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| cou-aa-302 study: Surgical Management of Advanced Pelvic Cancer Desmond C. Winter, Michael E. Kelly, 2021-11-01 An innovative guide to the practice of pelvic exenterative surgery for the management of advanced pelvic neoplasms Exenterative surgery plays an important role in the management of advanced pelvic cancer. However, while a large body of evidence regarding outcomes following pelvic exenteration now exists, practical strategies and management options remain unclear. Surgical Management of Advanced Pelvic Cancer addresses this problem by assembling world-leaders in the field to provide insights into the latest techniques and best practices. It includes detailed coverage of: Surgical anatomy Operative approaches and exenterative techniques Reconstruction options Current evidence on survival and quality of life outcomes Featuring essential information for those managing patients with advanced pelvic neoplasms, Surgical Management of Advanced Pelvic Cancer consolidates the latest data and practical advice in one indispensable guide. |
| cou-aa-302 study: Blandy's Urology Omar M. Aboumarzouk, 2019-05-06 Die 3. Auflage von Blandy?s Urology ist auf dem besten Weg, ein Klassiker zu werden. Die neueste Auflage eines der populärsten Fachbücher der Urologie vereint erfolgreich alles Wissenswerte zur allgemeinen Urologie und Chirurgie in der Urologie für die Zielgruppe der Urologen und Chirurgen. Hauptmerkmal ist die einzigartige Art und Weise von Blandy, urologische Erkrankungen und deren Management zu beschreiben: - Klare, direkte und unkomplizierte Beschreibungen von Krankheiten und Störungen mit Hunderten klinischer Fotos. - Eine Fülle exzellenter Schaubilder zu chirurgischen Eingriffen, die die besten Operationstechniken verdeutlichen. - Legt den Nachdruck auf die häufigsten Erkrankungen in der klinischen Praxis. - Jedes Thema ist einem anatomischen Bereich zugeordnet. Ein Fachbuch, das wegen seines direkten Zugangs zu dem Fachgebiet vor allem von Urologen und angehenden Chirurgen geschätzt wird. Eignet sich auch für die Prüfungsvorbereitung und als Auffrischung |
| cou-aa-302 study: PET/CT in Prostate Cancer Gary Cook, 2017-07-24 This pocket book explains the significant and well-documented impact that PET/CT can have on the management of prostate cancer through the provision of high-quality evidence regarding function and structure. Up-to-date information is supplied on the relevance of PET/CT to diagnosis, treatment planning, and therapy, including the emerging role of PET/CT with PSMA. Readers will also find clear explanation of the relation of the clinical and pathological background to imaging and the value of PET/CT compared with conventional radiological imaging. The book will be an excellent asset for referring clinicians, nuclear medicine/radiology physicians, radiographers/technologists, and nurses who routinely work in nuclear medicine and participate in multidisciplinary meetings. It is published within the Springer series Clinicians’ Guides to Radionuclide Hybrid Imaging, which presents contributions from professionals worldwide who share a common purpose in promoting nuclear medicine as an important imaging specialty for the diagnosis and management of oncological and non-oncological conditions. |
| cou-aa-302 study: Medicinal Chemistry of Anticancer Drugs Carmen Avendaño, J. Carlos Menéndez, 2015-06-11 Medicinal Chemistry of Anticancer Drugs, Second Edition, provides an updated treatment from the point of view of medicinal chemistry and drug design, focusing on the mechanism of action of antitumor drugs from the molecular level, and on the relationship between chemical structure and chemical and biochemical reactivity of antitumor agents. Antitumor chemotherapy is a very active field of research, and a huge amount of information on the topic is generated every year. Cytotoxic chemotherapy is gradually being supplemented by a new generation of drugs that recognize specific targets on the surface or inside cancer cells, and resistance to antitumor drugs continues to be investigated. While these therapies are in their infancy, they hold promise of more effective therapies with fewer side effects. Although many books are available that deal with clinical aspects of cancer chemotherapy, this book provides a sorely needed update from the point of view of medicinal chemistry and drug design. - Presents information in a clear and concise way using a large number of figures - Historical background provides insights on how the process of drug discovery in the anticancer field has evolved - Extensive references to primary literature |
