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| car t therapy india: Chimeric Antigen Receptor T-Cell Therapies for Cancer E-Book Daniel W. Lee, Nirali N. Shah, 2019-11-30 From patient referral to post-therapy management, Chimeric Antigen Receptor (CAR) T-Cell Therapies for Cancer: A Practical Guide presents a comprehensive view of CAR modified T-cells in a concise and practical format. Providing authoritative guidance on the implementation and management of CAR T-cell therapy from Drs. Daniel W. Lee and Nirali N. Shah, this clinical resource keeps you up to date on the latest developments in this rapidly evolving area. - Covers all clinical aspects, including patient referral, toxicities management, comorbidities, bridging therapy, post-CAR monitoring, and multidisciplinary approaches to supportive care. - Includes key topics on associated toxicities such as predictive biomarkers, infections, and multidisciplinary approaches to supportive care. - Presents current knowledge on FDA approved CAR T-cell products as well as developments on the horizon. - Editors and authors represent leading investigators in academia and worldwide pioneers of CAR therapy. |
| car t therapy india: Immunopharmacogenomics Yusuke Nakamura, 2015-09-18 This book proposes immunogenomics, or immunopharmacogenomics, as the next-generation big science to uncover the role that the immune system plays in the pathogenesis of many diseases, by summarizing the importance of the deep sequencing of T-cell and B-cell receptors. Immunogenomics/immunopharmacogenomics, a genetic characterization of the immune system made possible by next-generation sequencing (NGS), will be important for the further understanding of the pathogenesis of various disease conditions. Abnormal immune responses in the body lead to development of autoimmune diseases and food allergies. Rejection of recipient cells and tissues, as well as severe immune reactions to donor cells, is also the result of uncontrolled immune responses in the recipient body. There have been many reports indicating that activated immune responses caused by the interaction of drugs and HLA are present in drug-induced skin hypersensitivity and liver toxicity. The importance of the host immune responses has been recognized in cancer treatments, not only for immunotherapy but also for cytotoxic agents and molecular targeted drugs. Hence, characterization of the T-cell receptor and B-cell receptor repertoire by means of NGS deep sequencing will ultimately make possible the identification of the molecular mechanisms that underlie various diseases and drug responses. In addition, this approach may contribute to the identification of antigens associated with the onset or progression of autoimmune diseases as well as food allergies. Although the germline alterations and somatic mutations have been extensively analyzed, changes or alterations of the immune responses during the course of various disease conditions or during various treatments have not been analyzed. It is also clear that computational analyses to draw meaningful inferences of functional recognition receptors on the immune cells remain a huge challenge. |
| car t therapy india: Pediatric Neuro-oncology Katrin Scheinemann, Eric Bouffet, 2015-03-26 “The editors...have done an outstanding job of presenting...complex information in a lucid manner – this book is a must-read for the global community of aspiring students and neuro-oncology practitioners.” Amar Gajjar, MD in the Foreword This is a succinct introduction to pediatric neuro-oncology. It summarizes the key advances in molecular biology that have helped transform this rapidly evolving field and provides up-to-date coverage of major and emerging treatment modalities as well as supportive care. Separate chapters present each kind of pediatric brain cancer and its diagnosis and treatment. As more children survive brain cancer, the importance of quality of life issues and helping survivors to cope with the neuropsychological impact and long-term effects of current therapies has come into sharper focus; these topics are also addressed in the book, as are palliative care and pediatric neuro-oncology in countries with limited resources. The book is aimed at trainees and practitioners who seek an up-to-date text in pediatric neuro-oncology that is both comprehensive and concise. |
| car t therapy india: Advances in Precision Medicine Oncology Hilal Arnouk, Bassam Abdul Rasool Hassan, 2021 Recent advances in precision medicine and immuno-oncology have led to highly specific and efficacious cancer therapies such as monoclonal antibodies and immune checkpoint inhibitors (ICIs). This book provides an up-to-date overview of advances in the field of immuno-oncology. Chapters cover such topics as ICIs and how they mount a robust immune response against cancer cells as well as the response of ICIs to treatment predictive biomarkers and their potential immune-related adverse events (irAEs). Additionally, the book includes a comprehensive review of the powerful FDA-approved therapeutic agent doxorubicin, highlighting the molecular mechanisms behind doxorubicin's drug resistance and critical side effects. |
| car t therapy india: Gene and Cell Therapy: Biology and Applications Giridhara R. Jayandharan, 2018-09-12 Recent advances in stem cell biology, nanotechnology and gene therapy have opened new avenues for therapeutics. The availability of molecular therapeutics that rely on the delivery of DNA, RNA or proteins, harnessing enhanced delivery with nanoparticles, and the regenerative potential of stem cells (adult, embryonic or induced pluripotent stem cells) has had a tremendous impact on translational medicine. The chapters in this book cover a range of strategies for molecular and cellular therapies for human disease, their advantages, and central challenges to their widespread application. Potential solutions to these issues are also discussed in detail. Further, the book addresses numerous advances in the field of molecular therapeutics that will be of interest to the general scientific community. Lastly, the book provides specific examples of disease conditions for which these strategies have been transferred to the clinic. As such, it will be extremely useful for all students, researchers and clinicians working in the field of translational medicine and molecular therapeutics. |
| car t therapy india: Praying for Emily Tom Whitehead, Kari Whitehead, Emily Whitehead, 2020-10-06 Discover the incredible true story of Emily Whitehead, the first child to receive CAR-T cell treatment for her leukemia -- and learn how her family's faith journey guided them in the fight for her life. When their five-year-old daughter was diagnosed with leukemia, Tom and Kari Whitehead's world was shattered. They vowed to do whatever it took to help their daughter, and as they made decisions about how to best treat her, Tom found his faith coming to him in whispers, guiding his decisions and keeping his hope alive, while Kari placed great faith in science and the doctors surrounding her little girl. But as Emily's condition continued to worsen, they both prayed for a miracle. Then, their miracle arrived, in the form of an experimental treatment called CAR-T cell therapy that, against all odds, saved Emily's life. Because of Emily's miraculous recovery, this treatment is now used widely to treat cancer and has gone on to save hundreds of lives and promises to help thousands more. For all the acclaim and attention this important new approach to treating cancer has received, few know the full story of all it took to make this miracle happen. In Praying for Emily, the Whiteheads share their story, recounting the belief, resilience, and support that got them through the most difficult time of their lives. |
| car t therapy india: CDC Yellow Book 2018: Health Information for International Travel Centers for Disease Control and Prevention CDC, 2017-04-17 THE ESSENTIAL WORK IN TRAVEL MEDICINE -- NOW COMPLETELY UPDATED FOR 2018 As unprecedented numbers of travelers cross international borders each day, the need for up-to-date, practical information about the health challenges posed by travel has never been greater. For both international travelers and the health professionals who care for them, the CDC Yellow Book 2018: Health Information for International Travel is the definitive guide to staying safe and healthy anywhere in the world. The fully revised and updated 2018 edition codifies the U.S. government's most current health guidelines and information for international travelers, including pretravel vaccine recommendations, destination-specific health advice, and easy-to-reference maps, tables, and charts. The 2018 Yellow Book also addresses the needs of specific types of travelers, with dedicated sections on: · Precautions for pregnant travelers, immunocompromised travelers, and travelers with disabilities · Special considerations for newly arrived adoptees, immigrants, and refugees · Practical tips for last-minute or resource-limited travelers · Advice for air crews, humanitarian workers, missionaries, and others who provide care and support overseas Authored by a team of the world's most esteemed travel medicine experts, the Yellow Book is an essential resource for travelers -- and the clinicians overseeing their care -- at home and abroad. |
| car t therapy india: Immunotherapy of Hepatocellular Carcinoma Tim F. Greten, 2018-08-22 In this book we provide insights into liver – cancer and immunology. Experts in the field provide an overview over fundamental immunological questions in liver cancer and tumorimmunology, which form the base for immune based approaches in HCC, which gain increasing interest in the community due to first promising results obtained in early clinical trials. Hepatocellular carcinoma (HCC) is the third most common cause of cancer related death in the United States. Treatment options are limited. Viral hepatitis is one of the major risk factors for HCC, which represents a typical “inflammation-induced” cancer. Immune-based treatment approaches have revolutionized oncology in recent years. Various treatment strategies have received FDA approval including dendritic cell vaccination, for prostate cancer as well as immune checkpoint inhibition targeting the CTLA4 or the PD1/PDL1 axis in melanoma, lung, and kidney cancer. Additionally, cell based therapies (adoptive T cell therapy, CAR T cells and TCR transduced T cells) have demonstrated significant efficacy in patients with B cell malignancies and melanoma. Immune checkpoint inhibitors in particular have generated enormous excitement across the entire field of oncology, providing a significant benefit to a minority of patients. |
| car t therapy india: Biology and Treatment of Leukemia and Bone Marrow Neoplasms Vinod Pullarkat, Guido Marcucci, 2021-10-09 This book provides a concise update on current understanding of the biology of acute and chronic leukemias and other bone marrow neoplasms, including myelodysplastic and myeloproliferative disorders, and explores new and emerging treatments. There is a particular focus on the molecular abnormalities that are drivers of leukemia and on their detection by modern molecular techniques. Knowledge of the ways in which genomic and metabolic abnormalities in the hematologic neoplasms affect prognosis and treatment decision making is reviewed. Detailed attention is devoted to targeted therapies, including novel drugs, and to potential targets for future drug development. In addition, readers find in-depth discussion of cellular and antibody-based immunotherapies as well as the role of hematopoietic stem cell transplantation in the treatment of leukemias and bone marrow malignancies. The book is of special interest for hematologists, oncologists, and cancer researchers; it is also of value for hematology trainees and medical students. |
| car t therapy india: Immunotherapy – A Novel Facet of Modern Therapeutics Sujata P. Sawarkar, Vandana S. Nikam, Shariq Syed, 2020-12-16 This book illustrates the significance and relevance of immunotherapy in modern-day therapeutics. Focusing on the application of immunotherapy in oncology, neurodegenerative and autoimmune diseases, it discusses the drug delivery systems, and pre-clinical and clinical methodologies for immunotherapy-based drugs. It also comprehensively reviews various aspects of immunotherapy, such as regulatory affairs, quality control, safety, and pharmacovigilance. Further, the book discusses the in vitro validation of therapeutic strategies prior to patient application and management of immunotherapy-related side effects and presents case studies demonstrating the design and development (pre-clinical to clinical) of immunotherapy for various diseases. It also describes various design considerations and the scale-up synthesis of immunotherapeutics and screening methods. Lastly, it explores the important aspect of cost-effectiveness and rational immunotherapy strategies. |
