| car-t therapy israel: The EBMT/EHA CAR-T Cell Handbook Nicolaus Kröger, John Gribben, Christian Chabannon, Ibrahim Yakoub-Agha, Hermann Einsele, 2022-02-07 This first open access European CAR-T Handbook, co-promoted by the European Society for Blood and Marrow Transplantation (EBMT) and the European Hematology Association (EHA), covers several aspects of CAR-T cell treatments, including the underlying biology, indications, management of side-effects, access and manufacturing issues. This book, written by leading experts in the field to enhance readers’ knowledge and practice skills, provides an unparalleled overview of the CAR-T cell technology and its application in clinical care, to enhance readers’ knowledge and practice skills. |
| car-t therapy israel: The Molecular Basis of Cancer John Mendelsohn, Peter M. Howley, Mark A. Israel, Joe W. Gray, Craig B. Thompson, 2008-04-01 Successfully fighting cancer starts with understanding how it begins. This thoroughly revised 3rd Edition explores the scientific basis for our current understanding of malignant transformation and the pathogenesis and treatment of cancer. A team of leading experts thoroughly explain the molecular biologic principles that underlie the diagnostic tests and therapeutic interventions now being used in clinical trials and practice. Incorporating cutting-edge advances and the newest research, the book provides thorough descriptions of everything from molecular abnormalities in common cancers to new approaches for cancer therapy. Features sweeping updates throughout, including molecular targets for the development of anti-cancer drugs, gene therapy, and vaccines...keeping you on the cutting edge of your specialty. Offers a new, more user-friendly full-color format so the information that you need is easier to find. Presents abundant figures-all redrawn in full color-illustrating major concepts for easier comprehension. Features numerous descriptions of the latest clinical strategies-helping you to understand and take advantage of today’s state-of-the-art biotechnology advances. |
| car-t therapy israel: Engineering Technologies and Clinical Translation Mansoor M. Amiji, Lara Scheherazade Milane, 2021-08-25 Engineering Technologies and Clinical Translation: Volume 3: Delivery Strategies and Engineering Technologies in Cancer Immunotherapy examines the challenges of delivering immuno-oncology therapies, focusing specifically on the development of solutions for drug delivery and its clinical outcomes. Immuno-oncology (IO) is a growing field of medicine at the interface of immunology and cancer biology leading to development of novel therapeutic approaches, such as chimeric antigen receptor T-cell (CAR-T) and immune checkpoint blockade antibodies, that are clinically approved approaches for cancer therapy. Although currently approved IO approaches have shown tremendous promise for select types of cancers, broad application of IO strategies could even further improve the clinical success, especially for diseases such as pancreatic cancer, brain tumors where the success of IO so far has been limited. This volume of Delivery Strategies and Engineering Technologies in Cancer Immunotherapy discusses biomaterial, microfluidic, and biodegradable devices, engineered microbes, personalized medicine, clinical approval process, and many other IO technologies. Engineering Technologies and Clinical Translation: Volume 3: Delivery Strategies and Engineering Technologies in Cancer Immunotherapy creates a comprehensive treaty that engages the scientific and medical community who are involved in the challenges of immunology, cancer biology, and therapeutics with possible solutions from the nanotechnology and drug delivery side. - Explores engineering technologies and their clinical translation in a comprehensive way - Presents forecasting on the future of nanotechnology and drug delivery for IO - Engages the scientific and medical community who are involved in the challenges of immunology, cancer biology, and therapeutics with possible solutions from the nanotechnology and drug delivery side |
| car-t therapy israel: Context-Informed Perspectives of Child Risk and Protection in Israel Dorit Roer-Strier, Yochay Nadan, 2020-07-24 This volume adopts a context-informed framework exploring risk, maltreatment, well-being and protection of children in diverse groups in Israel. It incorporates the findings of seven case studies conducted at the Hebrew University of Jerusalem's NEVET Greenhouse of Context-Informed Research and Training for Children in Need. Each case study applies a context-informed approach to the study of perspectives of risk and protection among parents, children and professionals from different communities in Israel, utilizing varied qualitative methodologies. The volume analyses the importance of studying children and parents's perspectives in diverse societies and stresses the need for a context-informed perspective in designing prevention and intervention programs for children at risk and their families living in diverse societies. It further explores potential contribution to theory, research, practice, policy and training in the area of child maltreatment. |
| car-t therapy israel: Current Strategies in Cancer Gene Therapy Wolfgang Walther, 2017-01-17 This book describes important developments and emerging trends in experimental and clinical cancer gene therapy. It reflects the tremendous advances made over recent years with respect to immunogenes, suicide genes and gene correction therapies, as well as in gene suppression and miRNA therapies. Many of the described strategies focus on the generation of more efficient and specific means of attack at known and novel cellular targets associated with tumor development and progression. The book also details parallel improvements in vector design, vector delivery, and therapeutic efficacy. It offers readers a stimulating, broad overview of advances in the field, linking experimental strategies to their clinical applications. |
| car-t therapy israel: Chimeric Antigen Receptor T-Cell Therapies for Cancer E-Book Daniel W. Lee, Nirali N. Shah, 2019-11-30 From patient referral to post-therapy management, Chimeric Antigen Receptor (CAR) T-Cell Therapies for Cancer: A Practical Guide presents a comprehensive view of CAR modified T-cells in a concise and practical format. Providing authoritative guidance on the implementation and management of CAR T-cell therapy from Drs. Daniel W. Lee and Nirali N. Shah, this clinical resource keeps you up to date on the latest developments in this rapidly evolving area. - Covers all clinical aspects, including patient referral, toxicities management, comorbidities, bridging therapy, post-CAR monitoring, and multidisciplinary approaches to supportive care. - Includes key topics on associated toxicities such as predictive biomarkers, infections, and multidisciplinary approaches to supportive care. - Presents current knowledge on FDA approved CAR T-cell products as well as developments on the horizon. - Editors and authors represent leading investigators in academia and worldwide pioneers of CAR therapy. |
