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| bridging therapy car t: The EBMT/EHA CAR-T Cell Handbook Nicolaus Kröger, John Gribben, Christian Chabannon, Ibrahim Yakoub-Agha, Hermann Einsele, 2022-02-07 This first open access European CAR-T Handbook, co-promoted by the European Society for Blood and Marrow Transplantation (EBMT) and the European Hematology Association (EHA), covers several aspects of CAR-T cell treatments, including the underlying biology, indications, management of side-effects, access and manufacturing issues. This book, written by leading experts in the field to enhance readers’ knowledge and practice skills, provides an unparalleled overview of the CAR-T cell technology and its application in clinical care, to enhance readers’ knowledge and practice skills. |
| bridging therapy car t: Chimeric Antigen Receptor T-Cell Therapies for Cancer E-Book Daniel W. Lee, Nirali N. Shah, 2019-11-30 From patient referral to post-therapy management, Chimeric Antigen Receptor (CAR) T-Cell Therapies for Cancer: A Practical Guide presents a comprehensive view of CAR modified T-cells in a concise and practical format. Providing authoritative guidance on the implementation and management of CAR T-cell therapy from Drs. Daniel W. Lee and Nirali N. Shah, this clinical resource keeps you up to date on the latest developments in this rapidly evolving area. - Covers all clinical aspects, including patient referral, toxicities management, comorbidities, bridging therapy, post-CAR monitoring, and multidisciplinary approaches to supportive care. - Includes key topics on associated toxicities such as predictive biomarkers, infections, and multidisciplinary approaches to supportive care. - Presents current knowledge on FDA approved CAR T-cell products as well as developments on the horizon. - Editors and authors represent leading investigators in academia and worldwide pioneers of CAR therapy. |
| bridging therapy car t: Gene and Cellular Immunotherapy for Cancer Armin Ghobadi, John F. DiPersio, 2022-01-01 Clinical and preclinical exploration of gene and cellular immunotherapy have seen rapid growth and interest with the development and approval of five Chimeric Antigen Receptor T-cell (CAR-T) products for lymphoma and myeloma and one Bispecific T-Cell Engager (BiTE) for acute lymphoblastic leukemia (ALL). These advances have dramatically improved the management of patients with relapsed refractory lymphoma, myeloma and leukemia. Gene and Cellular Immunotherapy for Cancer offers readers a comprehensive review of current cellular and gene-based immunotherapies. Divided into eighteen cohesive chapters, this book provides an in-depth and detailed look into cellular-based immunotherapies including CAR-T, TCR-T, TIL, Viral CTLs, NK cells in addition to T/NK cell engagers, focusing on their historical perspectives, biology, development and manufacturing, toxicities and more. Edited by two leading experts on gene and cellular immunotherapy, the book will feature chapters written by a diverse collection of recognized and up-and-coming experts and researchers in the field, providing oncologists, immunologists, researchers and clinical and basic science trainees with a bench to bedside view of the latest developments in the field. |
| bridging therapy car t: Evidence-Based Physical Therapy for the Pelvic Floor Kari Bø, Bary Berghmans, Siv Mørkved, Marijke Van Kampen, 2014-11-04 Bridging the gap between evidence-based research and clinical practice, Physical Therapy for the Pelvic Floor has become an invaluable resource to practitioners treating patients with disorders of the pelvic floor. The second edition is now presented in a full colour, hardback format, encompassing the wealth of new research in this area which has emerged in recent years. Kari Bø and her team focus on the evidence, from basic studies (theories or rationales for treatment) and RCTs (appraisal of effectiveness) to the implications of these for clinical practice, while also covering pelvic floor dysfunction in specific groups, including men, children, elite athletes, the elderly, pregnant women and those with neurological diseases. Crucially, recommendations on how to start, continue and progress treatment are also given with detailed treatment strategies around pelvic floor muscle training, biofeedback and electrical stimulation. aligns scientific research with clinical practice detailed treatment strategies innovative practice guidelines supported by a sound evidence base colour illustrations of pelvic floor anatomy and related neuroanatomy/ neurophysiology MRIs and ultrasounds showing normal and dysfunctional pelvic floor incorporates vital new research and material uses key summary boxes throughout new edition to highlight quick reference points now in full colour throughout and a hardback format |
| bridging therapy car t: Pediatric Lymphomas Howard J. Weinstein, Melissa M. Hudson, Michael P. Link, 2007-01-20 This is a comprehensive textbook of Hodgkin's and non-Hodgkin's lymphomas written by leaders in the field of childhood lymphomas. It includes clinical, pathologic and molecular biology of each subtype of lymphoma. The pathology chapters are comprehensive and include excellent photographs. The book is at the level of subspecialists in pediatric hematology and oncology, radiation oncology, pediatric surgery and hematopathology. |
| bridging therapy car t: Blood and Marrow Transplant Handbook Richard T. Maziarz, Susan Schubach Slater, 2015-04-20 This updated and expanded edition developed by the Blood and Marrow Stem Cell Transplant team at Oregon Health & Science University Knight Cancer Institute features the latest medical management guidelines and standards of care for hematopoietic stem cell transplant patients. Spanning the timeline from the initial consultation throughout the transplant process, this handbook includes indications for transplantation and donor selection, treatment guidelines for addressing complications during and after transplant, and recommendations for long-term follow up care. Concise, comprehensive, and easy-to-use, Blood and Marrow Transplant Handbook, 2nd Edition presents a multidisciplinary approach to information for physicians and advanced practice medical providers who care for transplant patients, and also residents, fellows, and other trainees. |
| bridging therapy car t: Therapeutic Presence Arthur Robbins, 1998 In this text, Arthur Robbins explores the interaction between patient and therapist in depth, examining the concept of therapeutic presence, and the therapist's ability to maintain it. |
| bridging therapy car t: Counselling and Spiritual Accompaniment Brian Thorne, 2012-08-02 Counselling and Spiritual Accompaniment presents the key spiritually-focused writings of Brian Thorne, one of the most influential thinkers on the convergence of spirituality with counselling, along with new material reflecting his recent work in spiritual accompaniment. Reflects the increasing focus on spiritual issues as an essential part of therapy Represents the culmination of an intellectual quest, undertaken by the most senior figure in the field, to integrate spirituality with counselling and the person-centred approach Features chapters that span thirty years of work, along with new writings that bring readers up to date with the author's most recent work in spiritual accompaniment An invaluable guide for counsellors and therapists who acknowledge the importance of spirituality to their clients, but doubt their abilities to help in this area |
| bridging therapy car t: A CBT Practitioner's Guide to ACT Joseph Ciarrochi, Ann Bailey, 2008 If recent professional publications and conferences are any indication, acceptance- and mindfulness-based therapies are the future of clinical psychology. A CBT-Practitioner's Guide to ACT helps professionals whose clinical educations focused on traditional, change-based cognitive behavior therapies navigate the practical and theoretical challenges that come with the switch to the more promising, acceptance-based strategies. |
| bridging therapy car t: Building Intimate Relationships Rita DeMaria, Mo Therese Hannah, 2013-08-21 First Published in 2003. Routledge is an imprint of Taylor & Francis, an informa company. |
| bridging therapy car t: Childhood Acute Lymphoblastic Leukemia Ajay Vora, 2017-04-21 This book provides a comprehensive and up-to-date review of all aspects of childhood Acute Lymphoblastic Leukemia, from basic biology to supportive care. It offers new insights into the genetic pre-disposition to the condition and discusses how response to early therapy and its basic biology are utilized to develop new prognostic stratification systems and target therapy. Readers will learn about current treatment and outcomes, such as immunotherapy and targeted therapy approaches. Supportive care and management of the condition in resource poor countries are also discussed in detail. This is an indispensable guide for research and laboratory scientists, pediatric hematologists as well as specialist nurses involved in the care of childhood leukemia. |
| bridging therapy car t: Attachment Theory in Clinical Work with Children David Oppenheim, Douglas F. Goldsmith, 2007-03-08 Attachment research has tremendous potential for helping clinicians understand what happens when parent–child bonds are disrupted, and what can be done to help. Yet there remains a large gap between theory and practice in this area. This book reviews what is known about attachment and translates it into practical guidelines for therapeutic work. Leading scientist-practitioners present innovative strategies for assessing and intervening in parent–child relationship problems; helping young children recover from maltreatment or trauma; and promoting healthy development in adoptive and foster families. Detailed case material in every chapter illustrates the applications of research-based concepts and tools in real-world clinical practice. |
| bridging therapy car t: Biomedical Engineering W. Mark Saltzman, 2015-05-21 The second edition of this popular introductory undergraduate textbook uses examples, applications, and profiles of biomedical engineers to show students the relevance of the theory and how it can be used to solve real problems in human medicine. The essential molecular biology, cellular biology, and human physiology background is included for students to understand the context in which biomedical engineers work. Updates throughout highlight important advances made over recent years, including iPS cells, microRNA, nanomedicine, imaging technology, biosensors, and drug delivery systems, giving students a modern description of the various subfields of biomedical engineering. Over two hundred quantitative and qualitative exercises, many new to this edition, help consolidate learning, whilst a solutions manual, password-protected for instructors, is available online. Finally, students can enjoy an expanded set of leader profiles in biomedical engineering within the book, showcasing the broad range of career paths open to students who make biomedical engineering their calling. |
| bridging therapy car t: Stereotactic Body Radiation Therapy Simon S. Lo, Bin S. Teh, Jiade J. Lu, Tracey E. Schefter, 2012-08-28 Stereotactic body radiation therapy (SBRT) has emerged as an important innovative treatment for various primary and metastatic cancers. This book provides a comprehensive and up-to-date account of the physical/technological, biological, and clinical aspects of SBRT. It will serve as a detailed resource for this rapidly developing treatment modality. The organ sites covered include lung, liver, spine, pancreas, prostate, adrenal, head and neck, and female reproductive tract. Retrospective studies and prospective clinical trials on SBRT for various organ sites from around the world are examined, and toxicities and normal tissue constraints are discussed. This book features unique insights from world-renowned experts in SBRT from North America, Asia, and Europe. It will be necessary reading for radiation oncologists, radiation oncology residents and fellows, medical physicists, medical physics residents, medical oncologists, surgical oncologists, and cancer scientists. |