| car t therapy india: The Emperor of All Maladies Siddhartha Mukherjee, 2011-08-09 Winner of the Pulitzer Prize and a documentary from Ken Burns on PBS, this New York Times bestseller is “an extraordinary achievement” (The New Yorker)—a magnificent, profoundly humane “biography” of cancer—from its first documented appearances thousands of years ago through the epic battles in the twentieth century to cure, control, and conquer it to a radical new understanding of its essence. Physician, researcher, and award-winning science writer, Siddhartha Mukherjee examines cancer with a cellular biologist’s precision, a historian’s perspective, and a biographer’s passion. The result is an astonishingly lucid and eloquent chronicle of a disease humans have lived with—and perished from—for more than five thousand years. The story of cancer is a story of human ingenuity, resilience, and perseverance, but also of hubris, paternalism, and misperception. Mukherjee recounts centuries of discoveries, setbacks, victories, and deaths, told through the eyes of his predecessors and peers, training their wits against an infinitely resourceful adversary that, just three decades ago, was thought to be easily vanquished in an all-out “war against cancer.” The book reads like a literary thriller with cancer as the protagonist. Riveting, urgent, and surprising, The Emperor of All Maladies provides a fascinating glimpse into the future of cancer treatments. It is an illuminating book that provides hope and clarity to those seeking to demystify cancer. |
| car t therapy india: Gene and Cellular Immunotherapy for Cancer Armin Ghobadi, John F. DiPersio, 2022-01-01 Clinical and preclinical exploration of gene and cellular immunotherapy have seen rapid growth and interest with the development and approval of five Chimeric Antigen Receptor T-cell (CAR-T) products for lymphoma and myeloma and one Bispecific T-Cell Engager (BiTE) for acute lymphoblastic leukemia (ALL). These advances have dramatically improved the management of patients with relapsed refractory lymphoma, myeloma and leukemia. Gene and Cellular Immunotherapy for Cancer offers readers a comprehensive review of current cellular and gene-based immunotherapies. Divided into eighteen cohesive chapters, this book provides an in-depth and detailed look into cellular-based immunotherapies including CAR-T, TCR-T, TIL, Viral CTLs, NK cells in addition to T/NK cell engagers, focusing on their historical perspectives, biology, development and manufacturing, toxicities and more. Edited by two leading experts on gene and cellular immunotherapy, the book will feature chapters written by a diverse collection of recognized and up-and-coming experts and researchers in the field, providing oncologists, immunologists, researchers and clinical and basic science trainees with a bench to bedside view of the latest developments in the field. |
| car t therapy india: Childhood Acute Lymphoblastic Leukemia Ajay Vora, 2017-04-21 This book provides a comprehensive and up-to-date review of all aspects of childhood Acute Lymphoblastic Leukemia, from basic biology to supportive care. It offers new insights into the genetic pre-disposition to the condition and discusses how response to early therapy and its basic biology are utilized to develop new prognostic stratification systems and target therapy. Readers will learn about current treatment and outcomes, such as immunotherapy and targeted therapy approaches. Supportive care and management of the condition in resource poor countries are also discussed in detail. This is an indispensable guide for research and laboratory scientists, pediatric hematologists as well as specialist nurses involved in the care of childhood leukemia. |
| car t therapy india: Colon Cancer Diagnosis and Therapy Ganji Purnachandra Nagaraju, Dhananjay Shukla, Naveen Kumar Vishvakarma, 2021-06-10 Colorectal cancer (CRC) is a major global health challenge as the third leading cause for cancer related mortalities worldwide. Despite advances in therapeutic strategies, the five-year survival rate for CRC patients has remained the same over time due to the fact that patients are often diagnosed in advanced metastatic stages. Drug resistance is another common reason for poor prognosis. Researchers are now developing advanced therapeutic strategies such as immunotherapy, targeted therapy, and combination nanotechnology for drug delivery. In addition, the identification of new biomarkers will potentiate early stage diagnosis. This book is the first of three volumes on recent developments in colorectal diagnosis and therapy. Each volume can be read on its own, or together. Each volume focuses on different novel therapeutic advances, biomarkers, and identifies therapeutic targets for treatment. Written by leading international experts in the field, coverage also addresses the role of diet habits and lifestyle in reducing gastrointestinal disorders and incidence of CRC. Chapters discuss current and future diagnostic and therapeutic options for colorectal cancer patients, focusing on immunotherapeutic, nanomedicine, biomarkers, and dietary factors for the effective management of colon cancer. |
| car t therapy india: Immunologic Concepts in Transfusion Medicine Robert W Maitta, 2019-08-27 Immunological Concepts in Transfusion Medicine provides a thorough discussion of the immune aspects of blood component transfusion, with in-depth information on the intricacies of immune responses to blood components and the immune processes that may be initiated in response to blood exposure. Written to increase knowledge and awareness of immune challenges such as alloimmunization and transfusion-related acute lung injury, this title bridges current basic scientific discoveries and the potential effects seen in blood recipients. - Complies the knowledge and expertise of Dr. Robert Maitta, an expert in immune responses and antibody function/structure studies. - Helps clinicians in the daily practice of caring for patients in need of transfusion support, as well as physicians in training when considering utilizing blood transfusions in a limited scope or in the setting of massive transfusion. - Includes an immunology primer as an introduction to in-depth chapters covering allergic immune reactions to blood components, transfusion-related immunomodulation, fetal and neonatal alloimmune thrombocytopenia and neonatal neuthropenia, complications of haploidentical and mismatched HSC transplantation, chimeric antibody receptor therapies, and much more. - Consolidates today's available information on this timely topic into a single, convenient resource. |
| car t therapy india: In Search of Self in India and Japan Alan Roland, 1988 This book addresses a fundamental question - the universality of human nature ... Drawing upon work with patients and therapists in both India and Japan, he describes the profound difference between the Western individualized self and the familial self so central to Asian culture ... Of particular value is Roland's sensitive treatment of the evolving identity of women in the two cultures, as well as his exploration of the deeply significant spiritual self, a topic that is largely neglected in Western theory and practice.--Choice. |
| car t therapy india: Ending Medical Reversal Vinayak K. Prasad, Adam S. Cifu, 2019-05-14 Why medicine adopts ineffective or harmful medical practices only to abandon them—sometimes too late. Medications such as Vioxx and procedures such as vertebroplasty for back pain are among the medical advances that turned out to be dangerous or useless. What Dr. Vinayak K. Prasad and Dr. Adam S. Cifu call medical reversal happens when doctors start using a medication, procedure, or diagnostic tool without a robust evidence base—and then stop using it when it is found not to help, or even to harm, patients. In Ending Medical Reversal, Drs. Prasad and Cifu narrate fascinating stories from every corner of medicine to explore why medical reversals occur, how they are harmful, and what can be done to avoid them. They explore the difference between medical innovations that improve care and those that only appear to be promising. They also outline a comprehensive plan to reform medical education, research funding and protocols, and the process for approving new drugs that will ensure that more of what gets done in doctors' offices and hospitals is truly effective. |
| car t therapy india: Heparanase Israel Vlodavsky, Ralph D. Sanderson, Neta Ilan, 2020-04-09 Written by internationally recognized leaders in Heparanase biology, the book’s eight chapters offer an opportunity for scientists, clinicians and advanced students in cell biology, tumor biology and oncology to obtain a comprehensive understanding of Heparanase’s multifaceted activities in cancer, inflammation, diabetes and other diseases, as well as its related clinical applications. Proteases and their involvement in cancer progression have been well addressed and documented; however, the emerging premise presented within this book is that Heparanase is a master regulator of aggressive cancer phenotypes and crosstalk with the tumor microenvironment. This endoglycosidase contributes to tumor-mediated remodeling of the extracellular matrix and cell surfaces, augmenting the bioavailability of pro-tumorigenic and pro-inflammatory growth factors and cytokines that are bound to Heparan sulfate. Compelling evidence ties Heparanase with all steps of tumor progression including tumor initiation, growth, angiogenesis, metastasis, and chemoresistance, supporting the notion that Heparanase is an important contributor to the poor outcome of cancer patients and a validated target for therapy. Unlike Heparanase, heparanase-2, a close homolog of Heparanase, lacks enzymatic activity, inhibits Heparanase, and regulates selected genes that promote normal differentiation and tumor suppression. Written by internationally recognized leaders in Heparanase biology, this volume presents a comprehensive understanding of Heparanase’s multifaceted activities in cancer, inflammation, diabetes and other diseases, as well as its related clinical applications to scientists, clinicians and advanced students in cell biology, tumor biology and oncology. |
| car t therapy india: Radiopharmaceuticals for Therapy F. F. (Russ) Knapp, Ashutosh Dash, 2016-01-20 This book provides detailed information on therapeutic radiopharmaceuticals and discusses emerging technologies which have potential for broad clinical implementation. Recent advances in molecular biology, radiopharmaceutical chemistry and radioisotope production have stimulated a new era for the use of radiopharmaceuticals for targeted radionuclide therapy (TRT). Emerging clinical trials include use of peptides and monoclonal antibodies radiolabeled with therapeutic radionuclides for cancer therapy. In addition, small molecules are used for the treatment of chronic diseases such as metastatic bone pain palliation and radiation synovectomy of inflammatory joints. In the interventional arena, therapy of primary and metastatic liver cancer and arterial restenosis following angioplasty of both the coronary and peripheral arteries are being explored. Reactor and accelerator production of therapeutic radioisotopes is also integrated into these discussions. The development and use of radiopharmaceutical targeting characteristics required for treatment of specific disease processes and how these are implemented for radiopharmaceutical design strategies are also described. Radiopharmaceuticals for Therapy will benefit audiences in nuclear medicine and radionuclide therapy and will thus prove an invaluable source of up-to-date information for students, radiopharmaceutical scientists and professionals working in the radiopharmacy and nuclear medicine specialties. |
| car t therapy india: Carbonic Anhydrase: Mechanism, Regulation, Links to Disease, and Industrial Applications Susan C. Frost, Robert McKenna, 2013-10-22 The study of carbonic anhydrase has spanned multiple generations of scientists. Carbonic anhydrase was first discovered in 1932 by Meldrum and Roughton. Inhibition by sulfanilamide was shown in 1940 by Mann and Keilin. Even Hans Krebs contributed to early studies with a paper in 1948 showing the relationship of 25 different sulfonamides to CA inhibition. It was he who pointed out the importance of both the charged and uncharged character of these compounds for physiological experiments. The field of study that focuses on carbonic anhydrase (CA) has exploded in recent years with the identification of new families and isoforms. The CAs are metalloenzymes which are comprised of 5 structurally different families: the alpha, beta, gamma, and delta, and epsilon classes. The alpha class is found primarily in animals with several isoforms associated with human disease. The beta CAs are expressed primarily in plants and are the most divergent. The gamma CAs are the most ancient. These are structurally related to the beta CAs, but have a mechanism more similar to the alpha CAs. The delta CAs are found in marine algae and diflagellates. The epsilon class is found in prokaryotes in which it is part of the carboxysome shell perhaps supplying RuBisCO with CO2 for carbon fixation. With the excitement surrounding the discovery of disease-related CAs, scientists have redoubled their efforts to better understand structure-function relationships, to design high affinity, isotype-specific inhibitors, and to delineate signaling systems that play regulatory roles over expression and activity. We have designed the book to cover basic information of mechanism, structure, and function of the CA families. The authors included in this book bring to light the newest data with regard to the role of CA in physiology and pathology, across phylums, and in unique environmental niches. |