| car-t therapy israel: Therapeutic Antibodies Yuti Chernajovsky, Ahuva Nissim, 2007-11-22 This essential work, edited by two researchers at London’s famous Queen Mary’s medical school targets one of the most important areas in medical development today. These days, antibody therapeutics are the treatment of choice for several autoimmune and oncological conditions. They are, indeed, becoming the molecules of choice for further combination therapies and cell engineering. In this timely work, a slew of expert in the field of drug development summarize all the current developments and clinical successes. |
| car-t therapy israel: This Narrow Space Elisha Waldman, 2018-01-30 A memoir both bittersweet and inspiring by an American pediatric oncologist who spent seven years in Jerusalem treating children—Israeli Jews, Muslims, and Christians, and Palestinian Arabs from the West Bank and Gaza—who had all been diagnosed with cancer. In 2007, Elisha Waldman, a New York–based doctor in his mid-thirties, was offered his dream job: attending physician at Jerusalem’s Hadassah Medical Center. He had gone to medical school in Israel and spent time there as a teenager; now he was going to give something back to the land he loved. But in the wake of a financial crisis at the hospital, Waldman, with considerable regret, left Hadassah in 2014 and returned to the United States. This Narrow Space is his poignant memoir of seven years that were filled with a deep sense of accomplishment but also with frustration when regional politics got in the way of his patients’ care, and with tension over the fine line he had to walk when the religious traditions of some of his patients’ families made it difficult for him to give those children the care he felt they deserved. Navigating the baffling Israeli bureaucracy, the ever-present threat of full-scale war, and the cultural clashes that sometimes spilled into his clinic, Waldman learned to be content with small victories: a young patient whose disease went into remission, brokenhearted parents whose final hours with their child were made meaningful and comforting. Waldman also struggled with his own questions of identity and belief, and with the intractable conflict between Israelis and Palestinians that had become a fact of his daily life. What he learned about himself, about the complex country that he was now a part of, and about the brave and endearing children he cared for—whether they were from Rehavia, Me’ah She’arim, Ramallah, or Gaza City—will move and challenge readers everywhere. |
| car-t therapy israel: Haifa Republic: A Democratic Future for Israel Omri Boehm, 2021-08-17 A provocative argument for a new way of seeing Israel, Zionism, and the two-state solution. Haifa Republic: A Democratic Future for Israel is an urgent wake-up call. The philosopher Omri Boehm argues that it is long past time to recognize that there will not be a two-state solution to the conflict between Israel and the Palestinian people. After fifty years, Israel’s occupation of the West Bank constitutes annexation in all but name, even as the legitimate claims of the Arab population, soon to be a national majority, remain unaddressed. Meanwhile, daily life goes on under conditions rightly likened to apartheid. For liberals in Israel and America to continue to place their hopes in a two-state solution is a form of willful and culpable blindness, especially now that Israeli leaders across the political spectrum have begun to speak of ethnic cleansing. A catastrophe is in the making. But Haifa Republic also offers grounds for hope. Catastrophe can be averted, Boehm contends, by reconfiguring Israel as a single binational state in which Palestinians and Jews both possess human rights and equal citizenship. The original Zionists—Theodor Herzl, Ze’ev Jabotinsky, and, early in his career, David Ben-Gurion—all advocated such a federation, and as prime minister, Menachem Begin successfully submitted a kindred plan to the Knesset. A binational federation offers a last chance for the two peoples who call Palestine home to live in peace and mutual respect and to have a truly democratic future in common. |
| car-t therapy israel: Cell of Cells Cynthia Fox, 2007 Positioned at the cutting edge of science, 'Cell of Cells' charts the international race to utilize the stem cell. |
| car-t therapy israel: Psycho-Oncology for the Clinician Shulamith Kreitler, 2019-03-18 This volume strives to give oncologists and other medical practitioners a thorough picture of the oncology patient. It’s designed to show that psychological needs of the patient are an important aspect that should be considered for optimizing the effects of cancer treatment, no less than genetic, immunological, physiological and other medical features that are often considered as necessary components of personalized medicine. Using evidence-based information, the book describes the different ways cancer touches upon a person’s life, including emotional, physical, and social changes, important decisions, and support structure. It also details the phases every cancer patient encounters along the way, from getting tested and waiting for the diagnosis, to treatments, survival, and confronting one’s mortality. Psycho-oncology for the Clinician will serve to contribute to the further scientific development of psycho-oncology, expand its use as a treatment modality, strengthen its status as an essential component of cancer care, and promote the acceptance of psycho-oncology as the new evidence-based constituent of personalized medicine in oncology. |
| car-t therapy israel: Music in Biblical Life Jonathan L. Friedmann, 2013-01-22 Music was integral to the daily life of ancient Israel. It accompanied activities as diverse as manual labor and royal processionals. At key junctures and in core institutions, musical tones were used to deliver messages, convey emotions, strengthen communal bonds and establish human-divine contact. This book explores the intricate and multifaceted nature of biblical music through a detailed look into four major episodes and genres: the Song of the Sea (Exod. 15), King Saul and David's harp (1 Sam. 16), the use of music in prophecy, and the Book of Psalms. This investigation demonstrates how music helped shape and define the self-identity of ancient Israel. |
