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| car t cell therapy myasthenia gravis: Myasthenia Gravis Premkumar Christadoss, 2012-12-06 Autoimmune myasthenia gravis (MG) is a classical autoimmune disease, for which the target antigen, nicotinic acetylcholine receptor, has been cloned, sequenced and biochemically characterized. Antibodies to acetylcholine receptors destroy acetylcholine receptor at the neuromuscular junction, thus leading to defective neuromuscular transmission, muscle fatigue, and weakness. In the last few years, rapid advances have been made in unraveling the cellular and molecular mechanisms involved in the pathogenesis of MG, both in the animal model, experimental autoimmune MG (EAMG), and in human MG. Significant advances are being made in characterizing the cells and molecules involved in the autoimmune response to the acetylcholine receptor (AChR). These advances are leading to the development of specific methods of immunointervention in EAMG. Further understanding of the intricate involvement of the major histocompatibility complex (MHC) and non-MHC genes, T cell receptors (TCR), costimulator molecules, and specific cytokines in the afferent and efferent autoimmune response of AChR should pave the way to future antigen/clone-specific therapy of MG. This book is the outcome of the MG workshop proceedings in Mysore, India, 1998. The majority of the chapters in this book are contributed by world-renowned authors and their students. The book not only contains a timely review of specific topics, but also up-to-date findings. Immunologists and neurologists will find, in this volume, the latest in MG/EAMG cutting-edge research. Clinicians will be interested in the applications of the various immunointervention strategies into clinical trials in MG patients. Finally, students will not only be interested in reading the latest in EAMG/MG research, but will also find information to help them develop a future strategy to unravel the precise mechanism of disease. To summarize, in this book, the readers should find up-to-date information related to immunological mechanisms involved in MG pathogenesis and various modalities for possible approaches to immunointervention to treat MG. |
| car t cell therapy myasthenia gravis: HIV-1 Latency Guido Silvestri, Mathias Lichterfeld, 2018-10-11 This volume summarizes recent advances in understanding the mechanisms of HIV-1 latency, in characterizing residual viral reservoirs, and in developing targeted interventions to reduce HIV-1 persistence during antiretroviral therapy. Specific chapters address the molecular mechanisms that govern and regulate HIV-1 transcription and latency; assays and technical approaches to quantify viral reservoirs in humans and animal models; the complex interchange between viral reservoirs and the host immune system; computational strategies to model viral reservoir dynamics; and the development of therapeutic approaches that target viral reservoir cells. With contributions from an interdisciplinary group of investigators that cover a broad spectrum of subjects, from molecular virology to proof-of-principle clinical trials, this book is a valuable resource for basic scientists, translational investigators, infectious-disease physicians, individuals living with HIV/AIDS and the general public. |
| car t cell therapy myasthenia gravis: News and Views in the Management of Myasthenia Gravis Amelia Evoli, Nils Erik Gilhus, Jeff Guptill, 2021-12-03 Dr. Jeffrey Guptill has received research grants and contracts: from: US NIH, NINDS (K23NS085049, HHSN27100001), NIAID (HHSN272201300017I), Myasthenia Gravis Foundation of America, the Grifols Foundation, the Alzheimer’s Association, Ra Pharmaceuticals. He has also received personal compensation in the past year from Alexion, Kashiv, Argen-X, and Momenta, Inc for consulting services and from Grifols for educational activities. |
| car t cell therapy myasthenia gravis: Treatment of Autoimmune Disorders Michael Sticherling, Enno Christophers, 2003 Progress in basic and clinical immunology within the last two decades has provided profound insight into the immune system and its role in preventing endogenous and exogenous damage. In contrast, disbalances within this system can result in autoimmune disorders which may affect diverse organs and result in distinct clinical pictures. In many of these, however, the individual etiopathogenetic mechanisms are poorly understood and even more their clinical symptoms are hard to treat. The book offers insight into basic mechanisms of autoimmune disorders. It includes neurological, gastrointestinal, ophthalmological and skin diseases as well as current and future therapeutic options including immunomodulatory drugs and different vaccination strategies. By addressing diverse organ systems, both singular and shared features are elaborated. Thus an exchange of ideas is intended across research on single organ systems within a truly interdisciplinary setting. |
| car t cell therapy myasthenia gravis: Emergencies in Neuromuscular Disease Elio Agostoni, 2017-10-04 This book offers a practical tool for handling neuromuscular emergencies, and is divided by the main neuromuscular diseases on the basis of their anatomical and clinical location: diseases affecting the anterior horn of the spinal cord (tetanus), those that affect the nerve roots and nerves (SGB, multiple mononeuritis, porphyria), the neuromuscular junction (MG and botulism) and, lastly, muscle pathologies (rhabdomyolysis, malignant hyperthermia, periodic paralysis). It provides updated diagnostic/therapeutic protocols and decision-making algorithms for each pathology, and examines a range of scenarios on the basis of clinical cases. Emergencies in Neuromuscular Disease will be of interests for a wide variety of specialists including neurologist, neurophysiologists and anesthesiologists. |