| car t therapy india: The Peripheral T-Cell Lymphomas Owen A. O'Connor, Won Seog Kim, Pier L. Zinzani, 2021-06-01 THE PERIPHERAL T-CELL LYMPHOMAS Provides a comprehensive look at Peripheral T-Cell lymphomas, including the group’s unique geographic distribution, underlying genetics, and novel treatments Peripheral T-Cell lymphomas (PTCL) are a diverse group of lymphoid malignancies that develop from mature T cells and natural killer (NK) cells. PTCL represent 10-15% of all cases of non-Hodgkin lymphoma in the US, and up to 20-25% of cases in South America, Asia, and other regions around the world. The role of different etiologic factors and the variation of geographic distribution makes PTCL one of the most difficult types of cancer to understand and treat. For the first time in a single volume, The Peripheral T-Cell Lymphomas presents a comprehensive survey of this complex and rare group of blood cancers. Featuring contributions from an international team of leading authorities in the various aspects of PTCL, this authoritative text covers biology, epidemiology, classification, approved and emerging drugs, molecular genetics, and more. Detailed clinical chapters address diagnosis, prognosis, and treatment of each of the major PTCL subtypes identified in the 2018 WHO Classification of Tumors of Hematopoietic and Lymphoid Tissues. This much-needed resource: Covers the biological basis, epidemiology, classification, and treatment of PTCL Discusses the future of the field, including global collaboration efforts and novel approaches to PCTL Explores the role of biologics in PTCL and autologous and allogeneic stem-cell transplantation Offers new insights on molecular pathogenesis, innovative therapeutics, and novel drug combinations Features contributions from the Chairs The T-Cell Lymphoma Forum: the world’s largest meeting focused on PTCL Reflecting the unique epidemiology and genetic diversity of the PTCL, The Peripheral T-Cell Lymphomas is an indispensable source of data, insight, and references for the medical community, particularly oncologists and hematologists in both training and practice. |
| car t therapy india: The Breakthrough Charles Graeber, 2015-12-01 Follow along as this New York Times bestselling author details the astonishing scientific discovery of the code to unleashing the human immune system to fight in this captivating and heartbreaking book (The Wall Street Journal). For decades, scientists have puzzled over one of medicine's most confounding mysteries: Why doesn't our immune system recognize and fight cancer the way it does other diseases, like the common cold? As it turns out, the answer to that question can be traced to a series of tricks that cancer has developed to turn off normal immune responses -- tricks that scientists have only recently discovered and learned to defeat. The result is what many are calling cancer's penicillin moment, a revolutionary discovery in our understanding of cancer and how to beat it. In The Breakthrough, New York Times bestselling author of The Good Nurse Charles Graeber guides readers through the revolutionary scientific research bringing immunotherapy out of the realm of the miraculous and into the forefront of twenty-first-century medical science. As advances in the fields of cancer research and the human immune system continue to fuel a therapeutic arms race among biotech and pharmaceutical research centers around the world, the next step -- harnessing the wealth of new information to create modern and more effective patient therapies -- is unfolding at an unprecedented pace, rapidly redefining our relationship with this all-too-human disease. Groundbreaking, riveting, and expertly told, The Breakthrough is the story of the game-changing scientific discoveries that unleash our natural ability to recognize and defeat cancer, as told through the experiences of the patients, physicians, and cancer immunotherapy researchers who are on the front lines. This is the incredible true story of the race to find a cure, a dispatch from the life-changing world of modern oncological science, and a brave new chapter in medical history. |
| car t therapy india: Lost in the Valley of Death Harley Rustad, 2022-01-11 By patient accumulation of anecdote and detail, Rustad evolves Shetler’s story into something much more human, and humanly tragic, into a layered inquisition and a reportorial force....suffice it to say Rustad has done what the best storytellers do: tried to track the story to its last twig and then stepped aside. —New York Times Book Review In the vein of Jon Krakauer's Into the Wild, a riveting work of narrative nonfiction centering on the unsolved disappearance of an American backpacker in India—one of at least two dozen tourists who have met a similar fate in the remote and storied Parvati Valley. For centuries, India has enthralled westerners looking for an exotic getaway, a brief immersion in yoga and meditation, or in rare cases, a true pilgrimage to find spiritual revelation. Justin Alexander Shetler, an inveterate traveler trained in wilderness survival, was one such seeker. In his early thirties Justin Alexander Shetler, quit his job at a tech startup and set out on a global journey: across the United States by motorcycle, then down to South America, and on to the Philippines, Thailand, and Nepal, in search of authentic experiences and meaningful encounters, while also documenting his travels on Instagram. His enigmatic character and magnetic personality gained him a devoted following who lived vicariously through his adventures. But the ever restless explorer was driven to pursue ever greater challenges, and greater risks, in what had become a personal quest—his own hero’s journey. In 2016, he made his way to the Parvati Valley, a remote and rugged corner of the Indian Himalayas steeped in mystical tradition yet shrouded in darkness and danger. There, he spent weeks studying under the guidance of a sadhu, an Indian holy man, living and meditating in a cave. At the end of August, accompanied by the sadhu, he set off on a “spiritual journey” to a holy lake—a journey from which he would never return. Lost in the Valley of Death is about one man’s search to find himself, in a country where for many westerners the path to spiritual enlightenment can prove fraught, even treacherous. But it is also a story about all of us and the ways, sometimes extreme, we seek fulfillment in life. Lost in the Valley of Death includes 16 pages of color photographs. |
| car t therapy india: Top 100 Indian Innovations (2022) Indian Innovators Association, 2022-11-12 This book is a compilation of Indian Innovations, physical and embodied. Indian Unicorns, business models, commerce & Financial innovations are widely covered by media. Not much is known about product innovations, and the innovators behind product innovations are relatively unknown. This will be the first book that fills the gap. It is intended as yearbook to the published every year. |
| car t therapy india: Care Without Coverage Institute of Medicine, Board on Health Care Services, Committee on the Consequences of Uninsurance, 2002-06-20 Many Americans believe that people who lack health insurance somehow get the care they really need. Care Without Coverage examines the real consequences for adults who lack health insurance. The study presents findings in the areas of prevention and screening, cancer, chronic illness, hospital-based care, and general health status. The committee looked at the consequences of being uninsured for people suffering from cancer, diabetes, HIV infection and AIDS, heart and kidney disease, mental illness, traumatic injuries, and heart attacks. It focused on the roughly 30 million-one in seven-working-age Americans without health insurance. This group does not include the population over 65 that is covered by Medicare or the nearly 10 million children who are uninsured in this country. The main findings of the report are that working-age Americans without health insurance are more likely to receive too little medical care and receive it too late; be sicker and die sooner; and receive poorer care when they are in the hospital, even for acute situations like a motor vehicle crash. |
| car t therapy india: Cell and Gene Therapies Miguel-Angel Perales, Syed A. Abutalib, Catherine Bollard, 2018-11-27 In this book, experts in the field express their well-reasoned opinions on a range of complex, clinically relevant issues across the full spectrum of cell and gene therapies with the aim of providing trainee and practicing hematologists, including hematopoietic transplant physicians, with information that is relevant to clinical practice and ongoing research. Each chapter focuses on a particular topic, and the concise text is supported by numerous working tables, algorithms, and figures. Whenever appropriate, guidance is provided regarding the availability of potentially high-impact clinical trials. The rapid evolution of cell and gene therapies is giving rise to numerous controversies that need to be carefully addressed. In meeting this challenge, this book will appeal to all residents, fellows, and faculty members responsible for the care of hematopoietic cell transplant patients. It will also offer a robust, engaging tool to aid vital activities in the daily work of every hematology and oncology trainee. |
| car t therapy india: Good Genes Gone Bad Narendra Chirmule, 2022-03 The field of biotechnology has evolved over the past four decades, developing medicines which are curing diseases. But this journey of success has been tough and arduous, built upon the shoulders of major failures. Good Genes Gone Bad highlights seven such colossal failures in drug development-all of which culminated in the development of novel drugs-weaving together various analogies through the stories and thus allowing the reader to understand complex biological phenomena. These stories include treatment of medical conditions such as genetic clotting disorder (haemophilia), childhood-diarrhoea (rotavirus vaccine), preventing HIV infection, activation of the immune systems to treat cancer, gene therapy for treatment of diseases caused by gene-defects/mutations, cell therapy for treatment of leukaemias, and finally the success of Biocon's approval of the first biologic drug for breast cancer. Written by the former R&D head of Biocon, India's largest pharmaceutical company, Good Genes Gone Bad is a fascinating look at the complex world of medicine and drug development, providing the readers with a sense of magnitude of challenges and the extent of difficulty that it takes to make novel medicines. |
| car t therapy india: Cancer Chemotherapy, Immunotherapy, and Biotherapy Bruce Chabner, Dan Louis Longo, 2018 Publisher's Note: Products purchased from 3rd Party sellers are not guaranteed by the Publisher for quality, authenticity, or access to any online entitlements included with the product. Thoroughly revised and reformatted, the sixth edition of Cancer Chemotherapy, Immunotherapy and Biotherapy reflects recent significant changes in cancer treatment. This newly streamlined edition contains full-color illustrations, more tables for quick reference, and new immunotherapy and molecular targeted therapy content that brings you fully up to date with the state of the art in all current cancer therapies. Provides thorough, comprehensive coverage of the scientific and clinical aspects of immunotherapy, biotherapy, and chemotherapy. Includes significantly expanded information on immunotherapy and molecular targeted therapy, as well as the latest information on all drugs and biological agents--their mechanisms of action, interactions with other agents, toxicities, side effects, and mechanisms of resistance. Features a new, full-color format, a newly streamlined presentation. and more tables and figures throughout for quick access to high-yield information. Explains the rationale for use of drugs in specific schedules and combinations and offers guidelines for dose adjustment in specific situations. Enhance Your eBook Reading Experience Read directly on your preferred device(s), such as computer, tablet, or smartphone. Easily convert to audiobook, powering your content with natural language text-to-speech. |
| car t therapy india: You Can Beat Cancer Rachna Chhachhi, 2020-02-04 Expert Advice on Preventing and Reversing Cancer Foreword by SUBHASH CHANDRA Preface by HARSH MARIWALA According to WHO, the number of global cancer deaths is projected to increase by 45 percent, where over two-thirds of the deaths occur in low- and middle-income countries. This makes India, and you, vulnerable. There is already someone you know who has cancer. So, you know that the threat is real and near. But now there is a way out. Certified cancer nutrition coach Rachna Chhachhi shows you how to train your cells to respond to physical and emotional nurturing to fight cancer. In this book, you will learn all about preventing the world’s most feared disease with the help of holistic nutrition. You can also combine it with Western medicine, if you are already under treatment. Quoting the cases of her many clients across 27 countries who have defeated the odds after their diagnoses, and with the support of global cancer research, Chhachhi illustrates how to prevent, manage or reverse cancer for yourself. IN YOU CAN BEAT CANCER, SHE DISCUSSES: • What causes cancer • How not to fear the diagnosis • The necessity of practicing meditation, pranayama & gratitude • Ways to avoid cancer-triggering habits • The impact of natural immunotherapy • How epigenetics can change your genes’ response towards cancer cells • More than 100 unique anticancer recipes RACHNA CHHACHHI is a certified cancer nutrition coach and holds a PhD in holistic nutrition. She is best-known for her work with cancer and autoimmune patients. She has been writing on health for 20 years for mainstream Indian newspapers and magazines and has been extensively interviewed in media. “Rachna’s book is the need of the hour today to protect ourselves.” Manisha Koirala, Actor & Cancer Warrior “Gift this book to everyone you care for, everyone you want to gift a life without cancer.” Dr Subhash Chandra, Chairman, Essel Group “This book will be an important milestone in cancer prevention and management…” Harsh Mariwala, Chairman, Marico Ltd. |
