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| copper free click chemistry: Click Chemistry for Biotechnology and Materials Science Joerg Lahann, 2009-11-23 Mimicking natural biochemical processes, click chemistry is a modular approach to organic synthesis, joining together small chemical units quickly, efficiently and predictably. In contrast to complex traditional synthesis, click reactions offer high selectivity and yields, near-perfect reliability and exceptional tolerance towards a wide range of functional groups and reaction conditions. These ‘spring loaded’ reactions are achieved by using a high thermodynamic driving force, and are attracting tremendous attention throughout the chemical community. Originally introduced with the focus on drug discovery, the concept has been successfully applied to materials science, polymer chemistry and biotechnology. The first book to consider this topic, Click Chemistry for Biotechnology and Materials Science examines the fundamentals of click chemistry, its application to the precise design and synthesis of macromolecules, and its numerous applications in materials science and biotechnology. The book surveys the current research, discusses emerging trends and future applications, and provides an important nucleation point for research. Edited by one of the top 100 young innovators with the greatest potential to have an impact on technology in the 21st century according to Technology Review and with contributions from pioneers in the field, Click Chemistry for Biotechnology and Materials Science provides an ideal reference for anyone wanting to learn more about click reactions. |
| copper free click chemistry: Click Reactions in Organic Synthesis Srinivasan Chandrasekaran, 2016-09-13 Endlich ein Buch zu Click-Reaktionen mit Schwerpunkt auf der organischen Synthese. Beschrieben werden das Click-Konzept, die zugrunde liegenden Mechanismen und Hauptanwendungsgebiete. NÜTZLICH: Die Click-Chemie ist ein wirkungsvoller Ansatz, um auf einfache Weise komplexe organische Moleküle aus verfügbaren Ausgangsmaterialien zu erzeugen ? der Traum jedes Organikers. EINZIGARTIGER SCHWERPUNKT: Aufgrund des besonderen Schwerpunkts auf der organischen Synthese ist dieses Buch für jeden Synthesechemiker von hohem Interesse. HILFREICH: Click-Reaktionen sind stereospezifisch, einfach durchzuführen, hoch ergiebig und lassen sich in einfach zu entfernenden oder nicht schädlichen Lösungsmitteln durchführen. INTERDISZIPLINÄR: Das Click-Konzept ist bei der Herstellung natürlicher Produkte, bioaktiver Verbindungen, von Kohlenhydraten, Arzneimitteln, Polymeren, supramolekularer Strukturen und Materialien weit verbreitet. |
| copper free click chemistry: Click Triazoles Janez Košmrlj, 2012-05-30 B. R. Buckley and H. Heaney: Mechanistic Investigations of Copper(I)- Catalyzed Alkyne–Azide Cycloaddition Reactions.- J. D. Crowley and D. A. McMorran: “Click-Triazole” Coordination Chemistry: Exploiting 1,4-Disubstituted-1,2,3-Triazoles as Ligands.- S. Lee and A. H. Flood: Binding Anions in Rigid and Reconfigurable Triazole Receptors.- M. Watkinson: Click Triazoles as Chemosensors.- H.-F. Chow, C.-M. Lo and Y. Chen: Triazole-Based Polymer Gels.- T. Zheng, S. H. Rouhanifard, A. S. Jalloh, P. Wu: Click Triazoles for Bioconjugation.- S. Mignani, Y. Zhou, T. Lecourt and L. Micouin: Recent Developments in the Synthesis 1,4,5-Trisubstituted Triazoles. |
| copper free click chemistry: Chemical Glycobiology Randall Halcomb, American Chemical Society. Meeting, Peng George Wang, 2008 This ACS symposium book on Chemical Glycobiology summarizes the current status of the chemical techniques and tools developed to study the biological roles of carbohydrates and glycoconjugates. It is suitable for chemists and biochemists who are interested in synthesizing, understanding, and applying carbohydrate-related molecules or manipulating biological systems using carbohydrates. |
| copper free click chemistry: Development of Copper-free Click Chemistry and Application to Imaging Glycans in Living Systems Jeremy Michael Baskin, 2009 |
| copper free click chemistry: Green Chemistry Hosam El-Din M. Saleh, Martin Koller, 2018-02-28 To an increasing extent, green chemistry is a new chemical and engineering approach of chemistry and engineering, dedicated to make manufacturing processes and our world as a whole more sustainable world with a growing tendency. Green chemistry approaches are based on ecofriendly technologies, aiming to reduce or eliminate the use of solvents, or render them efficient and safer. Moreover, this scientific field is devoted to reduction or elimination of prevailing environmental and health threats, which typically accompany chemical products and traditional processes. The present book Green Chemistry contains 9 selected chapters, starting with a general introductory chapter on green chemistry, and covers many recent applications and developments based on the principles of green chemistry. This book is considered the appropriate way to communicate the advances in green materials and their applications to the scientific community. Chemists, scientists and researchers from related areas, and undergraduates involved in environmental issues and interested in approaches to improve the quality of life could find an inspiring and effective guide by reading this book. |
| copper free click chemistry: Computational and Experimental Studies Y. Villacampa, G.M. Carlomagno, S. Ivorra, C. A. Brebbia, 2018-03-28 Comprising specially selected papers on the subject of Computational Methods and Experimental Measurements, this book includes research from scientists, researchers and specialists who perform experiments, develop computer codes and carry out measurements on prototypes. Improvements relating to computational methods have generated an ever-increasing expansion of computational simulations that permeate all fields of science and technology. Validating the results of these improvements can be achieved by carrying out committed and accurate experiments, which have undertaken continuous development. Current experimental techniques have become more complex and sophisticated so that they require the intensive use of computers, both for running experiments as well as acquiring and processing the resulting data. This title explores new experimental and computational methods and covers various topics such as: Computer-aided Models; Image Analysis Applications; Noise Filtration of Shockwave Propagation; Finite Element Simulations. |