| car t cell therapy myasthenia gravis: Hospitalist Neurology Martin A. Samuels, 1999 Hospitalist Neurology, in the highly regarded Blue Books of Practical Neurology series, focuses on the clinical practice of in-patient neurology as well as the neurologic sequelae of non-neurologic conditions of hospitalized patients. It is meant to provide consulting hospital-based neurologists with a rational approach to evaluating neurological problems in a busy general hospital. |
| car t cell therapy myasthenia gravis: Antibody Engineering Patrick Chames, 2016-08-23 More than ever, antibodies are being recognized as a major drug modality in a variety of diseases, including cancer, autoimmune diseases, infectious diseases, or even neurodegenerative disorders. Over 30 therapeutic antibodies have been approved and novel molecules are entering clinical trials at an average rate of 50 per year and that is predicted to continue well into the future. Notwithstanding the many achievements already made in the field, there is still a lot of room for improvements for these molecules in terms of activity, and a plethora of approaches have been attempted to optimize these molecules. Antibody Engineering: Methods and Protocols, Second Edition was compiled to give complete and easy access to a variety of antibody engineering techniques, starting from the creation of antibody repertoires and efficient ways to select binders from these repertoires, to their production in various hosts, their detailed characterization using various well established techniques, and to the modification and optimization of these lead molecules in terms of binding activity, specificity, size, shape, and more. Written in the successful Methods in Molecular BiologyTM series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and notes on troubleshooting and avoiding known pitfalls. Authoritative and easily accessible, Antibody Engineering: Methods and Protocols, Second Edition serves as an invaluable resource for both experts and those new to the field, and most of all as a source of inspiration for the creation of the antibodies of tomorrow. |
| car t cell therapy myasthenia gravis: Neuromuscular Disorders Satish V. Khadilkar, Rakhil S. Yadav, Bhagyadhan A. Patel, 2017-12-28 This book provides a concise overview of the diagnosis and therapy of a wide variety of neuromuscular disorders, in tabulated form and with illustrative cases. Treating neuromuscular disorders calls for a sound, step-by-step clinical approach based on differential diagnosis and laboratory investigations. Yet to date, there has been no single, compact book that offers all the relevant information related to the management of these disorders. This book fills that gap, presenting the state of the art in the field and addressing practical problems together with their solutions. Each chapter covers disorder characteristics, clinical differentiating points, relevant investigations and their interpretation, available genetic testing, best management approaches and counselling. Illustrative cases provide valuable insights, while extensive tables and illustrations mean that information can be rapidly found. |
| car t cell therapy myasthenia gravis: Myasthenia Gravis and Related Disorders Henry J. Kaminski, 2002-10-03 An international panel of expert clinicians and leading scientists comprehensively review the clinical and basic science of this disease and its relatives, including acquired neuromytonia and Lambert-Eaton syndrome. For the clinician, the book describes the wide range of signs and symptoms that make these diseases difficult to diagnose, review in depth the available diagnostic methods and their limitations, offer practical treatment recommendations based on years of experience, and discuss several promising treatments now emerging. For the basic scientist, the text illuminates neuromuscular structure and function, describes in detail the acetylcholine receptor (the central target of pathology in myasthenia gravis), and illuminates the autoimmune pathogenesis. |
| car t cell therapy myasthenia gravis: Clinical Anesthesiology II Jonathan L. Benumof, Gerard R. Manecke, 2019-06-24 Written by experts in the anesthesiology field, this unique resource explores the various issues and complications that arise during the administration of anesthesiology in various clinical settings. To convey the depth and breadth of these potential obstacles, 26 real-life cases are explored and examined throughout the book. Each chapter includes a case summary, discussion questions, and selected references - all of which are supplemented by high quality illustrations and images that provide distinctive visual synopses of key teaching points. Clinical Anesthesiology II: Lessons from Morbidity and Mortality Conferences is an indispensable guide that functions as both a pragmatic reference and compelling read for practitioners and critical care medicine trainees. |
| car t cell therapy myasthenia gravis: Neuromuscular Disorders in Clinical Practice Bashar Katirji, Henry J. Kaminski, Robert L. Ruff, 2013-10-11 Comprehensive, thoroughly updated, and expanded, Neuromuscular Disorders in Clinical Practice, Second Edition encompasses all disorders of the peripheral nervous system, covering all aspects of neuromuscular diseases from diagnosis to treatment. Mirroring the first book, this two-volume edition is divided into two parts. Part one discusses the approach to neuromuscular disorders, covering principles and basics, neuromuscular investigations, and assessment and treatment of neurological disorders. Part two then addresses the complete range of specific neuromuscular diseases: neuronopathies, peripheral neuropathies, neuromuscular junction disorders, muscle ion channel disorders, myopathies, and miscellaneous neuromuscular disorders and syndromes. Neuromuscular Disorders in Clinical Practice, Second Edition is intended to serve as a comprehensive text for both novice and experienced practitioners. General neurologists as well as specialists in neuromuscular medicine and trainees in neuromuscular medicine, clinical neurophysiology and electromyography should find this book inclusive, comprehensive, practical and highly clinically focused. Additionally, specialists in physical medicine and rehabilitation, rheumatology, neurosurgery, and orthopedics will find the book of great value in their practice. |