| cou-aa-302 study: Precision Molecular Pathology of Prostate Cancer Brian D. Robinson, Juan Miguel Mosquera, Jae Y. Ro, Mukul Divatia, 2018-02-13 This volume focuses on our current understanding of the molecular underpinnings of prostate cancer and their potential application for precision medicine approaches. The emergence and applications of new technologies has allowed for a rapid expansion of our understanding of the molecular basis of prostate cancer and has revealed a remarkable genetic heterogeneity that may underlie the clinically variable behavior of the disease. The book consists of five sections which provide insight about the following: (1) General principles; (2) Molecular signatures of primary prostate cancer; (3) Molecular signatures of advanced prostate cancer; (4) Key molecular pathways in prostate cancer development and progression; (5) and Precision medicine approach: Diagnosis, treatment, prognosis. Precision Molecular Pathology of Prostate Cancer is an important resource for the practicing oncologist, urologist, and pathologist, and will also be useful for researchers in the prostate cancer community. |
| cou-aa-302 study: Cost-Effectiveness Analysis in Health Peter Muennig, Mark Bounthavong, 2016-02-03 The field's bestselling reference, updated with the latest tools, data, techniques, and the latest recommendations from the Second Panel on Cost-Effectiveness in Health and Medicine Cost-Effectiveness Analysis in Health is a practical introduction to the tools, methods, and procedures used worldwide to perform cost-effective research. Covering every aspect of a complete cost-effectiveness analysis, this book shows you how to find which data you need, where to find it, how to analyze it, and how to prepare a high-quality report for publication. Designed for the classroom or the individual learner, the material is presented in simple and accessible language for those who lack a biostatistics or epidemiology background, and each chapter includes real-world examples and tips and tricks that highlight key information. Exercises throughout allow you to test your understanding with practical application, and the companion website features downloadable data sets for students, as well as lecture slides and a test bank for instructors. This new third edition contains new discussion on meta-analysis and advanced modeling techniques, a long worked example using visual modeling software TreeAge Pro, and updated recommendations from the U.S. Public Health Service's Panel on Cost-Effectiveness in Health and Medicine. This is the second printing of the 3rd Edition, which has been corrected and revised for 2018 to reflect the latest standards and methods. Cost-effectiveness analysis is used to evaluate medical interventions worldwide, in both developed and developing countries. This book provides process-specific instruction in a concise, structured format to give you a robust working knowledge of common methods and techniques. Develop a thoroughly fleshed-out research project Work accurately with costs, probabilities, and models Calculate life expectancy and quality-adjusted life years Prepare your study and your data for publication Comprehensive analysis skills are essential for students seeking careers in public health, medicine, biomedical research, health economics, health policy, and more. Cost-Effectiveness Analysis in Health walks you through the process from a real-world perspective to help you build a skillset that's immediately applicable in the field. |
| cou-aa-302 study: Practical Medical Oncology Textbook Antonio Russo, Marc Peeters, Lorena Incorvaia, Christian Rolfo, 2021-10-06 This textbook combines essential information on clinical cancer medicine with a guide to the latest advances in molecular oncology and tumor biology. Providing a systematic overview of all types of solid tumors, including epidemiology and cancer prevention, genetic aspects of hereditary cancers, differential diagnosis, typical signs and symptoms, diagnostic strategies and staging, and treatment modalities, it also discusses new and innovative cancer treatments, particularly targeted therapy and immunotherapy. Expert commentaries at the end of each chapter highlight key points, offer insights, suggest further reading and discuss clinical application using case descriptions. This textbook is an invaluable, practice-oriented tool for medical students just beginning their clinical oncology studies, as well as for medical oncology residents and young professionals. |
| cou-aa-302 study: Qualitative Research from Start to Finish, First Edition Robert K. Yin, 2011-09-26 This lively, practical text presents a fresh and comprehensive approach to doing qualitative research. The book offers a unique balance of theory and clear-cut choices for customizing every phase of a qualitative study. A scholarly mix of classic and contemporary studies from multiple disciplines provides compelling, field-based examples of the full range of qualitative approaches. Readers learn about adaptive ways of designing studies, collecting data, analyzing data, and reporting findings. Key aspects of the researcher's craft are addressed, such as fieldwork options, the five phases of data analysis (with and without using computer-based software), and how to incorporate the researcher's “declarative” and “reflective” selves into a final report. Ideal for graduate-level courses, the text includes:* Discussions of ethnography, grounded theory, phenomenology, feminist research, and other approaches.* Instructions for creating a study bank to get a new study started.* End-of-chapter exercises and a semester-long, field-based project.* Quick study boxes, research vignettes, sample studies, and a glossary.* Previews for sections within chapters, and chapter recaps.* Discussion of the place of qualitative research among other social science methods, including mixed methods research. |
