| brigham and women's hospital research studies: The Lost Art of Healing Bernard Lown, 1999-02-02 The real crisis in medicine today is not about economics, insurance, or managed care--it's about the loss of the fundamental human relationship between doctor and patient. In this wise and passionate book, one of our most eminent physicians reacquaints us with a classic notion often overlooked in modern medicine: health care with a human face, in which the time-honored art of healing guides doctors in their approach to patient care and their use of medical technology. Drawing on four decades of practice as a cardiologist and a vast knowledge of literature and medical history, Dr. Lown probes the heart and soul of the doctor-patient relationship. Insightful and accessible to all, The Lost Art of Healing describes how true healers use sympathetic listening and touch to hone their diagnostic skills, how language affects the perception of illness, how doctors and patients can cultivate a relationship of trust, and how patients can obtain the most complete and beneficial care through a combination of healing techniques and conventional practices. As Dr. Lown explains, the art of healing does not mean abandoning the spectacular advances of modern science, but rather incorporating them into a sensitive, humane, enlightened approach to medical care. With its urgent message and poignant, fascinating vignettes, The Lost Art of Healing is a book of vital, universal importance. |
| brigham and women's hospital research studies: Principles and Practice of Clinical Trials Steven Piantadosi, Curtis L. Meinert, 2022-07-19 This is a comprehensive major reference work for our SpringerReference program covering clinical trials. Although the core of the Work will focus on the design, analysis, and interpretation of scientific data from clinical trials, a broad spectrum of clinical trial application areas will be covered in detail. This is an important time to develop such a Work, as drug safety and efficacy emphasizes the Clinical Trials process. Because of an immense and growing international disease burden, pharmaceutical and biotechnology companies continue to develop new drugs. Clinical trials have also become extremely globalized in the past 15 years, with over 225,000 international trials ongoing at this point in time. Principles in Practice of Clinical Trials is truly an interdisciplinary that will be divided into the following areas: 1) Clinical Trials Basic Perspectives 2) Regulation and Oversight 3) Basic Trial Designs 4) Advanced Trial Designs 5) Analysis 6) Trial Publication 7) Topics Related Specific Populations and Legal Aspects of Clinical Trials The Work is designed to be comprised of 175 chapters and approximately 2500 pages. The Work will be oriented like many of our SpringerReference Handbooks, presenting detailed and comprehensive expository chapters on broad subjects. The Editors are major figures in the field of clinical trials, and both have written textbooks on the topic. There will also be a slate of 7-8 renowned associate editors that will edit individual sections of the Reference. |
| brigham and women's hospital research studies: An Introduction to Global Health Delivery Joia Mukherjee, 2021-10-01 In the last two decades, the rise of global health studies at universities across the world reflects the interest of a growing generation of students motivated to be involved in progressive global change. Grassroots advocacy for health equity and strong leadership in the global South have catalyzed a paradigm shift from primarily preventative health programs to holistic systems providing health care as a human right. To succeed in this field, students must not only understand the elements needed to deliver equitable health care but also the historical and social factors that cause and propagate health disparities. An Introduction to Global Health Delivery, Second Edition is an immersive introduction to global health's origins, actors, interventions, and challenges from the ongoing impacts of racism to the momentum for the delivery of care that began with the AIDS movement through to the current era of COVID-19. Informed by physician Joia Mukherjee's quarter-century of experience fighting disease and poverty in more than a dozen countries, it delivers a clear-eyed overview of the movement underway to address injustice, reduce global health disparities, and deliver health care as a human right. This second edition extends the lens of global health delivery to address the challenges of COVID-19 and the prevention of future pandemics. It features updated chapters exploring pandemics, preparedness, and the intersection of key social movements with the right to health care, including Black Lives Matter, decolonization, and climate justice. Enriched with case studies and exercises that encourage readers to think critically about equitable global health delivery, An Introduction to Global Health Delivery, Second Edition is the essential starting point for readers of any background seeking a practical grounding in global health's promise and progress. |
| brigham and women's hospital research studies: Otolaryngology Prep and Practice Jennifer J. Shin , Michael J. Cunningham, 2012-12-01 |
| brigham and women's hospital research studies: The Migraine Solution Paul Rizzoli, M.D., M. A. NEPORENT LIZ, Elizabeth Loder, Liz Neporent, 2012-01-03 Authors Rizzoli, Dr. Elizabeth Loder, and Liz Neporent are among the top experts in the field of headache disorders. Here, they deliver a straightforward, engaging, up-to-date guide to migraine and its treatment. Original. |