| car t cell therapy myasthenia gravis: Myasthenia Gravis and Myasthenic Disorders Andrew G. Engel, 2012-04-03 Myasthenia Gravis and Myasthenic Disorders, Second Edition is a thoroughly re-written and updated version of the highly successful first edition published in 1999. Comprehensively written by leaders at the forefront of research, not to mention thoroughly referenced throughout and gorgeously illustrated, this new edition of the classic 1999 text will cement its place as the text on Myasthenia Gravis and related disorders for years to come. |
| car t cell therapy myasthenia gravis: Hematopoietic Stem Cell Transplantation and Cellular Therapies for Autoimmune Diseases Richard K. Burt, Dominique Farge, Milton A. Ruiz, Riccardo Saccardi, John A. Snowden, 2021-11-17 This book summarizes the global progress in medical and scientific research toward converting traditionally chronic autoimmune diseases into a drug-free reversible illness using hematopoietic stem cell transplantation (HSCT) and other cellular therapies such as T regulatory cells (Treg), mesenchymal stromal/stem cells, and chimeric antigen receptor T (CAR T) cells in order to reintroduce sustained immune tolerance. This title provides information on different types of stem cells and immune cells; post-transplant immune regeneration; cellular regulatory requirements; ethical and economic considerations; and the advantages and disadvantages of HSCT in the treatment of a variety of autoimmune diseases versus current conventional treatments. Arranged by disease, the text provides a comprehensive guide to HSCT for all types of autoimmune/immune disorders including monogenetic autoimmune diseases; autoimmune aplastic anemia; neurologic immune diseases including multiple sclerosis, chronic inflammatory demyelinating polyneuropathy, neuromyelitis optica, and stiff person syndrome; rheumatologic diseases such as systemic sclerosis and systemic lupus erythematosus; dermatologic diseases such as pemphigus; gastrointestinal disorders such as Crohn’s disease and celiac disease; and immune-mediated endocrinologic disease type I diabetes mellitus. Guidance is provided on the transplantation technique, cell collection and processing, conditioning regimens, infections, and early and late complications. Key Features Outlines therapies and techniques for HSCT for autoimmune diseases Discusses the advantages of HSCT over conventional therapies Reviews the entire process of stem cell therapy from harvest and ethics to indications, efficacy, and regulatory oversight |
| car t cell therapy myasthenia gravis: Cytokine Inhibitors Gennaro Ciliberto, 2000-11-14 Compiling an up-to-date and detailed survey of the role cytokines play in cell-to-cell communication, development, and differentiation, this comprehensive reference highlights the medical advantages of cytokine inhibition and pursues novel methods of discovery for more potent and specific blocking agents. Investigates the pathogenic role of |
| car t cell therapy myasthenia gravis: Advances in Autoimmune Myasthenia Gravis Rozen Le Panse, Linda L. Kusner, Sonia Berrih-Aknin, Anna Rostedt Punga, 2020-10-27 This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact. |
| car t cell therapy myasthenia gravis: Handbook of Myasthenia Gravis and Myasthenic Syndromes Robert P. Lisak, 1994-01-27 This practical resource provides up-to-the-minute examinations of every aspect of myasthenia gravis and myasthenic syndromes-presenting detailed descriptions of the etiology, pathogenesis, diagnosis, and treatment. Contains nearly 1900 helpful literature citations, tables, drawings, and photographs! Exploring new and emerging therapies for difficult cases, Handbook of Myasthenia Gravis and Myasthenic Syndromes discusses neuroophthalmological features of the disorders congenital, neonatal, and juvenile myasthenia gravis and myasthenic syndromes the clinical presentation and immunology of Lambert-Eaton syndrome the myasthenic neuromuscular junction, diagnostic tests in neuromuscular junction disorders, and the involvement of sites outside the junction the genetics of myasthenia gravis electrodiagnosis, serological diagnosis, and pharmacological diagnosis the value of experimental models in understanding acquired myasthenia gravis the immunopathogenesis of acquired myasthenia gravis and much more! |
| car t cell therapy myasthenia gravis: Essential Clinical Anesthesia Review Linda S. Aglio, Robert W. Lekowski, Richard D. Urman, 2015-01-08 This concise, evidence-based board review book, organized according to the ABA keyword list, covers all the fundamental concepts needed to pass written and re-certification board examinations. Each chapter begins with a case scenario or clinical problem from everyday practice, followed by concise discussion and clinical review questions and answers. Discussion progresses logically from preoperative assessment and intraoperative management to postoperative pain management, enhancing the reader's knowledge and honing diagnostic and clinical management skills. New guidelines and recently developed standards of care are also covered. Serving as a companion to the popular textbook Essential Clinical Anesthesia, this resourceful work reflects the clinical experiences of anesthesia experts at Harvard Medical School as well as individually known national experts in the field of anesthesiology. This practical review is an invaluable resource for anesthesiologists in training and practice, whether studying for board exams or as part of continuing education and ABA recertification. |