| bridging therapy car t: Healing Psychiatry David H Brendel, 2009-08-21 A new patient-centered approach to psychiatry that aims to resolve the field's conceptual tension between science and humanism by drawing on classical American pragmatism and contemporary pragmatic bioethics. Psychiatry today is torn by opposing sensibilities. Is it primarily a science of brain functioning or primarily an art of understanding the human mind in its social and cultural context? Competing conceptions of mental illness as amenable to scientific explanation or as deeply complex and beyond the reach of empirical study have left the field conceptually divided between science and humanism. In Healing Psychiatry David Brendel takes a novel approach to this stubborn problem. Drawing on the classical American pragmatism of Charles Sanders Peirce, William James, and John Dewey, as well as contemporary work of pragmatic bioethicists, Brendel proposes a clinical pragmatism that synthesizes scientific and humanistic approaches to mental health care. Psychiatry, he argues, must integrate scientific and humanistic models by emphasizing the practical, pluralistic, participatory, and provisional aspects of clinical diagnosis and treatment. Psychiatrists need to have the skill and flexibility to use scientific and humanistic approaches in a collaborative, open-ended clinical process; they must recognize the complexity of human suffering even as they strive for scientific rigor. This is the only way, he writes, that psychiatry can heal its conceptual rift and the emotional wounds of its patients. Healing Psychiatry explores these issues from both clinical and theoretical standpoints and uses case histories to support its basic argument. Brendel calls for an open-minded and flexible yet scientifically informed approach to understanding, diagnosing, and treating mental disorders. And he considers the future of psychiatry, applying the principles of clinical pragmatism to a broad range of ethical concerns in psychiatric training and research. |
| bridging therapy car t: Evidence-Based Practice in Action Sona Dimidjian, 2019-08-30 The evidence-based practice (EBP) movement has always been about implementing optimal health care practices. Practitioners have three primary roles they can play in relation to the research evidence in EBP: scientists, systematic reviewers, and research consumers. Learning EBP is an acculturation process begun during professional training that seamlessly integrates research and practice--Provided by publisher. |
| bridging therapy car t: Attachment in Group Psychotherapy Cheri L. Marmarosh, 2019-12-18 Attachment theory is influencing how we understand interpersonal relationships and how psychotherapy can help facilitate change for those struggling in relationships. More recently, researchers and clinicians have applied attachment theory to group treatment, one of the most effective forms of psychotherapy to address interpersonal difficulties. This book highlights some of the bridges between attachment theory and contemporary approaches to group treatment. In addition to applying attachment theory to innovative treatments, each chapter addresses a specific way in which attachment impacts the members’ capacity for empathy and perspective taking; the development of cohesion in the group; the automatic fight-flight response during group interactions; members’ ability to tolerate diversity; and the leaders’ capacity to foster safety within the group. This book will help group leaders gain a richer understanding of attachment theory and attachment based techniques that will ultimately benefit their groups. This book was originally published as a special issue of the International Journal of Group Psychotherapy. |
| bridging therapy car t: Immunopharmacogenomics Yusuke Nakamura, 2015-09-18 This book proposes immunogenomics, or immunopharmacogenomics, as the next-generation big science to uncover the role that the immune system plays in the pathogenesis of many diseases, by summarizing the importance of the deep sequencing of T-cell and B-cell receptors. Immunogenomics/immunopharmacogenomics, a genetic characterization of the immune system made possible by next-generation sequencing (NGS), will be important for the further understanding of the pathogenesis of various disease conditions. Abnormal immune responses in the body lead to development of autoimmune diseases and food allergies. Rejection of recipient cells and tissues, as well as severe immune reactions to donor cells, is also the result of uncontrolled immune responses in the recipient body. There have been many reports indicating that activated immune responses caused by the interaction of drugs and HLA are present in drug-induced skin hypersensitivity and liver toxicity. The importance of the host immune responses has been recognized in cancer treatments, not only for immunotherapy but also for cytotoxic agents and molecular targeted drugs. Hence, characterization of the T-cell receptor and B-cell receptor repertoire by means of NGS deep sequencing will ultimately make possible the identification of the molecular mechanisms that underlie various diseases and drug responses. In addition, this approach may contribute to the identification of antigens associated with the onset or progression of autoimmune diseases as well as food allergies. Although the germline alterations and somatic mutations have been extensively analyzed, changes or alterations of the immune responses during the course of various disease conditions or during various treatments have not been analyzed. It is also clear that computational analyses to draw meaningful inferences of functional recognition receptors on the immune cells remain a huge challenge. |
| bridging therapy car t: The Comprehensive Resource Model Lisa Schwarz, Frank Corrigan, Alastair Hull, Rajiv Raju, 2016-10-04 Traditional methods employed in psychotherapy have limited effectiveness when it comes to healing the psychological effects of trauma, in particular, complex trauma. While a client may seem to make significant breakthroughs in understanding their feelings and experiences on a rational level by talking with a therapist, this will make no difference to their post-traumatic symptoms if the midbrain is unable to modulate its activity in response. The Comprehensive Resource Model argues for a novel therapeutic approach, which uniquely bridges neuroscience and spirituality through a combination of somatic therapy, traditional psychotherapy, and indigenous healing concepts to provide effective relief to survivors of trauma. The Comprehensive Resource Model was developed in response to the need for a streamlined, integrative therapeutic model; one which engages a scaffolding of neurobiological resources in many brain structures simultaneously in order for clients to be fully embodied and conscious in the present moment while processing their traumatic material. All three phases of trauma therapy: resourcing, processing, and integration are done simultaneously. Demonstrating a nested model and employing brain and body-based physiological safety as the foundation of healing, chapters describe three primary categories of targeted processing: implicit and explicit survival terror, ‘Little T Truths’, and ‘Big T Truths’, all of which contribute to thorough healing of complex trauma and an expansion into higher states of consciousness and embodiment of the essential core self. This book describes the development and benefits of this pioneering new approach to trauma therapy. As such, it will be of key interest to academics, researchers and postgraduate students in the fields of psychiatry, psychotherapy, psychology and trauma studies. It will also appeal to practising therapists, psychiatrists, psychologists, psychiatric nurses, and to others involved in the treatment or management of patients with complex trauma disorders. |
| bridging therapy car t: Access to Health Care in America Institute of Medicine, Committee on Monitoring Access to Personal Health Care Services, 1993-02-01 Americans are accustomed to anecdotal evidence of the health care crisis. Yet, personal or local stories do not provide a comprehensive nationwide picture of our access to health care. Now, this book offers the long-awaited health equivalent of national economic indicators. This useful volume defines a set of national objectives and identifies indicatorsâ€measures of utilization and outcomeâ€that can sense when and where problems occur in accessing specific health care services. Using the indicators, the committee presents significant conclusions about the situation today, examining the relationships between access to care and factors such as income, race, ethnic origin, and location. The committee offers recommendations to federal, state, and local agencies for improving data collection and monitoring. This highly readable and well-organized volume will be essential for policymakers, public health officials, insurance companies, hospitals, physicians and nurses, and interested individuals. |
| bridging therapy car t: Education and Technology Support for Children and Young Adults With ASD and Learning Disabilities Kats, Yefim, Stasolla, Fabrizio, 2020-11-13 Among the disabilities covered at the state and federal levels, autism and related conditions are a sharply growing diagnostic category among children and young adults. In education, administrators and practitioners working with affected learners are continually faced with confronting difficult problems such as getting adequate personnel training and choosing appropriate tools and techniques that best fit the specific needs of their students while at the same time satisfying their budget, technical resources, curriculum, and profile of the ASD population they serve. The choice of appropriate tools is especially complex due to the intrinsic connection between technical specifications, educational/therapeutic methods, and the wide variety of ASDs and related conditions. In this respect, tools chosen to support children may need to target those diagnosed not only with ASD but also with such co-morbidity conditions as attention deficit disorder. The instructional strategies and use of technology currently have room for improvement for online, hybrid, and face-to-face counseling settings. Also, an effective evaluation of educational technologies and tools would be fundamentally incomplete without a thorough understanding and assessment of the related special education practices as well as psychological and neurological issues specific for ASD and learning disabilities. Education and Technology Support for Children and Young Adults With ASD and Learning Disabilities provides an in-depth analysis on the use of available technology solutions, instructional design methods, and assessment techniques in the context of standards and regulations in classroom or counseling settings. The chapters contain theoretical analyses, vital practical information, and case studies that can function as guidelines for those involved in helping children and young adults with ASD or learning disabilities in online, hybrid, or face-to-face environments. While highlighting topics such as inclusive education, online gaming environments, assistive technologies, and cognitive development, this book is ideally intended for administrators, instructional technology specialists, special education faculty, counselors, instructional designers, course developers, social workers, and psychologists along with practitioners, stakeholders, researchers, and academicians interested in education and technology support for children and young adults with ASD and learning disabilities. |
| bridging therapy car t: Autologous Stem Cell Transplantation Angelo Carella, 2020-08-26 This textbook integrates basic research and clinical aspects underlying the most recent results in those malignant diseases where progress is most effective. Recent evidence shows that higher doses are better in inducing higher cure rates in hematological neoplasias, although myeloblation related to dose intensity can be a limiting factor. The toxicity can now be controlled with autologous marrow and peripheral blood progenitor cell transplantation, used with or without growth factors. The combination of high dose chemoradiotherapy followed by re-infusion of autologous stem cells constitute a dramatic advance in the treatment of refactory and relapse hematological neoplasias. |