| copper free click chemistry: Handbook of In Vivo Chemistry in Mice Katsunori Tanaka, Kenward Vong, 2020-04-27 Provides timely, comprehensive coverage of in vivo chemical reactions within live animals This handbook summarizes the interdisciplinary expertise of both chemists and biologists performing in vivo chemical reactions within live animals. By comparing and contrasting currently available chemical and biological techniques, it serves not just as a collection of the pioneering work done in animal-based studies, but also as a technical guide to help readers decide which tools are suitable and best for their experimental needs. The Handbook of In Vivo Chemistry in Mice: From Lab to Living System introduces readers to general information about live animal experiments and detection methods commonly used for these animal models. It focuses on chemistry-based techniques to develop selective in vivo targeting methodologies, as well as strategies for in vivo chemistry and drug release. Topics include: currently available mouse models; biocompatible fluorophores; radionuclides for radiodiagnosis/radiotherapy; live animal imaging techniques such as positron emission tomography (PET) imaging; magnetic resonance imaging (MRI); ultrasound imaging; hybrid imaging; biocompatible chemical reactions; ligand-directed nucleophilic substitution chemistry; biorthogonal prodrug release strategies; and various selective targeting strategies for live animals. -Completely covers current techniques of in vivo chemistry performed in live animals -Describes general information about commonly used live animal experiments and detection methods -Focuses on chemistry-based techniques to develop selective in vivo targeting methodologies, as well as strategies for in vivo chemistry and drug release -Places emphasis on material properties required for the development of appropriate compounds to be used for imaging and therapeutic purposes in preclinical applications Handbook of In Vivo Chemistry in Mice: From Lab to Living System will be of great interest to pharmaceutical chemists, life scientists, and organic chemists. It will also appeal to those working in the pharmaceutical and biotechnology industries. |
| copper free click chemistry: Peptide, Protein and Enzyme Design , 2016-08-27 De Novo Enzyme Design, the newest volume in the Methods in Enzymology series, continues the legacy of this premier serial with quality chapters authored by leaders in the field. This volume includes the design of metal binding maquettes, insertion of non-natural cofactors, Cu metallopeptides, non-covalent interactions in peptide assemblies, peptide binding and bundling, heteronuclear metalloenzymes, florinated peptides, De Novo imaging agents, and protein-protein interaction. - Continues the legacy of this premier serial with quality chapters on de novo enzyme design - Represents the newest volume in the Methods in Enzymology series, providing premier, quality chapters authored by leaders in the field - Ideal reference for those interested in the study of enzyme design that looks at both structure and mechanism |
| copper free click chemistry: Click Chemistry Vinod K. Tiwari, |
| copper free click chemistry: Radiopharmaceutical Chemistry Jason S. Lewis, Albert D. Windhorst, Brian M. Zeglis, 2019-04-02 This book is a comprehensive guide to radiopharmaceutical chemistry. The stunning clinical successes of nuclear imaging and targeted radiotherapy have resulted in rapid growth in the field of radiopharmaceutical chemistry, an essential component of nuclear medicine and radiology. However, at this point, interest in the field outpaces the academic and educational infrastructure needed to train radiopharmaceutical chemists. For example, the vast majority of texts that address radiopharmaceutical chemistry do so only peripherally, focusing instead on nuclear chemistry (i.e. nuclear reactions in reactors), heavy element radiochemistry (i.e. the decomposition of radioactive waste), or solely on the clinical applications of radiopharmaceuticals (e.g. the use of PET tracers in oncology). This text fills that gap by focusing on the chemistry of radiopharmaceuticals, with key coverage of how that knowledge translates to the development of diagnostic and therapeutic radiopharmaceuticals for the clinic. The text is divided into three overarching sections: First Principles, Radiochemistry, and Special Topics. The first is a general overview covering fundamental and broad issues like “The Production of Radionuclides” and “Basics of Radiochemistry”. The second section is the main focus of the book. In this section, each chapter’s author will delve much deeper into the subject matter, covering both well established and state-of-the-art techniques in radiopharmaceutical chemistry. This section will be divided according to radionuclide and will include chapters on radiolabeling methods using all of the common nuclides employed in radiopharmaceuticals, including four chapters on the ubiquitously used fluorine-18 and a “Best of the Rest” chapter to cover emerging radionuclides. Finally, the third section of the book is dedicated to special topics with important information for radiochemists, including “Bioconjugation Methods,” “Click Chemistry in Radiochemistry”, and “Radiochemical Instrumentation.” This is an ideal educational guide for nuclear medicine physicians, radiologists, and radiopharmaceutical chemists, as well as residents and trainees in all of these areas. |
| copper free click chemistry: Click Chemistry in Glycoscience Zbigniew J. Witczak, Roman Bielski, 2013-03-18 Lays the foundation for new methods and applications of carbohydrate click chemistry Introduced by K. Barry Sharpless of The Scripps Research Institute in 2001, click chemistry mimics nature, giving researchers the tools needed to generate new substances quickly and reliably by joining small units together. With contributions from more than thirty pioneering researchers in the field, this text explores the many promising applications of click chemistry in glycoscience. Readers will learn both the basic concepts of carbohydrate click chemistry as well as its many biomedical applications, including synthetic antigens, analogs of cell-surface receptors, immobilized enzymes, targeted drug delivery systems, and multivalent cancer vaccines. Click Chemistry in Glycoscience examines a broad range of methodologies and strategies that have emerged from this rapidly evolving field. Each chapter describes new approaches, ideas, consequences, and applications resulting from the introduction of click processes. Divided into four sections, the book covers: Click chemistry strategies and decoupling Thio-click chemistry of carbohydrates Carbohydrate click chemistry for novel synthetic targets Carbohydrate click chemistry in biomedical sciences Thoroughly researched, the book reflects the most recent findings published in the literature. Diagrams and figures throughout the book enable readers to more easily grasp complex concepts and reaction processes. At the end of each chapter, references lead to the primary literature for further investigation of individual topics. The application of click chemistry to carbohydrates has tremendous implications for research. With this book as their guide, researchers have a solid foundation from which they can develop new methods and applications of carbohydrate click chemistry, including new carbohydrate-based therapeutics. |