| car-t therapy israel: Pharmacotherapeutic Botanicals for Cancer Chemoprevention Manish Kumar, Ashita Sharma, Praveen Kumar, 2020-07-20 The book presents a comprehensive and up-to-date overview of phytochemicals as efficient cancer therapeutics. Over the last few decades there has been a paradigm shift from conventional cancer therapeutic approaches to alternative and complementary medicinal approaches especially using phytoconstituents from natural products. As such, the book provides an in-depth understanding of phytochemicals targeting diverse signaling pathways involved in cancer along with the evaluation of the cancer modulatory effects of phytochemicals. It also highlights the potential modulatory effect of single nucleotide polymorphisms (SNPs) on the cancer-associated cellular pathways and their interactions with the phytochemicals. Further, it analyzes the drug delivery methods, bioavailability of active components of botanicals, and toxicity of phytochemicals. Lastly, the book elucidates the 3D cell culture and animal models systems to analyze the beneficial effects of phytochemicals in cancer. |
| car-t therapy israel: The ABC of the OPT Orna Ben-Naftali, Michael Sfard, Hedi Viterbo, 2018-05-10 A lexicon of the legal, administrative, and military terms and concepts central to the Israeli occupation of the Palestinian Territories. |
| car-t therapy israel: γδ T cells in Cancer Ilan Bank, Bruno Silva-Santos, Jurgen Kuball, Dieter Kabelitz, Seth Coffelt, Willi Born, 2021-02-22 We acknowledge the initiation and support of this Research Topic by the International Union of Immunological Societies (IUIS). Dr. Dieter Kabelitz currently serves as the chairman for the IUIS Education Committee. Topic Editor Prof. Ilan Bank is Chief Scientific Officer of GammaCell Bio-Technologies Ltd. Topic Editor Prof. Jurgen Kuball is co-founder and scientific advisor of GADETA. Topic Editor Prof. Bruno Silva-Santos is co-founder of Lymphact S.A., a company now owned by GammaDelta Therapeutics. All other Topic Editors declare no competing interests with regards to the Research Topic subject. |
| car-t therapy israel: Radiotherapy and Brachytherapy Yves Lemoigne, Alessandra Caner, 2009-09-11 This book reports the majority of lectures given during the NATO Advanced Study Institute ASI-982996, which was held at the European Scientific Institute of Archamps (ESI, Archamps – France) from November 15 to November 27, 2007. The ASI course was structured in two parts: the first was dedicated to what is often called “teletherapy”, i. e. radiotherapy with external beams, while the second focused on internal radiotherapy, also called “brachytherapy” or “curietherapy” in honour of Madame Curie who initiated the technique about a century ago. This ASI took place after the European School of Medical Physics, which devoted a 3 week period to medical imaging, a subject complementary to the topics of this book. Courses devoted to nuclear medicine and digital imaging techniques are collected in two volumes of the NATO Science Series entitled “Physics for Medical Imaging Applications” (ISBN 978-1-4020-5650-5) and “Molecular imaging: computer reconstruction and practice” (ISBN 978-1-4020- 8751-6). Every year in autumn ESI organises the European School of Medical Physics, which covers a large spectrum of topics ranging from Medical Imaging to Radiotherapy, over a period of 5 weeks. Thanks to the Cooperative Science and Technology sub-programme of the NATO Science Division, weeks four and five were replaced this year by the ASI course dedicated to “Physics of Modern Radiotherapy & Brachytherapy”. This allowed the participation of experts and students from 20 different countries, with diverse cultural background and p- fessional experience. |
| car-t therapy israel: Heparanase Israel Vlodavsky, Ralph D. Sanderson, Neta Ilan, 2020-04-09 Written by internationally recognized leaders in Heparanase biology, the book’s eight chapters offer an opportunity for scientists, clinicians and advanced students in cell biology, tumor biology and oncology to obtain a comprehensive understanding of Heparanase’s multifaceted activities in cancer, inflammation, diabetes and other diseases, as well as its related clinical applications. Proteases and their involvement in cancer progression have been well addressed and documented; however, the emerging premise presented within this book is that Heparanase is a master regulator of aggressive cancer phenotypes and crosstalk with the tumor microenvironment. This endoglycosidase contributes to tumor-mediated remodeling of the extracellular matrix and cell surfaces, augmenting the bioavailability of pro-tumorigenic and pro-inflammatory growth factors and cytokines that are bound to Heparan sulfate. Compelling evidence ties Heparanase with all steps of tumor progression including tumor initiation, growth, angiogenesis, metastasis, and chemoresistance, supporting the notion that Heparanase is an important contributor to the poor outcome of cancer patients and a validated target for therapy. Unlike Heparanase, heparanase-2, a close homolog of Heparanase, lacks enzymatic activity, inhibits Heparanase, and regulates selected genes that promote normal differentiation and tumor suppression. Written by internationally recognized leaders in Heparanase biology, this volume presents a comprehensive understanding of Heparanase’s multifaceted activities in cancer, inflammation, diabetes and other diseases, as well as its related clinical applications to scientists, clinicians and advanced students in cell biology, tumor biology and oncology. |
| car-t therapy israel: Life Over Cancer Keith Block, 2009-04-21 Dr. Keith Block is at the global vanguard of innovative cancer care. As medical director of the Block Center for Integrative Cancer Treatment in Evanston, Illinois, he has treated thousands of patients who have lived long, full lives beyond their original prognoses. Now he has distilled almost thirty years of experience into the first book that gives patients a systematic, research-based plan for developing the physical and emotional vitality they need to meet the demands of treatment and recovery. Based on a profound understanding of how body and mind can work together to defeat disease, this groundbreaking book offers: • Innovative approaches to conventional treatments, such as “chronotherapy”–chemotherapy timed to patients’ unique circadian rhythms for enhanced effectiveness and reduced toxicity • Dietary choices that make the biochemical environment hostile to cancer growth and recurrence, and strengthen the immune system’s ability to attack remaining cancer cells • Precise supplement protocols to tame treatment side effects, relieve disease-related symptoms, and modify processes like inflammation and glycemia that can fuel cancer if left untreated • A new paradigm for exercise and stress reduction that restores your strength, reduces anxiety and depression, and supports the body’s own ability to heal • A complete program for remission maintenance–a proactive plan to make sure the cancer never returns Also included are “quick-start” maps to help you find the information you need right now and many case histories that will support and inspire you. Encouraging, compassionate, and authoritative, Life over Cancer is the guide patients everywhere have been waiting for. |