| bridging therapy car t: Bridging the Gap Shiu Y. Tsao, 2021 Recognising rare diseases' impracticability of having extensive clinical trials necessary for regulatory approval, the US Orphan Drug Act appropriately facilitates the commercialization of orphan drugs. However, even common cancers also have rather specific but uncommon clinical situations for which extensive clinical trials are hardly practicable. Moreover, although such very costly and extensive trials often depend on industry support, uncommon situations are unattractive. Eventually, many specific treatments for designated clinical oncology situations often lack regulatory approvals merely because of suboptimal trial data. Now, this EBM (evidence-based medicine) book by expert authors with first-hand clinical experience is about off-label but acceptable treatment options. The attempt is to patch up the low response rates and considerable adverse events of novel immunotherapy. Currently, without any such off-label treatments, some cancer patients may well be left out in the cold. Although off-label treatments lack regulatory approval, they are backed by EBM and have good safety profiles. It's inappropriate to announce nothing else can be done merely because all approved options have already been exhausted. In expert hands, despite the on compassionate grounds proviso, the safety profiles of such off-label prescriptions may even compare favourably with orthodox chemotherapy given at top doses. |
| bridging therapy car t: Mental Health Intervention and Treatment of First Responders and Emergency Workers Bowers, Clint A., Beidel, Deborah C., Marks, Madeline R., 2019-08-30 The stress that comes with being a first responder has been known to lead to depression, anxiety, substance abuse, and suicide. However, few clinicians are informed about these health concerns and how to adequately treat them in this population. Therefore, there is an urgent need for practitioners to understand the latest information regarding treatments that will be useful to this specific population. Mental Health Intervention and Treatment of First Responders and Emergency Workers is an essential reference source that focuses on the latest research for diagnosing and treating mental health issues experienced by emergency personnel and seeks to generate awareness and inform clinicians about the unique circumstances encountered by these professionals. While highlighting topics including anxiety disorders and stress management, this book is ideally designed for clinicians, therapists, psychologists, psychiatrists, practitioners, medical professionals, EMTs, law enforcement, fire departments, military, academicians, researchers, policymakers, and students seeking current research on psychological therapy methods regarding first responders. |
| bridging therapy car t: Fast Facts: CAR T-Cell Therapy in Diffuse Large B-Cell Lymphoma Richard J. Buka, Dee Moloney, 2021-10-31 Diffuse large B-cell lymphoma (DLBCL) is the most common form of high-grade non-Hodgkin lymphoma. While treatment with immunochemotherapy has generally shown good outcomes, specific subgroups of patients with high-risk disease have an unfavorable prognosis. Extensive efforts have been made to improve outcomes in these patients. As such, CD19-targeted chimeric antigen receptor (CAR) T-cell therapy has become the new standard of care for patients with relapsed or refractory DLBCL after at least two prior lines of therapy. It is an exciting new therapeutic intervention that is integral to the concept of personalized medicine. Table of Contents: • DLBCL: an overview • CAR T cells • CAR T-cell products • Delivering CAR T-cell therapy and managing patient expectations • CAR T-cell therapy-related toxicities |
| bridging therapy car t: Understanding Strength and Conditioning as Sport Coaching Tania Cassidy, Phil Handcock, Brian Gearity, Lisette Burrows, 2020-05-07 Contemporary strength and conditioning coaching is, for the most part, informed by the exercise sciences, with little engagement being made with sociocultural and pedagogical perspectives which have emerged in sports coaching research over the last two decades. In Understanding Strength and Conditioning as Sport Coaching: Bridging the Biophysical, Pedagogical and Sociocultural Foundations of Practice, the authors – whose expertise span strength and conditioning, sports coaching and pedagogy – help students and coaches to integrate perspectives from these disciplines to enhance their strength and conditioning coaching practice. The book encourages readers to add moral, ethical and political considerations to the technical aspects of their coaching practice. It discusses and applies concepts to a full range of strength and conditioning settings, including elite performance, young athletes, ageing athletes and returning to play following injury. Featuring an eResource, and structured around rich, narrative pedagogical cases reflecting the issues faced by practising strength and conditioning coaches, the book offers a thoroughly engaging introduction to pedagogical and sociocultural concepts and literature in a strength and conditioning context. This is a vital book for students of strength and conditioning, and an important resource for practising strength and conditioning coaches and sport science staff. |
| bridging therapy car t: The Significance of Dreams Peter Fonagy, Horst Kachele, Marianne Leuzinger-Bohleber, David Taylor, 2018-03-22 This book looks at dreams from a twenty-first century perspective. It takes its inspiration from Freud's insights, but pursues psychoanalytic interest into both neuroscience and the modern psychoanalytic consulting room. The book looks at laboratory research on dreaming alongside the modern clinical use of dreams and links together clinical and empirical research, integrating classical ideas with the plurality of psychoanalytic theoretical constructs available to modern researchers. Psychoanalysts writing about dreams have traditionally represented the cutting edge of clinical and theoretical development, and this book is no exception. Many of the contributions, as well as the epistemological position taken by the writers, represent a kind of radical openness to new ways of thinking about the clinical situation and about theory. In line with the ambition of the editors, this volume represents an integration of theories and disciplines, and a scientific context for modern psychoanalysis. The link between clinical research and extraclinical research via the royal road of dreaming is a theme that runs through all the contributions. |
| bridging therapy car t: Treatment of Eating Disorders Margo Maine, Beth Hartman McGilley, Douglas Bunnell, 2010-09-08 Eating disorders (EDs) affect at least 11 million people in the United States each year and spread across age, race, ethnicity and socio-economic class. While professional literature on the subject has grown a great deal in the past 30 years, it tends to be exclusively research-based and lacking expert clinical commentary on treatment. This volume focuses on just such commentary, with chapters authored by both expert clinicians and researchers. Core issues such as assessment and diagnosis, the correlation between EDs and weight and nutrition, and medical/psychiatric management are discussed, as are the underrepresented issues of treatment differences based on gender and culture, the applications of neuroscience, EDNOS, comorbid psychiatric disorders and the impact of psychiatric medications. This volume uniquely bridges the gap between theoretical findings and actual practice, borrowing a bench-to-bedside approach from medical research. - Includes real-world clinical findings that will improve the level of care readers can provide, consolidated in one place - Underrepresented issues such as gender, culture, EDNOS and comorbidity are covered in full - Represents outstanding scholarship, with each chapter written by an expert in the topic area |
| bridging therapy car t: Why We Revolt Victor Montori, 2020-09-29 The Mayo Clinic physician and founder of The Patient Revolution offers a “thoroughly convincing. . . call to action for medical industry reform” (Kirkus). Winner of the 2018 PenCraft Award for Literary Excellence, Why We Revolt exposes the corruption and negligence that are endemic in America’s healthcare system—and offers a blueprint for revolutionizing patient care across the country. Through a series of essays and first-hand accounts, Dr. Victor M. Montori demonstrates how the system has been increasingly exploited and industrialized, putting profit before patients. As costs soar, the United States continues to fall behind other countries on patient outcomes. Offering concrete, direct actions we can take to bring positive change to the healthcare system, Why We Revolt is an inspiring call-to-action for physicians, policymakers, and patients alike. Dr. Montori shows how we can work together to create a system that offers tailored healthcare in a kind and careful way. All proceeds from Why We Revolt go directly to Patient Revolution, a non-profit organization founded by Dr. Montori that empowers patients, caregivers, community advocates, and clinicians to rebuild our healthcare system. |
| bridging therapy car t: The Business of Healthcare Innovation Lawton Robert Burns, 2005-08-25 The Business of Healthcare Innovation is the first wide-ranging analysis of business trends in the manufacturing segment of the health care industry. In this leading edge volume, Professor Burns focuses on the key role of the 'producers' as the main source of innovation in health systems. Written by professors of the Wharton School and industry executives, this book provides a detailed overview of the pharmaceutical, biotechnology, genomics/proteomics, medical device and information technology sectors. It analyses the market structures of these sectors as well as the business models and corporate strategies of firms operating within them. Most importantly, the book describes the growing convergence between these sectors and the need for executives in one sector to increasingly draw upon trends in the others. It will be essential reading for students and researchers in the field of health management, and of great interest to strategy scholars, industry practitioners and management consultants. |
| bridging therapy car t: Anticoagulation Therapy Ozcan Basaran, Murat Biteker, 2016-09-08 The available parenteral and oral anticoagulants have a large clinical use. Understanding biochemistry of anticoagulants may help to improve therapeutic strategies. Resistance to vitamin K antagonist drugs might be a problem for rodent populations. Patients who have thrombogenic risk factors should be anticoagulated. The need for cardiac implantable electronic devices is increasing, and there is a substantial number of patients who are on oral anticoagulant therapy. Prothrombin complex concentrate and other plasma concentrates are useful to deal with over-coagulated situations. The efficacy and safety of non-vitamin K antagonist oral anticoagulants have been proven in large phase III trials. The real-world data suggest even better outcomes with these agents compared to vitamin K antagonists. |
| bridging therapy car t: ECMO Extracorporeal Cardiopulmonary Support in Critical Care 5th Edition Elso, 2017-02-01 |
| bridging therapy car t: The BioMechanics Method for Corrective Exercise Price, Justin, 2019 The BioMechanics Method for Corrective Exercise enables health and fitness professionals to identify common musculoskeletal imbalances in their clients and apply appropriate corrective exercises to swiftly eliminate muscle and joint pain and improve physical function. |
| bridging therapy car t: Healing the Rift Leo Kim, 2010-12-01 Outlines an organic chemist's long-standing efforts to bridge gaps between spirituality and twenty-first-century science, describing his experiences of working with cancer patients, his philosophies about the existence of God, and his beliefs about the universe's harmonious blending of mind and spirit. |
| bridging therapy car t: Cases on Cross-Cultural Counseling Strategies King, Bonnie C., Stewart, Tiffany A., 2019-08-30 It is essential for counselors and counseling professionals to understand the impact of their personal biases and how these biases can impact the counseling process, in addition to respecting and honoring the beliefs of their clients. Communication and the sharing of experiences between counsellors is an effective strategy for perfecting methods to identify and address these biases. Cases on Cross-Cultural Counseling Strategies is a comprehensive research book that explores creative healing approaches used by counselors working with diverse clients in a variety of geographical locations, developmental levels, and complex and varied identities. Each case study applies the Multicultural and Social Justice Counseling Competencies (MSJCCs) to the counseling relationship and looks at unique aspects of the client’s identity, specific approaches taken by the counselor, and the outcomes of the counseling relationship. Featuring a broad range of topics such as higher education, international counseling, and gender bias in counseling, this book is ideal for counselors, therapists, psychologists, counselor educators, graduate students, practitioners, academicians, and researchers. |