| car t therapy india: Cancer Immunotherapy Principles and Practice Lisa H. Butterfield, Howard L. Kaufman, Francesco M. Marincola, 2017 Part 1: Intratumoral Signatures Associated With Immune Responsiveness |
| car t therapy india: Adjuvant Therapy for Breast Cancer Monica Castiglione, Martine J. Piccart, 2009-07-11 Adjuvant treatment is administered prior to or as follow up to surgical procedures for breast cancer. Proven success in using medical therapies allowing for breast conserving procedures or reducing risk of occurrence. Although there has been much progress towards a cure, including the introduction of new targeted therapies, metastasizing cancer remains highly incurable. |
| car t therapy india: Advanced Concepts in Human Immunology: Prospects for Disease Control Pooja Jain, Lishomwa C. Ndhlovu, 2020-08-11 This book highlights information derived primarily from clinical samples, with particular reference to theoretical and scientific aspects of the human immune system. This text will focus on topics that range from host-pathogen interactions in infectious disease to host immune response in cancer, allergic diseases, neuroinflammatory diseases, and autoimmune disorders. The reader will also have a well-rounded understanding of the behavior of the immune system with particular emphasis on the role of immunoproteomics in immunotherapy, neuroprotective immunity for neurodegenerative and neuroinfectious disease, leukemia-associated dendritic cell induction of adaptive immunity dysregulation, and the role of immune checkpoint inhibitors in cancer, infection, as well as neuroinflammation. Taken together, the contents of this book are intended for both clinicians and researchers in academia and industry. |
| car t therapy india: Cure Cancer with Urine Therapy Jagdish R. Bhurani, 2020-07-22 Auto-Urine Therapy known as “Shivambu” is an ancient method of treatment, which has been continuing from generation to generation. In the ancient days, many sages and rishimunis followed and practiced urine therapy. Lord Shiva himself recommended the action and ritual of Shivambu Kalpa to Mother Parvati mentioned in ancient book Damar Tantra. The powerful practice for healing, Auto-Urine Therapy, has been referred to as “Shivambu Kalpa Vidhi” in 5000-year-old documents called Damar Tantra in the Vedas. God has given a wonderful gift to man, his own water – Shivambu. Shiv means beneficial and salubrious, and Ambu means water. The combined Sanskrit word is Shivambu (beneficial water). They termed Shivambu as the holy liquid. This book is published to enlighten everyone who is diagnosed with cancer to adopt Urine Therapy before going for surgery or chemotherapy. It is safe and does not have any side effects. It can prevent and control/cure cancer. It is free of cost and can be practiced at home. People living with diabetes can cure diabetes by adopting Urine Therapy. |
| car t therapy india: Ethics Dumping Doris Schroeder, Julie Cook, François Hirsch, Solveig Fenet, Vasantha Muthuswamy, 2017-12-04 This open access book provides original, up-to-date case studies of “ethics dumping” that were largely facilitated by loopholes in the ethics governance of low and middle-income countries. It is instructive even to experienced researchers since it provides a voice to vulnerable populations from the fore mentioned countries. Ensuring the ethical conduct of North-South collaborations in research is a process fraught with difficulties. The background conditions under which such collaborations take place include extreme differentials in available income and power, as well as a past history of colonialism, while differences in culture can add a new layer of complications. In this context, up-to-date case studies of unethical conduct are essential for research ethics training. |
| car t therapy india: Global Trends 2040 National Intelligence Council, 2021-03 The ongoing COVID-19 pandemic marks the most significant, singular global disruption since World War II, with health, economic, political, and security implications that will ripple for years to come. -Global Trends 2040 (2021) Global Trends 2040-A More Contested World (2021), released by the US National Intelligence Council, is the latest report in its series of reports starting in 1997 about megatrends and the world's future. This report, strongly influenced by the COVID-19 pandemic, paints a bleak picture of the future and describes a contested, fragmented and turbulent world. It specifically discusses the four main trends that will shape tomorrow's world: - Demographics-by 2040, 1.4 billion people will be added mostly in Africa and South Asia. - Economics-increased government debt and concentrated economic power will escalate problems for the poor and middleclass. - Climate-a hotter world will increase water, food, and health insecurity. - Technology-the emergence of new technologies could both solve and cause problems for human life. Students of trends, policymakers, entrepreneurs, academics, journalists and anyone eager for a glimpse into the next decades, will find this report, with colored graphs, essential reading. |
| car t therapy india: Critical Care Hematology Shakti Bedanta Mishra, |
| car t therapy india: Tumour Angiogenesis R. John Bicknell, Claire E. Lewis, Napoleone Ferrara, 1997 Tumour Angiogenesis is the first comprehensive book to cover all areas of this rapidly expanding research area. Each chapter is written by world experts in the field and topics covered include in vivo models, mechanisms, inhibition, and the role of macrophages, cytokines, proteases,extracellular matrix components, nitric oxide, prostanoids and oncogenes/tumour suppressor genes in angiogenesis. Other chapters examine the role of specific growth factors in angiogenesis - these include vascular endothelial growth factor, the basic fibroblast growth factor family, transforminggrowth factor-beta, tumour necrosis factor-alpha, platelet-derived endothelial cell growth factor/thymidine phosphorylase and pleiotrophin and related molecules. Clinical issues are addressed in chapters that deal with the prognostic and predictive value of tumour microvessel density and thetherapeutic significance of microregional blood flow. The two final chapters examine the feasibility of targeting tumour vasculature using either antibodies or gene therapy. |
| car t therapy india: Stem Cell Therapy: A Rising Tide: How Stem Cells Are Disrupting Medicine and Transforming Lives Neil H. Riordan, 2017-06-20 Stem cells are the repair cells of your body. When there aren't enough of them, or they aren't working properly, chronic diseases can manifest and persist. From industry leaders, sport stars, and Hollywood icons to thousands of everyday, ordinary people, stem cell therapy has helped when standard medicine failed. Many of them had lost hope. These are their stories. Neil H Riordan, author of MSC: Clinical Evidence Leading Medicine's Next Frontier, the definitive textbook on clinical stem cell therapy, brings you an easy-to-read book about how and why stem cells work, and why they're the wave of the future. |
| car t therapy india: WHO List of Priority Medical Devices for Cancer Management World Health Organization, 2017-05-09 This is the model list and clearing house of appropriate, basic, and priority medical devices based on the list of clinical interventions selected from clinical guidelines on prevention, screening, diagnosis, treatment, palliative care, monitoring, and end of life care. This publication addresses medical devices that can be used for the management of cancer and specifically describes medical devices for six types of cancer: breast, cervical, colorectal, leukemia, lung, and prostate. This book is intended for ministries of health, public health planners, health technology managers, disease management, researchers, policy makers, funding, and procurement agencies and support and advocacy groups for cancer patients. |
| car t therapy india: Emerging Engineering Approaches in Cancer Immunotherapy Xin Ming, Yuanzeng Min, Chao Wang, Yueyin Pan, 2022-10-06 |
| car-t therapy india: Chimeric Antigen Receptor T-Cell Therapies for Cancer E-Book Daniel W. Lee, Nirali N. Shah, 2019-11-30 From patient referral to post-therapy management, Chimeric Antigen Receptor (CAR) T-Cell Therapies for Cancer: A Practical Guide presents a comprehensive view of CAR modified T-cells in a concise and practical format. Providing authoritative guidance on the implementation and management of CAR T-cell therapy from Drs. Daniel W. Lee and Nirali N. Shah, this clinical resource keeps you up to date on the latest developments in this rapidly evolving area. - Covers all clinical aspects, including patient referral, toxicities management, comorbidities, bridging therapy, post-CAR monitoring, and multidisciplinary approaches to supportive care. - Includes key topics on associated toxicities such as predictive biomarkers, infections, and multidisciplinary approaches to supportive care. - Presents current knowledge on FDA approved CAR T-cell products as well as developments on the horizon. - Editors and authors represent leading investigators in academia and worldwide pioneers of CAR therapy. |
| car-t therapy india: Immunopharmacogenomics Yusuke Nakamura, 2015-09-18 This book proposes immunogenomics, or immunopharmacogenomics, as the next-generation big science to uncover the role that the immune system plays in the pathogenesis of many diseases, by summarizing the importance of the deep sequencing of T-cell and B-cell receptors. Immunogenomics/immunopharmacogenomics, a genetic characterization of the immune system made possible by next-generation sequencing (NGS), will be important for the further understanding of the pathogenesis of various disease conditions. Abnormal immune responses in the body lead to development of autoimmune diseases and food allergies. Rejection of recipient cells and tissues, as well as severe immune reactions to donor cells, is also the result of uncontrolled immune responses in the recipient body. There have been many reports indicating that activated immune responses caused by the interaction of drugs and HLA are present in drug-induced skin hypersensitivity and liver toxicity. The importance of the host immune responses has been recognized in cancer treatments, not only for immunotherapy but also for cytotoxic agents and molecular targeted drugs. Hence, characterization of the T-cell receptor and B-cell receptor repertoire by means of NGS deep sequencing will ultimately make possible the identification of the molecular mechanisms that underlie various diseases and drug responses. In addition, this approach may contribute to the identification of antigens associated with the onset or progression of autoimmune diseases as well as food allergies. Although the germline alterations and somatic mutations have been extensively analyzed, changes or alterations of the immune responses during the course of various disease conditions or during various treatments have not been analyzed. It is also clear that computational analyses to draw meaningful inferences of functional recognition receptors on the immune cells remain a huge challenge. |
| car-t therapy india: Pediatric Neuro-oncology Katrin Scheinemann, |
| car-t therapy india: Advances in Precision Medicine Oncology Hilal Arnouk, Bassam Abdul Rasool Hassan, 2021 Recent advances in precision medicine and immuno-oncology have led to highly specific and efficacious cancer therapies such as monoclonal antibodies and immune checkpoint inhibitors (ICIs). This book provides an up-to-date overview of advances in the field of immuno-oncology. Chapters cover such topics as ICIs and how they mount a robust immune response against cancer cells as well as the response of ICIs to treatment predictive biomarkers and their potential immune-related adverse events (irAEs). Additionally, the book includes a comprehensive review of the powerful FDA-approved therapeutic agent doxorubicin, highlighting the molecular mechanisms behind doxorubicin's drug resistance and critical side effects. |