| copper free click chemistry: Bioconjugate Techniques Greg T. Hermanson, 2010-07-26 Bioconjugate Techniques, 2nd Edition, is the essential guide to the modification and cross linking of biomolecules for use in research, diagnostics, and therapeutics. It provides highly detailed information on the chemistry, reagent systems, and practical applications for creating labeled or conjugate molecules. It also describes dozens of reactions with details on hundreds of commercially available reagents and the use of these reagents for modifying or cross linking peptides and proteins, sugars and polysaccharides, nucleic acids and oligonucleotides, lipids, and synthetic polymers. A one-stop source for proven methods and protocols for synthesizing bioconjugates in the lab Step-by-step presentation makes the book an ideal source for researchers who are less familiar with the synthesis of bioconjugates More than 600 figures that visually describe the complex reactions associated with the synthesis of bioconjugates Includes entirely new chapters on the latest areas in the field of bioconjugation as follows: Microparticles and nanoparticlesSilane coupling agentsDendrimers and dendronsChemoselective ligationQuantum dotsLanthanide chelatesCyanine dyesDiscrete PEG compoundsBuckyballs,fullerenes, and carbon nanotubesMass tags and isotope tagsBioconjugation in the study of protein interactions |
| copper free click chemistry: Visible Light Photocatalysis in Organic Chemistry Corey R.J. Stephenson, Tehshik P. Yoon, David W.C. MacMillan, 2018-05-29 Filling the need for a ready reference that reflects the vast developments in this field, this book presents everything from fundamentals, applications, various reaction types, and technical applications. Edited by rising stars in the scientific community, the text focuses solely on visible light photocatalysis in the context of organic chemistry. This primarily entails photoinduced electron transfer and energy transfer chemistry sensitized by polypyridyl complexes, yet also includes the use of organic dyes and heterogeneous catalysts. A valuable resource to the synthetic organic community, polymer and medicinal chemists, as well as industry professionals. |
| copper free click chemistry: Science of Synthesis: Click Chemistry Floris P. J. T. Rutjes, 2021-11-24 This reference work presents the state-of-the-art in the field of click chemistry, collecting the most useful, practical, and reliable methods. Click chemistry is a discipline that has grown rapidly since the introduction of this term by Barry Sharpless and Huisgen approximately two decades ago. Initially, click reactions mostly involved copper-catalyzed azide-alkyne cycloadditions and their applications to connect molecules, but gradually new types of click reactions were developed which also allowed a much wider range of applications throughout the chemical, biological, and materials sciences. This volume provides an overview of the most widely used click reactions and their scope and limitations. Written by pioneers and leaders in the field and including representative applications and experimental procedures. Newcomers to the field are enabled to instantly apply these reactions in synthesis. |
| copper free click chemistry: C-H Bond Activation in Organic Synthesis Jie Jack Li, 2015-04-07 Greener than conventional methods, C-H activation methods have flourished during the last decade and become especially attractive to organic chemists. Edited by a practioner in this rapidly developing field, C-H Bond Activation in Organic Synthesis provides an overview of this exciting playground of chemistry. The book summarizes the state of the a |
| copper free click chemistry: Click Chemistry for Biotechnology and Materials Science Joerg Lahann, 2009-12-15 Mimicking natural biochemical processes, click chemistry is a modular approach to organic synthesis, joining together small chemical units quickly, efficiently and predictably. In contrast to complex traditional synthesis, click reactions offer high selectivity and yields, near-perfect reliability and exceptional tolerance towards a wide range of functional groups and reaction conditions. These ‘spring loaded’ reactions are achieved by using a high thermodynamic driving force, and are attracting tremendous attention throughout the chemical community. Originally introduced with the focus on drug discovery, the concept has been successfully applied to materials science, polymer chemistry and biotechnology. The first book to consider this topic, Click Chemistry for Biotechnology and Materials Science examines the fundamentals of click chemistry, its application to the precise design and synthesis of macromolecules, and its numerous applications in materials science and biotechnology. The book surveys the current research, discusses emerging trends and future applications, and provides an important nucleation point for research. Edited by one of the top 100 young innovators with the greatest potential to have an impact on technology in the 21st century according to Technology Review and with contributions from pioneers in the field, Click Chemistry for Biotechnology and Materials Science provides an ideal reference for anyone wanting to learn more about click reactions. |
| copper free click chemistry: N-Heterocyclic Carbenes in Transition Metal Catalysis Frank Glorius, 2007-02-05 In this book leading experts have surveyed major areas of application of NHC metal complexes in catalysis. The authors have placed a special focus on nickel- and palladium-catalyzed reactions, on applications in metathesis reactions, on oxidation reactions and on the use of chiral NHC-based catalysts. This compilation is rounded out by an introductory chapter and a chapter dealing with synthetic routes to NHC metal complexes. |
| copper free click chemistry: Click Polymerization Anjun Qin, Ben Zhong Tang, 2018-08-28 Click Polymerization has been edited by world renowned experts and provides an authoritative guide to this reaction type. |
| copper free click chemistry: Copper-Mediated Cross-Coupling Reactions Gwilherm Evano, Nicolas Blanchard, 2013-11-11 Providing comprehensive insight into the use of copper in cross-coupling reactions, Copper-Mediated Cross-Coupling Reactions provides a complete up-to-date collection of the available reactions and catalytic systems for the formation of carbon-heteroatom and carbon-carbon bonds. This essential reference covers a broad scope of copper-mediated reactions, their variations, key advances, improvements, and an array of academic and industrial applications that have revolutionized the field of organic synthesis. The text also discusses the mechanism of these transformations, the use of copper as cost-efficient alternative to palladium, as well as recently developed methods for conducting copper-mediated reactions with supported catalysts. |