| bridging therapy car t: Socio-Emotional Relationship Therapy Carmen Knudson-Martin, Melissa A. Wells, Sarah K. Samman, 2015-02-02 This path-breaking volume introduces Socio-Emotional Relationship Therapy for clinical work with troubled couples. Practice-focused and engaging, it integrates real-world knowledge of the intersections of gender, culture, power, and identity in relationships with empirical findings on the neurobiology of attraction. Case examples detail the process of therapists in the moment as they develop both their clinical skills and their understanding of the social contexts fueling couples' difficulties. Applications of the method, which can be used with same-sex couples as well as heterosexual ones, are shown in addressing infidelity, tapping into partners' spirituality, and modeling and encouraging mutual respect and support. Among the topics covered: Undoing gendered power in heterosexual couple relationships. Interpersonal neurobiology, couples, and the societal context. How gender discourses hijack couple therapy—and how it can be avoided. How SERT therapists develop interventions that address the larger context. Building a circle of care in same-sex couple relationships. Couple therapy with adult survivors of child abuse: gender, power, and trust. Socio-Emotional Relationship Therapy opens out practical new possibilities for marriage and family therapists, clinical psychologists, social workers, and counselors seeking ideas for more meaningful couples work. |
| bridging therapy car t: Bridging the Gap: Integrative Oncology and the Practice of Traditional Chinese Medicine Bianca Di Giulio, James Munson, 2019-08-13 The book's inherent value, currently, is in its uniqueness. There are few books on Integrative Oncology (IO). There are few books on the entirety of traditional Chinese medicine in the treatment of cancer. There are even fewer, if any, books that deal with the topics of Integrative Oncology and the use of traditional Chinese medicine as a whole in the treatment of people with cancer. While very broad and deep topics, this makes for a varied audience of interest that includes not just the TCM practitioner or student, but Western health practitioners and patients as well as laypeople interested in the topic of oncology.For those interested in the topic of IO, it gives one of the few non-biased, honest and critical views of the state of IO in contrast to what is promoted by various institutions and societies.For the Western health practitioner and/or patient, many of whom are completely unfamiliar with TCM and how it works or can be used, it provides information on the breadth of TCM and how it can be applied in various ways to help improve outcomes.For the TCM practitioner or student, it provides much needed information on how to go about caring for a patient with cancer to include clinical pearls and important Western medical information and terminology. |
| bridging therapy car t: Intercultural Counseling Gerald Monk, John Winslade, Stacey Sinclair, marcela polanco, 2019-08 Intercultural Counseling: Bridging the Us and Them Divide provides a thoroughly fresh approach to addressing cultural differences that includes a complete reconceptualization of multiculturalism. The text grapples with new forces in the areas of decolonial and intercultural study that expose problems with taken-for-granted counseling activities embedded within Eurocentric-based practice. The book conceptualizes mental health and healing in the terms that diverse communities recognize and embrace and highlights the range of healing practices within these communities. Underpinning the text is the message that providing counseling services is an activity that is simultaneously complex, ambiguous, nuanced, and subtle. Utilizing a postmodern lens and emphasizing a social constructionist approach, the book works to dismantle existing one-dimensional characterizations of cultural difference, as well as personal and professional assumptions related to multicultural practice. It provides readers with a fresh way of thinking that seeks to bridge cultural divides and fully realize the ambitions of the multicultural counseling movement. The book begins with an exploration of the social justice implications underpinning cultural identity politics and the Us vs Them divide. In the following chapters, readers closely examine the inherent complexity of culture, historical events and beliefs that have shaped social and political divides, issues of power and privilege, gender as a domain of cultural experience, identity construction, concepts of community, and more. The book has a dedicated section to exploring contemporary expressions of gender, sexuality, and relational identities and practices. The concepts of discourse, positioning, and deconstruction are emphasized throughout to encourage innovative thought regarding cultural diversity. The book includes personal stories that illustrate many elements covered in the text, making the theory and practice of intercultural counseling come alive. Activities are included that encourage readers to apply concepts to their own lives, as well to the lives of their clients. Emphasizing thoughtful and intentional participation in a constantly evolving dialogue, Intercultural Counseling is an ideal core textbook for upper-level undergraduate courses in the helping professions, as well as graduate-level training courses in counseling, counselor education, marriage and family therapy, psychology, and social work. For a look at the specific features and benefits of Intercultural Counseling, visit cognella.com/intercultural-counseling-features-and-benefits. |
| bridging therapy car t: Reflections on Human Potential Brian E. Levitt, 2008 International collection of writers shed light on the person-centred approach and build bridges to the emerging discipline of positive psychology. |
| bridging therapy car t: Principles and Practice of Pediatric Oncology Philip A. Pizzo, David G. Poplack, 2011 Providing a comprehensive review of the multiple disciplines that make up the care and research agendas for children with cancer, this thoroughly updated edition provides state-of-the-art information on the molecular genetics and biology of cancer as well as new approaches to diagnosis and management. |
| bridging therapy car-t: The EBMT/EHA CAR-T Cell Handbook Nicolaus Kröger, John Gribben, Christian Chabannon, Ibrahim Yakoub-Agha, Hermann Einsele, 2022-02-07 This first open access European CAR-T Handbook, co-promoted by the European Society for Blood and Marrow Transplantation (EBMT) and the European Hematology Association (EHA), covers several aspects of CAR-T cell treatments, including the underlying biology, indications, management of side-effects, access and manufacturing issues. This book, written by leading experts in the field to enhance readers’ knowledge and practice skills, provides an unparalleled overview of the CAR-T cell technology and its application in clinical care, to enhance readers’ knowledge and practice skills. |
| bridging therapy car-t: Chimeric Antigen Receptor T-Cell Therapies for Cancer E-Book Daniel W. Lee, Nirali N. Shah, 2019-11-30 From patient referral to post-therapy management, Chimeric Antigen Receptor (CAR) T-Cell Therapies for Cancer: A Practical Guide presents a comprehensive view of CAR modified T-cells in a concise and practical format. Providing authoritative guidance on the implementation and management of CAR T-cell therapy from Drs. Daniel W. Lee and Nirali N. Shah, this clinical resource keeps you up to date on the latest developments in this rapidly evolving area. - Covers all clinical aspects, including patient referral, toxicities management, comorbidities, bridging therapy, post-CAR monitoring, and multidisciplinary approaches to supportive care. - Includes key topics on associated toxicities such as predictive biomarkers, infections, and multidisciplinary approaches to supportive care. - Presents current knowledge on FDA approved CAR T-cell products as well as developments on the horizon. - Editors and authors represent leading investigators in academia and worldwide pioneers of CAR therapy. |
| bridging therapy car-t: Gene and Cellular Immunotherapy for Cancer Armin Ghobadi, John F. DiPersio, 2022-01-01 Clinical and preclinical exploration of gene and cellular immunotherapy have seen rapid growth and interest with the development and approval of five Chimeric Antigen Receptor T-cell (CAR-T) products for lymphoma and myeloma and one Bispecific T-Cell Engager (BiTE) for acute lymphoblastic leukemia (ALL). These advances have dramatically improved the management of patients with relapsed refractory lymphoma, myeloma and leukemia. Gene and Cellular Immunotherapy for Cancer offers readers a comprehensive review of current cellular and gene-based immunotherapies. Divided into eighteen cohesive chapters, this book provides an in-depth and detailed look into cellular-based immunotherapies including CAR-T, TCR-T, TIL, Viral CTLs, NK cells in addition to T/NK cell engagers, focusing on their historical perspectives, biology, development and manufacturing, toxicities and more. Edited by two leading experts on gene and cellular immunotherapy, the book will feature chapters written by a diverse collection of recognized and up-and-coming experts and researchers in the field, providing oncologists, immunologists, researchers and clinical and basic science trainees with a bench to bedside view of the latest developments in the field. |
| bridging therapy car-t: Evidence-Based Physical Therapy for the Pelvic Floor Kari Bø, Bary Berghmans, Siv Mørkved, Marijke Van Kampen, 2014-11-04 Bridging the gap between evidence-based research and clinical practice, Physical Therapy for the Pelvic Floor has become an invaluable resource to practitioners treating patients with disorders of the pelvic floor. The second edition is now presented in a full colour, hardback format, encompassing the wealth of new research in this area which has emerged in recent years. Kari Bø and her team focus on the evidence, from basic studies (theories or rationales for treatment) and RCTs (appraisal of effectiveness) to the implications of these for clinical practice, while also covering pelvic floor dysfunction in specific groups, including men, children, elite athletes, the elderly, pregnant women and those with neurological diseases. Crucially, recommendations on how to start, continue and progress treatment are also given with detailed treatment strategies around pelvic floor muscle training, biofeedback and electrical stimulation. aligns scientific research with clinical practice detailed treatment strategies innovative practice guidelines supported by a sound evidence base colour illustrations of pelvic floor anatomy and related neuroanatomy/ neurophysiology MRIs and ultrasounds showing normal and dysfunctional pelvic floor incorporates vital new research and material uses key summary boxes throughout new edition to highlight quick reference points now in full colour throughout and a hardback format |
| bridging therapy car-t: Therapeutic Presence Arthur Robbins, 1998 In this text, Arthur Robbins explores the interaction between patient and therapist in depth, examining the concept of therapeutic presence, and the therapist's ability to maintain it. |
| bridging therapy car-t: Counselling and Spiritual Accompaniment Brian Thorne, 2012-08-02 Counselling and Spiritual Accompaniment presents the key spiritually-focused writings of Brian Thorne, one of the most influential thinkers on the convergence of spirituality with counselling, along with new material reflecting his recent work in spiritual accompaniment. Reflects the increasing focus on spiritual issues as an essential part of therapy Represents the culmination of an intellectual quest, undertaken by the most senior figure in the field, to integrate spirituality with counselling and the person-centred approach Features chapters that span thirty years of work, along with new writings that bring readers up to date with the author's most recent work in spiritual accompaniment An invaluable guide for counsellors and therapists who acknowledge the importance of spirituality to their clients, but doubt their abilities to help in this area |