| car-t therapy india: Gene and Cell Therapy: Biology and Applications Giridhara R. Jayandharan, 2018-09-12 Recent advances in stem cell biology, nanotechnology and gene therapy have opened new avenues for therapeutics. The availability of molecular therapeutics that rely on the delivery of DNA, RNA or proteins, harnessing enhanced delivery with nanoparticles, and the regenerative potential of stem cells (adult, embryonic or induced pluripotent stem cells) has had a tremendous impact on translational medicine. The chapters in this book cover a range of strategies for molecular and cellular therapies for human disease, their advantages, and central challenges to their widespread application. Potential solutions to these issues are also discussed in detail. Further, the book addresses numerous advances in the field of molecular therapeutics that will be of interest to the general scientific community. Lastly, the book provides specific examples of disease conditions for which these strategies have been transferred to the clinic. As such, it will be extremely useful for all students, researchers and clinicians working in the field of translational medicine and molecular therapeutics. |
| car-t therapy india: Praying for Emily Tom Whitehead, Kari Whitehead, Emily Whitehead, 2020-10-06 Discover the incredible true story of Emily Whitehead, the first child to receive CAR-T cell treatment for her leukemia -- and learn how her family's faith journey guided them in the fight for her life. When their five-year-old daughter was diagnosed with leukemia, Tom and Kari Whitehead's world was shattered. They vowed to do whatever it took to help their daughter, and as they made decisions about how to best treat her, Tom found his faith coming to him in whispers, guiding his decisions and keeping his hope alive, while Kari placed great faith in science and the doctors surrounding her little girl. But as Emily's condition continued to worsen, they both prayed for a miracle. Then, their miracle arrived, in the form of an experimental treatment called CAR-T cell therapy that, against all odds, saved Emily's life. Because of Emily's miraculous recovery, this treatment is now used widely to treat cancer and has gone on to save hundreds of lives and promises to help thousands more. For all the acclaim and attention this important new approach to treating cancer has received, few know the full story of all it took to make this miracle happen. In Praying for Emily, the Whiteheads share their story, recounting the belief, resilience, and support that got them through the most difficult time of their lives. |
| car-t therapy india: CDC Yellow Book 2018: Health Information for International Travel Centers for Disease Control and Prevention CDC, 2017-04-17 THE ESSENTIAL WORK IN TRAVEL MEDICINE -- NOW COMPLETELY UPDATED FOR 2018 As unprecedented numbers of travelers cross international borders each day, the need for up-to-date, practical information about the health challenges posed by travel has never been greater. For both international travelers and the health professionals who care for them, the CDC Yellow Book 2018: Health Information for International Travel is the definitive guide to staying safe and healthy anywhere in the world. The fully revised and updated 2018 edition codifies the U.S. government's most current health guidelines and information for international travelers, including pretravel vaccine recommendations, destination-specific health advice, and easy-to-reference maps, tables, and charts. The 2018 Yellow Book also addresses the needs of specific types of travelers, with dedicated sections on: · Precautions for pregnant travelers, immunocompromised travelers, and travelers with disabilities · Special considerations for newly arrived adoptees, immigrants, and refugees · Practical tips for last-minute or resource-limited travelers · Advice for air crews, humanitarian workers, missionaries, and others who provide care and support overseas Authored by a team of the world's most esteemed travel medicine experts, the Yellow Book is an essential resource for travelers -- and the clinicians overseeing their care -- at home and abroad. |
| car-t therapy india: Pharmacotherapeutic Botanicals for Cancer Chemoprevention Manish Kumar, Ashita Sharma, Praveen Kumar, 2020-07-20 The book presents a comprehensive and up-to-date overview of phytochemicals as efficient cancer therapeutics. Over the last few decades there has been a paradigm shift from conventional cancer therapeutic approaches to alternative and complementary medicinal approaches especially using phytoconstituents from natural products. As such, the book provides an in-depth understanding of phytochemicals targeting diverse signaling pathways involved in cancer along with the evaluation of the cancer modulatory effects of phytochemicals. It also highlights the potential modulatory effect of single nucleotide polymorphisms (SNPs) on the cancer-associated cellular pathways and their interactions with the phytochemicals. Further, it analyzes the drug delivery methods, bioavailability of active components of botanicals, and toxicity of phytochemicals. Lastly, the book elucidates the 3D cell culture and animal models systems to analyze the beneficial effects of phytochemicals in cancer. |
| car-t therapy india: Immunotherapy of Hepatocellular Carcinoma Tim F. Greten, 2018-08-22 In this book we provide insights into liver – cancer and immunology. Experts in the field provide an overview over fundamental immunological questions in liver cancer and tumorimmunology, which form the base for immune based approaches in HCC, which gain increasing interest in the community due to first promising results obtained in early clinical trials. Hepatocellular carcinoma (HCC) is the third most common cause of cancer related death in the United States. Treatment options are limited. Viral hepatitis is one of the major risk factors for HCC, which represents a typical “inflammation-induced” cancer. Immune-based treatment approaches have revolutionized oncology in recent years. Various treatment strategies have received FDA approval including dendritic cell vaccination, for prostate cancer as well as immune checkpoint inhibition targeting the CTLA4 or the PD1/PDL1 axis in melanoma, lung, and kidney cancer. Additionally, cell based therapies (adoptive T cell therapy, CAR T cells and TCR transduced T cells) have demonstrated significant efficacy in patients with B cell malignancies and melanoma. Immune checkpoint inhibitors in particular have generated enormous excitement across the entire field of oncology, providing a significant benefit to a minority of patients. |
| car-t therapy india: Biology and Treatment of Leukemia and Bone Marrow Neoplasms Vinod Pullarkat, Guido Marcucci, 2021-10-09 This book provides a concise update on current understanding of the biology of acute and chronic leukemias and other bone marrow neoplasms, including myelodysplastic and myeloproliferative disorders, and explores new and emerging treatments. There is a particular focus on the molecular abnormalities that are drivers of leukemia and on their detection by modern molecular techniques. Knowledge of the ways in which genomic and metabolic abnormalities in the hematologic neoplasms affect prognosis and treatment decision making is reviewed. Detailed attention is devoted to targeted therapies, including novel drugs, and to potential targets for future drug development. In addition, readers find in-depth discussion of cellular and antibody-based immunotherapies as well as the role of hematopoietic stem cell transplantation in the treatment of leukemias and bone marrow malignancies. The book is of special interest for hematologists, oncologists, and cancer researchers; it is also of value for hematology trainees and medical students. |
| car-t therapy india: Handbook of Cancer Chemotherapy Roland T. Skeel, Samir N. Khleif, 2011 Skeel's Handbook of Cancer Chemotherapy combines in one place the most current rationale and specific details necessary to safely administer chemotherapy for most adult cancers. The handbook is a practical, diseased-focused pocket reference that emphasizes the best current medical practice as it relates to the delivery of chemotherapeutic drugs. By focusing on specific plans for treatment, the book is an invaluable resource for the daily care of cancer patients. |
| car-t therapy india: In Search of Self in India and Japan Alan Roland, 1988 This book addresses a fundamental question - the universality of human nature ... Drawing upon work with patients and therapists in both India and Japan, he describes the profound difference between the Western individualized self and the familial self so central to Asian culture ... Of particular value is Roland's sensitive treatment of the evolving identity of women in the two cultures, as well as his exploration of the deeply significant spiritual self, a topic that is largely neglected in Western theory and practice.--Choice. |
| car-t therapy india: The Emperor of All Maladies Siddhartha Mukherjee, 2011-08-09 Winner of the Pulitzer Prize and a documentary from Ken Burns on PBS, this New York Times bestseller is “an extraordinary achievement” (The New Yorker)—a magnificent, profoundly humane “biography” of cancer—from its first documented appearances thousands of years ago through the epic battles in the twentieth century to cure, control, and conquer it to a radical new understanding of its essence. Physician, researcher, and award-winning science writer, Siddhartha Mukherjee examines cancer with a cellular biologist’s precision, a historian’s perspective, and a biographer’s passion. The result is an astonishingly lucid and eloquent chronicle of a disease humans have lived with—and perished from—for more than five thousand years. The story of cancer is a story of human ingenuity, resilience, and perseverance, but also of hubris, paternalism, and misperception. Mukherjee recounts centuries of discoveries, setbacks, victories, and deaths, told through the eyes of his predecessors and peers, training their wits against an infinitely resourceful adversary that, just three decades ago, was thought to be easily vanquished in an all-out “war against cancer.” The book reads like a literary thriller with cancer as the protagonist. Riveting, urgent, and surprising, The Emperor of All Maladies provides a fascinating glimpse into the future of cancer treatments. It is an illuminating book that provides hope and clarity to those seeking to demystify cancer. |
| car-t therapy india: Gene and Cellular Immunotherapy for Cancer Armin Ghobadi, John F. DiPersio, 2022-01-01 Clinical and preclinical exploration of gene and cellular immunotherapy have seen rapid growth and interest with the development and approval of five Chimeric Antigen Receptor T-cell (CAR-T) products for lymphoma and myeloma and one Bispecific T-Cell Engager (BiTE) for acute lymphoblastic leukemia (ALL). These advances have dramatically improved the management of patients with relapsed refractory lymphoma, myeloma and leukemia. Gene and Cellular Immunotherapy for Cancer offers readers a comprehensive review of current cellular and gene-based immunotherapies. Divided into eighteen cohesive chapters, this book provides an in-depth and detailed look into cellular-based immunotherapies including CAR-T, TCR-T, TIL, Viral CTLs, NK cells in addition to T/NK cell engagers, focusing on their historical perspectives, biology, development and manufacturing, toxicities and more. Edited by two leading experts on gene and cellular immunotherapy, the book will feature chapters written by a diverse collection of recognized and up-and-coming experts and researchers in the field, providing oncologists, immunologists, researchers and clinical and basic science trainees with a bench to bedside view of the latest developments in the field. |
| car-t therapy india: Vernacular Medicine in Colonial India Shinjini Das, 2019-03-14 Interrelated histories of colonial medicine, market and family reveal how Western homeopathy was translated and made vernacular in colonial India. |
| car-t therapy india: Bollywood and Globalization Rini Bhattacharya Mehta, Rajeshwari V. Pandharipande, 2011-06 This book is a collection of incisive articles on the interactions between Indian Popular Cinema and the political and cultural ideologies of a new post-Global India. |
| car-t therapy india: Immunologic Concepts in Transfusion Medicine Robert W Maitta, 2019-08-27 Immunological Concepts in Transfusion Medicine provides a thorough discussion of the immune aspects of blood component transfusion, with in-depth information on the intricacies of immune responses to blood components and the immune processes that may be initiated in response to blood exposure. Written to increase knowledge and awareness of immune challenges such as alloimmunization and transfusion-related acute lung injury, this title bridges current basic scientific discoveries and the potential effects seen in blood recipients. - Complies the knowledge and expertise of Dr. Robert Maitta, an expert in immune responses and antibody function/structure studies. - Helps clinicians in the daily practice of caring for patients in need of transfusion support, as well as physicians in training when considering utilizing blood transfusions in a limited scope or in the setting of massive transfusion. - Includes an immunology primer as an introduction to in-depth chapters covering allergic immune reactions to blood components, transfusion-related immunomodulation, fetal and neonatal alloimmune thrombocytopenia and neonatal neuthropenia, complications of haploidentical and mismatched HSC transplantation, chimeric antibody receptor therapies, and much more. - Consolidates today's available information on this timely topic into a single, convenient resource. |