| car t cell therapy myasthenia gravis: CDC Yellow Book 2018: Health Information for International Travel Centers for Disease Control and Prevention CDC, 2017-04-17 THE ESSENTIAL WORK IN TRAVEL MEDICINE -- NOW COMPLETELY UPDATED FOR 2018 As unprecedented numbers of travelers cross international borders each day, the need for up-to-date, practical information about the health challenges posed by travel has never been greater. For both international travelers and the health professionals who care for them, the CDC Yellow Book 2018: Health Information for International Travel is the definitive guide to staying safe and healthy anywhere in the world. The fully revised and updated 2018 edition codifies the U.S. government's most current health guidelines and information for international travelers, including pretravel vaccine recommendations, destination-specific health advice, and easy-to-reference maps, tables, and charts. The 2018 Yellow Book also addresses the needs of specific types of travelers, with dedicated sections on: · Precautions for pregnant travelers, immunocompromised travelers, and travelers with disabilities · Special considerations for newly arrived adoptees, immigrants, and refugees · Practical tips for last-minute or resource-limited travelers · Advice for air crews, humanitarian workers, missionaries, and others who provide care and support overseas Authored by a team of the world's most esteemed travel medicine experts, the Yellow Book is an essential resource for travelers -- and the clinicians overseeing their care -- at home and abroad. |
| car t cell therapy myasthenia gravis: The Autoimmune Epidemic Donna Jackson Nakazawa, 2009-02-10 From the Foreword: [An] astounding book . . . put simply, there is no doubt that autoimmune diseases are on the rise and increasing environmental exposures of toxins and chemicals is fueling this rise.--Dr. Douglas Kerr, Director, Johns Hopkins Transverse Myelitis Center. |
| car t cell therapy myasthenia gravis: Autoimmune Neurology , 2016-03-11 Autoimmune Neurology presents the latest information on autoimmune neurologic disease, the immune response to the body where organs run wild, causing the immune system to attack itself. Autoimmunity is a main element in numerous nervous system diseases and can target any structure within the central or peripheral nervous system. Over the past 20 years, significant advances in our understanding of the pathophysiology of autoimmune disorders, including the use of biomarkers has led to new diagnosis and treatment options. Neurologic conditions associated with autoimmune reactions include dementia, neuromuscular disease, epilepsy, sleep disorders, diabetes, and other common neurologic disorders and disease. This current tutorial-reference will be a must-have title for clinical neurologists, research neurologists, neuroscientists, and any medical professional working with autoimmune disease and disorders. - Includes comprehensive coverage of autoimmune neurology - Details the latest techniques for the study, diagnosis, and treatment of diseases and disorders, including dementia, neuromuscular disease, epilepsy, and sleep disorders - Presents a focused reference for clinical practitioners and the clinical neurology and neurology research communities |
| car t cell therapy myasthenia gravis: Neurobiology of Brain Disorders Michael J. Zigmond, Joseph T. Coyle, Lewis P. Rowland, 2014-12-03 Neurobiology of Brain Disorders is the first book directed primarily at basic scientists to offer a comprehensive overview of neurological and neuropsychiatric disease. This book links basic, translational, and clinical research, covering the genetic, developmental, molecular, and cellular mechanisms underlying all major categories of brain disorders. It offers students, postdoctoral fellows, and researchers in the diverse fields of neuroscience, neurobiology, neurology, and psychiatry the tools they need to obtain a basic background in the major neurological and psychiatric diseases, and to discern connections between basic research and these relevant clinical conditions. This book addresses developmental, autoimmune, central, and peripheral neurodegeneration; infectious diseases; and diseases of higher function. The final chapters deal with broader issues, including some of the ethical concerns raised by neuroscience and a discussion of health disparities. Included in each chapter is coverage of the clinical condition, diagnosis, treatment, underlying mechanisms, relevant basic and translational research, and key unanswered questions. Written and edited by a diverse team of international experts, Neurobiology of Brain Disorders is essential reading for anyone wishing to explore the basic science underlying neurological and neuropsychiatric diseases. - Links basic, translational, and clinical research on disorders of the nervous system, creating a format for study that will accelerate disease prevention and treatment - Covers a vast array of neurological disorders, including ADHD, Down syndrome, autism, muscular dystrophy, diabetes, TBI, Parkinson, Huntington, Alzheimer, OCD, PTSD, schizophrenia, depression, and pain - Illustrated in full color - Each chapter provides in-text summary points, special feature boxes, and research questions - Provides an up-to-date synthesis of primary source material |
| car t cell therapy myasthenia gravis: Immune Checkpoint Inhibitors in Cancer Fumito Ito, Marc Ernstoff, 2018-09-03 Get a quick, expert overview of the latest clinical information and guidelines for cancer checkpoint inhibitors and their implications for specific types of cancers. This practical title by Drs. Fumito Ito and Marc Ernstoff synthesizes the most up-to-date research and clinical guidance available on immune checkpoint inhibitors and presents this information in a compact, easy-to-digest resource. It's an ideal concise reference for trainee and practicing medical oncologists, as well as those in research. - Discusses the current understanding of how to best harness the immune system against different types of cancer at various stages. - Helps you translate current research and literature into practical information for daily practice. - Presents information logically organized by disease site. - Covers tumor immunology and biology; toxicities associated with immune checkpoint inhibitors; and future outlooks. - Consolidates today's available information on this timely topic into one convenient resource. |