| bridging therapy car-t: Blood and Marrow Transplant Handbook Richard T. Maziarz, Susan Schubach Slater, 2015-04-20 This updated and expanded edition developed by the Blood and Marrow Stem Cell Transplant team at Oregon Health & Science University Knight Cancer Institute features the latest medical management guidelines and standards of care for hematopoietic stem cell transplant patients. Spanning the timeline from the initial consultation throughout the transplant process, this handbook includes indications for transplantation and donor selection, treatment guidelines for addressing complications during and after transplant, and recommendations for long-term follow up care. Concise, comprehensive, and easy-to-use, Blood and Marrow Transplant Handbook, 2nd Edition presents a multidisciplinary approach to information for physicians and advanced practice medical providers who care for transplant patients, and also residents, fellows, and other trainees. |
| bridging therapy car-t: A CBT Practitioner's Guide to ACT Joseph Ciarrochi, Ann Bailey, 2008 If recent professional publications and conferences are any indication, acceptance- and mindfulness-based therapies are the future of clinical psychology. A CBT-Practitioner's Guide to ACT helps professionals whose clinical educations focused on traditional, change-based cognitive behavior therapies navigate the practical and theoretical challenges that come with the switch to the more promising, acceptance-based strategies. |
| bridging therapy car-t: Building Intimate Relationships Rita DeMaria, Mo Therese Hannah, 2013-08-21 First Published in 2003. Routledge is an imprint of Taylor & Francis, an informa company. |
| bridging therapy car-t: Attachment Theory in Clinical Work with Children David Oppenheim, Douglas F. Goldsmith, 2007-03-08 Attachment research has tremendous potential for helping clinicians understand what happens when parent–child bonds are disrupted, and what can be done to help. Yet there remains a large gap between theory and practice in this area. This book reviews what is known about attachment and translates it into practical guidelines for therapeutic work. Leading scientist-practitioners present innovative strategies for assessing and intervening in parent–child relationship problems; helping young children recover from maltreatment or trauma; and promoting healthy development in adoptive and foster families. Detailed case material in every chapter illustrates the applications of research-based concepts and tools in real-world clinical practice. |
| bridging therapy car-t: Biomedical Engineering W. Mark Saltzman, 2015-05-21 The second edition of this popular introductory undergraduate textbook uses examples, applications, and profiles of biomedical engineers to show students the relevance of the theory and how it can be used to solve real problems in human medicine. The essential molecular biology, cellular biology, and human physiology background is included for students to understand the context in which biomedical engineers work. Updates throughout highlight important advances made over recent years, including iPS cells, microRNA, nanomedicine, imaging technology, biosensors, and drug delivery systems, giving students a modern description of the various subfields of biomedical engineering. Over two hundred quantitative and qualitative exercises, many new to this edition, help consolidate learning, whilst a solutions manual, password-protected for instructors, is available online. Finally, students can enjoy an expanded set of leader profiles in biomedical engineering within the book, showcasing the broad range of career paths open to students who make biomedical engineering their calling. |
| bridging therapy car-t: Childhood Acute Lymphoblastic Leukemia Ajay Vora, 2017-04-21 This book provides a comprehensive and up-to-date review of all aspects of childhood Acute Lymphoblastic Leukemia, from basic biology to supportive care. It offers new insights into the genetic pre-disposition to the condition and discusses how response to early therapy and its basic biology are utilized to develop new prognostic stratification systems and target therapy. Readers will learn about current treatment and outcomes, such as immunotherapy and targeted therapy approaches. Supportive care and management of the condition in resource poor countries are also discussed in detail. This is an indispensable guide for research and laboratory scientists, pediatric hematologists as well as specialist nurses involved in the care of childhood leukemia. |
| bridging therapy car-t: Pediatric Lymphomas Howard J. Weinstein, Melissa M. Hudson, Michael P. Link, 2007-01-20 This is a comprehensive textbook of Hodgkin's and non-Hodgkin's lymphomas written by leaders in the field of childhood lymphomas. It includes clinical, pathologic and molecular biology of each subtype of lymphoma. The pathology chapters are comprehensive and include excellent photographs. The book is at the level of subspecialists in pediatric hematology and oncology, radiation oncology, pediatric surgery and hematopathology. |
| bridging therapy car-t: Healing Psychiatry David H Brendel, 2009-08-21 A new patient-centered approach to psychiatry that aims to resolve the field's conceptual tension between science and humanism by drawing on classical American pragmatism and contemporary pragmatic bioethics. Psychiatry today is torn by opposing sensibilities. Is it primarily a science of brain functioning or primarily an art of understanding the human mind in its social and cultural context? Competing conceptions of mental illness as amenable to scientific explanation or as deeply complex and beyond the reach of empirical study have left the field conceptually divided between science and humanism. In Healing Psychiatry David Brendel takes a novel approach to this stubborn problem. Drawing on the classical American pragmatism of Charles Sanders Peirce, William James, and John Dewey, as well as contemporary work of pragmatic bioethicists, Brendel proposes a clinical pragmatism that synthesizes scientific and humanistic approaches to mental health care. Psychiatry, he argues, must integrate scientific and humanistic models by emphasizing the practical, pluralistic, participatory, and provisional aspects of clinical diagnosis and treatment. Psychiatrists need to have the skill and flexibility to use scientific and humanistic approaches in a collaborative, open-ended clinical process; they must recognize the complexity of human suffering even as they strive for scientific rigor. This is the only way, he writes, that psychiatry can heal its conceptual rift and the emotional wounds of its patients. Healing Psychiatry explores these issues from both clinical and theoretical standpoints and uses case histories to support its basic argument. Brendel calls for an open-minded and flexible yet scientifically informed approach to understanding, diagnosing, and treating mental disorders. And he considers the future of psychiatry, applying the principles of clinical pragmatism to a broad range of ethical concerns in psychiatric training and research. |
| bridging therapy car-t: Evidence-Based Practice in Action Sona Dimidjian, 2019-08-30 The evidence-based practice (EBP) movement has always been about implementing optimal health care practices. Practitioners have three primary roles they can play in relation to the research evidence in EBP: scientists, systematic reviewers, and research consumers. Learning EBP is an acculturation process begun during professional training that seamlessly integrates research and practice--Provided by publisher. |
| bridging therapy car-t: Stereotactic Body Radiation Therapy Simon S. Lo, Bin S. Teh, Jiade J. Lu, Tracey E. Schefter, 2012-08-28 Stereotactic body radiation therapy (SBRT) has emerged as an important innovative treatment for various primary and metastatic cancers. This book provides a comprehensive and up-to-date account of the physical/technological, biological, and clinical aspects of SBRT. It will serve as a detailed resource for this rapidly developing treatment modality. The organ sites covered include lung, liver, spine, pancreas, prostate, adrenal, head and neck, and female reproductive tract. Retrospective studies and prospective clinical trials on SBRT for various organ sites from around the world are examined, and toxicities and normal tissue constraints are discussed. This book features unique insights from world-renowned experts in SBRT from North America, Asia, and Europe. It will be necessary reading for radiation oncologists, radiation oncology residents and fellows, medical physicists, medical physics residents, medical oncologists, surgical oncologists, and cancer scientists. |
| bridging therapy car-t: The Comprehensive Resource Model Lisa Schwarz, Frank Corrigan, Alastair Hull, Rajiv Raju, 2016-10-04 Traditional methods employed in psychotherapy have limited effectiveness when it comes to healing the psychological effects of trauma, in particular, complex trauma. While a client may seem to make significant breakthroughs in understanding their feelings and experiences on a rational level by talking with a therapist, this will make no difference to their post-traumatic symptoms if the midbrain is unable to modulate its activity in response. The Comprehensive Resource Model argues for a novel therapeutic approach, which uniquely bridges neuroscience and spirituality through a combination of somatic therapy, traditional psychotherapy, and indigenous healing concepts to provide effective relief to survivors of trauma. The Comprehensive Resource Model was developed in response to the need for a streamlined, integrative therapeutic model; one which engages a scaffolding of neurobiological resources in many brain structures simultaneously in order for clients to be fully embodied and conscious in the present moment while processing their traumatic material. All three phases of trauma therapy: resourcing, processing, and integration are done simultaneously. Demonstrating a nested model and employing brain and body-based physiological safety as the foundation of healing, chapters describe three primary categories of targeted processing: implicit and explicit survival terror, ‘Little T Truths’, and ‘Big T Truths’, all of which contribute to thorough healing of complex trauma and an expansion into higher states of consciousness and embodiment of the essential core self. This book describes the development and benefits of this pioneering new approach to trauma therapy. As such, it will be of key interest to academics, researchers and postgraduate students in the fields of psychiatry, psychotherapy, psychology and trauma studies. It will also appeal to practising therapists, psychiatrists, psychologists, psychiatric nurses, and to others involved in the treatment or management of patients with complex trauma disorders. |
| bridging therapy car-t: Attachment in Group Psychotherapy Cheri L. Marmarosh, 2019-12-18 Attachment theory is influencing how we understand interpersonal relationships and how psychotherapy can help facilitate change for those struggling in relationships. More recently, researchers and clinicians have applied attachment theory to group treatment, one of the most effective forms of psychotherapy to address interpersonal difficulties. This book highlights some of the bridges between attachment theory and contemporary approaches to group treatment. In addition to applying attachment theory to innovative treatments, each chapter addresses a specific way in which attachment impacts the members’ capacity for empathy and perspective taking; the development of cohesion in the group; the automatic fight-flight response during group interactions; members’ ability to tolerate diversity; and the leaders’ capacity to foster safety within the group. This book will help group leaders gain a richer understanding of attachment theory and attachment based techniques that will ultimately benefit their groups. This book was originally published as a special issue of the International Journal of Group Psychotherapy. |