| car-t therapy india: Ending Medical Reversal Vinayak K. Prasad, Adam S. Cifu, 2019-05-14 Why medicine adopts ineffective or harmful medical practices only to abandon them—sometimes too late. Medications such as Vioxx and procedures such as vertebroplasty for back pain are among the medical advances that turned out to be dangerous or useless. What Dr. Vinayak K. Prasad and Dr. Adam S. Cifu call medical reversal happens when doctors start using a medication, procedure, or diagnostic tool without a robust evidence base—and then stop using it when it is found not to help, or even to harm, patients. In Ending Medical Reversal, Drs. Prasad and Cifu narrate fascinating stories from every corner of medicine to explore why medical reversals occur, how they are harmful, and what can be done to avoid them. They explore the difference between medical innovations that improve care and those that only appear to be promising. They also outline a comprehensive plan to reform medical education, research funding and protocols, and the process for approving new drugs that will ensure that more of what gets done in doctors' offices and hospitals is truly effective. |
| car-t therapy india: Childhood Acute Lymphoblastic Leukemia Ajay Vora, 2017-04-21 This book provides a comprehensive and up-to-date review of all aspects of childhood Acute Lymphoblastic Leukemia, from basic biology to supportive care. It offers new insights into the genetic pre-disposition to the condition and discusses how response to early therapy and its basic biology are utilized to develop new prognostic stratification systems and target therapy. Readers will learn about current treatment and outcomes, such as immunotherapy and targeted therapy approaches. Supportive care and management of the condition in resource poor countries are also discussed in detail. This is an indispensable guide for research and laboratory scientists, pediatric hematologists as well as specialist nurses involved in the care of childhood leukemia. |
| car-t therapy india: Heparanase Israel Vlodavsky, Ralph D. Sanderson, Neta Ilan, 2020-04-09 Written by internationally recognized leaders in Heparanase biology, the book’s eight chapters offer an opportunity for scientists, clinicians and advanced students in cell biology, tumor biology and oncology to obtain a comprehensive understanding of Heparanase’s multifaceted activities in cancer, inflammation, diabetes and other diseases, as well as its related clinical applications. Proteases and their involvement in cancer progression have been well addressed and documented; however, the emerging premise presented within this book is that Heparanase is a master regulator of aggressive cancer phenotypes and crosstalk with the tumor microenvironment. This endoglycosidase contributes to tumor-mediated remodeling of the extracellular matrix and cell surfaces, augmenting the bioavailability of pro-tumorigenic and pro-inflammatory growth factors and cytokines that are bound to Heparan sulfate. Compelling evidence ties Heparanase with all steps of tumor progression including tumor initiation, growth, angiogenesis, metastasis, and chemoresistance, supporting the notion that Heparanase is an important contributor to the poor outcome of cancer patients and a validated target for therapy. Unlike Heparanase, heparanase-2, a close homolog of Heparanase, lacks enzymatic activity, inhibits Heparanase, and regulates selected genes that promote normal differentiation and tumor suppression. Written by internationally recognized leaders in Heparanase biology, this volume presents a comprehensive understanding of Heparanase’s multifaceted activities in cancer, inflammation, diabetes and other diseases, as well as its related clinical applications to scientists, clinicians and advanced students in cell biology, tumor biology and oncology. |
| car-t therapy india: Carbonic Anhydrase: Mechanism, Regulation, Links to Disease, and Industrial Applications Susan C. Frost, Robert McKenna, 2013-10-22 The study of carbonic anhydrase has spanned multiple generations of scientists. Carbonic anhydrase was first discovered in 1932 by Meldrum and Roughton. Inhibition by sulfanilamide was shown in 1940 by Mann and Keilin. Even Hans Krebs contributed to early studies with a paper in 1948 showing the relationship of 25 different sulfonamides to CA inhibition. It was he who pointed out the importance of both the charged and uncharged character of these compounds for physiological experiments. The field of study that focuses on carbonic anhydrase (CA) has exploded in recent years with the identification of new families and isoforms. The CAs are metalloenzymes which are comprised of 5 structurally different families: the alpha, beta, gamma, and delta, and epsilon classes. The alpha class is found primarily in animals with several isoforms associated with human disease. The beta CAs are expressed primarily in plants and are the most divergent. The gamma CAs are the most ancient. These are structurally related to the beta CAs, but have a mechanism more similar to the alpha CAs. The delta CAs are found in marine algae and diflagellates. The epsilon class is found in prokaryotes in which it is part of the carboxysome shell perhaps supplying RuBisCO with CO2 for carbon fixation. With the excitement surrounding the discovery of disease-related CAs, scientists have redoubled their efforts to better understand structure-function relationships, to design high affinity, isotype-specific inhibitors, and to delineate signaling systems that play regulatory roles over expression and activity. We have designed the book to cover basic information of mechanism, structure, and function of the CA families. The authors included in this book bring to light the newest data with regard to the role of CA in physiology and pathology, across phylums, and in unique environmental niches. |
| car-t therapy india: Radical Remission Kelly A. Turner, PhD, 2014-03-18 In her New York Times bestseller, Radical Remission: Surviving Cancer Against All Odds, Dr. Kelly A. Turner, founder of the Radical Remission Project, uncovers nine factors that can lead to a spontaneous remission from cancer—even after conventional medicine has failed. While getting her Ph.D. at the University of California, Berkley, Dr. Turner, a researcher, lecturer, and counselor in integrative oncology, was shocked to discover that no one was studying episodes of radical (or unexpected) remission—when people recover against all odds without the help of conventional medicine, or after conventional medicine has failed. She was so fascinated by this kind of remission that she embarked on a ten month trip around the world, traveling to ten different countries to interview fifty holistic healers and twenty radical remission cancer survivors about their healing practices and techniques. Her research continued by interviewing over 100 Radical Remission survivors and studying over 1000 of these cases. Her evidence presents nine common themes that she believes may help even terminal patients turn their lives around. |
| car-t therapy india: Advances in Nutraceutical Applications in Cancer: Recent Research Trends and Clinical Applications Sheeba Varghese Gupta, Yashwant V Pathak, 2019-10-23 Dietary supplements and nutraceuticals such as Vitamin A and D, Omega-3 and probiotics are used as part of the cancer treatment as complimenting the main therapy. Several Nutraceuticals have shown to boost the immune responses, while emerging clinical studies and other research suggests that some plant-based agents may, indeed, impact late-stage cancer, influencing molecular processes corrupted by tumor cells to evade detection, expand clonally, and invade surrounding tissues. Advances in Nutraceutical Applications in Cancer: Recent Research Trends and Clinical Applications is an attempt to collect evidence and related clinical information of application of Nutraceuticals to be used in cancer treatment or compliment the cancer treatment. It contains 16 chapters written by experts in related field’s and covers many different aspects of the formulation and development of Nutraceuticals for cancer applications. This book covers efficacy, safety and toxicological aspects of nutraceuticals. It also addresses various novel drug delivery systems of nutraceuticals with anticancer properties, as well as nutraceuticals as supplements for cancer prevention. Features: Offers a comprehensive view of neutraceuticals’ role in cancer prevention and treatment Covers the applications and implications of neutraceuticals in prostate, colorectal, breast and gynecological cancers Discusses the principles of neutrigenomics and neutrigenetics in cancer prevention Explors the role of probiotics and micronutrients in cancer treatment and prevention Nutraceuticals can alter the gut microbiota. Gut microbiome undergoes changes during the disease status and followed by the cancer treatment. Nutraceutical’s role in proliferation and prevention of gynecological cancers, nutraceutical’s role in proliferation and prevention of prostate cancer and role of micronutrients in cancer prevention, both pros and cons, are some of the topics discussed in various chapters in this book. This book is addressed to scientists, clinicians, and students who are working in the area of Nutraceutical applications in cancer treatment. |
| car-t therapy india: Integrative Body-Mind-Spirit Social Work Mo Yee Lee, 2009-03-25 In recent years, interest in non-Western curative techniques among Americans has grown by leaps and bounds. Integrative Body-Mind-Spirit Social Work is the first book to strongly connect Western therapeutic techniques with Eastern philosophy and practices, while also providing a comprehensive and pragmatic agenda for social work, and mental health professionals. This breakthrough text, written by a cast of highly regarded researchers from both Asia and America, presents a holistic, therapeutic approach that ties Eastern philosophy and practical techniques to Western forms of therapy in order to help bring about positive, transformative changes in individuals and families.Integrative therapy focuses on the mind-body-spirit relationship, recognizes spirituality as a fundamental domain of human existence, acknowledges and utilizes the mind's power as well as the body's, and reaches beyond self-actualization or symptom reduction to broaden a perception of self that connects individuals to a larger sense of themselves and to their communities. Here, the authors provide a pragmatic, step-by-step description of assessment and treatment techniques that employ an integrative, holistic perspective. They begin by establishing the conceptual framework of integrative body-mind-spirit social work, then expertly describe, step-by-step, assessment and treatment techniques that utilize integrative and holistic perspectives. Several case studies demonstrate the approach in action, such as one with breast cancer patients who participated in body-mind-spirit and social support groups and another in which trauma survivors used meditation to get onto a path of healing. These examples provide solid empirical evidence that integrative body-mind-spirit social work is indeed a practical therapeutic approach in bringing about tangible changes in clients. The authors also discuss ethical issues and give tips for learning integrative body-mind-spirit social work.Professionals in social work, psychology, counseling, and nursing, as well as graduate students in courses on integral, alternative, or complementary clinical practice will find this a much-needed resource that complements the growing interest in alternatives to traditional Western psychotherapy. |
| car-t therapy india: Cancer as a Metabolic Disease Thomas Seyfried, 2012-05-18 The book addresses controversies related to the origins of cancer and provides solutions to cancer management and prevention. It expands upon Otto Warburg's well-known theory that all cancer is a disease of energy metabolism. However, Warburg did not link his theory to the hallmarks of cancer and thus his theory was discredited. This book aims to provide evidence, through case studies, that cancer is primarily a metabolic disease requring metabolic solutions for its management and prevention. Support for this position is derived from critical assessment of current cancer theories. Brain cancer case studies are presented as a proof of principle for metabolic solutions to disease management, but similarities are drawn to other types of cancer, including breast and colon, due to the same cellular mutations that they demonstrate. |
| car-t therapy india: Handbook of Research on Natural Products and Their Bioactive Compounds as Cancer Therapeutics Pandurangan, Ashok Kumar, Anandasadagopan, Suresh Kumar, Alhumaydhi, Fahad A., 2022-03-18 Many chemotherapeutic agents are available in today’s market that are highly effective against a variety of cancer types; however, the major drawbacks of these chemotherapeutic agents are the many side effects. As an alternative to these chemotherapeutic agents, there are a number of natural agents that are effective against cancer that have been tested in preclinical and clinical models over the years. These natural products must be documented and discussed in order to provide a thorough overview of all the options available for cancer treatment. The Handbook of Research on Natural Products and Their Bioactive Compounds as Cancer Therapeutics emphasizes the list of natural agents against all types of cancers and discusses the current state of research in the fields of natural products and their derivatives against cancer in preclinical and clinical models. This book also provides insight into the applications of meditation and mindfulness-based interventions in clinical and non-clinical conditions. Covering topics such as cancer therapy, antioxidants, and flavonoids, it is ideal for students, research scholars, academicians, professors, scientists, oncologists, doctors, and medical practitioners. |