| brigham and women's hospital research studies: Developing a Protocol for Observational Comparative Effectiveness Research: A User's Guide Agency for Health Care Research and Quality (U.S.), 2013-02-21 This User’s Guide is a resource for investigators and stakeholders who develop and review observational comparative effectiveness research protocols. It explains how to (1) identify key considerations and best practices for research design; (2) build a protocol based on these standards and best practices; and (3) judge the adequacy and completeness of a protocol. Eleven chapters cover all aspects of research design, including: developing study objectives, defining and refining study questions, addressing the heterogeneity of treatment effect, characterizing exposure, selecting a comparator, defining and measuring outcomes, and identifying optimal data sources. Checklists of guidance and key considerations for protocols are provided at the end of each chapter. The User’s Guide was created by researchers affiliated with AHRQ’s Effective Health Care Program, particularly those who participated in AHRQ’s DEcIDE (Developing Evidence to Inform Decisions About Effectiveness) program. Chapters were subject to multiple internal and external independent reviews. More more information, please consult the Agency website: www.effectivehealthcare.ahrq.gov) |
| brigham and women's hospital research studies: The Harvard Medical School Guide to Tai Chi Peter M. Wayne, PhD, 2013-04-09 A longtime teacher and Harvard researcher presents the latest science on the benefits of T’ai Chi as well as a practical daily program for practitioners of all ages Conventional medical science on the Chinese art of T’ai Chi now shows what T’ai Chi masters have known for centuries: regular practice leads to more vigor and flexibility, better balance and mobility, and a sense of well-being. Cutting-edge research from Harvard Medical School also supports the long-standing claims that T’ai Chi also has a beneficial impact on the health of the heart, bones, nerves and muscles, immune system, and the mind. This research provides fascinating insight into the underlying physiological mechanisms that explain how T’ai Chi actually works. Dr. Peter M. Wayne, a longtime T’ai Chi teacher and a researcher at Harvard Medical School, developed and tested protocols similar to the simplified program he includes in this book, which is suited to people of all ages, and can be done in just a few minutes a day. This book includes: • The basic program, illustrated by more than 50 photographs • Practical tips for integrating T’ai Chi into everyday activities • An introduction to the traditional principles of T’ai Chi • Up-to-date summaries of the research on the health benefits of T’ai Chi • How T’ai Chi can enhance work productivity, creativity, and sports performance • And much more |
| brigham and women's hospital research studies: Evidence-Based Otolaryngology Jennifer Shin, Christopher Hartnick, Gregory Randolph, 2009-12-29 Recognizing the clinician's need for quick access to a comprehensive and immediately useful presentation of evidence-based material, the authors and editors have condensed the research on the most common otorhinolaryngological complaints into this indispensable volume. Their unique approach color-codes the level of research backing each set of evidence in order to make assessment of the evidence as quick and useful as possible. Each clinical problem is presented with a color key, letting the physician know the level of evidence available: green (high-level evidence), yellow (low–moderate levels of evidence), or red (major disagreement or only minimal low-level evidence). The content of each chapter is structured in the same manner so the reader quickly becomes accustomed to finding precisely the information needed for each new case. Featuring sections on general otolaryngology, head and neck surgery, pediatrics, and otology, Evidence-Based Otolaryngology not only presents the research, but gives the clinician immediately applicable recommendations for patient treatment. |
| brigham and women's hospital research studies: The Lupus Encyclopedia Donald E. Thomas Jr., 2023-09-05 Now completely updated! The best-selling, most comprehensive guide to lupus, its complications, and management. Lupus is an autoimmune disease that can attack any body organ. It is three times more common in the United States today than it was in the 1980s, so there is an increased need for accurate, practical information on this potentially devastating disease. Lupus expert and clinician Donald E. Thomas, Jr., MD, provides all the helpful information patients need so they can understand and treat this disease. Highlighting amazing advancements in the diagnosis and treatment of lupus, this edition includes new and expanded information on: • The latest FDA-approved medications • How lupus affects different body parts • Advanced labs that improve lupus diagnosis and treatment • The role of the microbiome and anti-inflammatory diets • Updated recommendations for those who are pregnant or breastfeeding • Childhood-onset lupus • The interaction between COVID-19 and lupus • Non-drug treatments, complementary medicine, and medical cannabis The gold standard since it was first published and carefully reviewed by experts in the field, the latest edition of The Lupus Encyclopedia is essential for patients, health care providers, and families. Bonus content on insurance issues and information about working with lupus and disability is also available online. Endorsed by The Lupus Foundation of America Contributors: Jemima Albayda, MD; Divya Angra, MD; Alan N. Baer, MD; Sasha Bernatsky, MD, PhD; George Bertsias, MD, PhD; Ashira D. Blazer, MD; Ian Bruce, MD; Jill Buyon, MD; Yashaar Chaichian, MD; Maria Chou, MD; Sharon Christie, Esq; Angelique N. Collamer, MD; Ashté Collins, MD; Caitlin O. Cruz, MD; Mark M. Cruz, MD; Dana DiRenzo, MD; Jess D. Edison, MD; Titilola Falasinnu, PhD; Andrea Fava, MD; Cheri Frey, MD; Neda F. Gould, PhD; Nishant Gupta, MD; Sarthak Gupta, MD; Sarfaraz Hasni, MD; David Hunt, MD; Mariana J. Kaplan, MD; Alfred Kim, MD; Deborah Lyu Kim, DO; Rukmini Konatalapalli, MD; Fotios Koumpouras, MD; Vasileios C. Kyttaris, MD; Jerik Leung, MPH; Hector A. Medina, MD; Timothy Niewold, MD; Julie Nusbaum, MD; Ginette Okoye, MD; Sarah L. Patterson, MD; Ziv Paz, MD; Darryn Potosky, MD; Rachel C. Robbins, MD; Neha S. Shah, MD; Matthew A. Sherman, MD; Yevgeniy Sheyn, MD; Julia F. Simard, ScD; Jonathan Solomon, MD; Rodger Stitt, MD; George Stojan, MD; Sangeeta Sule, MD; Barbara Taylor, CPPM, CRHC; George Tsokos, MD; Ian Ward, MD; Emma Weeding, MD; Arthur Weinstein, MD; Sean A. Whelton, MD |