| car t cell therapy myasthenia gravis: Neurogenic Dysphagia Tobias Warnecke, Rainer Dziewas, Susan Langmore, 2021-03-05 This book is a clinical manual that covers the whole spectrum of swallowing and its disorders. It starts with physiology of swallowing, pathophysiology of disordered deglutition, diagnostic methods (clinical and instrumental) and ends with an in-depth’s and up-to-date presentation of current treatment options. The clinically most relevant topics of dysphagia management on the stroke unit and the intensive care unit are dealt with in separate chapters. Also the closely intertwined issue of nutritional management is specifically addressed. Most importantly, the book covers all obligatory topics of the Flexible Endoscopic Evaluation of Swallowing (FEES)-curriculum, an educational initiative that started in Germany in 2014 and is currently being extended to other European and non-European countries. The book is richly illustrated and an online video section provides a number of typical patient cases. FEES is probably the most commonly chosen method for the objective assessment of swallowing and its disorders. It is used in stroke units, intensive care facilities, geriatric wards but also in rehabilitation clinics and within dedicated outpatient services. This book on neurogenic dysphagia therefore addresses a wide range of different medical disciplines, such as neurologists, geriatricians, intensive care physicians, rehabilitation physicians, gastroenterologists, otolaryngologists, phoniatrists and also speech-language pathologists. |
| car t cell therapy myasthenia gravis: Paraneoplastic Neurologic Disorders , 2024-03-15 This book extensively reviews Paraneoplastic Neurological Syndromes in light of the most recent descriptions of autoantibodies against neuronal cell surface antigens (only partly associated with paraneoplastic disorders) and the introduction of new immuno-oncological drugs that can contribute to causing diseases that are pathogenetically indistinguishable from paraneoplastic syndromes. These two new developments have not been addressed in other volumes available on the market. Section 1 focuses on immunological defense mechanisms against tumors. Besides investigating the pathogenetic mechanisms of these disorders, this section will also explore what the introduction of new drugs used in immune checkpoint inhibitor cancer therapy is teaching us in terms of immunopathogenesis. The second section will present individual syndromes (phenotypical clinical manifestations) of the CNS, PNS, NMJ and muscle. These chapters will, however, be preceded by an epidemiological analysis and a chapter describing the clinical approach to patients with these disorders. Consideration will also be given in specific chapters to general therapeutic strategies and the techniques used to search for diagnostically relevant autoantibodies. Presentation of the individual diseases will be followed by a third section investigating the role of antibody markers, presented in three chapters differentiating cytoplasmic, nuclear and neuronal cell surface reactivities. The innovative component of the final two sections compared to previously published volumes lies in their presentation of the profile of paraneoplastic diseases by tumor type. Special attention will be given to thymoma (involved particularly with novel antibodies against surface antigens), and neuroendocrine tumours, which are as yet comparatively unexplored in the literature. Lastly, a clinical update will be provided on gynecological, hematological and testicular malignancies. The last section will address side effects of the new immuno-oncological drugs increasingly used in cancer therapy. The high number of neurological complications that occur when tumor checkpoints are inhibited against immune defences provides the ideal experimental model for understanding the pathogenesis of these diseases. - Profiles paraneoplastic diseases by tumor type - Identifies the pathogenetic mechanisms of PNS and provides epidemiological analysis - Presents individual syndromes of the CNS, PNS, NMJ, and muscle - Investigates the role of antibody markers - Differentiates cytoplasmic, nuclear, and neuronal cell surface reactivities - Discusses immune-oncological drugs causing diseases that are indistinguishable from PNS - Reviews therapeutic strategies and clinical approach to PNS patients |
| car t cell therapy myasthenia gravis: Immunotherapy Aung Naing, Joud Hajjar, 2022-01-01 The field of immuno-oncology continues to rapidly evolve as new insights to fight and treat cancer emerge. The fourth edition of Immunotherapy provides the most current overview of immuno-oncology in different cancer types and toxicities associated with immunotherapy. While immunotherapy has revolutionized the treatment landscape of several solid malignancies, several challenges still exist. Only a subset of patients derive clinical benefits; some do not respond at all, and others respond initially, only for their disease to progress later. Because these drugs can activate a broad range of immune cells, patients suffer from a unique set of side effects known as immune-related adverse events. As more immunotherapeutic agents are used in the clinic, it is important to provide updates about current and ongoing developments in the field to further research efforts and inform treatment decisions. The fourth edition will have a new focus on strategies to overcome the challenges associated with immunotherapy. Chapters will discuss topics such as biomarkers of response, resistance mechanisms, role of imaging in predicting immune-related adverse events, and management of immune-related adverse events. Written by leading experts conducting cutting-edge research, readers will gain up-to-date knowledge on the current state and future of immunotherapy. |
