Cell Therapy for Repair of the Injured Brain: Five Principles
Various cell sources are considered to accomplish suc-cessful cell therapy for brain regeneration, including adult stem cells, embryonic stem cells, or induced plu-ripotent stem cells (iPSCs; …
Traumatic Brain Injury and Stem Cell Therapy - jrmds.in
Study revealed that a variety of stem cells like mesenchymal stem cell (MSCs), Neural stem cells, Endothelial progenitor cells (EPCs) and Multipotent adult progenitor cells (MAPCs) can treat …
Stem cell therapy for brain repair after injury - Future of Surgery
developing improved systems for delivering therapies directly into the brains of patients with TBI becomes important. This includes the development of innovative mechanisms of delivery of …
Neural Stem Cell-Based Therapies and Glioblastoma …
Neural stem cells (NSC) are specific types of adult stem cells found in the subependymal zone and the dentate gyrus, and are responsible for the regeneration of neurons, astrocytes, and …
STEM CELLS AND REGENERATIVE MEDICINE - University of …
Stem cells have generated incredible interest for repairing failing tissues and organs, which appear to be the only reasonable therapeutic strategy. It stimulates the body's own repair …
Stem-Cell Therapy as a Potential Strategy for Radiation …
In the present review, we discuss recent studies evaluating stem-cell therapies for the irradiated brain and their therapeutic effects on ameliorating radiation-related brain injury as well as their …
Directional induction of neural stem cells, a new therapy for ...
Neural stem cells (NSCs) play a unique role in the treatment of neurological diseases for their abilities to self-renew and form different neural lineage cells, such as neurons and glial...
Recent Advances in Stem Cell-Based Therapeutics for Stroke
Among the many treatment strategies tailored towards repairing the injured brain, stem cell-based therapeutics have been demonstrated as safe and effective in animal models of stroke, and are …
Stem Cell Therapy for Neurodegenerative Diseases: How Do …
Stem cells, on the other hand, have been reported to bypass the BBB and successfully home to their target in the brain and initiate repair, making them a promising approach in cellular …
STEM CELL THERAPY IN STROKE - Journal of Universitas …
Stem cells can be taken from aborted or aborted human fetuses and will be injected into the patient's brain. Stem cells are expected to regenerate brain areas damaged by stroke and …
Advancing cell therapy for neurodegenerative diseases
Cell-based therapies are being developed for various neurodegenerative diseases that affect the central ner-vous system (CNS). Concomitantly, the roles of individual cell types in …
Stem Cell Therapy for Ischemic Brain Injury: Early ... - Springer
the treatment window of stem cell therapy in ischemic brain injury after cardiac arrest to provide new insight into stem cell therapy for cardiac arrest–induced global cerebral ischemia injury. …
CONCISE REVIEW: STEM CELL THERAPY FOR STROKE …
Four decades of preclinical research demonstrating survival, functional integration, and behavioral effects of transplanted stem cells in experimental stroke models have provided ample scientific …
Stem cell therapy for Alzheimer’s disease and related …
In this review, we will discuss current research advances in AD pathogenesis and stem cell technologies; additionally, the potential challenges and strategies for using cell-based...
A cell therapy approach to restore microglial Trem2 function …
Here, we show that systemic hematopoietic cell transplantation followed by enhancement of microglia replace-ment restores microglial function in a Trem2 mutant mouse model of AD.