| brigham and women's hospital research studies: Evidence-Based Imaging L. Santiago Medina, C. Craig Blackmore, Kimberly Applegate, 2011-04-28 Evidence-Based Imaging is a user-friendly guide to the evidence-based science and merit defining the appropriate use of medical imaging in both adult and pediatric patients. Chapters are divided into major areas of medical imaging and cover the most prevalent diseases in developed countries, including the four major causes of mortality and morbidity: injury, coronary artery disease, cancer, and cerebrovascular disease. This book gives the reader a clinically-relevant overview of evidence-based imaging, with topics including epidemiology, patient selection, imaging strategies, test performance, cost-effectiveness, radiation safety and applicability. Each chapter is framed around important and provocative clinical questions relevant to the daily physician’s practice. Key points and summarized answers are highlighted so the busy clinician can quickly understand the most important evidence-based imaging data. A wealth of illustrations and summary tables reinforces the key evidence. This revised, softcover edition adds ten new chapters to the material from the original, hardcover edition, covering radiation risk in medical imaging, the economic and regulatory impact of evidence-based imaging in the new healthcare reform environment in the United States, and new topics on common disorders. By offering a clear understanding of the science behind the evidence, Evidence-Based Imaging fills a void for radiologists, family practitioners, pediatricians, surgeons, residents, and others with an interest in medical imaging and a desire to implement an evidence-based approach to optimize quality in patient care. |
| brigham and women's hospital research studies: Clinical Decision Support Systems Eta S. Berner, 2013-06-29 Written by nationally and internationally recognised experts on the design, evaluation and application of such systems, this book examines the impact of practitioner and patient use of computer-based diagnostic tools. It serves simultaneously as a resource book on diagnostic systems for informatics specialists; a textbook for teachers or students in health or medical informatics training programs; and as a comprehensive introduction for clinicians, with or without expertise in the applications of computers in medicine, who are interested in learning about current developments in computer-based diagnostic systems. Designed for a broad range of clinicians in need of decision support. |
| brigham and women's hospital research studies: Understanding Clinical Research Renato D. Lopes, Robert A. Harrington, 2013-05-22 A complete guide to understanding and applying clinical research results Ideal for both researchers and healthcare providers Understanding Clinical Research addresses both the operational challenges of clinical trials and the needs of clinicians to comprehend the nuances of research methods to accurately analyze study results. This timely resource covers all aspects of clinical trials--from study design and statistics to regulatory oversight--and it delivers a detailed yet streamlined overview of must-know research topics. The text features an accessible three-part organization that traces the evolution of clinical research and explains the bedrock principles and unique challenges of clinical experimentation and observational research. Reinforcing this content are real-life case examples--drawn from the authors' broad experience--that put chapter concepts into action and contribute to a working knowledge of integral research techniques. FEATURES: The most definitive guide to promoting excellence in clinical research, designed to empower healthcare providers to assess a study's strengths and weaknesses with confidence and apply this knowledge to optimize patient outcomes In-depth coverage of fundamental research methods and protocols from preeminent authorities provides readers with an instructive primer and a springboard for ongoing clinical research education Clear, comprehensive three-part organization: Section One: Evolution of Clinical Research offers a succinct history of clinical trials, drug regulations, and the role of the FDA while covering the impact of information technology and academic research organizations Section Two: Principles of Clinical Experimentation takes you through the typical phases of clinical trials in the development of medical products, from initial human subject research to postapproval surveillance studies Section Three: Observational Research highlights the underlying principles, pitfalls, and methods for case-control studies, cohort studies, registries, and subgroup analyses within randomized trials |
| brigham and women's hospital research studies: Women's Neurology Mary Angela O' Neal, 2017 'Women's Neurology' details how to best care for women with neurological disorders. It can be challenging for physicians to stay on top of the latest research about how sex and gender affect the course of specific diseases, medication effects, and best neurological care. The book's raison d'être is therefore to heighten caregivers' awareness about the gender differences in neurological care |
| brigham and women's hospital research studies: Medical Crisis Counseling Irene Pollin, Susan Baird Kanaan, 1995 Nearly 15% of the US population has been diagnosed with a chronic medical condition. These patients - and their families - confront serious psychosocial challenges as they face living with a lasting medical illness. This is where medical crisis counseling (MCC) steps in. MCC is short-term intervention (1-10 sessions) that focuses on three critical, interacting areas in the patient's life: the disease, the emotional response, and the family's response. Four assumptions lie at the heart of MCC: The medical condition is the focus; medical crises are temporary and offer opportunities for learning; the adjustment issues faced by people with illness can be predicted; and people have strengths that help them identify and realize concrete goals. This book describes the MCC model and richly illustrates its therapeutic objectives and intervention techniques for each of the eight expectable issues of chronic illness: control, self-image, dependency, stigma, abandonment, anger, isolation, and death. Via numerous case examples, the impact of chronic illness on the patient's family members is described and methods are offered to promote better communication and adjustment around the medical problem. |