| copper free click chemistry: Bioactive Surfaces Hans G. Börner, Jean-Francois Lutz, 2013-08-03 Erik Wischerhoff, Nezha Badi, André Laschewsky and Jean-François Lutz Smart Polymer Surfaces: Concepts and Applications in Biosciences; S. Petersen, M. Gattermayer and M. Biesalski Hold on at the Right Spot: Bioactive Surfaces for the Design of Live-Cell Micropatterns; Julien Polleux Interfacing Cell Surface Receptors to Hybrid Nanopatterned Surfaces: A Molecular Approach for Dissecting the Adhesion Machinery; Abigail Pulsipher and Muhammad N. Yousaf Self-Assembled Monolayers as Dynamic Model Substrates for Cell Biology; D. Volodkin, A. Skirtach and H. Möhwald LbL Films as Reservoirs for Bioactive Molecules; R. Gentsch and H. G. Börner Designing Three-Dimensional Materials at the Interface to Biology; Joerg C. Tiller Antimicrobial Surfaces; |
| copper free click chemistry: Organic Polymers Arpit Sand, Elsayed Zaki, 2020-03-11 This book, Organic Polymers, covers aspects that are of immediate concern to a new entrant to the field of polymers. Taken as a whole, these eight chapters aim to help the readers easily assimilate other specialized and exhaustive treatises on the subject. Topics dealing with the chemistry and technology of polymers are presented in a careful and logical manner so as to provide an easy and enjoyable read. Several examples and analogies are included so to make the main concepts easy to follow and tables and figures are included so that the book can serve, to a limited extent, as a hand book dealing with polysaccharides with different parameters. This book is meant for students studying polysaccharides and those working on graft copolymers and other allied polymer industries but without a formal educational background in organic polymers. |
| copper free click chemistry: Merck's Index , 1907 |
| copper free click chemistry: The Chemistry of Gold Extraction John Marsden, Iain House, 2006 Extensively revised and updated, this edition provides the broad base of knowledge required by all working in the gold extraction and gold processing industries. It bridges the gap between research and industry by emphasizing practical applications of chemical principles and techniques. |
| copper free click chemistry: Respecting Truth Lee McIntyre, 2015-06-05 Throughout history, humans have always indulged in certain irrationalities and held some fairly wrong-headed beliefs. But in his newest book, philosopher Lee McIntyre shows how we've now reached a watershed moment for ignorance in the modern era, due to the volume of misinformation, the speed with which it can be digitally disseminated, and the savvy exploitation of our cognitive weaknesses by those who wish to advance their ideological agendas. In Respecting Truth: Willful Ignorance in the Internet Age, McIntyre issues a call to fight back against this slide into the witless abyss. In the tradition of Galileo, the author champions the importance of using tested scientific methods for arriving at true beliefs, and shows how our future survival is dependent on a more widespread, reasonable world. |
| copper free click chemistry: Chemistry 2e Paul Flowers, Richard Langely, William R. Robinson, Klaus Hellmut Theopold, 2019-02-14 Chemistry 2e is designed to meet the scope and sequence requirements of the two-semester general chemistry course. The textbook provides an important opportunity for students to learn the core concepts of chemistry and understand how those concepts apply to their lives and the world around them. The book also includes a number of innovative features, including interactive exercises and real-world applications, designed to enhance student learning. The second edition has been revised to incorporate clearer, more current, and more dynamic explanations, while maintaining the same organization as the first edition. Substantial improvements have been made in the figures, illustrations, and example exercises that support the text narrative. Changes made in Chemistry 2e are described in the preface to help instructors transition to the second edition. |
| copper free click chemistry: Macromolecular Syntheses Charles Gilbert Overberger, 2002 This book is an up-to-date collection of presentations and posters given at a tutorial and workshop sponsored by the Polymer Division of the American Chemical Society. The material included encompasses recent research results, overviews of critical areas and short presentations in the form of posters and preprints. The book is targeted at established workers in the field of fluoropolymers as well as those wishing to develop a quick understanding of current knowledge and trends in this important field. |
| copper free click chemistry: Interventional Nuclear Medicine Richard Paul Spencer, 1984 |
| copper free click chemistry: Click Chemistry Chen Yu, Tong Zong Rui, 2017 Click chemistry, which is also referred to as linkage chemistry, dynamic, combinatorial chemistry or quick linking combinatorial chemistry describes the reaction that joins molecular fragments as simply, efficient and versatile as clicking a mouse. The two units with specific click structures can be linked by a click reaction no matter what is attached to the structure, and only the specific click structures can be joined. It emphasises the development of new combinatorial chemistries on the basis of the synthesis of efficient and highly selective carbon-heteroatom bonds (C-X-C), and effectively prepares molecules with high diversity via these simple reactions. It significantly simplified and promoted the development of synthesis chemistry. Click chemistry has become one of the most useful and attractive synthetic strategies in many fields. In this book, the definition of click chemistry is explained, the characteristics and types of click chemistry are introduced, and some specific reaction types are focused on. The progress for using click chemistry for the synthesis and functionalisation of hydrogels, elastomers, surface modifications, membrane preparations, assemble polyaromatic structures, biomedical fields and optical sensing in biological analyses are described in detail. The problems and challenges for using click chemistry in different fields are analysed. |
| copper free click chemistry: Amide Bond Activation Michal Szostak, 2019-07-12 The amide bond represents a privileged motif in chemistry. The recent years have witnessed an explosion of interest in the development of new chemical transformations of amides. These developments cover an impressive range of catalytic N–C bond activation in electrophilic, Lewis acid, radical, and nucleophilic reaction pathways, among other transformations. Equally relevant are structural and theoretical studies that provide the basis for chemoselective manipulation of amidic resonance. This monograph on amide bonds offers a broad survey of recent advances in activation of amides and addresses various approaches in the field. |