Current State of Stem Cell Treatments for Cerebral Palsy: A …
Regenerative therapies using stem cells often seek to replace dead cells and support the remaining cells. Differentiate — The ability to transform into specialized cell types found in the …
Restoring Neurological Function Using Stem Cells
stem cells actually work by pumping out various types of proteins and other molecules, including very powerful growth factors, that enhance the brain’s natural ability to repair itself. These …
Stem Cell Repor ts - Cell Press
Stem cell-based therapies have emerged as promising strategies to enhance post-stroke recovery. Building on a large body of preclinical evidence, clinical trials are currently ongoing …
Advancements in Brain Stem Cell Therapy: Unlocking the …
Stem cells used in brain stem cell therapy can be broadly categorized into two types: Embryonic Stem Cells (ESCs) and induced Pluripotent Stem Cells (iPSCs). ESCs are obtained from early …
Wrapping stem cells with wireless electrical - Nature
In this work, to overcome this hurdle, we propose to use the graphene nanosheets as nanopatches to wrap the membrane of NSCs to in situ generate electric signals to stimulate …
Stem Cell Therapy for Repair of the Injured Brain: Five …
Various cell sources are considered to accomplish suc-cessful cell therapy for brain regeneration, including adult stem cells, embryonic stem cells, or induced plu-ripotent stem cells (iPSCs; …
Traumatic Brain Injury and Stem Cell Therapy - jrmds.in
Study revealed that a variety of stem cells like mesenchymal stem cell (MSCs), Neural stem cells, Endothelial progenitor cells (EPCs) and Multipotent adult progenitor cells (MAPCs) can treat …
Stem cell therapy for brain repair after injury - Future of …
developing improved systems for delivering therapies directly into the brains of patients with TBI becomes important. This includes the development of innovative mechanisms of delivery of …
Neural Stem Cell-Based Therapies and Glioblastoma …
Neural stem cells (NSC) are specific types of adult stem cells found in the subependymal zone and the dentate gyrus, and are responsible for the regeneration of neurons, astrocytes, and …
STEM CELLS AND REGENERATIVE MEDICINE - University of …
Stem cells have generated incredible interest for repairing failing tissues and organs, which appear to be the only reasonable therapeutic strategy. It stimulates the body's own repair …
Stem-Cell Therapy as a Potential Strategy for Radiation …
In the present review, we discuss recent studies evaluating stem-cell therapies for the irradiated brain and their therapeutic effects on ameliorating radiation-related brain injury as well as their …
Directional induction of neural stem cells, a new therapy for ...
Neural stem cells (NSCs) play a unique role in the treatment of neurological diseases for their abilities to self-renew and form different neural lineage cells, such as neurons and glial...
Recent Advances in Stem Cell-Based Therapeutics for Stroke
Among the many treatment strategies tailored towards repairing the injured brain, stem cell-based therapeutics have been demonstrated as safe and effective in animal models of stroke, and …
Stem Cell Therapy for Neurodegenerative Diseases: How Do …
Stem cells, on the other hand, have been reported to bypass the BBB and successfully home to their target in the brain and initiate repair, making them a promising approach in cellular …
STEM CELL THERAPY IN STROKE - Journal of Universitas …
Stem cells can be taken from aborted or aborted human fetuses and will be injected into the patient's brain. Stem cells are expected to regenerate brain areas damaged by stroke and …
Advancing cell therapy for neurodegenerative diseases
Cell-based therapies are being developed for various neurodegenerative diseases that affect the central ner-vous system (CNS). Concomitantly, the roles of individual cell types in …
Stem Cell Therapy for Ischemic Brain Injury: Early ... - Springer
the treatment window of stem cell therapy in ischemic brain injury after cardiac arrest to provide new insight into stem cell therapy for cardiac arrest–induced global cerebral ischemia injury. …
CONCISE REVIEW: STEM CELL THERAPY FOR STROKE …
Four decades of preclinical research demonstrating survival, functional integration, and behavioral effects of transplanted stem cells in experimental stroke models have provided ample scientific …
Stem cell therapy for Alzheimer’s disease and related …
In this review, we will discuss current research advances in AD pathogenesis and stem cell technologies; additionally, the potential challenges and strategies for using cell-based...
A cell therapy approach to restore microglial Trem2 function …
Here, we show that systemic hematopoietic cell transplantation followed by enhancement of microglia replace-ment restores microglial function in a Trem2 mutant mouse model of AD.