| brigham and women's hospital research studies: Network Medicine Joseph Loscalzo, Albert-László Barabási, Edwin K. Silverman, 2017-02-01 Big data, genomics, and quantitative approaches to network-based analysis are combining to advance the frontiers of medicine as never before. Network Medicine introduces this rapidly evolving field of medical research, which promises to revolutionize the diagnosis and treatment of human diseases. With contributions from leading experts that highlight the necessity of a team-based approach in network medicine, this definitive volume provides readers with a state-of-the-art synthesis of the progress being made and the challenges that remain. Medical researchers have long sought to identify single molecular defects that cause diseases, with the goal of developing silver-bullet therapies to treat them. But this paradigm overlooks the inherent complexity of human diseases and has often led to treatments that are inadequate or fraught with adverse side effects. Rather than trying to force disease pathogenesis into a reductionist model, network medicine embraces the complexity of multiple influences on disease and relies on many different types of networks: from the cellular-molecular level of protein-protein interactions to correlational studies of gene expression in biological samples. The authors offer a systematic approach to understanding complex diseases while explaining network medicine’s unique features, including the application of modern genomics technologies, biostatistics and bioinformatics, and dynamic systems analysis of complex molecular networks in an integrative context. By developing techniques and technologies that comprehensively assess genetic variation, cellular metabolism, and protein function, network medicine is opening up new vistas for uncovering causes and identifying cures of disease. |
| brigham and women's hospital research studies: Research on Women's Health , 1997 |
| brigham and women's hospital research studies: Virtual Clinical Trials National Academies of Sciences, Engineering, and Medicine, Health and Medicine Division, Board on Health Sciences Policy, Forum on Drug Discovery, Development, and Translation, 2019-11-16 Successful drug development relies on accurate and efficient clinical trials to deliver the best and most effective pharmaceuticals and clinical care to patients. However, the current model for clinical trials is outdated, inefficient and costly. Clinical trials are limited by small sample sizes that do not reflect variations among patients in the real world, financial burdens on participants, and slow processes, and these factors contribute to the disconnect between clinical research and clinical practice. On November 28-29, the National Academies of Sciences, Engineering, and Medicine convened a workshop to investigate the current clinical trials system and explore the potential benefits and challenges of implementing virtual clinical trials as an enhanced alternative for the future. This publication summarizes the presentations and discussions from the workshop. |
| brigham and women's hospital research studies: Reaching Down the Rabbit Hole Allan H. Ropper, Brian David Burrell, 2014-09-30 A Harvard neurologist’s “gripping” account of his day-to-day work that “rarely falls into jargon and always keeps the narrative lively and engaging” (Kirkus Reviews, starred review). Tell the doctor where it hurts—it sounds simple enough, unless the problem affects the very organ that produces awareness and generates speech. What is it like to try to heal the body when the mind is under attack? In this book, Dr. Allan H. Ropper and Brian David Burrell take us behind the scenes at Harvard Medical School’s neurology unit to show how a seasoned diagnostician faces down bizarre, life-altering afflictions. Like Alice in Wonderland, Dr. Ropper inhabits a world where absurdities abound: • A figure skater whose body has become a ticking time bomb • A salesman who drives around and around a traffic rotary, unable to get off • A college quarterback who can’t stop calling the same play • A child molester who, after falling on the ice, is left with a brain that is very much dead inside a body that is very much alive • A mother of two young girls, diagnosed with ALS, who has to decide whether a life locked inside her own head is worth living How does one begin to treat such cases, to counsel people whose lives may be changed forever? How does one train the next generation of clinicians to deal with the moral and medical aspects of brain disease? Dr. Ropper and his colleague answer these questions by taking the reader into a rarefied world where lives and minds hang in the balance. “Entertaining . . . Like an episode of the popular television series House, the book presents mysterious medical cases . . . In the hands of a lesser writer, this book might have been nothing more than a collection of colorful tales about the many ways a human brain can break down. But Dr. Ropper and Mr. Burrell manage to tell a more profound story about the value of men over machines.” —The New York Times Book Review “A captivating stroll through the concepts and realities of neurological science.” —Publishers Weekly “A must-read . . . each chapter reads like a detective story . . . This is medical writing at its best; in the tradition of Rouche, Lewis Thomas, and Oliver Sacks.” —V. S. Ramachandran, New York Times–bestselling author of The Tell-Tale Brain |
| brigham and women's hospital research studies: Examining the Impact of Real-World Evidence on Medical Product Development National Academies of Sciences, Engineering, and Medicine, Health and Medicine Division, Board on Health Sciences Policy, Forum on Drug Discovery, Development, and Translation, 2019-04-05 Randomized controlled trials (RCTs) have traditionally served as the gold standard for generating evidence about medical interventions. However, RCTs have inherent limitations and may not reflect the use of medical products in the real world. Additionally, RCTs are expensive, time consuming, and cannot answer all questions about a product or intervention. Evidence generated from real-world use, such as real-world evidence (RWE) may provide valuable information, alongside RCTs, to inform medical product decision making. To explore the potential for using RWE in medical product decision making, the National Academies of Sciences, Engineering, and Medicine planned a three-part workshop series. The series was designed to examine the current system of evidence generation and its limitations, to identify when and why RWE may be an appropriate type of evidence on which to base decisions, to learn from successful initiatives that have incorporated RWE, and to describe barriers that prevent RWE from being used to its full potential. This publication summarizes the discussions from the entire workshop series. |