| copper free click chemistry: Comprehensive Practical Chemistry XII Dr. N . K. Verma, B. K. Vermani, Dr. Neera Verma, K . K. Rehani, 2011-11 |
| copper free click chemistry: Activity-Based Protein Profiling Benjamin F. Cravatt, Ku-Lung Hsu, Eranthie Weerapana, 2019-01-25 This volume provides a collection of contemporary perspectives on using activity-based protein profiling (ABPP) for biological discoveries in protein science, microbiology, and immunology. A common theme throughout is the special utility of ABPP to interrogate protein function and small-molecule interactions on a global scale in native biological systems. Each chapter showcases distinct advantages of ABPP applied to diverse protein classes and biological systems. As such, the book offers readers valuable insights into the basic principles of ABPP technology and how to apply this approach to biological questions ranging from the study of post-translational modifications to targeting bacterial effectors in host-pathogen interactions. |
| copper free click chemistry: Modified Nucleic Acids Kazuhiko Nakatani, Yitzhak Tor, 2016-04-04 This book spans diverse aspects of modified nucleic acids, from chemical synthesis and spectroscopy to in vivo applications, and highlights studies on chemical modifications of the backbone and nucleobases. Topics discussed include fluorescent pyrimidine and purine analogs, enzymatic approaches to the preparation of modified nucleic acids, emission and electron paramagnetic resonance (EPR) spectroscopy for studying nucleic acid structure and dynamics, non-covalent binding of low- and high-MW ligands to nucleic acids and the design of unnatural base pairs. This unique book addresses new developments and is designed for graduate level and professional research purposes. |
| copper free click chemistry: Cisplatin Bernhard Lippert, 1999 30 years after its discovery as an antitumor agent, cisplatin represents today one of the most successful drugs in chemotherapy. This book is intended to reminisce this event, to take inventory, and to point out new lines of development in this field. Divided in 6 sections and 22 chapters, the book provides an up-to-date account on topics such as - the chemistry and biochemistry of cisplatin, - the clinical status of Pt anticancer drugs, - the impact of cisplatin on inorganic and coordination chemistry, - new developments in drug design, testing and delivery. It also includes a chapter describing the historical development of the discovery of cisplatin. The ultimate question - How does cisplatin kill a cell? - is yet to be answered, but there are now new links suggesting how Pt binding to DNA may trigger a cascade of cellular reactions that eventually result in apoptosis. p53 and a series of damage recognition proteins of the HMG-domain family appear to be involved. The book addresses the problem of mutagenicity of Pt drugs and raises the question of the possible relevance of the minor DNA adducts, e.g. of interstrand cross-links, and the possible use of trans-(NH3)2Pt(II)-modified oligonucleotides in antisense and antigene strategies. Our present understanding of reactions of cisplatin with DNA is based upon numerous model studies (from isolated model nucleobases to short DNA fragments) and application of a large body of spectroscopic and other physico-chemical techniques. Thanks to these efforts there is presently no other metal ion whose reactions with nucleic acids are better understood than Pt. In a series of chapters, basic studies on the interactions of Pt electrophiles with nucleobases, oligonucleotides, DNA, amino acids, peptides and proteins are reported, which use, among others, sophisticated NMR techniques or X-ray crystallography, to get remarkable understanding of details on such reactions. Reactivity of cisplatin, once bound to DNA and formerly believed to be inert enough to stay, is an emerging phenomenon. It has (not yet) widely been studied but is potentially extremely important. Medicinal bioinorganic chemistry - the role of metal compounds in medicine - has received an enormous boost from cisplatin, and so has bioinorganic chemistry as a whole. There is hardly a better example than cisplatin to demonstrate what bioinorganic chemistry is all about: The marriage between classic inorganic (coordination) chemistry and the other life sciences - medicine, pharmacy, biology, biochemistry. Cisplatin has left its mark also on areas that are generally considered largely inorganic. The subject of mixed-valance Pt compounds is an example: From the sleeping beauty it made its way to the headlines of scientific journals, thanks to a class of novel Pt antitumor agents, the so-called platinum pyrimidine blues. In the aftermath diplatinum (III) compounds were recognized and studies in large numbers, and now an organometalic chemistry of these diplatinum (III) species is beginning to emerge. The final section of the book is concerned with new developments such as novel di- and trinuclear Pt(II) drugs with DNA binding properties different from those of cisplatin, with orally active Pt(IV) drugs which are presently in clinical studies, and with attempts to modify combinatorial chemistry in such a way that it may become applicable to fast screening of Pt antitumor drugs. The potential of including computational methods in solving questions of Pt-DNA interactions is critically dealt with in the concluding chapter. |
| copper free click chemistry: Peptide-Based Materials Timothy Deming, 2012-01-10 Synthesis of Polypeptides by Ring-Opening Polymerization of α-Amino Acid N-Carboxyanhydrides, by Jianjun Cheng and Timothy J. Deming.- Peptide Synthesis and Self-Assembly, by S. Maude, L. R. Tai, R. P. W. Davies, B. Liu, S. A. Harris, P. J. Kocienski and A. Aggeli.- Elastomeric Polypeptides, by Mark B. van Eldijk, Christopher L. McGann, Kristi L. Kiick andJan C. M. van Hest.- Self-Assembled Polypeptide and Polypeptide Hybrid Vesicles: From Synthesis to Application, by Uh-Joo Choe, Victor Z. Sun, James-Kevin Y. Tan and Daniel T. Kamei.- Peptide-Based and Polypeptide-Based Hydrogels for Drug Delivery and Tissue Engineering, by Aysegul Altunbas and Darrin J. Pochan.- |