| car-t therapy india: The Breakthrough Charles Graeber, 2015-12-01 Follow along as this New York Times bestselling author details the astonishing scientific discovery of the code to unleashing the human immune system to fight in this captivating and heartbreaking book (The Wall Street Journal). For decades, scientists have puzzled over one of medicine's most confounding mysteries: Why doesn't our immune system recognize and fight cancer the way it does other diseases, like the common cold? As it turns out, the answer to that question can be traced to a series of tricks that cancer has developed to turn off normal immune responses -- tricks that scientists have only recently discovered and learned to defeat. The result is what many are calling cancer's penicillin moment, a revolutionary discovery in our understanding of cancer and how to beat it. In The Breakthrough, New York Times bestselling author of The Good Nurse Charles Graeber guides readers through the revolutionary scientific research bringing immunotherapy out of the realm of the miraculous and into the forefront of twenty-first-century medical science. As advances in the fields of cancer research and the human immune system continue to fuel a therapeutic arms race among biotech and pharmaceutical research centers around the world, the next step -- harnessing the wealth of new information to create modern and more effective patient therapies -- is unfolding at an unprecedented pace, rapidly redefining our relationship with this all-too-human disease. Groundbreaking, riveting, and expertly told, The Breakthrough is the story of the game-changing scientific discoveries that unleash our natural ability to recognize and defeat cancer, as told through the experiences of the patients, physicians, and cancer immunotherapy researchers who are on the front lines. This is the incredible true story of the race to find a cure, a dispatch from the life-changing world of modern oncological science, and a brave new chapter in medical history. |
| car-t therapy india: The Peripheral T-Cell Lymphomas Owen A. O'Connor, Won Seog Kim, Pier L. Zinzani, 2021-06-01 THE PERIPHERAL T-CELL LYMPHOMAS Provides a comprehensive look at Peripheral T-Cell lymphomas, including the group’s unique geographic distribution, underlying genetics, and novel treatments Peripheral T-Cell lymphomas (PTCL) are a diverse group of lymphoid malignancies that develop from mature T cells and natural killer (NK) cells. PTCL represent 10-15% of all cases of non-Hodgkin lymphoma in the US, and up to 20-25% of cases in South America, Asia, and other regions around the world. The role of different etiologic factors and the variation of geographic distribution makes PTCL one of the most difficult types of cancer to understand and treat. For the first time in a single volume, The Peripheral T-Cell Lymphomas presents a comprehensive survey of this complex and rare group of blood cancers. Featuring contributions from an international team of leading authorities in the various aspects of PTCL, this authoritative text covers biology, epidemiology, classification, approved and emerging drugs, molecular genetics, and more. Detailed clinical chapters address diagnosis, prognosis, and treatment of each of the major PTCL subtypes identified in the 2018 WHO Classification of Tumors of Hematopoietic and Lymphoid Tissues. This much-needed resource: Covers the biological basis, epidemiology, classification, and treatment of PTCL Discusses the future of the field, including global collaboration efforts and novel approaches to PCTL Explores the role of biologics in PTCL and autologous and allogeneic stem-cell transplantation Offers new insights on molecular pathogenesis, innovative therapeutics, and novel drug combinations Features contributions from the Chairs The T-Cell Lymphoma Forum: the world’s largest meeting focused on PTCL Reflecting the unique epidemiology and genetic diversity of the PTCL, The Peripheral T-Cell Lymphomas is an indispensable source of data, insight, and references for the medical community, particularly oncologists and hematologists in both training and practice. |
| car-t therapy india: Lost in the Valley of Death Harley Rustad, 2022-01-11 By patient accumulation of anecdote and detail, Rustad evolves Shetler’s story into something much more human, and humanly tragic, into a layered inquisition and a reportorial force....suffice it to say Rustad has done what the best storytellers do: tried to track the story to its last twig and then stepped aside. —New York Times Book Review In the vein of Jon Krakauer's Into the Wild, a riveting work of narrative nonfiction centering on the unsolved disappearance of an American backpacker in India—one of at least two dozen tourists who have met a similar fate in the remote and storied Parvati Valley. For centuries, India has enthralled westerners looking for an exotic getaway, a brief immersion in yoga and meditation, or in rare cases, a true pilgrimage to find spiritual revelation. Justin Alexander Shetler, an inveterate traveler trained in wilderness survival, was one such seeker. In his early thirties Justin Alexander Shetler, quit his job at a tech startup and set out on a global journey: across the United States by motorcycle, then down to South America, and on to the Philippines, Thailand, and Nepal, in search of authentic experiences and meaningful encounters, while also documenting his travels on Instagram. His enigmatic character and magnetic personality gained him a devoted following who lived vicariously through his adventures. But the ever restless explorer was driven to pursue ever greater challenges, and greater risks, in what had become a personal quest—his own hero’s journey. In 2016, he made his way to the Parvati Valley, a remote and rugged corner of the Indian Himalayas steeped in mystical tradition yet shrouded in darkness and danger. There, he spent weeks studying under the guidance of a sadhu, an Indian holy man, living and meditating in a cave. At the end of August, accompanied by the sadhu, he set off on a “spiritual journey” to a holy lake—a journey from which he would never return. Lost in the Valley of Death is about one man’s search to find himself, in a country where for many westerners the path to spiritual enlightenment can prove fraught, even treacherous. But it is also a story about all of us and the ways, sometimes extreme, we seek fulfillment in life. Lost in the Valley of Death includes 16 pages of color photographs. |
| car-t therapy india: Coronavirus Disease - COVID-19 Nima Rezaei, 2021-05-10 In December 2019, the world witnessed the occurrence of a new coronavirus to humanity. The disease spread quickly and became known as a pandemic globally, affecting both society and the health care system, both the elderly and young groups of people, and both the men’s and women’s groups. It was a universal challenge that immediately caused a surge in scientific research. Be a part of a world rising in fighting against the pandemic, the Coronavirus Disease - COVID-19 was depicted in the early days of the pandemic, but updated by more than 200 scientists and clinicians to include many facets of this new infectious pandemic, including i, characteristics, ecology, and evolution of coronaviruses; ii, epidemiology, genetics, and pathogenesis (immune responses and oxidative stress) of the disease; iii, diagnosis, prognosis, and clinical manifestations of the disease in pediatrics, geriatrics, pregnant women, and neonates; iv, challenges of co-occurring the disease with tropical infections, cardiovascular diseases, hypertension, and cancer and to the settings of dentistry, hematology, ophthalmology, and pharmacy; v, transmission, prevention, and potential treatments, ranging from supportive ventilator support and nutrition therapy to potential virus- and host-based therapies, immune-based therapies, photobiomodulation, antiviral photodynamic therapy, and vaccines; vi, the resulting consequences on social lives, mental health, education, tourism industry and economy; and vii, multimodal approaches to solve the problem by bioinformatic methods, innovation and ingenuity, globalization, social and scientific networking, interdisciplinary approaches, and art integration. We are approaching December 2020 and the still presence of COVID-19, asking us to call it COVID (without 19). |
| car-t therapy india: Top 100 Indian Innovations (2022) Indian Innovators Association, 2022-11-12 This book is a compilation of Indian Innovations, physical and embodied. Indian Unicorns, business models, commerce & Financial innovations are widely covered by media. Not much is known about product innovations, and the innovators behind product innovations are relatively unknown. This will be the first book that fills the gap. It is intended as yearbook to the published every year. |
| car-t therapy india: You Can Beat Cancer Rachna Chhachhi, 2020-02-04 Expert Advice on Preventing and Reversing Cancer Foreword by SUBHASH CHANDRA Preface by HARSH MARIWALA According to WHO, the number of global cancer deaths is projected to increase by 45 percent, where over two-thirds of the deaths occur in low- and middle-income countries. This makes India, and you, vulnerable. There is already someone you know who has cancer. So, you know that the threat is real and near. But now there is a way out. Certified cancer nutrition coach Rachna Chhachhi shows you how to train your cells to respond to physical and emotional nurturing to fight cancer. In this book, you will learn all about preventing the world’s most feared disease with the help of holistic nutrition. You can also combine it with Western medicine, if you are already under treatment. Quoting the cases of her many clients across 27 countries who have defeated the odds after their diagnoses, and with the support of global cancer research, Chhachhi illustrates how to prevent, manage or reverse cancer for yourself. IN YOU CAN BEAT CANCER, SHE DISCUSSES: • What causes cancer • How not to fear the diagnosis • The necessity of practicing meditation, pranayama & gratitude • Ways to avoid cancer-triggering habits • The impact of natural immunotherapy • How epigenetics can change your genes’ response towards cancer cells • More than 100 unique anticancer recipes RACHNA CHHACHHI is a certified cancer nutrition coach and holds a PhD in holistic nutrition. She is best-known for her work with cancer and autoimmune patients. She has been writing on health for 20 years for mainstream Indian newspapers and magazines and has been extensively interviewed in media. “Rachna’s book is the need of the hour today to protect ourselves.” Manisha Koirala, Actor & Cancer Warrior “Gift this book to everyone you care for, everyone you want to gift a life without cancer.” Dr Subhash Chandra, Chairman, Essel Group “This book will be an important milestone in cancer prevention and management…” Harsh Mariwala, Chairman, Marico Ltd. |
| car-t therapy india: Cancer Chemotherapy, Immunotherapy, and Biotherapy Bruce Chabner, Dan Louis Longo, 2018 Publisher's Note: Products purchased from 3rd Party sellers are not guaranteed by the Publisher for quality, authenticity, or access to any online entitlements included with the product. Thoroughly revised and reformatted, the sixth edition of Cancer Chemotherapy, Immunotherapy and Biotherapy reflects recent significant changes in cancer treatment. This newly streamlined edition contains full-color illustrations, more tables for quick reference, and new immunotherapy and molecular targeted therapy content that brings you fully up to date with the state of the art in all current cancer therapies. Provides thorough, comprehensive coverage of the scientific and clinical aspects of immunotherapy, biotherapy, and chemotherapy. Includes significantly expanded information on immunotherapy and molecular targeted therapy, as well as the latest information on all drugs and biological agents--their mechanisms of action, interactions with other agents, toxicities, side effects, and mechanisms of resistance. Features a new, full-color format, a newly streamlined presentation. and more tables and figures throughout for quick access to high-yield information. Explains the rationale for use of drugs in specific schedules and combinations and offers guidelines for dose adjustment in specific situations. Enhance Your eBook Reading Experience Read directly on your preferred device(s), such as computer, tablet, or smartphone. Easily convert to audiobook, powering your content with natural language text-to-speech. |