| car-t therapy israel: The State of Israel vs. the Jews Sylvain Cypel, 2024-08-06 A PopMatters Best Book of the Year A perceptive study of how Israel’s actions, which run counter to the traditional historical values of Judaism, are putting Jewish people worldwide in an increasingly untenable position, now with a new introduction. More than a decade ago, the historian Tony Judt considered whether the behavior of Israel was becoming not only “bad for Israel itself” but also, on a wider scale, “bad for the Jews.” Under the leadership of Benjamin Netanyahu, this issue has grown ever more urgent. In The State of Israel vs. the Jews, veteran journalist Sylvain Cypel addresses it in depth, exploring Israel’s rightward shift on the international scene and with regard to the diaspora. Cypel reviews the little-known details of the military occupation of Palestinian territory, the mindset of ethnic superiority that reigns throughout an Israeli “colonial camp” that is largely in the majority, and the adoption of new laws, the most serious of which establishes two-tier citizenship between Jews and non-Jews. He shows how Israel has aligned itself with authoritarian regimes and adopted the practices of a security state, including the use of technologies such as the software that enabled the tracking and, ultimately, the assassination of Saudi Arabian journalist Jamal Khashoggi. Lastly, The State of Israel vs. the Jews examines the impact of Israel’s evolution in recent years on the two main communities of the Jewish diaspora, in France and the United States, considering how and why public figures in each differ in their approaches. |
| car-t therapy israel: Optimal Control Applied to Biological Models Suzanne Lenhart, John T. Workman, 2007-05-07 From economics and business to the biological sciences to physics and engineering, professionals successfully use the powerful mathematical tool of optimal control to make management and strategy decisions. Optimal Control Applied to Biological Models thoroughly develops the mathematical aspects of optimal control theory and provides insight into t |
| car-t therapy israel: Methods in Community-Based Participatory Research for Health Barbara A. Israel, Eugenia Eng, Amy J. Schulz, Edith A. Parker, 2005-08-19 Written by distinguished experts in the field, this book shows how researchers, practitioners, and community partners can work together to establish and maintain equitable partnerships using a Community-Based Participatory Research (CBPR) approach to increase knowledge and improve health and well-being of the communities involved. CBPR is a collaborative approach to research that draws on the full range of research designs, including case study, etiologic, longitudinal, experimental, and nonexperimental designs. CBPR data collection and analysis methods involve both quantitative and qualitative approaches. What distinguishes CBPR from other approaches to research is the active engagement of all partners in the process. This book provides a comprehensive and thorough presentation of CBPR study designs, specific data collection and analysis methods, and innovative partnership structures and process methods. This book informs students, practitioners, researchers, and community members about methods and applications needed to conduct CBPR in the widest range of research areas—including social determinants of health, health disparities, health promotion, community interventions, disease management, health services, and environmental health. |
| car-t therapy israel: Gene and Cellular Immunotherapy for Cancer Armin Ghobadi, John F. DiPersio, 2022-01-01 Clinical and preclinical exploration of gene and cellular immunotherapy have seen rapid growth and interest with the development and approval of five Chimeric Antigen Receptor T-cell (CAR-T) products for lymphoma and myeloma and one Bispecific T-Cell Engager (BiTE) for acute lymphoblastic leukemia (ALL). These advances have dramatically improved the management of patients with relapsed refractory lymphoma, myeloma and leukemia. Gene and Cellular Immunotherapy for Cancer offers readers a comprehensive review of current cellular and gene-based immunotherapies. Divided into eighteen cohesive chapters, this book provides an in-depth and detailed look into cellular-based immunotherapies including CAR-T, TCR-T, TIL, Viral CTLs, NK cells in addition to T/NK cell engagers, focusing on their historical perspectives, biology, development and manufacturing, toxicities and more. Edited by two leading experts on gene and cellular immunotherapy, the book will feature chapters written by a diverse collection of recognized and up-and-coming experts and researchers in the field, providing oncologists, immunologists, researchers and clinical and basic science trainees with a bench to bedside view of the latest developments in the field. |
| car-t therapy israel: Coffins on Our Shoulders Dan Rabinowitz, Khawla Abu-Baker, 2005-09-12 Written jointly by an Israeli anthropologist and a Palestinian family therapist, this analysis of the Arab-Israeli conflict combines the perspectives of two prominent segments of the Middle Eastern puzzle - Israeli Jews and the Palestinian citizens of Israel. |