| brigham and women's hospital research studies: Fostering Integrity in Research National Academies of Sciences, Engineering, and Medicine, Policy and Global Affairs, Committee on Science, Engineering, Medicine, and Public Policy, Committee on Responsible Science, 2018-01-13 The integrity of knowledge that emerges from research is based on individual and collective adherence to core values of objectivity, honesty, openness, fairness, accountability, and stewardship. Integrity in science means that the organizations in which research is conducted encourage those involved to exemplify these values in every step of the research process. Understanding the dynamics that support †or distort †practices that uphold the integrity of research by all participants ensures that the research enterprise advances knowledge. The 1992 report Responsible Science: Ensuring the Integrity of the Research Process evaluated issues related to scientific responsibility and the conduct of research. It provided a valuable service in describing and analyzing a very complicated set of issues, and has served as a crucial basis for thinking about research integrity for more than two decades. However, as experience has accumulated with various forms of research misconduct, detrimental research practices, and other forms of misconduct, as subsequent empirical research has revealed more about the nature of scientific misconduct, and because technological and social changes have altered the environment in which science is conducted, it is clear that the framework established more than two decades ago needs to be updated. Responsible Science served as a valuable benchmark to set the context for this most recent analysis and to help guide the committee's thought process. Fostering Integrity in Research identifies best practices in research and recommends practical options for discouraging and addressing research misconduct and detrimental research practices. |
| brigham and women's hospital research studies: A National Cancer Clinical Trials System for the 21st Century Institute of Medicine, Board on Health Care Services, Committee on Cancer Clinical Trials and the NCI Cooperative Group Program, 2010-07-08 The National Cancer Institute's (NCI) Clinical Trials Cooperative Group Program has played a key role in developing new and improved cancer therapies. However, the program is falling short of its potential, and the IOM recommends changes that aim to transform the Cooperative Group Program into a dynamic system that efficiently responds to emerging scientific knowledge; involves broad cooperation of stakeholders; and leverages evolving technologies to provide high-quality, practice-changing research. |
| brigham and women's hospital research studies: Cardiac Regeneration Masaki Ieda, Wolfram-Hubertus Zimmermann, 2017-10-27 This Volume of the series Cardiac and Vascular Biology offers a comprehensive and exciting, state-of-the-art work on the current options and potentials of cardiac regeneration and repair. Several techniques and approaches have been developed for heart failure repair: direct injection of cells, programming of scar tissue into functional myocardium, and tissue-engineered heart muscle support. The book introduces the rationale for these different approaches in cell-based heart regeneration and discusses the most important considerations for clinical translation. Expert authors discuss when, why, and how heart muscle can be salvaged. The book represents a valuable resource for stem cell researchers, cardiologists, bioengineers, and biomedical scientists studying cardiac function and regeneration. |
| brigham and women's hospital research studies: Powerful Medicines Jerry Avorn, M.D., 2008-12-10 If you believe that the latest blockbuster medication is worth a premium price over your generic brand, or that doctors have access to all the information they need about a drug’s safety and effectiveness each time they write a prescription, Dr. Jerry Avorn has some sobering news. Drawing on more than twenty-five years of patient care, teaching, and research at Harvard Medical School, he shares his firsthand experience of the wide gap in our knowledge of the effectiveness of one medication as compared to another. In Powerful Medicines, he reminds us that every pill we take represents a delicate compromise between the promise of healing, the risk of side effects, and an increasingly daunting price. The stakes on each front grow higher every year as new drugs with impressive power, worrisome side effects, and troubling costs are introduced. This is a comprehensive behind-the-scenes look at issues that affect everyone: our shortage of data comparing the worth of similar drugs for the same condition; alarming lapses in the detection of lethal side effects; the underuse of life-saving medications; lavish marketing campaigns that influence what doctors prescribe; and the resulting upward spiral of costs that places vital drugs beyond the reach of many Americans. In this engagingly written book, Dr. Avorn asks questions that will interest every consumer: How can a product judged safe by the Food and Drug Administration turn out to have unexpectedly lethal side effects? Why has the nation’s drug bill been growing at nearly 20 percent per year? How can physicians and patients pick the best medication in its class? How do doctors actually make their prescribing decisions, and why do those decisions sometimes go wrong? Why do so many Americans suffer preventable illnesses and deaths that proper drug use could have averted? How can the nation gain control over its escalating drug budget without resorting to rationing or draconian governmental controls? Using clinical case histories taken from his own work as a practitioner, researcher, and advocate, Dr. Avorn demonstrates the impressive power of the well-conceived prescription as well as the debacles that can result when medications are misused. He describes an innovative program that employs the pharmaceutical industry’s own marketing techniques to reduce use of some of the most overprescribed and overpriced products. Powerful Medicines offers timely and practical advice on how the nation can improve its drug-approval process, and how patients can work with doctors to make sure their prescriptions are safe, effective, and as affordable as possible. This is a passionate and provocative call for action as well as a compelling work of clear-headed science. |