| car t cell therapy myasthenia gravis: Essential Clinical Anesthesia Charles Vacanti, Scott Segal, Pankaj Sikka, Richard Urman, 2011-07-11 The clinical practice of anesthesia has undergone many advances in the past few years, making this the perfect time for a new state-of-the-art anesthesia textbook for practitioners and trainees. The goal of this book is to provide a modern, clinically focused textbook giving rapid access to comprehensive, succinct knowledge from experts in the field. All clinical topics of relevance to anesthesiology are organized into 29 sections consisting of more than 180 chapters. The print version contains 166 chapters that cover all of the essential clinical topics, while an additional 17 chapters on subjects of interest to the more advanced practitioner can be freely accessed at www.cambridge.org/vacanti. Newer techniques such as ultrasound nerve blocks, robotic surgery and transesophageal echocardiography are included, and numerous illustrations and tables assist the reader in rapidly assimilating key information. This authoritative text is edited by distinguished Harvard Medical School faculty, with contributors from many of the leading academic anesthesiology departments in the United States and an introduction from Dr S. R. Mallampati. This book is your essential companion when preparing for board review and recertification exams and in your daily clinical practice. |
| car t cell therapy myasthenia gravis: Clinical Neuroimmunology Jack P. Antel, 2005 Clinical Neurimmunology is the major reference text in the field, providing broad and comprehensive coverage of the interaction between the nervous and immune systems in both normal and diseased states. Understanding this interaction is fundamental to developing therapeutic approaches to disease and injury of the nervous system that are currently only marginally amenable to therapy. Neuroimmunology is a well-recognised and growing specialty world wide, both at the basic science and clinical level. It is a fast moving field and this is the most up to date text available. Chapters are dedicated to the role of the immune system in disorders affecting both the central and peripheral nervous systems, including important neurodegenerative diseases (such as multiple sclerosis and HIV-related neural degeneration) which cause life-long disability. Extensive coverage is given to a whole array of immune-directed therapies. The book has a strong international team of well respected, high profile editors and authors. The first edition published to extensive and positive reviews and has established itself as the principal reference source in the field. This second edition summarizes recent advances in clinical neuroimmunology in a comprehensive and unbiased way. |
| car t cell therapy myasthenia gravis: Cells Are the New Cure Robin L. Smith, Max Gomez, 2023-12-19 The future of medicine is happening now. Revolutionary new science is providing cures that were considered science fiction just a few years ago—and not with pills, surgery, or radiation, but with human cells. Promising treatments now in extensive clinical trials could have dramatic impacts on cancer, autoimmune diseases, organ replacement, heart disease, and even aging itself. The key to these breakthroughs is the use of living cells as medicine instead of traditional drugs. Discover the advances that are alleviating the effects of strokes, Alzheimer's disease, and even allergies. Cells Are the New Cure takes you into the world of regenerative medicine, which enables doctors to repair injured and aging tissues and even create artificial body parts and organs in the lab. Cellular medicine experts Robin L. Smith, MD, and Max Gomez, PhD, outline the new technologies that make it possible to harness the immune system to fight cancer and reverse autoimmune diseases like multiple sclerosis, type 1 diabetes, and rheumatoid arthritis. CRISPR, a new technology for targeted gene editing, promises to eradicate genetic diseases, allowing us to live longer lives—possibly even beyond age 100 in good health. Cells Are the New Cure takes you on a tour of the most exciting and cutting-edge developments in medicine. The content inside these pages could save your life or the life of someone you love. |
| car t cell therapy myasthenia gravis: Engineered immune cells in cancer immunotherapy (EICCI) Cristina Maccalli, Axel Schambach, Francisco Martin, Cameron Turtle, 2023-02-28 |
| car t cell therapy myasthenia gravis: Geriatric Diseases Nages Nagaratnam, Kujan Nagaratnam, Gary Cheuk, 2018-04-06 This volume provides a comprehensive overview of the unique clinical entities of diseases in older patients. The book arranges the organ systems in 21 sections, which include over 100 collective chapters on various age-related diseases in these organ systems. The text is specifically designed for ease-of-use and include learning tools that include multiple choice, short answer, and extended matching questions, case vignettes, self-assessments, and rich tables and illustrations. Each section includes a review of the anatomy, physiology and pathology that are specific to aging patients. The text covers the complex factors that present diagnosis challenges, including the interaction of the disease process with co-existing morbidities, aged- related physiological changes and pre-existing functional challenges and psychosocial circumstances. The text also works with the previously published text Diseases in the Elderly: Age-Related Changes and Pathophysiology, which is tailored to complement this resource. Written by experts in the field, Geriatric Diseases: Clinical Expression, Management and Impact is the ultimate guide on clinical expression and management of diseases in the elderly for medical students, residents, fellows, geriatricians, gerontologists, primary care physicians, internal medicine specialists, emergency room physicians, specialist nurses, and all other physicians and medical professionals treating older patients. |