| car-t therapy israel: Advances in Cancer Immunotherapy Shin Mukai, 2024-09-18 Cancer immunotherapy utilizes the immune system to identify and target cancer cells. Over the past decades, researchers have advanced these treatments by (1) uncovering how tumors evade the immune system and (2) developing techniques to trigger an anti-tumor immune response and block tumor immune escape. These immunotherapies can be administered alone or in combination with other treatments, leading to an improved survival rate and quality of life for cancer patients. Indeed, several immunotherapies have received approval from the United States Food and Drug Administration (FDA) for the treatment of various cancers. For instance, blocking PD-1/PD-L1 has increased the five-year survival rate for patients with advanced non-small-cell lung cancer. However, the effectiveness of current immunotherapies varies significantly among patients, and they can cause severe side effects. Although there is still a need for improvement, cancer immunotherapy is regarded as a promising therapeutic modality. This book focuses on the preclinical development and evolving clinical landscape of cancer immunotherapy, encouraging synthetic organic/medicinal chemists, immunologists, and biologists to develop new, safe, and affordable treatments. |
| car-t therapy israel: Fly Already Etgar Keret, 2019-09-03 From a genius (New York Times) storyteller: a new, subversive, hilarious, heart-breaking collection. There is sweetheartedness and wisdom and eloquence and transcendence in his stories because these virtues exist in abundance in Etgar himself... I am very happy that Etgar and his work are in the world, making things better. --George Saunders There's no one like Etgar Keret. His stories take place at the crossroads of the fantastical, searing, and hilarious. His characters grapple with parenthood and family, war and games, marijuana and cake, memory and love. These stories never go to the expected place, but always surprise, entertain, and move... In Arctic Lizard, a young boy narrates a post-apocalyptic version of the world where a youth army wages an unending war, rewarded by collecting prizes. A father tries to shield his son from the inevitable in Fly Already. In One Gram Short, a guy just wants to get a joint to impress a girl and ends up down a rabbit hole of chaos and heartache. And in the masterpiece Pineapple Crush, two unlikely people connect through an evening smoke down by the beach, only to have one of them imagine a much deeper relationship. The thread that weaves these pieces together is our inability to communicate, to see so little of the world around us and to understand each other even less. Yet somehow, in these pages, through Etgar's deep love for humanity and our hapless existence, a bright light shines through and our universal connection to each other sparks alive. |
| car-t therapy israel: Lifestyle Redesign , 2015 |
| car-t therapy israel: Israel on the Appomattox Melvin Patrick Ely, 2010-12-01 WINNER OF THE BANCROFT PRIZEA New York Times Book Review and Atlantic Monthly Editors' ChoiceThomas Jefferson denied that whites and freed blacks could live together in harmony. His cousin, Richard Randolph, not only disagreed, but made it possible for ninety African Americans to prove Jefferson wrong. Israel on the Appomattox tells the story of these liberated blacks and the community they formed, called Israel Hill, in Prince Edward County, Virginia. There, ex-slaves established farms, navigated the Appomattox River, and became entrepreneurs. Free blacks and whites did business with one another, sued each other, worked side by side for equal wages, joined forces to found a Baptist congregation, moved west together, and occasionally settled down as man and wife. Slavery cast its grim shadow, even over the lives of the free, yet on Israel Hill we discover a moving story of hardship and hope that defies our expectations of the Old South. |
| car-t therapy israel: Human Germline Genome Modification and the Right to Science Andrea Boggio, Cesare P. R. Romano, Jessica Almqvist, 2022-06-30 The advent of the CRISPR/Cas9 class of genome editing tools is transforming not just science and medicine, but also law. When the genome of germline cells is modified, the modifications could be inherited, with far-reaching effects in time and scale. Legal systems are struggling with keeping up with the CRISPR revolution and both lawyers and scientists are often confused about existing regulations. This book contains an analysis of the national regulatory framework in eighteen selected countries. Written by national legal experts, it includes all major players in bioengineering, plus an analysis of the emerging international standards and a discussion of how international human rights standards should inform national and international regulatory frameworks. The authors propose a set of principles for the regulation of germline engineering, based on international human rights law, that can be the foundation for regulating heritable gene editing both at the level of countries as well as globally. |
| car-t therapy israel: The Israeli Solution Caroline Glick, 2014-03-04 A landmark manifesto issuing a bold call for a one-state solution to the Israeli-Palestine conflict. The reigning consensus in elite and academic circles is that the United States must seek to resolve the Palestinians' conflict with Israel by implementing the so-called two-state solution. Establishing a Palestinian state, so the thinking goes, would be a panacea for all the region’s ills. In a time of partisan gridlock, the two-state solution stands out for its ability to attract supporters from both sides of America's ideological divide. But the great irony is that it is one of the most irrational and failed policies the United States has ever adopted. Between 1970 and 2013, the United States presented nine different peace plans for Israel and the Palestinians, and for the past twenty years, the two state solution has been the centerpiece of U.S. Middle East policy. But despite this laser focus, American efforts to implement a two-state peace deal have failed—and with each new attempt, the Middle East has become less stable, more violent, more radicalized, and more inimical to democratic values and interests. In The Israeli Solution, Caroline Glick, senior contributing editor to the Jerusalem Post, examines the history and misconceptions behind the two-state policy, most notably: - The huge errors made in counting the actual numbers of Jews and Arabs in the region. The 1997 Palestinian Census, upon which most two-state policy is based, wildly exaggerated the numbers of Palestinians living in the West Bank and Gaza. - Neglect of the long history of Palestinian anti-Semitism, refusal to negotiate in good faith, terrorism, and denial of Israel’s right to exist. - Disregard for Israel’s stronger claims to territorial sovereignty under international law, as well as the long history of Jewish presence in the region. - Indifference to polling data that shows the Palestinian people admire Israeli society and governance. Despite a half-century of domestic and international terrorism, anti-semitism, and military attacks from regional neighbors who reject its right to exist, Israel has thrived as the Middle East’s lone democracy. After a century spent chasing a two-state policy that hasn’t brought the Israelis and Palestinians any closer to peace, The Israeli Solution offers an alternative path to stability in the Middle East based on Israeli sovereignty over Judea and Samaria. |