| car-t therapy india: Cure Cancer with Urine Therapy Jagdish R. Bhurani, 2020-07-22 Auto-Urine Therapy known as “Shivambu” is an ancient method of treatment, which has been continuing from generation to generation. In the ancient days, many sages and rishimunis followed and practiced urine therapy. Lord Shiva himself recommended the action and ritual of Shivambu Kalpa to Mother Parvati mentioned in ancient book Damar Tantra. The powerful practice for healing, Auto-Urine Therapy, has been referred to as “Shivambu Kalpa Vidhi” in 5000-year-old documents called Damar Tantra in the Vedas. God has given a wonderful gift to man, his own water – Shivambu. Shiv means beneficial and salubrious, and Ambu means water. The combined Sanskrit word is Shivambu (beneficial water). They termed Shivambu as the holy liquid. This book is published to enlighten everyone who is diagnosed with cancer to adopt Urine Therapy before going for surgery or chemotherapy. It is safe and does not have any side effects. It can prevent and control/cure cancer. It is free of cost and can be practiced at home. People living with diabetes can cure diabetes by adopting Urine Therapy. |
| car-t therapy india: Bio-Energy Self Treatments Sivachanemougame Kalyanasundaram, 2020-03-30 Bio-Energy Self Treatments (BEST) is an alternative medical therapy book. It is very simple to perform and has no cost. It is an advanced touch therapy method. Bio-energy is the natural energy in our body by which our internal organs function. This treatment is for self-use and to treat others for any disease.- Five Elements- Internal Organs- Pulse Diagnosis- Bio-Energy Self Treatments- Emergency Treatments (like Faint, BP, Heart Attack)- The Pain Treatments for the Head and Extremities (Hands and Legs)- Few Diseases and their Treatments (for Reference)This book explains the aforementioned topics in a simple and clear way. |
| car-t therapy india: Handbook of Research on Evidence-Based Perspectives on the Psychophysiology of Yoga and Its Applications Telles, Shirley, Gupta, Ram Kumar, 2020-08-28 While yoga was originally intended to be practiced for spiritual growth, there is an increasing interest in applying yoga in all areas of life. It is important to understand this ancient science and way of life through as many perspectives as possible (e.g., based on biomedical engineering). As its popularity and interest grows, more practitioners want to know about the proven physiological effects and uses in healthcare. The Handbook of Research on Evidence-Based Perspectives on the Psychophysiology of Yoga and Its Applications provides research exploring the theoretical and practical aspects of yoga therapy and its physiological effects from diverse, evidence-based viewpoints. The book adds in-depth information regarding the (1) physiological effects of yoga; (2) neurobiological effects of yoga meditation; (3) psychological benefits related to yoga, such as mental wellbeing; (4) molecular changes associated with yoga practice; and (5) therapeutic applications (for lymphedema, mental health disorders, non-communicable diseases, attention deficit hyperactivity disorder, and trauma, among other conditions). Featuring coverage on a broad range of topics such as pain management, psychotherapy, and trauma treatment, this book is ideally designed for yoga practitioners, physicians, medical professionals, health experts, mental health professionals, therapists, counselors, psychologists, spiritual leaders, academicians, researchers, and students. |
| car-t therapy india: Cell and Gene Therapies Miguel-Angel Perales, Syed A. Abutalib, Catherine Bollard, 2018-11-27 In this book, experts in the field express their well-reasoned opinions on a range of complex, clinically relevant issues across the full spectrum of cell and gene therapies with the aim of providing trainee and practicing hematologists, including hematopoietic transplant physicians, with information that is relevant to clinical practice and ongoing research. Each chapter focuses on a particular topic, and the concise text is supported by numerous working tables, algorithms, and figures. Whenever appropriate, guidance is provided regarding the availability of potentially high-impact clinical trials. The rapid evolution of cell and gene therapies is giving rise to numerous controversies that need to be carefully addressed. In meeting this challenge, this book will appeal to all residents, fellows, and faculty members responsible for the care of hematopoietic cell transplant patients. It will also offer a robust, engaging tool to aid vital activities in the daily work of every hematology and oncology trainee. |
| car-t therapy india: Cancer Immunotherapy Principles and Practice Lisa H. Butterfield, Howard L. Kaufman, Francesco M. Marincola, 2017 Part 1: Intratumoral Signatures Associated With Immune Responsiveness |
| car-t therapy india: Curing Cancer with Carrots Ann Cameron, 2015-10-18 In 2013, Ann Cameron cured Stage 4 colon cancer without chemotherapy or radiation, by drinking carrot juice. Since then, others with a variety of cancers have reported similar successes. Cameron wanted to find out why such an apparently simple cancer cure--just carrots--works. Based on her extensive reading in scientific journals focused on nutrition and cancer, her ground-breaking book describes the details of the carrot treatment and the scientific evidence for its power. In this book, she shares little-known research that is revolutionizing scientific thinking about cancer and how to treat it. The research comes from the exciting new field of epigenetics--the study of how chemical switching mechanisms in our bodies change the expression of our genes. Our environment, the foods we eat, and the way we live can silence pro-cancer genes or turn them on, set anti-cancer genes on alert or turn them off. Genes aren't our destiny. Neither is cancer. Cancer develops when the body loses its ability to recognize and eliminate rogue cells--cells that take over the body if they don't quit dividing. In some cases--probably many--carrots can restore the body's natural power to regulate growth and kill defective cells. The scientific information in this book could be a life-saver and a beacon of hope for you or someone you know. Equally helpful, it offers the practical knowledge Cameron gained from her journey through cancer and back to health--how to use the internet to research proposed treatments and the quality of hospitals and doctors; how to reduce the cost of cancer care; and how to arrive at individual treatment decisions that are best for you. |
| car-t therapy india: Hypnotism and Mysticism of India Ormond McGill, 1979-01-01 |
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This review covers the evolution of CAR‑T therapy against various tumors, including hematological and solid tumors, highlights challenges faced by CAR‑T cell therapy, and …
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CAR T-cell therapies in Germany - Gilead Government Affairs
and therapy as well as novel options for the treatment of patients, while at the same time driving long-term cost savings.1 Since 2018, oncologists in Germany have had access to innovative, …
CAR T-Cell Therapy - University of Utah
Sep 18, 2024 · Bridging Therapy Rest Days CAR-T Infusion Day 0 Monitor for CAR-T side effects (If admitted ~7-10 days) Minimum twice weekly clinic visits Stay local for follow-up to Day +30 …
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About ImmunoACT and the promoter: Immuno-adoptive Cell Therapy Private Limited (ImmunoACT) is a pioneer in the field of Cell and Gene Therapy. It is in the process of …
Protocol - The New England Journal of Medicine
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therapy. Reimbursement for CAR T-cell therapy is typically less than the costs incurred for providing it, although strides have been made to ease this financial burden. When it was first …
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that CAR-T cell therapy exhibited remarkable efficacy and acceptable safety in R/R B-NHL, with the best objective response rate (ORR) of 66% and complete response rate (CRR) of 46% [9].
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Chimeric Antigen Receptor (CAR) T-Cell Therapy Autologous CAR T-cell therapy involves engineering a patient’s own T cells to recognize and attack cancer cells. “Autologous” means …
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Axi-cel，Liso-cel の3 つのCAR-T では膜貫通部位と共刺激 分子の組み合わせが異なる2。 CAR-T細胞療法の流れ CAR-T 細胞療法の適応を検討する段階から輸注後まで の管理は大きく3 つ …
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but also intracellular antigens. Thus TCR-T therapy has shown unprecedented promise in the treatment of solid tumors, and has become an extremely attractive treatment modality. This …
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There are two different types of CAR-T therapy: autologous and allogeneic. In autologous CAR-T therapy, a patient’s own lymphocytes are used as starting material to manufacture their own …
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Chimeric Antigen Receptor T-Cell (CAR T) Therapy
Chimeric antigen receptor (CAR) T-cell therapy is an adoptive T-cell therapy that uses engineered T cells from a patient’s own immune system to attack cancer cells by targeting proteins …
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Jan 22, 2019 · – For cell and gene therapy products, the trial is usually conducted in the disease population, not in healthy volunteers • To make recommendations regarding the proposed ... • …
De keerzijde van CAR-T: risico’s en bijwerkingen - NTVH
CAR-T-celdosis, de proliferatie van CAR-T-cellen en het aantal blasten in het beenmerg.3 Ook de serumwaarden en dynamiek van een aantal factoren, zoals ferritine, interleukine-6 (IL-6) en C …
CAR-T Therapy - ECPC
CAR-T therapy is not yet reimbursed in every MS, which is an added barrier to cross-border patient access. Thus, cross-border access, be it regional, national or between insurers, could …
Considerations in Validating Car T Cell Therapy MFG …
Car T Cell Therapy Manufacturing Processes Justin McCue James Powell. Rachel Yost. Clinton Weber. Juno Therapeutics. ... Do not duplicate, disseminat e, or distribute. 2 Overview • CAR T …
CAR-T therapy - publicdocuments.sth.nhs.uk
1. CAR-T Clinic The first step is a consultation at our CAR-T clinic to meet with our medical team and specialist nurses. You will meet your consultant and other members of the CAR-T therapy …
The next-generation CAR-T therapy landscape - Nature
Roughly two thirds of cell therapy companies are in the CAR-T space, with CAR-T assets encompassing just over 50% of cell therapy assets. Within the CAR-T space, roughly half of …
고형암 표적 CAR-T 치료제 개발 동향 - koreabio.org
고형암에서 CAR-T의 효과를 개선시키기 위한 노력으로 면역관문억제제와의 병용 요법이 시 도되고 있다. 앞서, CAR-T의 PD-1 유전자 knockout 방법과 유사한 작용기전으로 종양세포가 CAR-T의 …
CAR-T-Zell-Therapie - Rosenfluh Publikationen AG
Chimeric Antigen Receptor T (CAR-T) Therapy Chimeric antigen receptor T (CAR-T) cells have entered clinical practice and are now avai-lable as a treatment option for certain patients with …
UNITED STATES DEPARTMENT OF HEALTH AND HUMAN …
FDA CBER Guidance Webinar: Considerations for the Development of CAR T Cell Products March 7, 2024 2 I’ll pass it to Kim to kick us off. Kim, whenever you’re ready.
Presentation Slides CAR T-Cell - Leukemia & Lymphoma …
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Le terapie geniche CAR-T - Agenzia Italiana del Farmaco
Le CAR-T autorizzate. Tra ttamenti di “terza linea” Le terapie CAR-T rappresentano la prima forma di terapia genica approvata per il trattamento della leucemia linfoblastica B e di alcune …
患者及照护者教育 CAR-T 细胞治疗：成人患者及照护者指 南
⾃体 car-t 细胞治疗将从您的⾎液中采集部分 t 细胞。 这些细胞将被送往实验室，在其 中添加新基因。 这被称为基因修饰。 这种新基因将有助于发现并杀死癌细胞。 ⼀旦 t 细 胞有了这种新基 …
Review of CAR-T cell therapy for the WHO Model List of …
CAR-T cell therapy is used as third-line treatment for relapsed or refractory (r/r) DLBCL (3, 4). 7. Review of efficacy and safety Summary of the methodological approach We are developing a …
National Coverage Determination 110.24: Chimeric Antigen …
Dec 30, 2022 · CAR T-cell therapy as an investigational agent that meet requirements in . NCD 310.1. ffective e August 7, 2019. We remind you that the use of allogenic T-cells from healthy …
Chimeric Antigen Receptor (CAR) T-Cell Therapy - The …
Introduction to CAR T-Cell Therapy. This booklet serves as a guide to help you better understand the CAR T-cell therapy process. CAR T-cell therapy is a type of immunotherapy, meaning your …
Advancement of Cell Therapy in China – Challenges and …
Apr 16, 2023 · China. While initial global approvals of CAR-T therapies were gained by large pharmaceutical companies such as Novartis and Bristol Myers Squibb, in China, on the other …
Rare genetic disorders in India: Current status, challenges, …
Review Rare genetic disorders in India: Current status, challenges, and CRISPR-based therapy PALLABI BHATTACHARYYA 1,,K ANIKAH MEHNDIRATTA 1,2,, SOUVIK MAITI 1,3 and …
DEVELOPMENTAL THERAPEUTICS High Cost of Chimeric …
evidence that CAR T-cells can persist in vivo to maintain remissions for more than a decade.2 Since the first CAR T-cell therapy was approved by the US Food and Drug Administration in …
CAR-T 細胞療法の基礎と今後の臨床展開 - J-STAGE
CAR-T細胞療法の基礎と今後の臨床展開 赤塚 美樹 キメラ抗原受容体（ChimericAntigenReceptor，CAR）-T細胞療法は遺伝子改変T細胞による養子免疫療法の一 …
Billing Instructions for Beneficiaries Enrolled in Medicare …
Oct 24, 2019 · immunotherapy, is Chimeric Antigen Receptor (CAR) T-cell therapy. CAR T-cells have been genetically altered to improve the ability of the T-cells to fight cancer. The genetic …
CMS Manual System - Centers for Medicare & Medicaid Services
claims: CAR T-cell therapy International Classification of Diseases, 10th Revision, Procedure Coding System (ICD-10-PCS): XW033C3, XW043C3, XW23346, XW24346, XW23376, and …