| car t cell therapy myasthenia gravis: Neurology Robin Howard, Dimitri M. Kullman, David Werring, Michael Zandi, 2024-05-13 A fully updated and authoritative neurology resource The Queen Square Textbook has established itself as a favourite companion to clinical neurosciences training and teaching around the world, whilst retaining its role as an invaluable reference guide for physicians and other healthcare professionals working in neurology, general medicine and related specialties. The book continues to reflect the core values essential to the practice of clinical neurology in the 21st-century. The third edition has been extensively revised and updated to take account of the rapid pace of progress in the neurosciences and patient care. Contemporary neurology has been changed by the COVID-19 pandemic, the climate emergency and the growing inequalities in healthcare resources. The new edition has been extensively revised to reflect these challenges and affords a greater emphasis on management and rehabilitation whilst continuing to reflect the coherence of a text produced from a single, closely-knit, centre of excellence. Highlights of the new edition include: An updated approach to clinical examination, decision-making and diagnosis New developments in neuroimmunology, pathology and genetics Reflections on the history of our specialty, how the 'neurology method' has evolved and why this remains relevant to contemporary practice. Neuropalliative care Ethical and legal issues in clinical neurology The future direction of research in the neuroscience and clinical neurology The latest developments in the understanding and management of stroke, movement disorders, epilepsy, cognitive impairment, multiple sclerosis, infections, myelopathy, anterior horn cell disease, disorders of nerve and muscle, neuro-oncology, neurological disorders of hearing, balance and vision and the neurological care of critical illness, sleep, neuropsychiatry, pain, autonomic and urological disorders. An emphasis on treatment and rehabilitation of the person with a neurological disease The new edition marks a significant transition to reflect contemporary neurological practice during uncertain times. It mirrors the enormous changes in investigation, diagnosis and treatment that have occurred in recent years whilst maintaining the underlying principle that we do not treat diagnoses but, rather, we care for people affected by neurological disease. |
| car t cell therapy myasthenia gravis: Small Molecules in Hematology Uwe M. Martens, 2018-08-01 This book, written by respected experts, discusses in detail the latest developments in targeted therapy for hematologic malignancies using small molecules. It covers a wide range of small molecules including tyrosine kinase inhibitors, immunomodulatory drugs, the IDH-2 inhibitor enasidenib, the BCL-2 inhibitor venetoclax, and the proteasome inhibitor carfilzomib. For each molecule, aspects such as the chemical structure, mechanism of action, drug targets, drug interactions, preclinical studies, clinical trials, treatment applications, and toxicity are discussed. Extensive research into the molecular mechanisms of cancer has heralded a new age of targeted therapy. The field of precision cancer therapy is now growing rapidly, and the advances being made will mean significant changes in the treatment algorithms for cancer patients. Numerous novel targets that are crucial for the survival of cancer cells can be attacked by small molecules such as protein tyrosine kinase inhibitors. An accompanying volume addresses the use of small molecules in oncology, and the two volumes together represent the third edition of the book originally published under the same title. |
| car t cell therapy myasthenia gravis: Oxford Textbook of Palliative Medicine Nathan I. Cherny, Marie T. Fallon, Stein Kaasa, Russell K. Portenoy, David C. Currow, 2021-09-08 This sixth edition of the Oxford Textbook of Palliative Medicine takes us now into the third decade for this definitive award-winning textbook. It has been rigorously updated to offer a truly global perspective, highlighting the best current evidence-based practices, and collective wisdom from more than 200 experts around the world. This leading textbook covers all the new and emerging topics, updated and restructured to reflect major developments in the increasingly widespread acceptance of palliative medicine as a fundamental public health need. The sixth edition includes new sections devoted to family and caregiver issues, cardio-respiratory symptoms and disorders, and genitourinary symptoms and disorders. In addition, the multi-disciplinary nature of palliative care is emphasized throughout the textbook, covering areas from ethical and communication issues, the treatment of symptoms, and the management of pain. The Oxford Textbook of Palliative Medicine is a truly comprehensive text. No hospital, hospice, palliative care service, or medical library should be without this essential source of information. This sixth edition of the Oxford Textbook of Palliative Medicine is dedicated to the memory of Professor Kenneth Fearon husband of Professor Marie Fallon and a surgeon who became a world leader in the research and management of anorexia and cachexia. He modeled a work-life balance that is so critical in our field, with devotion to both his patients and his family. |