| bridging therapy car-t: Immunopharmacogenomics Yusuke Nakamura, 2015-09-18 This book proposes immunogenomics, or immunopharmacogenomics, as the next-generation big science to uncover the role that the immune system plays in the pathogenesis of many diseases, by summarizing the importance of the deep sequencing of T-cell and B-cell receptors. Immunogenomics/immunopharmacogenomics, a genetic characterization of the immune system made possible by next-generation sequencing (NGS), will be important for the further understanding of the pathogenesis of various disease conditions. Abnormal immune responses in the body lead to development of autoimmune diseases and food allergies. Rejection of recipient cells and tissues, as well as severe immune reactions to donor cells, is also the result of uncontrolled immune responses in the recipient body. There have been many reports indicating that activated immune responses caused by the interaction of drugs and HLA are present in drug-induced skin hypersensitivity and liver toxicity. The importance of the host immune responses has been recognized in cancer treatments, not only for immunotherapy but also for cytotoxic agents and molecular targeted drugs. Hence, characterization of the T-cell receptor and B-cell receptor repertoire by means of NGS deep sequencing will ultimately make possible the identification of the molecular mechanisms that underlie various diseases and drug responses. In addition, this approach may contribute to the identification of antigens associated with the onset or progression of autoimmune diseases as well as food allergies. Although the germline alterations and somatic mutations have been extensively analyzed, changes or alterations of the immune responses during the course of various disease conditions or during various treatments have not been analyzed. It is also clear that computational analyses to draw meaningful inferences of functional recognition receptors on the immune cells remain a huge challenge. |
| bridging therapy car-t: Education and Technology Support for Children and Young Adults With ASD and Learning Disabilities Kats, Yefim, Stasolla, Fabrizio, 2020-11-13 Among the disabilities covered at the state and federal levels, autism and related conditions are a sharply growing diagnostic category among children and young adults. In education, administrators and practitioners working with affected learners are continually faced with confronting difficult problems such as getting adequate personnel training and choosing appropriate tools and techniques that best fit the specific needs of their students while at the same time satisfying their budget, technical resources, curriculum, and profile of the ASD population they serve. The choice of appropriate tools is especially complex due to the intrinsic connection between technical specifications, educational/therapeutic methods, and the wide variety of ASDs and related conditions. In this respect, tools chosen to support children may need to target those diagnosed not only with ASD but also with such co-morbidity conditions as attention deficit disorder. The instructional strategies and use of technology currently have room for improvement for online, hybrid, and face-to-face counseling settings. Also, an effective evaluation of educational technologies and tools would be fundamentally incomplete without a thorough understanding and assessment of the related special education practices as well as psychological and neurological issues specific for ASD and learning disabilities. Education and Technology Support for Children and Young Adults With ASD and Learning Disabilities provides an in-depth analysis on the use of available technology solutions, instructional design methods, and assessment techniques in the context of standards and regulations in classroom or counseling settings. The chapters contain theoretical analyses, vital practical information, and case studies that can function as guidelines for those involved in helping children and young adults with ASD or learning disabilities in online, hybrid, or face-to-face environments. While highlighting topics such as inclusive education, online gaming environments, assistive technologies, and cognitive development, this book is ideally intended for administrators, instructional technology specialists, special education faculty, counselors, instructional designers, course developers, social workers, and psychologists along with practitioners, stakeholders, researchers, and academicians interested in education and technology support for children and young adults with ASD and learning disabilities. |
| bridging therapy car-t: Access to Health Care in America Institute of Medicine, Committee on Monitoring Access to Personal Health Care Services, 1993-02-01 Americans are accustomed to anecdotal evidence of the health care crisis. Yet, personal or local stories do not provide a comprehensive nationwide picture of our access to health care. Now, this book offers the long-awaited health equivalent of national economic indicators. This useful volume defines a set of national objectives and identifies indicatorsâ€measures of utilization and outcomeâ€that can sense when and where problems occur in accessing specific health care services. Using the indicators, the committee presents significant conclusions about the situation today, examining the relationships between access to care and factors such as income, race, ethnic origin, and location. The committee offers recommendations to federal, state, and local agencies for improving data collection and monitoring. This highly readable and well-organized volume will be essential for policymakers, public health officials, insurance companies, hospitals, physicians and nurses, and interested individuals. |
| bridging therapy car-t: Mental Health Intervention and Treatment of First Responders and Emergency Workers Bowers, Clint A., Beidel, Deborah C., Marks, Madeline R., 2019-08-30 The stress that comes with being a first responder has been known to lead to depression, anxiety, substance abuse, and suicide. However, few clinicians are informed about these health concerns and how to adequately treat them in this population. Therefore, there is an urgent need for practitioners to understand the latest information regarding treatments that will be useful to this specific population. Mental Health Intervention and Treatment of First Responders and Emergency Workers is an essential reference source that focuses on the latest research for diagnosing and treating mental health issues experienced by emergency personnel and seeks to generate awareness and inform clinicians about the unique circumstances encountered by these professionals. While highlighting topics including anxiety disorders and stress management, this book is ideally designed for clinicians, therapists, psychologists, psychiatrists, practitioners, medical professionals, EMTs, law enforcement, fire departments, military, academicians, researchers, policymakers, and students seeking current research on psychological therapy methods regarding first responders. |
| bridging therapy car-t: Understanding Strength and Conditioning as Sport Coaching Tania Cassidy, Phil Handcock, Brian Gearity, Lisette Burrows, 2020-05-07 Contemporary strength and conditioning coaching is, for the most part, informed by the exercise sciences, with little engagement being made with sociocultural and pedagogical perspectives which have emerged in sports coaching research over the last two decades. In Understanding Strength and Conditioning as Sport Coaching: Bridging the Biophysical, Pedagogical and Sociocultural Foundations of Practice, the authors – whose expertise span strength and conditioning, sports coaching and pedagogy – help students and coaches to integrate perspectives from these disciplines to enhance their strength and conditioning coaching practice. The book encourages readers to add moral, ethical and political considerations to the technical aspects of their coaching practice. It discusses and applies concepts to a full range of strength and conditioning settings, including elite performance, young athletes, ageing athletes and returning to play following injury. Featuring an eResource, and structured around rich, narrative pedagogical cases reflecting the issues faced by practising strength and conditioning coaches, the book offers a thoroughly engaging introduction to pedagogical and sociocultural concepts and literature in a strength and conditioning context. This is a vital book for students of strength and conditioning, and an important resource for practising strength and conditioning coaches and sport science staff. |
| bridging therapy car-t: Autologous Stem Cell Transplantation Angelo Carella, 2020-08-26 This textbook integrates basic research and clinical aspects underlying the most recent results in those malignant diseases where progress is most effective. Recent evidence shows that higher doses are better in inducing higher cure rates in hematological neoplasias, although myeloblation related to dose intensity can be a limiting factor. The toxicity can now be controlled with autologous marrow and peripheral blood progenitor cell transplantation, used with or without growth factors. The combination of high dose chemoradiotherapy followed by re-infusion of autologous stem cells constitute a dramatic advance in the treatment of refactory and relapse hematological neoplasias. |
| bridging therapy car-t: Bridging the Gap Shiu Y. Tsao, 2021 Recognising rare diseases' impracticability of having extensive clinical trials necessary for regulatory approval, the US Orphan Drug Act appropriately facilitates the commercialization of orphan drugs. However, even common cancers also have rather specific but uncommon clinical situations for which extensive clinical trials are hardly practicable. Moreover, although such very costly and extensive trials often depend on industry support, uncommon situations are unattractive. Eventually, many specific treatments for designated clinical oncology situations often lack regulatory approvals merely because of suboptimal trial data. Now, this EBM (evidence-based medicine) book by expert authors with first-hand clinical experience is about off-label but acceptable treatment options. The attempt is to patch up the low response rates and considerable adverse events of novel immunotherapy. Currently, without any such off-label treatments, some cancer patients may well be left out in the cold. Although off-label treatments lack regulatory approval, they are backed by EBM and have good safety profiles. It's inappropriate to announce nothing else can be done merely because all approved options have already been exhausted. In expert hands, despite the on compassionate grounds proviso, the safety profiles of such off-label prescriptions may even compare favourably with orthodox chemotherapy given at top doses. |
| bridging therapy car-t: The Science of the Sacred Nicole Redvers, N.D., 2019-03-26 Indigenous naturopathic doctor Nicole Redvers pairs evidence-based research with traditional healing modalities, addressing modern health problems and medical processes Modern medical science has finally caught up to what traditional healing systems have known for centuries. Many traditional healing techniques and medicines are often assumed to be archaic, outdated, or unscientific compared to modern Western medicine. Nicole Redvers, a naturopathic physician and member of the Deninu K'ue First Nation, analyzes modern Western medical practices using evidence-informed Indigenous healing practices and traditions from around the world--from sweat lodges and fermented foods to Ayurvedic doshas and meditation. Organized around various sciences, such as physics, genetics, and microbiology, the book explains the connection between traditional medicine and current research around epigenetics and quantum physics, for example, and includes over 600 citations. Redvers, who has traveled and worked with Indigenous groups around the world, shares the knowledge and teachings of health and wellness that have been passed down through the generations, tying this knowledge with current scientific advances. Knowing that the science backs up the traditional practice allows us to have earlier and more specific interventions that integrate age-old techniques with the advances in modern medicine and technology. |