| copper free click chemistry: Transition Metal and Rare Earth Compounds Hartmut Yersin, 2014-03-12 There exists a large literature on the spectroscopic properties of copper(II) com- 9 pounds. This is due to the simplicity of the d electron configuration, the wide variety of stereochemistries that copper(II) compounds can adopt, and the f- xional geometric behavior that they sometimes exhibit [1]. The electronic and geometric properties of a molecule are inexorably linked and this is especially true with six-coordinate copper(II) compounds which are subject to a Jahn-T- ler effect.However,the spectral-structural correlations that are sometimes d- wn must often be viewed with caution as the information contained in a typical solution UV-Vis absorption spectrum of a copper(II) compound is limited. Meaningful spectral-structural correlations can be obtained in a related series of compounds where detailed spectroscopic data is available. In the fol- 4– lowing sections two such series are examined; the six-coordinate CuF and 6 2+ Cu(H O) ions doped as impurities in single crystal hosts.Using low tempera- 2 6 ture polarized optical spectroscopy and electron paramagnetic resonance, a very detailed picture can be drawn about the geometry of these ions in both their ground and excited electronic states. We then compare the spectrosco- cally determined structural data with that obtained from X-ray diffraction or EXAFS measurements. |
| copper free click chemistry: Cycloadditions in Bioorthogonal Chemistry Milan Vrabel, Thomas Carell, 2016-05-28 The series Topics in Current Chemistry Collections presents critical reviews from the journal Topics in Current Chemistry organized in topical volumes. The scope of coverage is all areas of chemical science including the interfaces with related disciplines such as biology, medicine and materials science. The goal of each thematic volume is to give the non-specialist reader, whether in academia or industry, a comprehensive insight into an area where new research is emerging which is of interest to a larger scientific audience. Each review within the volume critically surveys one aspect of that topic and places it within the context of the volume as a whole. The most significant developments of the last 5 to 10 years are presented using selected examples to illustrate the principles discussed. The coverage is not intended to be an exhaustive summary of the field or include large quantities of data, but should rather be conceptual, concentrating on the methodological thinking that will allow the non-specialist reader to understand the information presented. Contributions also offer an outlook on potential future developments in the field. |
| copper free click chemistry: Nano Hydrogels Jiya Jose, Sabu Thomas, Vijay Kumar Thakur, 2022-01-06 This book introduces the reader to important aspects of the nano-hydrogels. It covers the development of hydrogels and their biology, chemistry and properties. Focus is also given to innovative characterization techniques and advances in structural design, with special emphasis on molecular structure, dynamic behavior and structural modifications of hydrogels. This book serves as a consolidated reference work for the diverse aspects of hydrogels, creating a valuable resource for students and researchers in academia and industry. |
| copper free click chemistry: Copper in N-Heterocyclic Chemistry Ananya Srivastava, 2020-11-13 Copper in N-Heterocyclic Chemistry provides an overview of copper-catalyzed synthesis and functionalization of N-heterocyclic compounds, covering all recent developments in a way that is ideal for researchers and students working in the area of synthetic organic chemistry and medicinal chemistry. The book explores N-heterocyclic compounds as unique structural units in the development of natural products and pharmaceuticals, along with the remarkable progress made in the area of high atom economic strategies, and more recently, copper-catalyzed C-H activation and its applications in organic synthesis. Readers will find troubleshooting protocols, as well as the advantages and limitations of each method discussed. As copper catalysts show versatile chemical reactivity in many aspects, including their oxidation states 0–3 are accessible and their ability to facilitate bond formations due to their ability to serve as Lewis acids, oxidizing agents and catalysts, this book is an ideal resource on the topics explored. - Discusses novel synthetic methods developed over the past decade for copper-catalyzed synthesis of N-heterocyclic compounds - Covers the most recent methodologies adapted in synthetic chemistry for applications in natural products and pharmaceuticals - Includes troubleshooting protocols, as well as the advantages and limitations of each method discussed in detail |
| copper free click chemistry: Green Chemistry Applications Murat Eyvaz, Ebubekir Yüksel, 2019-09-18 Green chemistry is defined as the use of a dozen principles that reduce or eliminate hazardous materials in the design, manufacture, and use of chemical products. Today, it is understood that focusing on precautions to reduce or eliminate existing pollution sources is more effective than looking for a cleaning path after exiting. This book presents the principles of green chemistry for clean production in light of the latest technological developments and increasing environmental awareness. Chapters cover such topics as synthesis and applications of nanomaterials for energy and environmental applications, climate process, alternative green energy sources, and removal of emerging pollutants from water. |
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Oct 14, 2014 · The copper wire from your house needs to be connected to an open, available spot in that streetbox, which translates the signals to fiber optic cables. If there's no open, available …
can't upgrade dsl - AT&T Community Forums
Feb 16, 2016 · IF AT&T would have built out Fiber To The Premises (FTTP) instead of copper based U Verse they might have a chance to gain potential customers, do you really believe …
Internet Upgrade. - AT&T Community Forums
Jun 25, 2018 · I was offered a upgrade to my internet service and sent a new ATT uverse modem , a easy wire change but instructions to web site was " Site not available" , so then what ??? a …
How long before U-Verse Services in Houston are restored?
Mar 22, 2016 · No, I did not and I'm not sure that they would consider such a thing if they have to do it for every household with U-verse services in the Houston area. They just keep telling me …
Getting robbed by AT&T - AT&T Community Forums
Dec 12, 2021 · ATT stopped copper upgrades end of 2015… the only faster speed you will see is either being upgraded to fiber or moving to a different location where fiber is not offered but …
Building a house and can't get a straight answer
Feb 3, 2016 · I am in the process of building a home. We are not planning to install coax in the house. We are also not planning on installing phone jacks anywhere but the home security …
Horrible Customer Service - AT&T Community Forums
Aug 7, 2019 · im not sure why they are so adamant to send an engineer out, they dont do any physical work on the wires they write the jobs for the techs to go out, they figure out the path …
Uverse does not work for a large family - AT&T Community Forums
Jul 22, 2014 · There have been tests where a lucky few copper-served customers got more than 4 streams for a while, but those tests have ended and no repetition of that in sight.