| car t cell therapy myasthenia gravis: The Little Black Book of Neurology E-Book Osama O. Zaidat, Alan J. Lerner, J.Douglas Miles, 2019-04-30 Widely known and well-respected, The Little Black Book of Neurology has been a thorough yet portable reference in this complex field for more than 30 years, presenting definitions, classifications, and guidance on diagnosis and management for a wide range of neurological disorders. The 6th Edition offers updated and expanded coverage of neuropharmacology and neuroimaging – plus a new, more user-friendly, fast-access format that makes the book ideal for quick clinical consultation or as a refresher for the Boards. - Presents a comprehensive, yet concise, all-in-one introduction to neurology in a portable, alphabetical format – now newly structured to make reference faster and easier than ever. - Enables you to access critical guidance at a glance with new tables of differential diagnosis, patient evaluation, and treatment options. - Covers many new topics including significantly expanded sections on sleep, neuromuscular disorders, and critical care. - Includes four new appendices: Neurocritical Emergencies • Therapeutic Care • AAN Guideline Summaries • and Scales – highlighting evidence-based guidelines when available, enabling you to make more informed clinical judgments. - Offers updated and expanded coverage of neuropharmacology and neuroimaging. |
| car t cell therapy myasthenia gravis: IgG4 Autoantibodies in the Context of IgG4 Autoimmunity Inga Koneczny, Vuslat Yilmaz, Maartje G. Huijbers, Erdem Tüzün, Luis Querol , Pilar Martinez, 2024-10-29 Many autoimmune diseases are induced by pathogenic autoantibodies, that bind to self-antigen expressed in cells and tissues, and induce disease by the recruitment of immune cells, activation of the classical complement pathway or induction of antigen cross-linking and endocytosis. These pathogenic mechanisms are, however, not available to antibodies of the IgG4 subclass, as these differ structurally from the other IgG subclasses, leaving them “immunologically inert”. In general, it is thought that IgG4 is part of an anti-inflammatory immune response to an overreactive pro-inflammatory response, e.g. in the context of helminth infection and allergy. |
| car t cell therapy myasthenia gravis: Disorders of Voluntary Muscle George Karpati, David Hilton-Jones, Robert C. Griggs, 2001-07-12 Rewritten and redesigned, this remains the one essential text on the diseases of skeletal muscle. |
| car t cell therapy myasthenia gravis: Messenger RNA Therapeutics Stefan Jurga, Jan Barciszewski, 2022-09-20 This book focuses on the fundamentals and applications of messenger RNA (mRNA)-based therapeutics and discusses the strengths and key challenges of this emerging class of drugs. In the past 30 years, extensive research and technological development in many areas have contributed to the emergence of in vitro transcribed mRNA as a therapeutic that has now reached clinical testing. Formulations that protect the mRNA from nucleases and accelerate its cellular uptake, combined with improvements to the mRNA molecules themselves, have been critical advancements for mRNAs to become viable therapeutics. Though once regarded as a serious impediment, the transient nature of mRNA technology is now considered a major advantage in making mRNA therapies safe and, ultimately, a potential game changer in the field of medicine. This new book in the RNA Technologies series provides a state-of-the-art overview on the emerging field of mRNA therapeutics covering essential strategies for formulation, delivery, and application. It also reviews the promising role in cancer immunotherapy, respiratory diseases, and chronic HBV infection and discusses RNA vaccines in light of the current COVID-19 pandemic. mRNA-based approaches have great potential to revolutionize molecular biology, cell biology, biomedical research, and medicine. Thus, this handbook is an essential resource for researchers in academia and industry contributing to the development of this new area of therapeutics. |
| car t cell therapy myasthenia gravis: Plasmapheresis and the Immunobiology of Myasthenia Gravis Peter C. Dau, 1979 |
| car t cell therapy myasthenia gravis: Neuroimmunology Amanda L. Piquet, Enrique Alvarez, 2021-03-08 This book provides a clinical focus on neuroinflammatory diseases as well as a review in pathophysiology and treatment approaches. Organized into six parts, the book begins with a basic review of the immune system and concepts for learning and treating neuroimmune conditions. The next four sections cover specific subfields of neuroimmunology and autoimmune neurology - the clinical and diagnostic features of multiple sclerosis, other autoimmune conditions of the central nervous system, autoimmune conditions of the peripheral nervous system, and systemic autoimmune conditions that affect the nervous system. To conclude, Section six discusses various clinical approaches to specific presentations in neuroimmunology, including pediatric demyelinating diseases. These sections provide practical clinical information to improve the reader’s knowledge in this complex field. The chapters are written by world renown authors with extensive knowledge to help provide up to date information. The full scope of autoimmune neurology is discussed, which is a unique feature of this book. Neuroimmunology serves as a resource for those in training including residents and fellows to provide clear clinical reasoning and background in a rapidly advancing field. |
| car t cell therapy myasthenia gravis: Canadian Immunization Guide Canada. Comité consultatif national de l'immunisation, Canada. National Advisory Committee on Immunization, 2006 The seventh edition of the Canadian Immunization Guide was developed by the National Advisory Committee on Immunization (NACI), with the support ofthe Immunization and Respiratory Infections Division, Public Health Agency of Canada, to provide updated information and recommendations on the use of vaccines in Canada. The Public Health Agency of Canada conducted a survey in 2004, which confi rmed that the Canadian Immunization Guide is a very useful and reliable resource of information on immunization. |
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