| cou-aa-302 study: Shock Waves Stephane Hallegatte, Mook Bangalore, Laura Bonzanigo, Marianne Fay, Tamaro Kane, Ulf Narloch, Julie Rozenberg, David Treguer, Adrien Vogt-Schilb, 2015-11-23 Ending poverty and stabilizing climate change will be two unprecedented global achievements and two major steps toward sustainable development. But the two objectives cannot be considered in isolation: they need to be jointly tackled through an integrated strategy. This report brings together those two objectives and explores how they can more easily be achieved if considered together. It examines the potential impact of climate change and climate policies on poverty reduction. It also provides guidance on how to create a “win-win†? situation so that climate change policies contribute to poverty reduction and poverty-reduction policies contribute to climate change mitigation and resilience building. The key finding of the report is that climate change represents a significant obstacle to the sustained eradication of poverty, but future impacts on poverty are determined by policy choices: rapid, inclusive, and climate-informed development can prevent most short-term impacts whereas immediate pro-poor, emissions-reduction policies can drastically limit long-term ones. |
| cou-aa-302 study: Infantry in Battle Infantry School (U.S.), 1934 |
| cou-aa-302 study: The 71F Advantage National Defense University Press, 2010-09 Includes a foreword by Major General David A. Rubenstein. From the editor: 71F, or 71 Foxtrot, is the AOC (area of concentration) code assigned by the U.S. Army to the specialty of Research Psychology. Qualifying as an Army research psychologist requires, first of all, a Ph.D. from a research (not clinical) intensive graduate psychology program. Due to their advanced education, research psychologists receive a direct commission as Army officers in the Medical Service Corps at the rank of captain. In terms of numbers, the 71F AOC is a small one, with only 25 to 30 officers serving in any given year. However, the 71F impact is much bigger than this small cadre suggests. Army research psychologists apply their extensive training and expertise in the science of psychology and social behavior toward understanding, preserving, and enhancing the health, well being, morale, and performance of Soldiers and military families. As is clear throughout the pages of this book, they do this in many ways and in many areas, but always with a scientific approach. This is the 71F advantage: applying the science of psychology to understand the human dimension, and developing programs, policies, and products to benefit the person in military operations. This book grew out of the April 2008 biennial conference of U.S. Army Research Psychologists, held in Bethesda, Maryland. This meeting was to be my last as Consultant to the Surgeon General for Research Psychology, and I thought it would be a good idea to publish proceedings, which had not been done before. As Consultant, I'd often wished for such a document to help explain to people what it is that Army Research Psychologists do for a living. In addition to our core group of 71Fs, at the Bethesda 2008 meeting we had several brand-new members, and a number of distinguished retirees, the grey-beards of the 71F clan. Together with longtime 71F colleagues Ross Pastel and Mark Vaitkus, I also saw an unusual opportunity to capture some of the history of the Army Research Psychology specialty while providing a representative sample of current 71F research and activities. It seemed to us especially important to do this at a time when the operational demands on the Army and the total force were reaching unprecedented levels, with no sign of easing, and with the Army in turn relying more heavily on research psychology to inform its programs for protecting the health, well being, and performance of Soldiers and their families. |
| cou-aa-302 study: Hepatotoxicity Hyman J. Zimmerman, 1999 Written by the foremost authority in the field, this volume is a comprehensive review of the multifaceted phenomenon of hepatotoxicity. Dr. Zimmerman examines the interface between chemicals and the liver; the latest research in experimental hepatotoxicology; the hepatotoxic risks of household, industrial, and environmental chemicals; and the adverse effects of drugs on the liver. This thoroughly revised, updated Second Edition features a greatly expanded section on the wide variety of drugs that can cause liver injury. For quick reference, an appendix lists these medications and their associated hepatic injuries. Also included are in-depth discussions of drug metabolism and factors affecting susceptibility to liver injury. |