Thiacycloalkynes for Copper-Free Click Chemistry
Bioorthogonal Reagents DOI: 10.1002/anie.201106325 Thiacycloalkynes for Copper-Free Click Chemistry** Gabriela de Almeida, Ellen M. Sletten, Hitomi Nakamura, Krishnan K. …
CLICK CHEMISTRY AND BIOORTHOGONAL CHEMISTRY
Scientific Background on the Nobel Prize in Chemistry 2022 CLICK CHEMISTRY AND BIOORTHOGONAL CHEMISTRY The Nobel Committee for Chemistry THE ROYAL …
Click Chemistry Reagents - Thermo Fisher Scientific
Click Chemistry Reagents Introduction Click chemistry describes a class of chemical reactions that use bio-orthogonal or biologically unique moities to label and detect a molecule of interest …
Synaffix Licenses CliCr® Chemistry from Cristal Therapeutics …
CliCr®, a platform based on the 7-membered TMTHSI molecule, is a powerful copper-free click chemistry reagent that meets all demands of the life science industry in terms of reactivity, …
Non-Nucleoside Building Blocks for Copper-Assisted and …
Non-Nucleoside Building Blocks for Copper-Assisted and Copper-Free Click Chemistry for the Efficient Synthesis of RNA Conjugates K. N. Jayaprakash, †Chang Geng Peng, David …
Transfer Dissociation Mass Spectrometry Labeling, Copper …
Labeling, Copper-Free Click Chemistry, Reductive Cleavage, and Electron-Transfer Dissociation Mass Spectrometry Junfeng Ma†¶§*, Wei-Han Wang‡¶Փ, Zengxia Li#¶, Jeffrey Shabanowitz‡, …
Click CRM brochure - FINAL - finabio.net
Copper-Free Click Chemistry A B DBCO-AF488 and DBCO-AF555 were conjugated to CRM 197-azide at molar ratio of Dye/CRM 197 of 2-10x molar ratios, 25 µl of DBCO-dye/DMSO solutions …
Tunable Macrocyclic Polyparaphenylene Nanolassos via …
RESEARCH ARTICLE 1 Tunable Macrocyclic Polyparaphenylene Nanolassos via Copper-Free Click Chemistry Dr. Tobias A. Schaub,*[a] Dr. Anna Zieleniewska,[b] Dr. Ramandeep Kaur,[b] …
Click chemistry: a transformative technology in nuclear …
Click chemistry: a transformative technology in nuclear medicine David Bauer 1, Samantha M. Sarrett 1,2,3,4, Jason S. Lewis 1,4 and Brian M. Zeglis 1,2,3,4,5 The 2022 Nobel Prize in …
Copper-free click chemistry for the in situ crosslinking of ...
Copper-free click chemistry for the in situ crosslinking of photodegradable star polymersw Jeremiah A. Johnson,a Jeremy M. Baskin,b Carolyn R. Bertozzi,bc Jeffrey T. Kobersteind and …
Copper-Free ‘Click’ Chemistry-Based Synthesis and
A novel method of synthesis involving copper free ‘click’ chemistry (Dibenzocyclooctyl, DBCO) moiety with an azide-labeled reaction partner, known as Strain-Promoted
Bioorthogonal Chemistry - gbdong.cm.utexas.edu
Copper-Free Click Chemistry Still most common bioorthogonal reaction used, due to wide variety of derivatives and many groups working on perfecting it Advantages: Small azide, much faster …
Maleimide and Cyclooctyne Based Hexakis-Adducts of …
cyclooctynes to carry out copper-free strain promoted alkyne-azide cycloadditions (SPAAC).37 In the present work, we describe the synthesis of a new derivative for the copper-free click …
Site-specific terminal and internal labeling of RNA by poly(A ...
relevant functional tags via copper-catalyzed (CuAAC) or metal-free strain-promoted (SPAAC) click chemistry for all four possible nucleotides (A, C, G and U), at a wide range of …
Bioorthogonal Click Chemistry: Invention to Applications in …
extending the click concept Carolyn R. Bertozzi pioneered copper-free click reac-tion compatible with living systems, enabling cell-surface engineering and glycan imaging [24]. ... [21, 22] and …
Volume 12 Number 31 21 August 2021 Chemical Science
Chemical Science rsc.li/chemical-science Volume 12 Number 31 21 August 2021 Pages 10399–10674 ISSN 2041-6539 EDGE ARTICLE Chun-yang Zhang et al. A copper-free and …
cLick DNa aND RNa LigatiON – a BiOcOMpatiBLE tRiazOLE …
Click Chemistry for several years and, in this newsletter, we highlight an excellent example of click ligation to generate a biocompatible internucleotide linkage (Page 1), a simplified kit-based …
Copper-Free Click Chemistry
Copper-free Click Chemistry Jeremy M. Baskin and Carolyn R. Bertozzi 3.1 Introduction Biological systems exhibit astounding chemical complexity. A single mammalian cell contains thousands …
copper-free click chemistry , Robert Winefield , Asokan …
copper-free click chemistry Stephanie C. Bishop 1 , Robert Winefield 1 , Asokan Anbanandam 2 , and Jed N. Lampe 1 * 1 Department of Pharmacology, Toxicology and Therapeutics, The …
Copper-free click chemistry in living animals - PNAS
Copper-free click chemistry in living animals Pamela V. Changa,1, Jennifer A. Preschera,1, Ellen M. Slettena, ... mation, we refer to these cycloadditions with the term “Cu-free click …
Making dimers of oligomeric membrane proteins using …
Making dimers of oligomeric membrane proteins using copper-free click chemistry [version 1; referees: 4 approved with reservations] F1000Research 2016, 5:1061 (doi: …
Copper-Free Click Chemistry for Dynamic in vivo Imaging
Copper-free click chemistry for dynamic in vivo imaging Jeremy M. Baskin*, Jennifer A. Prescher*, Scott T. Laughlin*, Nicholas J. Agard*, Pamela V. Chang*, Isaac A. Miller*, ... often referred to …
Copper(I)-Catalyzed Alkyne Azide Cycloaddition (CuAAC) …
Jan 19, 2023 · Click chemistry is an efficientand modern technique applied ... (II),64,66−69 and (iv) use of solvent-free copper nanoparticles (CuNPs).10 A wide variety of copper-derived …
Chapter 5
copper-free click chemistry) is ideal for QD conjugation due to the biological and chemical orthogonality of azides and strained alkynes as well as the mild conjugation conditions. The …
Click chemistry in the synthesis of antibody-drug conjugates
Aug 17, 2023 · Alternatively, some researchers prefer to use the copper-free azide- alkyne cycloaddition, also known as strain-promoted azide-alkyne ... Click chemistry reactions in the …