| brigham and women's hospital research studies: Academic Global Surgery Mamta Swaroop, Sanjay Krishnaswami, 2015-12-17 This seventh book in the series of Success in Academic Surgery look to sustain the field and facilitate the next generation of leaders in Academic Global Surgery. It brings together a catalogue of current knowledge, needs, and pathways to a career in the field. Academic Global Surgery involves educational, research and clinical collaborations between academic humanitarian surgeons in high-income countries (HIC), their low and middle-income country (LMIC) partners and their respective academic institutions. The goal of these collaborations is improving understanding of surgical disease, and increasing access to and capacity for surgical care in resource-poor regions. In the last few years, the rapid exchange of ideas through social media and other technologies has combined with an increasing appreciation of worldwide health disparities to put the issue of global health at the forefront of our consciousness. Although traditionally neglected within public health initiatives, surgical disease is now recognized as a major contributor to death and disability worldwide, while surgical therapy in resource-poor areas is increasingly being shown to be cost-effective. In response to this growing recognition, what began as mission trips and short-term clinical volunteerism in the developing world has evolved into a burgeoning new field with a broader scope. While the tremendous recent interest from medical students and residents in Globa l Surgery has stimulated an exponential growth of interest in this field, current surgical literature has highlighted the need for further development and delineation of this new discipline within academic surgery. |
| brigham and women's hospital research studies: You Can Stop Humming Now Daniela Lamas, 2018-03-27 For readers of Atul Gawande and Jerome Groopman, a book of beautifully crafted stories about what life is like for patients kept alive by modern medical technology. Modern medicine is a world that glimmers with new technology and cutting-edge research. To the public eye, medical stories often begin with sirens and flashing lights and culminate in survival or death. But these are only the most visible narratives. As a critical care doctor treating people at their sickest, Daniela Lamas is fascinated by a different story: what comes after for those whose lives are extended by days, months, or years as a result of our treatments and technologies? You Can Stop Humming Now, Lamas explores the complex answers to this question through intimate accounts of patients and their families. A grandfather whose failing heart has been replaced by a battery-operated pump; a salesman who found himself a kidney donor on social media; a college student who survived a near fatal overdose and returned home, alive but not the same; and a young woman navigating an adulthood she never thought she'd live to see -- these moving narratives paint a detailed picture of the fragile border between sickness and health. Riveting, gorgeously told, and deeply personal, You Can Stop Humming Now is a compassionate, uncompromising look at the choices and realities that many of us, and our families, may one day face. Gripping, soaring, inspiring.-Atul Gawande, author of Being Mortal |
| brigham and women's hospital research studies: Integrative Geriatric Medicine Mikhail Kogan, 2017-12-05 Integrative Geriatric Medicine summarizes a patient-centered, wholistic approaches to medical care of the elderly. Deeply rooted in life style interventions such as nutrition, movement therapies, and mind-body and spirituality approaches integrative geriatrics allows patients to have different path to their healthcare, one that utilizes pharmaceuticals and invasive procedures only when safer integrative approaches are not available or not effective. |
| brigham and women's hospital research studies: Common Pitfalls in the Evaluation and Management of Headache Elizabeth W. Loder, Rebecca C. Burch, Paul B. Rizzoli, 2014-04-10 Discussing real-world cases, this practical guide highlights areas of diagnostic uncertainty and shows common pitfalls in headache diagnosis and treatment. |
| brigham and women's hospital research studies: In the Company of the Poor Michael Griffin, Jennie Weiss Block, 2013 This book reflects intersection between the lives, commitments, and strategies of two highly respected figures Dr. Paul Farmer and Fr. Gustavo Gutierrez joined in their option for the poor, their defense of life, and their commitment to liberation. Farmer has credited liberation theology as the inspiration for his effort to do social justice medicine, while Gutierrez has recognized Farmer's work as particularly compelling example of the option for the poor, and the impact that theology can have outside the church. Draws on their respective writings, major addresses by both at Notre Dame, and a transcript of a dialogue between them. |
| brigham and women's hospital research studies: Advances in Patient Safety Kerm Henriksen, 2005 v. 1. Research findings -- v. 2. Concepts and methodology -- v. 3. Implementation issues -- v. 4. Programs, tools and products. |
| brigham and women's hospital research studies: Pharmacoepidemiology Brian L. Strom, Stephen E. Kimmel, Sean Hennessy, 2019-12-16 Dieses Lehrbuch, ein wegweisender Klassiker, bietet in der 6. Auflage noch mehr Inhalte für Leser, die aktuelle Informationen zur Pharmakoepidemiologie benötigen. Die vorliegende Auflage wurde vollständig überarbeitet und aktualisiert. Sie bietet einen Überblick über sämtliche Facetten des Fachgebiets, aus Sicht von Lehre und Forschung, aus Sicht der Industrie und von Regulierungsbehörden. Datenquellen, Anwendungen und Methodiken werden verständlich erläutert. |