| car-t therapy israel: Psychosocial Aspects of Pediatric Oncology Shulamith Kreitler, Myriam Weyl Ben Arush, 2004-05-31 Publisher description |
| car-t therapy israel: Rise and Kill First Ronen Bergman, 2018-01-30 NEW YORK TIMES BESTSELLER • The first definitive history of the Mossad, Shin Bet, and the IDF’s targeted killing programs, hailed by The New York Times as “an exceptional work, a humane book about an incendiary subject.” WINNER OF THE NATIONAL JEWISH BOOK AWARD IN HISTORY NAMED ONE OF THE TEN BEST BOOKS OF THE YEAR BY JENNIFER SZALAI, THE NEW YORK TIMES NAMED ONE OF THE BEST BOOKS OF THE YEAR BY The Economist • The New York Times Book Review • BBC History Magazine • Mother Jones • Kirkus Reviews The Talmud says: “If someone comes to kill you, rise up and kill him first.” This instinct to take every measure, even the most aggressive, to defend the Jewish people is hardwired into Israel’s DNA. From the very beginning of its statehood in 1948, protecting the nation from harm has been the responsibility of its intelligence community and armed services, and there is one weapon in their vast arsenal that they have relied upon to thwart the most serious threats: Targeted assassinations have been used countless times, on enemies large and small, sometimes in response to attacks against the Israeli people and sometimes preemptively. In this page-turning, eye-opening book, journalist and military analyst Ronen Bergman—praised by David Remnick as “arguably [Israel’s] best investigative reporter”—offers a riveting inside account of the targeted killing programs: their successes, their failures, and the moral and political price exacted on the men and women who approved and carried out the missions. Bergman has gained the exceedingly rare cooperation of many current and former members of the Israeli government, including Prime Ministers Shimon Peres, Ehud Barak, Ariel Sharon, and Benjamin Netanyahu, as well as high-level figures in the country’s military and intelligence services: the IDF (Israel Defense Forces), the Mossad (the world’s most feared intelligence agency), Caesarea (a “Mossad within the Mossad” that carries out attacks on the highest-value targets), and the Shin Bet (an internal security service that implemented the largest targeted assassination campaign ever, in order to stop what had once appeared to be unstoppable: suicide terrorism). Including never-before-reported, behind-the-curtain accounts of key operations, and based on hundreds of on-the-record interviews and thousands of files to which Bergman has gotten exclusive access over his decades of reporting, Rise and Kill First brings us deep into the heart of Israel’s most secret activities. Bergman traces, from statehood to the present, the gripping events and thorny ethical questions underlying Israel’s targeted killing campaign, which has shaped the Israeli nation, the Middle East, and the entire world. “A remarkable feat of fearless and responsible reporting . . . important, timely, and informative.”—John le Carré |
| car-t therapy israel: A Land Twice Promised Noa Baum, 2016-06-07 An Israeli woman writes about growing up amid war and ancestral trauma and later building a friendship with a Palestinian woman in America. Israeli storyteller Noa Baum grew up in Jerusalem in the shadow of the ancestral traumas of the holocaust and ongoing wars. Stories of the past and fear of annihilation in the wars of the ’60s, ’70s, and ’80s shaped her perceptions and identity. In America, she met a Palestinian woman who had grown up under Israeli Occupation, and as they shared memories of war years in Jerusalem, an unlikely friendship blossomed. A Land Twice Promised delves into the heart of one of the world’s most enduring and complex conflicts. Baum’s deeply personal memoir recounts her journey from girlhood in post-Holocaust Israel to her adult encounter with “the other.” With honesty, compassion, and humor, she captures the drama of a nation at war and her discovery of humanity in the enemy. Winner of the 2017 Anne Izard Storytellers’ Choice Award, among others, this compelling memoir demonstrates the transformative power of art and challenges each reader to take the first step toward peace. Praise for A Land Twice Promised “A penetrating, introspective memoir that mines the depths of the chasm between the Israeli and Palestinian experiences, the torment of family loss and conflict, and the therapy of storytelling as a cleansing art. You will not think in the same way at the end of this captivating book as you did at the beginning.” —David K. Shipler, Pulitzer Prize–winning author of Arab and Jew: Wounded Spirits in a Promised Land |
| car-t therapy israel: Alternatives in Cancer Therapy Ross Pelton, 2009-09-29 Alternatives in Cancer Therapy offers help for all patients coping with cancer. The therapies discussed in this book are primarily non-toxic, have few, if any, side effects, and tend to strengthen the immune system. They can be used as supplemental regimens that help maximize the effectiveness of traditional therapies such as surgery, radiation, and chemotherapy. Patients have a right to know all of their treatment options, and Dr. Ross Pelton presents dozens of choices, including: * Shark Cartilage * Gerson Therapy * Mistletoe * Isoprinosine * Laetrile * Selenium * Beta-Carotene * Hydrogen Peroxide * Vitamins C and E * The Hoxsey Treatment Non-traditional therapies can enhance the quality of life, and improve overall health while treating the disease. Alternatives in Cancer Therapy provides information on the research, efficacy, potential side effects, and availability of each treatment. |
| car-t therapy israel: Chimeric Antigen Receptor T Cells Kamilla Swiech, Kelen Cristina Ribeiro Malmegrim, Virgínia Picanço-Castro, 2020-11-24 This volume provides comprehensive methods from expert scientists working in the Chimeric Antigen Receptor T Cell (CAR-T Cell) field. Chapters guide readers through the state-of-art of CAR-T cell technology, CAR design and vector production, CAR-T cell generation and manufacturing, CAR-T cell characterization, and quality control. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Chimeric Antigen Receptor T Cells: Development and Production aims to be useful in the production of CAR-T cells, especially for therapeutic purposes. |