Copper free labeling of Azide-modified RNA - Jena Bioscience
2.2 Set-up of copper-free CLICK labeling reaction • Add calculated volumes of Azide-RNA probe (V RNA) and DBCO-containing detection reagent (V DBCO) to a sterile, RNAse-free tube. • …
Nanopore detection of modified RNA and DNA with nucleic acid
However, a significant challenge arises when employing copper-free click chemistry for the conjugation of azide-labeled RNA with oligonucleotides. The inherent negative charge of RNA …
Application of click chemistry in nanoparticle modification …
strain-promoted alkyne and azide enabled copper-free click chemistry [14]. Furthermore, inverse-demand Diels-Alder reaction with tetrazine (Tz) and trans-cyclooctene (TCO) provided …
Copper-free click chemistry for attachment of
Copper-free click chemistry for attachment of biomolecules in magnetic tweezers Jorine M. Eeftens, Jaco van der Torre, Daniel R. Burnham and Cees Dekker* Abstract
生細胞系への適用を指向したシクロオクチン 誘導体 …
reaction is often called “copper─free click chemistry（ CFCC）”. This short review summarizes the recent advance in CFCC using cyclooctynes. はじめに Sharplessらが提唱した，“click …
Bioconjugation of a Near-Infrared DNA-Stabilized Silver …
May 8, 2023 · the copper-free click reactions to three azido-modifiedpeptides (PYY-peptide 5, d-peptide 6, coiled-coil peptide 7)37−39 and a small azido-modifiedprotein, human insulin …
Biodegradable DNA-enabled poly(ethylene glycol
Copper-free click chemistry eliminates the use of harmful free radicals, initia-tors, or catalysts required by other polymerization or linking techniques, thus reducing the
Nanoscale - ResearchGate
Copper-free click chemistry as an emerging tool for the programmed ligation of DNA-functionalised gold nanoparticles† Amelie Heuer-Jungemann,a Robert Kirkwood,a Afaf H. El …
Fast, copper-free click chemistry: a convenient solid-phase …
Fast, copper-free click chemistry: a convenient solid-phase approach to oligonucleotide conjugationw Ishwar Singh,a Joseph S. Vyleb and Frances Heaney*a
Click chemistry with copper -- a biocompatible version
Compared to the copper-free click chemistry reaction, which can take up to an hour, the ligand-accelerated copper-catalyzed click chemistry reaction can achieve effective labeling within 3-5 …
Specific Labeling of Zinc Finger Proteins using Noncanonical …
prepared for each batch reaction. For copper-free click chemistry reactions, fluorescein-dibenzylcyclooctyne (DBCO, Click Chemistry Tools, Scottsdale, AZ) or Cy5-DBCO was directly …
Copper-free click chemistry in living animals - ResearchGate
Copper-free click chemistry in living animals Pamela V. Changa,1, Jennifer A. Preschera,1, Ellen M. Slettena, Jeremy M. Baskina, Isaac A. Millera, Nicholas J. Agarda ...
Synthesis of Heterobifunctional Protein Fusions Using …
Protein Chemistry DOI: 10.1002/anie.201108130 Synthesis of Heterobifunctional Protein Fusions Using Copper-Free Click Chemistry and the Aldehyde Tag** Jason E. Hudak, Robyn M. …
Simple connections take the prize - Nature
In biomaterials research, copper-free click chemistry is widely used to build functional materials meant for biomedical applications, such as drug delivery, and for the manipula-
Procedure for Fast and Regioselective Copper-Free Click …
Mar 26, 2022 · free conditions the reaction was fast, yielding 1,4-disubstituted regioisomers with high regioselectivity. Key words: cycloadditions, regioselectivity, copper-free click chemistry, …
Chapter 14 Modification of DNA Nanostructures with
stranded DNA molecules with azide-modified peptide, denoted “PeB,” using copper-free click chemistry. This PeB peptide, derived from the neutralizing antibody HC19, effectively targets …
Reactivity of Biarylazacyclooctynones in Copper-Free Click …
for in vivo labeling while avoiding the use of the toxic copper(I) catalysts traditionally employed in “click chemistry” with terminal alkynes.3,4 As a result, the reaction between cyclo-octynes and …
Chapter 15
bioorthogonal copper-free “click chemistry” onto liposomes. Even if new click chemistry reactions like inverse electron-demand Diels–Alder cycloaddition (iEDDA) can now be applied to the …
Evaluating the safety, tolerability, and immunogenicity of a 24 …
using a novel approach of cell-free protein synthesis, copper-free click chemistry, and site-specific conjugation to develop a multivalent pneumococcal conjugate vaccine that produces broader …
Application of Click Chemistry in Biomedical Hydrogels - ACS …
sive understanding of “click” chemistry. 2.1. Copper-Ion-Catalyzed Azide−Alkyne Cycloaddi-tion Reaction (CuAAC Reaction). The CuAAC reaction is a modified Huisgen 1,3-dipolar …
Visualizing biologically active small molecules in cells using …
Aug 16, 2018 · Original report on strained alkynes for copper-free azide–alkyne ligation in vivo56 Original report on copper-fr ee click chemistry for dynamic in vivo imaging57. Development of …
NEW APPROACHES IN HYDROGEL SYNTHESIS – CLICK …
“Click chemistry”, in particular copper (I)-catalyzed azide-alkyne cycloaddition (CuAAC), has been widely used in the preparation of complex architectures, ... the other hand, catalyst-free “click …
High Density Orthogonal Surface Immobilization via …
copper(I)-catalyzed click chemistry is ideal for many applications,6-8 the cytotoxicity of the Cu catalyst can limit bioorthogonal conjuga-tion. Recently, catalyst-free click reactions have …
Bioconjugation of a Near-Infrared DNA-Stabilized Silver
strategies. Here, a copper-free click chemistry method for linking a well-characterized DNA-AgNC to molecules of interest is presented. Three differentpeptides and a small protein, human …
University of Groningen Strain-Promoted Copper-Free Click …
Strain-Promoted Copper-Free “Click” Chemistry for 18F Radiolabeling of Bombesin Lachlan S. Campbell-Verduyn, Liza Mirfeizi, Anne K. Schoonen, Rudi A. Dierckx, Philip H. Elsinga,* and …