| brigham and women's hospital research studies: The Oxford Textbook of Clinical Research Ethics Ezekiel J. Emanuel, Christine C. Grady, Robert A. Crouch, Reidar K. Lie, Franklin G. Miller, David D. Wendler, 2011-02 The Oxford Textbook of Clinical Research Ethics is the first comprehensive and systematic reference on clinical research ethics. Under the editorship of experts from the U.S. National Institutes of Health of the United States, the book's 73 chapters offer a wide-ranging and systematic examination of all aspects of research with human beings. Considering the historical triumphs of research as well as its tragedies, the textbook provides a framework for analyzing the ethical aspects of research studies with human beings. Through both conceptual analysis and systematic reviews of empirical data, the contributors examine issues ranging from scientific validity, fair subject selection, risk benefit ratio, independent review, and informed consent to focused consideration of international research ethics, conflicts of interests, and other aspects of responsible conduct of research. The editors of The Oxford Textbook of Clinical Research Ethics offer a work that critically assesses and advances scholarship in the field of human subjects research. Comprehensive in scope and depth, this book will be a crucial resource for researchers in the medical sciences, as well as teachers and students. |
| brigham and women's hospital research studies: Blind Spot Salmaan Keshavjee, 2014-08-16 Neoliberalism has been the defining paradigm in global health since the latter part of the twentieth century. What started as an untested and unproven theory that the creation of unfettered markets would give rise to political democracy led to policies that promoted the belief that private markets were the optimal agents for the distribution of social goods, including health care. A vivid illustration of the infiltration of neoliberal ideology into the design and implementation of development programs, this case study, set in post-Soviet Tajikistan’s remote eastern province of Badakhshan, draws on extensive ethnographic and historical material to examine a “revolving drug fund” program—used by numerous nongovernmental organizations globally to address shortages of high-quality pharmaceuticals in poor communities. Provocative, rigorous, and accessible, Blind Spot offers a cautionary tale about the forces driving decision making in health and development policy today, illustrating how the privatization of health care can have catastrophic outcomes for some of the world’s most vulnerable populations. |
| brigham and women's hospital research studies: Clinical Trials in Heart Disease JoAnn E. Manson, 2004 This new edition covers important new trials in cardiology therapies and prevention of cardiovascular problems. The world authorities on pharmacologic clinical trials write about the trials, the outcomes and importance for clinical practice. This book gives the general cardiologist insight into the development of new therapies in cardiology as well as the process of how trials were used for those therapies. In addition to providing a manual for how to establish trials, trials for treatment and prevention are covered. |
| brigham and women's hospital research studies: Brachytherapy Phillip M. Devlin, 2007 Written by the foremost experts in the field, this volume is a comprehensive text and practical reference on contemporary brachytherapy. The book provides detailed, site-specific information on applications and techniques of brachytherapy in the head and neck, central nervous system, breast, thorax, gastrointestinal tract, and genitourinary tract, as well as on gynecologic brachytherapy, low dose rate and high dose rate sarcoma brachytherapy, vascular brachytherapy, and pediatric applications. The book thoroughly describes and compares the four major techniques used in brachytherapy—intracavity, interstitial, surface-dose or mold therapy, and transluminal. Chapters detail particular techniques that are appropriate in specific clinical situations. |
| brigham and women's hospital research studies: Evolution of Translational Omics Institute of Medicine, Board on Health Sciences Policy, Board on Health Care Services, Committee on the Review of Omics-Based Tests for Predicting Patient Outcomes in Clinical Trials, 2012-09-13 Technologies collectively called omics enable simultaneous measurement of an enormous number of biomolecules; for example, genomics investigates thousands of DNA sequences, and proteomics examines large numbers of proteins. Scientists are using these technologies to develop innovative tests to detect disease and to predict a patient's likelihood of responding to specific drugs. Following a recent case involving premature use of omics-based tests in cancer clinical trials at Duke University, the NCI requested that the IOM establish a committee to recommend ways to strengthen omics-based test development and evaluation. This report identifies best practices to enhance development, evaluation, and translation of omics-based tests while simultaneously reinforcing steps to ensure that these tests are appropriately assessed for scientific validity before they are used to guide patient treatment in clinical trials. |