| cou-aa-302 study: Gene Drives on the Horizon National Academies of Sciences, Engineering, and Medicine, Division on Earth and Life Studies, Board on Life Sciences, Committee on Gene Drive Research in Non-Human Organisms: Recommendations for Responsible Conduct, 2016-08-28 Research on gene drive systems is rapidly advancing. Many proposed applications of gene drive research aim to solve environmental and public health challenges, including the reduction of poverty and the burden of vector-borne diseases, such as malaria and dengue, which disproportionately impact low and middle income countries. However, due to their intrinsic qualities of rapid spread and irreversibility, gene drive systems raise many questions with respect to their safety relative to public and environmental health. Because gene drive systems are designed to alter the environments we share in ways that will be hard to anticipate and impossible to completely roll back, questions about the ethics surrounding use of this research are complex and will require very careful exploration. Gene Drives on the Horizon outlines the state of knowledge relative to the science, ethics, public engagement, and risk assessment as they pertain to research directions of gene drive systems and governance of the research process. This report offers principles for responsible practices of gene drive research and related applications for use by investigators, their institutions, the research funders, and regulators. |
| cou-aa-302 study: The Coding Manual for Qualitative Researchers Johnny Saldana, 2009-02-19 The Coding Manual for Qualitative Researchers is unique in providing, in one volume, an in-depth guide to each of the multiple approaches available for coding qualitative data. In total, 29 different approaches to coding are covered, ranging in complexity from beginner to advanced level and covering the full range of types of qualitative data from interview transcripts to field notes. For each approach profiled, Johnny Saldaña discusses the method’s origins in the professional literature, a description of the method, recommendations for practical applications, and a clearly illustrated example. |
| cou-aa-302 study: Alcoholics Anonymous Bill W., 2014-09-04 A 75th anniversary e-book version of the most important and practical self-help book ever written, Alcoholics Anonymous. Here is a special deluxe edition of a book that has changed millions of lives and launched the modern recovery movement: Alcoholics Anonymous. This edition not only reproduces the original 1939 text of Alcoholics Anonymous, but as a special bonus features the complete 1941 Saturday Evening Post article “Alcoholics Anonymous” by journalist Jack Alexander, which, at the time, did as much as the book itself to introduce millions of seekers to AA’s program. Alcoholics Anonymous has touched and transformed myriad lives, and finally appears in a volume that honors its posterity and impact. |
| cou-aa-302 study: Families Caring for an Aging America National Academies of Sciences, Engineering, and Medicine, Health and Medicine Division, Board on Health Care Services, Committee on Family Caregiving for Older Adults, 2016-12-08 Family caregiving affects millions of Americans every day, in all walks of life. At least 17.7 million individuals in the United States are caregivers of an older adult with a health or functional limitation. The nation's family caregivers provide the lion's share of long-term care for our older adult population. They are also central to older adults' access to and receipt of health care and community-based social services. Yet the need to recognize and support caregivers is among the least appreciated challenges facing the aging U.S. population. Families Caring for an Aging America examines the prevalence and nature of family caregiving of older adults and the available evidence on the effectiveness of programs, supports, and other interventions designed to support family caregivers. This report also assesses and recommends policies to address the needs of family caregivers and to minimize the barriers that they encounter in trying to meet the needs of older adults. |
| cou-aa-302 study: Urologic Oncology Axel S. Merseburger, Maximilian Burger, 2019-08-21 This comprehensive and timely textbook covers all aspects of the evidence-based management of genitourinary cancers and explains the fundamental principles underlying the available diagnostic and treatment approaches, including chemotherapy, radiotherapy, immunotherapy, and surgery. For each type of cancer – prostate, bladder, renal, testicular, and penile, plus rare urologic malignancies – clinical presentation, diagnosis, and treatment strategies are described in detail and information is provided on etiology, epidemiology, risk factors, and pathology, including TNM classification. Careful attention is also devoted to the complications that may be encountered when treating urologic malignancies and to the management of these complications. The text is complemented by the inclusion of numerous high-definition photographs and illustrations. Urologic Oncology will be a valuable reference and source of guidance for all oncologists, urologists and practitioners in related disciplines who treat patients with urologic cancers. |