| car-t therapy israel: Gene Therapy of Cancer Wolfgang Walther, 2022-06-22 This third edition provides new and updated chapters on gene therapeutic strategies of cancer. Chapters guide readers through suicide and oncolytic gene therapy, gene replacement and gene suppression therapy, vector development and refinement, immunogene therapy, TCR and CAR engineering, tumor vaccination using DNA or RNA vaccines, and antitumoral immune stimulation at different levels. Written in the format of the highly successful Methods in Molecular Biology series, each chapter includes an introduction to the topic, lists necessary materials and reagents, includes tips on troubleshooting and known pitfalls, and step-by-step, readily reproducible protocols. Authoritative and cutting-edge, Gene Therapy of Cancer: Methods and Protocols, Third Edition aims to be a useful and practical guide to new researchers and experts looking to expand their knowledge. |
| car-t therapy israel: Introduction to Antibody Engineering Florian Rüker, Gordana Wozniak-Knopp, 2021-01-04 This highly readable textbook serves as a concise and engaging primer to the emerging field of antibody engineering and its various applications. It introduces readers to the basic science and molecular structure of antibodies, and explores how to characterize and engineer them. Readers will find an overview of the latest methods in antibody identification, improvement and biochemical engineering. Furthermore, alternative antibody formats and bispecific antibodies are discussed. The book’s content is based on lectures for the specializations “Protein Engineering” and “Medical Biotechnology” within the Master’s curriculum in “Biotechnology.” The lectures have been held at the University of Natural Resources and Life Sciences, Vienna, in cooperation with the Medical University of Vienna, since 2012 and are continuously adapted to reflect the latest developments in the field. The book addresses Master’s and PhD students in biotechnology, molecular biology and immunology, and all those who are interested in antibody engineering. |
| car-t therapy israel: My Promised Land Ari Shavit, 2013-11-19 NEW YORK TIMES BESTSELLER • A NEW YORK TIMES BOOK REVIEW AND ECONOMIST BEST BOOK OF THE YEAR “A deeply reported, deeply personal history of Zionism and Israel that does something few books even attempt: It balances the strength and weakness, the idealism and the brutality, the hope and the horror, that has always been at Zionism’s heart.”—Ezra Klein, The New York Times Winner of the Natan Book Award, the National Jewish Book Award, and the Anisfield-Wolf Book Award Ari Shavit’s riveting work, now updated with new material, draws on historical documents, interviews, and private diaries and letters, as well as his own family’s story, to create a narrative larger than the sum of its parts: both personal and of profound historical dimension. As he examines the complexities and contradictions of the Israeli condition, Shavit asks difficult but important questions: Why did Israel come to be? How did it come to be? Can it survive? Culminating with an analysis of the issues and threats that Israel is facing, My Promised Land uses the defining events of the past to shed new light on the present. Shavit’s analysis of Israeli history provides a landmark portrait of a small, vibrant country living on the edge, whose identity and presence play a crucial role in today’s global political landscape. |
| car-t therapy israel: A Cure Within Neil Canavan, 2018 Cancer. There are few words in the English language having such a visceral, personal impact. Cancer patient. Cancer survivor. Pretty much anyone over the age of 30 knows one. A family member. A friend. Someone lost too soon. Someone forever changed. But we don't really like to talk about it, because there's really not much we can do. We fight cancer, sure, but we rarely win. Defeating cancer is one of medical science's greatest challenges. So when a novel approach to treatment seems promising, there is an intense interest in its progress and those who are making it. This book is about both - the progress and the pioneers - and its focus is the revolutionary science of something called cancer immunotherapy. This medical marvel, cancer immunotherapy - also called immuno-oncology - is still in its infancy. Yet, mobilizing the immune system to recognize and attack cancer has long been imagined, and occasionally attempted, for more than 100 years: It is only just recently that significant - in fact, unprecedented - progress has been made. With the use of newly approved immunotherapy treatments, there are now reports of hundreds, if not thousands of cancer patients with advanced disease living years beyond all prior expectation. Some of these once-terminally ill patients are now called cured. This has never happened before. As Dr. Jill O'Donnell-Tormey comments in the Foreword, It has taken decades of basic research and billions of dollars of investment to build the foundation upon which today's lifesaving treatments are based. This book offers a uniquely entertaining yet inspiring glimpse into the lives and minds of the academic and industry pioneers who forged this new field. It is a story of how an obscure and oft-derided field of cancer research - and the tenacious few scientists who refused to abandon it - came from behind to become the new 'darling of oncology.' The book's author, Neil Canavan, is an experienced commentator on new developments in medical science. His portraits of 25 of the pioneers in immunotherapy are the culmination of two years of travel to laboratories, offices, and conferences around the world and countless hours of conversation with individuals immersed in a vitally important, promising assault on a dread disease that kills more than eight million people each year worldwide. -- from dust jacket. |