| bridging therapy car-t: The Significance of Dreams Peter Fonagy, Horst Kachele, Marianne Leuzinger-Bohleber, David Taylor, 2018-03-22 This book looks at dreams from a twenty-first century perspective. It takes its inspiration from Freud's insights, but pursues psychoanalytic interest into both neuroscience and the modern psychoanalytic consulting room. The book looks at laboratory research on dreaming alongside the modern clinical use of dreams and links together clinical and empirical research, integrating classical ideas with the plurality of psychoanalytic theoretical constructs available to modern researchers. Psychoanalysts writing about dreams have traditionally represented the cutting edge of clinical and theoretical development, and this book is no exception. Many of the contributions, as well as the epistemological position taken by the writers, represent a kind of radical openness to new ways of thinking about the clinical situation and about theory. In line with the ambition of the editors, this volume represents an integration of theories and disciplines, and a scientific context for modern psychoanalysis. The link between clinical research and extraclinical research via the royal road of dreaming is a theme that runs through all the contributions. |
| bridging therapy car-t: Fast Facts: CAR T-Cell Therapy in Diffuse Large B-Cell Lymphoma Richard J. Buka, Dee Moloney, 2021-10-31 Diffuse large B-cell lymphoma (DLBCL) is the most common form of high-grade non-Hodgkin lymphoma. While treatment with immunochemotherapy has generally shown good outcomes, specific subgroups of patients with high-risk disease have an unfavorable prognosis. Extensive efforts have been made to improve outcomes in these patients. As such, CD19-targeted chimeric antigen receptor (CAR) T-cell therapy has become the new standard of care for patients with relapsed or refractory DLBCL after at least two prior lines of therapy. It is an exciting new therapeutic intervention that is integral to the concept of personalized medicine. Table of Contents: • DLBCL: an overview • CAR T cells • CAR T-cell products • Delivering CAR T-cell therapy and managing patient expectations • CAR T-cell therapy-related toxicities |
| bridging therapy car-t: Treatment of Eating Disorders Margo Maine, Beth Hartman McGilley, Douglas Bunnell, 2010-09-08 Eating disorders (EDs) affect at least 11 million people in the United States each year and spread across age, race, ethnicity and socio-economic class. While professional literature on the subject has grown a great deal in the past 30 years, it tends to be exclusively research-based and lacking expert clinical commentary on treatment. This volume focuses on just such commentary, with chapters authored by both expert clinicians and researchers. Core issues such as assessment and diagnosis, the correlation between EDs and weight and nutrition, and medical/psychiatric management are discussed, as are the underrepresented issues of treatment differences based on gender and culture, the applications of neuroscience, EDNOS, comorbid psychiatric disorders and the impact of psychiatric medications. This volume uniquely bridges the gap between theoretical findings and actual practice, borrowing a bench-to-bedside approach from medical research. - Includes real-world clinical findings that will improve the level of care readers can provide, consolidated in one place - Underrepresented issues such as gender, culture, EDNOS and comorbidity are covered in full - Represents outstanding scholarship, with each chapter written by an expert in the topic area |
| bridging therapy car-t: The Business of Healthcare Innovation Lawton Robert Burns, 2005-08-25 The Business of Healthcare Innovation is the first wide-ranging analysis of business trends in the manufacturing segment of the health care industry. In this leading edge volume, Professor Burns focuses on the key role of the 'producers' as the main source of innovation in health systems. Written by professors of the Wharton School and industry executives, this book provides a detailed overview of the pharmaceutical, biotechnology, genomics/proteomics, medical device and information technology sectors. It analyses the market structures of these sectors as well as the business models and corporate strategies of firms operating within them. Most importantly, the book describes the growing convergence between these sectors and the need for executives in one sector to increasingly draw upon trends in the others. It will be essential reading for students and researchers in the field of health management, and of great interest to strategy scholars, industry practitioners and management consultants. |
| bridging therapy car-t: Why We Revolt Victor Montori, 2020-09-29 The Mayo Clinic physician and founder of The Patient Revolution offers a “thoroughly convincing. . . call to action for medical industry reform” (Kirkus). Winner of the 2018 PenCraft Award for Literary Excellence, Why We Revolt exposes the corruption and negligence that are endemic in America’s healthcare system—and offers a blueprint for revolutionizing patient care across the country. Through a series of essays and first-hand accounts, Dr. Victor M. Montori demonstrates how the system has been increasingly exploited and industrialized, putting profit before patients. As costs soar, the United States continues to fall behind other countries on patient outcomes. Offering concrete, direct actions we can take to bring positive change to the healthcare system, Why We Revolt is an inspiring call-to-action for physicians, policymakers, and patients alike. Dr. Montori shows how we can work together to create a system that offers tailored healthcare in a kind and careful way. All proceeds from Why We Revolt go directly to Patient Revolution, a non-profit organization founded by Dr. Montori that empowers patients, caregivers, community advocates, and clinicians to rebuild our healthcare system. |
| bridging therapy car-t: Anticoagulation Therapy Ozcan Basaran, Murat Biteker, 2016-09-08 The available parenteral and oral anticoagulants have a large clinical use. Understanding biochemistry of anticoagulants may help to improve therapeutic strategies. Resistance to vitamin K antagonist drugs might be a problem for rodent populations. Patients who have thrombogenic risk factors should be anticoagulated. The need for cardiac implantable electronic devices is increasing, and there is a substantial number of patients who are on oral anticoagulant therapy. Prothrombin complex concentrate and other plasma concentrates are useful to deal with over-coagulated situations. The efficacy and safety of non-vitamin K antagonist oral anticoagulants have been proven in large phase III trials. The real-world data suggest even better outcomes with these agents compared to vitamin K antagonists. |
| bridging therapy car-t: The BioMechanics Method for Corrective Exercise Price, Justin, 2019 The BioMechanics Method for Corrective Exercise enables health and fitness professionals to identify common musculoskeletal imbalances in their clients and apply appropriate corrective exercises to swiftly eliminate muscle and joint pain and improve physical function. |
| bridging therapy car-t: Bridging the Gap from Rehab to Performance Sue Falsone, 2017 In Bridging the Gap from Rehab to Performance, physical therapist Sue Falsone walks the reader through the thought process and physical practice of guiding an injured athlete from injury through rehab and back to the field of play. To both health care professionals and strength and conditioning experts alike, she describes the path as her athletes move through pain and healing toward optimal function and advanced performance. |
| bridging therapy car-t: Healing the Rift Leo Kim, 2010-12-01 Outlines an organic chemist's long-standing efforts to bridge gaps between spirituality and twenty-first-century science, describing his experiences of working with cancer patients, his philosophies about the existence of God, and his beliefs about the universe's harmonious blending of mind and spirit. |
| bridging therapy car-t: ECMO Extracorporeal Cardiopulmonary Support in Critical Care 5th Edition Elso, 2017-02-01 |
| bridging therapy car-t: Cases on Cross-Cultural Counseling Strategies King, Bonnie C., Stewart, Tiffany A., 2019-08-30 It is essential for counselors and counseling professionals to understand the impact of their personal biases and how these biases can impact the counseling process, in addition to respecting and honoring the beliefs of their clients. Communication and the sharing of experiences between counsellors is an effective strategy for perfecting methods to identify and address these biases. Cases on Cross-Cultural Counseling Strategies is a comprehensive research book that explores creative healing approaches used by counselors working with diverse clients in a variety of geographical locations, developmental levels, and complex and varied identities. Each case study applies the Multicultural and Social Justice Counseling Competencies (MSJCCs) to the counseling relationship and looks at unique aspects of the client’s identity, specific approaches taken by the counselor, and the outcomes of the counseling relationship. Featuring a broad range of topics such as higher education, international counseling, and gender bias in counseling, this book is ideal for counselors, therapists, psychologists, counselor educators, graduate students, practitioners, academicians, and researchers. |
| bridging therapy car-t: The Morningside Model of Generative Instruction Kent R. Johnson, Elizabeth M. Street, 2004 Johnson and STreet describe a technology of instruction, based on scientific research, that has improved the academic performance of children, adolescents, and adults and 86 schools and agencies throughout the US and Canada. This book combines well-designed instructional materials, fast-paced classroom presentation, and focused practic to fluency. The result is expert and confident learners who apply skills and strategies to think about the world around them, continue to learn on their own, and solve problems of daily living. |
| bridging therapy car-t: Psychological and Social Aspects of Psychiatric Disability LeRoy J. Spaniol, Cheryl Gagne, Martin Koehler, 1997 |
| bridging therapy car-t: Bridging the Gap: Integrative Oncology and the Practice of Traditional Chinese Medicine Bianca Di Giulio, James Munson, 2019-08-13 The book's inherent value, currently, is in its uniqueness. There are few books on Integrative Oncology (IO). There are few books on the entirety of traditional Chinese medicine in the treatment of cancer. There are even fewer, if any, books that deal with the topics of Integrative Oncology and the use of traditional Chinese medicine as a whole in the treatment of people with cancer. While very broad and deep topics, this makes for a varied audience of interest that includes not just the TCM practitioner or student, but Western health practitioners and patients as well as laypeople interested in the topic of oncology.For those interested in the topic of IO, it gives one of the few non-biased, honest and critical views of the state of IO in contrast to what is promoted by various institutions and societies.For the Western health practitioner and/or patient, many of whom are completely unfamiliar with TCM and how it works or can be used, it provides information on the breadth of TCM and how it can be applied in various ways to help improve outcomes.For the TCM practitioner or student, it provides much needed information on how to go about caring for a patient with cancer to include clinical pearls and important Western medical information and terminology. |
Bridging Therapy and Lymphodepleting Chemotherapy - CAR …
Bridging therapy —Some patients may receive bridging therapy while CAR T cell therapy is being manufactured —The purpose is to maximize disease control and minimize organ toxicity until …
CAR T 102: Introduction to the Patient Cell Therapy Journey
•Bridging therapy may be given to maintain disease control during CAR T cell manufacturing •Appropriate bridging therapy should be discussed and coordinated between the referring …
Considerations for the Development of Chimeric Antigen …
In this guidance, we, FDA, provide CAR T cell-specific recommendations regarding chemistry, manufacturing, and control (CMC), pharmacology and toxicology, and design of clinical studies …
CAR T-Cell Therapy - University of Utah
Sep 18, 2024 · •What is CAR T-cell therapy and what is the process? •What are the potential side effects of CAR T-cell therapy? •What can I expect during my hospital admission?