| cou-aa-302 study: Tumor Microenvironment Alexander Birbrair, 2021-10-18 This volume discusses novel concepts in cancer biology, focusing on different factors that affect the tumor microenvironment. Topics covered include sex-based differences in the tumor microenironment, dormancy in the tumor microenvironment, the influence of obesity on the tumor microenvironment, and much more. Taken alongside its companion volumes, Tumor Microenvironment: Novel Concepts covers the latest research on various aspects of the tumor microenvironment, as well as future directions. Useful for introducing the newer generation of researchers to the history of how scientists studied the tumor microenvironment as well as how this knowledge is currently applied for cancer treatments, it will be essential reading for advanced cell biology and cancer biology students, as well as researchers seeking an update on research on the tumor microenvironment. |
| cou-aa-302 study: Springs of Texas Gunnar M. Brune, 2002 This text explores the natural history of Texas and more than 2900 springs in 183 Texas counties. It also includes an in-depth discussion of the general characteristics of springs - their physical and prehistoric settings, their historical significance, and their associated flora and fauna. |
| cou-aa-302 study: Radioguided Surgery Giuliano Mariani, Armando E. Giuliano, H. William Strauss, 2010-05-10 This multidisciplinary textbook is designed to be the standard on the subject and is geared for use by physicians who are involved in the care and/or diagnosis of cancer patients. Comprehensive coverage is provided on all aspects of radioguided surgery. Practical information is readily accessible and throughout there is an emphasis on improved decision making. Tables present the indications, performance, and interpretation of procedures at a glance. A wealth of illustrations, including a full-color insert, enhances the application of new concepts. |
| cou-aa-302 study: Fundamentals of Fluid Film Lubrication Bernard J. Hamrock, Steven R. Schmid, Bo O. Jacobson, 2004-03-15 Specifically focusing on fluid film, hydrodynamic, and elastohydrodynamic lubrication, this edition studies the most important principles of fluid film lubrication for the correct design of bearings, gears, and rolling operations, and for the prevention of friction and wear in engineering designs. It explains various theories, procedures, and equations for improved solutions to machining challenges. Providing more than 1120 display equations and an introductory section in each chapter, Fundamentals of Fluid Film Lubrication, Second Edition facilitates the analysis of any machine element that uses fluid film lubrication and strengthens understanding of critical design concepts. |
| cou-aa-302 study: Historical Painting Techniques, Materials, and Studio Practice Arie Wallert, Erma Hermens, Marja Peek, 1995-08-24 Bridging the fields of conservation, art history, and museum curating, this volume contains the principal papers from an international symposium titled Historical Painting Techniques, Materials, and Studio Practice at the University of Leiden in Amsterdam, Netherlands, from June 26 to 29, 1995. The symposium—designed for art historians, conservators, conservation scientists, and museum curators worldwide—was organized by the Department of Art History at the University of Leiden and the Art History Department of the Central Research Laboratory for Objects of Art and Science in Amsterdam. Twenty-five contributors representing museums and conservation institutions throughout the world provide recent research on historical painting techniques, including wall painting and polychrome sculpture. Topics cover the latest art historical research and scientific analyses of original techniques and materials, as well as historical sources, such as medieval treatises and descriptions of painting techniques in historical literature. Chapters include the painting methods of Rembrandt and Vermeer, Dutch 17th-century landscape painting, wall paintings in English churches, Chinese paintings on paper and canvas, and Tibetan thangkas. Color plates and black-and-white photographs illustrate works from the Middle Ages to the 20th century. |