| car-t therapy israel: Innovations in Development, Translational Research and Manufacturing of CAR T cells Michael Hudecek, Qasim Rafiq, Stephen Goldrick, Ulrike Koehl, Helene Negre, Carmen Sanges, 2024-10-03 Immunotherapy with genetically engineered immune cell products is a transformative treatment modality with potential applications in various fields of medicine. A prime example is chimeric antigen receptor (CAR)-modified T cells in hematology and oncology, and the advent of CAR T cell therapies to treat infectious diseases, autoimmune disorders, and cardiovascular diseases. The medical need and demand from patients and caregivers require radical innovations to accelerate and improve pre-clinical development and clinical translation, provision of gene-transfer vectors, and immune cell product manufacturing as well as a critical reflection and discussion on ethical and socioeconomic aspects. The goal of this special issue of Frontiers in Immunology is to provide a comprehensive and multi-faceted view on the current state-of-the-art, imminent and future directions the field is taking in order to accelerate the pre-clinical development, clinical translation, and manufacturing of CAR T cells, increase access and sustainability of CAR T cell therapy for health care systems (in developed and in developing countries). This special issue will focus on the medical and scientific dimension incl. approved and emerging indications, new areas in medicine, advanced gene-transfer and gene-editing technologies, innovations in pre-clinical assessment (efficacy, toxicology, genomic safety), innovations in scalable automated manufacturing (bioprocessing), the implementation of high content data acquisition, machine learning and artificial intelligence, innovations in clinical trial design; and consider the ethical, socioeconomic and societal dimension of CAR T cells in particular and gene-engineered immune cell therapy in general. |
| car-t therapy israel: Cancer Chemotherapy, Immunotherapy, and Biotherapy Bruce Chabner, Dan Louis Longo, 2018 Publisher's Note: Products purchased from 3rd Party sellers are not guaranteed by the Publisher for quality, authenticity, or access to any online entitlements included with the product. Thoroughly revised and reformatted, the sixth edition of Cancer Chemotherapy, Immunotherapy and Biotherapy reflects recent significant changes in cancer treatment. This newly streamlined edition contains full-color illustrations, more tables for quick reference, and new immunotherapy and molecular targeted therapy content that brings you fully up to date with the state of the art in all current cancer therapies. Provides thorough, comprehensive coverage of the scientific and clinical aspects of immunotherapy, biotherapy, and chemotherapy. Includes significantly expanded information on immunotherapy and molecular targeted therapy, as well as the latest information on all drugs and biological agents--their mechanisms of action, interactions with other agents, toxicities, side effects, and mechanisms of resistance. Features a new, full-color format, a newly streamlined presentation. and more tables and figures throughout for quick access to high-yield information. Explains the rationale for use of drugs in specific schedules and combinations and offers guidelines for dose adjustment in specific situations. Enhance Your eBook Reading Experience Read directly on your preferred device(s), such as computer, tablet, or smartphone. Easily convert to audiobook, powering your content with natural language text-to-speech. |
r/Cars - For Car Enthusiasts - Reddit
r/Cars is the largest automotive enthusiast community on the Internet. We're Reddit's central hub for vehicle-related discussion, industry news, reviews, projects, DIY guides, advice, stories, …
Former CarMax employee here. If you plan to go in for an ... - Reddit
Feb 3, 2021 · Where younger an estimated value and when you come in our car buyer puts in his notes and we show you side by side. Where you thought you were and didn't mention that …
How much do car salesmen REALLY make? : r/askcarsales - Reddit
Apr 26, 2022 · Is 6 figures in car sales the norm? EDIT: 25M, single, no kids. Currently in civil engineering with $78k salary in LCOL area (central texas). Seems like folks are making well …
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Sep 7, 2018 · r/Cars is the largest automotive enthusiast community on the Internet. We're Reddit's central hub for vehicle-related discussion, industry news, reviews, projects, DIY …
Car dealership scratch-off mailer scam (Update) : r/Scams - Reddit
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Nothing Under - Reddit
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I also know that being young and driving a newer car is the reason behind all this, but any advice/tips about all this is much needed! Is the monthly rate really normal for someone my …
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4 days ago · Forum: HoseHeads Sprint Car General Forum Moderators: dirtonly / dmantx / hosehead First
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Aug 26, 2023 · 31 votes, 30 comments. 36K subscribers in the E90 community. Hub for all BMW 3 series, 2006-2013. Anyone is welcome!
r/Cars - For Car Enthusiasts - Reddit
r/Cars is the largest automotive enthusiast community on the Internet. We're Reddit's central hub for vehicle-related discussion, industry news, reviews, projects, DIY guides, advice, stories, …
Former CarMax employee here. If you plan to go in for an ... - Reddit
Feb 3, 2021 · Where younger an estimated value and when you come in our car buyer puts in his notes and we show you side by side. Where you thought you were and didn't mention that …
How much do car salesmen REALLY make? : r/askcarsales - Reddit
Apr 26, 2022 · Is 6 figures in car sales the norm? EDIT: 25M, single, no kids. Currently in civil engineering with $78k salary in LCOL area (central texas). Seems like folks are making well …
Hoseheadforums.com Home
Aug 17, 2013 · Bodnar Motorsports building new car for 2019 viewed (10751) Wicked Energy Gum to Sponsor the Northwest Focus Midget Series viewed (8765) Heartland Motorsports …
best places to search for used cars : r/cars - Reddit
Sep 7, 2018 · r/Cars is the largest automotive enthusiast community on the Internet. We're Reddit's central hub for vehicle-related discussion, industry news, reviews, projects, DIY …
Car dealership scratch-off mailer scam (Update) : r/Scams - Reddit
Mar 12, 2019 · I posted a couple of days ago about a scratch-off contest mailer that I had received from a local car dealership. My "game piece" seemed to indicate that I had won the Grand …
Nothing Under - Reddit
r/NothingUnder: Dresses and clothing with nothing underneath. Women in outfits perfect for flashing, easy access, and teasing men.
What’s the best auto insurance? : r/Insurance - Reddit
I also know that being young and driving a newer car is the reason behind all this, but any advice/tips about all this is much needed! Is the monthly rate really normal for someone my …
HoseHeads Sprint Car General Forum - Oval Track Racing Forums
4 days ago · Forum: HoseHeads Sprint Car General Forum Moderators: dirtonly / dmantx / hosehead First
I've been scouring the internet for a working download link to
Aug 26, 2023 · 31 votes, 30 comments. 36K subscribers in the E90 community. Hub for all BMW 3 series, 2006-2013. Anyone is welcome!