Preparing for CAR T cell therapy: patient selection, bridging
Mar 22, 2022 · In this Review, we summarize current knowledge and examine opportunities to improve clinical out-comes following CAR T cell infusion by optimizing patient selection, …
Management of adults and children receiving CAR T-cell …
Dec 16, 2021 · BRIDGING THERAPY ‘Bridging’ therapy, administered in the 4-6 weeks between leukapheresis and CAR-T administration, aims to reduce disease burden and, in doing so, …
Chimeric Antigen Receptor (CAR) T-Cell Therapy Handbook
CAR T-cell therapy changes some of your body’s T-cells after they have been collected from your bloodstream. In a laboratory, your T-cells will be reprogrammed to produce special receptors
The Evolving Role of Bridging Therapy during CAR-T Therapy
process required to treat a patient with CAR T-cells, bridging therapy (BT), administered after leukapheresis but prior to CAR T infusion, has become an important component of safely …
CAR T 101
CAR T Academy Patient Journey Through the CAR T Cell Therapy Process 3 Reference: 1. Beaupierre A, et al. Clin J Oncol Nurs. 2019;23:27-34. • Patients may require bridging therapy …
Safety and efficacy of CD22 and CD19 CAR-T bridging auto …
Combining CAR-T cells with allogeneic hematopoietic stem cell transplantation (allo-HSCT) may be a promising strategy; however, the bene t of CAR-T-cell therapy fi bridging allo-HSCT …
Effectiveness of Bridging Therapy Corresponds to Improved …
• Bridging therapy helps control disease during manufacturing, potentially reducing the risk of toxicities by debulking • The impact of disease control prior to CAR -T infusion on post infusion
CAR T-Cell Therapy - bmtinfonet.org
Chimeric antigen receptor T-cell therapy (CAR T-cell therapy) is a treatment that engineers the patient’s own immune system to fight
Role of bridging RT in relapsed/refractory diffuse large B-cell ...
Anti-CD19 chimeric antigen receptor (CAR)-T cell therapy is an effective treatment option for relapsed/refractory diffuse large B-cell lymphoma (DLBCL) [1]. CAR-T manufacturing and...
Association of bridging therapy utilization with clinical …
Background Chimeric antigen receptor (CAR) T- cell therapy recipients may receive bridging therapy while awaiting product manufacturing to control disease. Yet, data are lacking …
The CD19 CAR T-cell Therapy Journey - accc-cancer.org
•Review qualifications for CD19 CAR T-cell therapy •Describe the CAR T-cell therapy journey •Discuss coping with CAR T-cell therapy both short- and long-term complications
Role of bridging therapy during chimeric antigen receptor T …
Some data are also available regarding the use of bridging therapy with CAR T in commercial use. A study published by the U.S. Lym-phoma CAR T Consortium evaluated the use of axi-cel …
Approaches for bridging therapy prior to chimeric antigen …
Feb 15, 2024 · In this report, we review bridging treatment strategies and clinical outcomes in children and young adults with R/R B-ALL treated with CD19-specific CAR T cells, and define …
Impact of bridging chemotherapy on clinical outcome of …
Autologous chimeric antigen receptor (CAR) T cell therapy targeting CD19 is effective in B-cell malignancies such as acute lymphoblastic leukemia (ALL) [1–3]. Prior to infusion, T cells...
Patient Evaluation in CAR T Therapy - CAR T Academy
Patient Journey Through the CAR T Cell Therapy Process 2 • Patients may require bridging therapy to maintain disease control while the CAR T cell product is being manufactured • …
Bridging therapies used in trials testing CAR-T therapies.
the approval of each CAR-T cell therapy, we looked at which bridging therapies were used, whether multiple therapies were combined, response rates, and the reported adverse events …
Bridging Therapy and Lymphodepleting Chemotherapy
Bridging therapy —Some patients may receive bridging therapy while CAR T cell therapy is being manufactured —The purpose is to maximize disease control and minimize organ toxicity until …
CAR T 102: Introduction to the Patient Cell Therapy Journey
•Bridging therapy may be given to maintain disease control during CAR T cell manufacturing •Appropriate bridging therapy should be discussed and coordinated between the referring …
Considerations for the Development of Chimeric Antigen …
In this guidance, we, FDA, provide CAR T cell-specific recommendations regarding chemistry, manufacturing, and control (CMC), pharmacology and toxicology, and design of clinical studies …
CAR T-Cell Therapy - University of Utah
Sep 18, 2024 · •What is CAR T-cell therapy and what is the process? •What are the potential side effects of CAR T-cell therapy? •What can I expect during my hospital admission?
Preparing for CAR T cell therapy: patient selection, bridging …
Mar 22, 2022 · In this Review, we summarize current knowledge and examine opportunities to improve clinical out-comes following CAR T cell infusion by optimizing patient selection, …
Management of adults and children receiving CAR T-cell …
Dec 16, 2021 · BRIDGING THERAPY ‘Bridging’ therapy, administered in the 4-6 weeks between leukapheresis and CAR-T administration, aims to reduce disease burden and, in doing so, …
Chimeric Antigen Receptor (CAR) T-Cell Therapy Handbook
CAR T-cell therapy changes some of your body’s T-cells after they have been collected from your bloodstream. In a laboratory, your T-cells will be reprogrammed to produce special receptors
The Evolving Role of Bridging Therapy during CAR-T Therapy
process required to treat a patient with CAR T-cells, bridging therapy (BT), administered after leukapheresis but prior to CAR T infusion, has become an important component of safely …
CAR T 101
CAR T Academy Patient Journey Through the CAR T Cell Therapy Process 3 Reference: 1. Beaupierre A, et al. Clin J Oncol Nurs. 2019;23:27-34. • Patients may require bridging therapy …
Safety and efficacy of CD22 and CD19 CAR-T bridging auto …
Combining CAR-T cells with allogeneic hematopoietic stem cell transplantation (allo-HSCT) may be a promising strategy; however, the bene t of CAR-T-cell therapy fi bridging allo-HSCT …
Effectiveness of Bridging Therapy Corresponds to Improved …
• Bridging therapy helps control disease during manufacturing, potentially reducing the risk of toxicities by debulking • The impact of disease control prior to CAR -T infusion on post infusion
CAR T-Cell Therapy - bmtinfonet.org
Chimeric antigen receptor T-cell therapy (CAR T-cell therapy) is a treatment that engineers the patient’s own immune system to fight
Role of bridging RT in relapsed/refractory diffuse large B-cell ...
Anti-CD19 chimeric antigen receptor (CAR)-T cell therapy is an effective treatment option for relapsed/refractory diffuse large B-cell lymphoma (DLBCL) [1]. CAR-T manufacturing and...
Association of bridging therapy utilization with clinical …
Background Chimeric antigen receptor (CAR) T- cell therapy recipients may receive bridging therapy while awaiting product manufacturing to control disease. Yet, data are lacking …
The CD19 CAR T-cell Therapy Journey - accc-cancer.org
•Review qualifications for CD19 CAR T-cell therapy •Describe the CAR T-cell therapy journey •Discuss coping with CAR T-cell therapy both short- and long-term complications
Role of bridging therapy during chimeric antigen receptor T …
Some data are also available regarding the use of bridging therapy with CAR T in commercial use. A study published by the U.S. Lym-phoma CAR T Consortium evaluated the use of axi …
Approaches for bridging therapy prior to chimeric antigen …
Feb 15, 2024 · In this report, we review bridging treatment strategies and clinical outcomes in children and young adults with R/R B-ALL treated with CD19-specific CAR T cells, and define …
Impact of bridging chemotherapy on clinical outcome of …
Autologous chimeric antigen receptor (CAR) T cell therapy targeting CD19 is effective in B-cell malignancies such as acute lymphoblastic leukemia (ALL) [1–3]. Prior to infusion, T cells...
Patient Evaluation in CAR T Therapy - CAR T Academy
Patient Journey Through the CAR T Cell Therapy Process 2 • Patients may require bridging therapy to maintain disease control while the CAR T cell product is being manufactured • …
Bridging therapies used in trials testing CAR-T therapies.
the approval of each CAR-T cell therapy, we looked at which bridging therapies were used, whether multiple therapies were combined, response rates, and the reported adverse events …