| cou-aa-302 study: Climate Intervention National Research Council, Division on Earth and Life Studies, Ocean Studies Board, Board on Atmospheric Sciences and Climate, Committee on Geoengineering Climate: Technical Evaluation and Discussion of Impacts, 2015-06-17 The signals are everywhere that our planet is experiencing significant climate change. It is clear that we need to reduce the emissions of carbon dioxide and other greenhouse gases from our atmosphere if we want to avoid greatly increased risk of damage from climate change. Aggressively pursuing a program of emissions abatement or mitigation will show results over a timescale of many decades. How do we actively remove carbon dioxide from the atmosphere to make a bigger difference more quickly? As one of a two-book report, this volume of Climate Intervention discusses CDR, the carbon dioxide removal of greenhouse gas emissions from the atmosphere and sequestration of it in perpetuity. Climate Intervention: Carbon Dioxide Removal and Reliable Sequestration introduces possible CDR approaches and then discusses them in depth. Land management practices, such as low-till agriculture, reforestation and afforestation, ocean iron fertilization, and land-and-ocean-based accelerated weathering, could amplify the rates of processes that are already occurring as part of the natural carbon cycle. Other CDR approaches, such as bioenergy with carbon capture and sequestration, direct air capture and sequestration, and traditional carbon capture and sequestration, seek to capture CO2 from the atmosphere and dispose of it by pumping it underground at high pressure. This book looks at the pros and cons of these options and estimates possible rates of removal and total amounts that might be removed via these methods. With whatever portfolio of technologies the transition is achieved, eliminating the carbon dioxide emissions from the global energy and transportation systems will pose an enormous technical, economic, and social challenge that will likely take decades of concerted effort to achieve. Climate Intervention: Carbon Dioxide Removal and Reliable Sequestration will help to better understand the potential cost and performance of CDR strategies to inform debate and decision making as we work to stabilize and reduce atmospheric concentrations of carbon dioxide. |
| cou-aa-302 study: Stereotactic Body Radiation Therapy Simon S. Lo, Bin S. Teh, Jiade J. Lu, Tracey E. Schefter, 2012-08-28 Stereotactic body radiation therapy (SBRT) has emerged as an important innovative treatment for various primary and metastatic cancers. This book provides a comprehensive and up-to-date account of the physical/technological, biological, and clinical aspects of SBRT. It will serve as a detailed resource for this rapidly developing treatment modality. The organ sites covered include lung, liver, spine, pancreas, prostate, adrenal, head and neck, and female reproductive tract. Retrospective studies and prospective clinical trials on SBRT for various organ sites from around the world are examined, and toxicities and normal tissue constraints are discussed. This book features unique insights from world-renowned experts in SBRT from North America, Asia, and Europe. It will be necessary reading for radiation oncologists, radiation oncology residents and fellows, medical physicists, medical physics residents, medical oncologists, surgical oncologists, and cancer scientists. |
| cou-aa-302 study: Career Development and Counseling Steven D. Brown, Robert W. Lent, 2012-06-29 This is a must-have for any researcher in vocational psychology or career counseling, or anyone who wishes to understand the empirical underpinnings of the practice of career counseling. -Mark Pope, EdD College of Education, University of Missouri - St. Louis past president of the American Counseling Association Today's career development professional must choose from a wide array of theories and practices in order to provide services for a diverse range of clients. Career Development and Counseling: Putting Theory and Research to Work focuses on scientifically based career theories and practices, including those derived from research in other disciplines. Driven by the latest empirical and practical evidence, this text offers the most in-depth, far-reaching, and comprehensive career development and counseling resource available. Career Development and Counseling includes coverage of: Major theories of career development, choice, and adjustment Informative research on occupational aspirations, job search success, job satisfaction, work performance, career development with people of color, and women's career development Assessment of interests, needs and values, ability, and other important constructs Occupational classification and sources of occupational information Counseling for school-aged youth, diverse populations, choice-making, choice implementation, work adjustment, and retirement Special needs and applications including those for at-risk, intellectually talented, and work-bound youth; people with disabilities; and individuals dealing with job loss, reentry, and career transitions Edited by two of the leading figures in career development, and featuring contributions by many of the most well-regarded specialists in the field, Career Development and Counseling: Putting Theory and Research to Work is the one book that every career counselor, vocational psychologist, and serious student of career development must have. |