| brigham and women's hospital research studies: Implementing a National Cancer Clinical Trials System for the 21st Century Institute of Medicine, Board on Health Care Services, National Cancer Policy Forum, 2011-09-19 Clinical trials enable scientific discoveries to advance patient care, in addition to informing and guiding subsequent research. The National Cancer Institute's (NCI's) Clinical Trials Cooperative Group Program works to advance patient care and research. The Cooperative Group Program has been instrumental in establishing the standards for cancer patient care and clinical research methods. Despite broad participation in the program, financial strain and procedural burdens limit the ability of the Cooperative Group Program to undertake medical practice-changing clinical research. Thus, the Institute of Medicine's (IOM's) National Cancer Policy Forum and the American Society of Clinical Oncology held a workshop on March 21, 2011 to follow up on the 2010 IOM report, A National Clinical Trials System for the 21st Century: Reinvigorating the NCI Cooperative Group Program, which made recommendations to strengthen the NCI Cooperative Group Program. In keeping with the established commitment to excellence Implementing a National Cancer Clinical Trials System for the 21st Century outlines how to improve the current system by incorporating innovative science and trial design into cancer clinical trials. It also examines the impact of increasing quality in regards to speed, efficiency, design, launch, and conduct, as well as improving prioritization, and incentivized participation. |
| brigham and women's hospital research studies: Psychedelic Neuroscience Tanya Calvey, 2018-11-21 We are in the midst of what is being called the 'psychedelic renaissance' with growing interest into how psychedelics alter consciousness, brain function and brain connectivity. The acute, often profound, effects of the psychedelic experience can induce lasting improvements in mental health demonstrating that chemistry forms the basis of mystical experience, consciousness and mental wellbeing. - This volume is a collection of chapters by world leaders in fields of neurobiology, neuropsychiatry, psychology, ethnography and pharmacology, addressing the neurobiological mechanisms of action of various classic and atypical psychedelics, their therapeutic potential as well as the possible risks associated with their use |
| brigham and women's hospital research studies: Food Insecurity and Public Health Louise Ivers, 2015-05-06 Affecting more than 800 million people, food insecurity is a global problem that runs deeper than hunger and undernutrition. In addition to the obvious impact on physical well-being, food insecurity can result in risky coping strategies, increased expenditures on medical costs or transportation, and mental health issues. A review of the concepts an |
| brigham and women's hospital research studies: The Resolution of Inflammation Adriano Rossi, Deborah A. Sawatzky, 2008-03-17 This book provides readers with an up-to-date and comprehensive view on the resolution of inflammation and on new developments in this area, including pro-resolution mediators, apoptosis, macrophage clearance of apoptotic cells, possible novel drug developments. |
| brigham and women's hospital research studies: Pediatric and Adolescent Gynecology S. Jean Herriot Emans, Marc R. Laufer, Donald Peter Goldstein, 2005 The #1 clinical reference on pediatric and adolescent gynecology is now in its updated Fifth Edition. Written by experts from The Children's Hospital in Boston and other leading medical centers, this handbook presents contemporary approaches to diagnosis and medical and surgical management of gynecologic problems in infants, children and adolescents. This edition features cutting-edge information on urology and complementary and alternative medicine and expanded coverage of surgical techniques for correcting structural abnormalities of the reproductive tract. More than 400 illustrations—including 8 pages of full-color plates—complement the text. The book also includes outstanding algorithms and tables and abundant case examples. |
Boston Hospital & Medical Center | Brigham and Women's Hospital
Brigham and Women’s Hospital is one of the top hospitals in America with more than 790 beds, and a premier teaching hospital of Harvard Medical School. Learn more.
About Brigham and Women's Hospital| Brigham and Women's …
Brigham and Women’s Hospital is a world-class academic medical center based in Boston, Massachusetts. The Brigham serves patients from New England, across the United States and …
Brigham and Women's Hospital, 75 Francis St, Boston, MA, 02115
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Gynecology Services - Brigham and Women's Hospital
Learn about Brigham and Women's Gynecology Services for comprehensive gynecologic care including infertility, pain and bleeding issues, abnormal pap smears, and more.
Boston Hospital & Medical Center | Brigham and Women's Hospital
Brigham and Women’s Hospital is one of the top hospitals in America with more than 790 beds, and a premier teaching hospital of Harvard Medical School. Learn more.
About Brigham and Women's Hospital| Brigham and Women's …
Brigham and Women’s Hospital is a world-class academic medical center based in Boston, Massachusetts. The Brigham serves patients from New England, across the United States and …
Brigham and Women's Hospital, 75 Francis St, Boston, MA, 02115
Find location parking, directions, and phone number for Brigham and Women's Hospital, 75 Francis St (main campus entrance), Boston, MA, 02115.
Brigham and Women's Hospital Locations and Affiliates
Find information including directions, parking and contact information for Brigham and Women's Hospital main campus in the greater Boston area and New England.
Find a Doctor Call 1-855-278-8010 - Brigham and Women's Hospital
Call Brigham and Women’s new patient toll-free number at 1-855-278-8010 or search our physician directory by name, medical specialty, and location.
Orthopaedic Surgery - Brigham and Women's Hospital
The Department of Orthopaedic Surgery at Brigham and Women’s Hospital has one of the largest and most comprehensive teams of orthopaedic specialists available anywhere, offering a full …
Apply for a Job/Search Open Positions | Brigham and Women's …
Search for open positions to apply for a clinical, research or professional job at Brigham and Women's Hospital.
Finding a Doctor - Brigham and Women's Hospital
Learn more about the doctors at Brigham and Women's Hospital and how to find the right physician for you.
Patient Login Gateway Access - Brigham and Women's Hospital
Access your secure Patient Gateway online account to view your health record information and physician communications at Brigham and Women's Hospital.
Gynecology Services - Brigham and Women's Hospital
Learn about Brigham and Women's Gynecology Services for comprehensive gynecologic care including infertility, pain and bleeding issues, abnormal pap smears, and more.