| cou-aa-302 study: The Stigma of Addiction Jonathan D. Avery, Joseph J. Avery, 2019-01-09 This book explores the stigma of addiction and discusses ways to improve negative attitudes for better health outcomes. Written by experts in the field of addiction, the text takes a reader-friendly approach to the essentials of addiction stigma across settings and demographics. The authors reveal the challenges patients face in the spaces that should be the safest, including the home, the workplace, the justice system, and even the clinical community. The text aims to deliver tools to professionals who work with individuals with substance use disorders and lay persons seeking to combat stigma and promote recovery. The Stigma of Addiction is an excellent resource for psychiatrists, addiction medicine specialists, students across specialties, researchers, public health officials, and individuals with substance use disorders and their families. |
| cou-aa-302 study: Oncology Informatics Bradford W. Hesse, David Ahern, Ellen Beckjord, 2016-03-17 Oncology Informatics: Using Health Information Technology to Improve Processes and Outcomes in Cancer Care encapsulates National Cancer Institute-collected evidence into a format that is optimally useful for hospital planners, physicians, researcher, and informaticians alike as they collectively strive to accelerate progress against cancer using informatics tools. This book is a formational guide for turning clinical systems into engines of discovery as well as a translational guide for moving evidence into practice. It meets recommendations from the National Academies of Science to reorient the research portfolio toward providing greater cognitive support for physicians, patients, and their caregivers to improve patient outcomes. Data from systems studies have suggested that oncology and primary care systems are prone to errors of omission, which can lead to fatal consequences downstream. By infusing the best science across disciplines, this book creates new environments of Smart and Connected Health. Oncology Informatics is also a policy guide in an era of extensive reform in healthcare settings, including new incentives for healthcare providers to demonstrate meaningful use of these technologies to improve system safety, engage patients, ensure continuity of care, enable population health, and protect privacy. Oncology Informatics acknowledges this extraordinary turn of events and offers practical guidance for meeting meaningful use requirements in the service of improved cancer care. Anyone who wishes to take full advantage of the health information revolution in oncology to accelerate successes against cancer will find the information in this book valuable. Presents a pragmatic perspective for practitioners and allied health care professionals on how to implement Health I.T. solutions in a way that will minimize disruption while optimizing practice goals Proposes evidence-based guidelines for designers on how to create system interfaces that are easy to use, efficacious, and timesaving Offers insight for researchers into the ways in which informatics tools in oncology can be utilized to shorten the distance between discovery and practice |
| cou-aa-302 study: A Study of Saisiyat Morphology Elizabeth Zeitoun, Tai-hwa Chu, a tahesh kabaybaw Lalo, 2015-02-28 Saisiyat is a Formosan language spoken in the north-western part of Taiwan. It is divided into two groups, a northern and a southern group. The Northern group used to speak the Taai dialect (also known as the Northern dialect) and lives in the upper reaches of the Shangping river in Wufeng Township, Hsinchu County. It is now largely acculturated to the Atayal. The Southern group speaks the Tungho dialect, also referred to as the Southern dialect. Most of the population is distributed throughout the valley delineated by the Eastern and the Southern rivers in Nanchuang Township, Miaoli County and further divided into two major communities, Tungho and Penglai dispersed in a number of villages/settlements. A small amount of the population among the Southern group is also located in the upper reaches of the Shihtan River in Shihtan Township, Miaoli County and forms a third community, referred to as Shihtan. The major difference between the two dialects is said to lie in their phonologies but no study has so far attempted to determine the amount of lexical and morpho-syntactic variation. The goal of this monograph is to provide a functional and empirically-based study of the morphology of Tungho Saisiyat in an attempt to clarify the morphological units, morphological processes, major lexical categories of this language and further discuss its nominal and verbal morphology. The choice to orient this study towards morphology is explained by the fact that even though Saisiyat is now one of the best documented Formosan languages – there is one grammatical sketch and numerous studies on various aspects of Saisiyat grammar – there are still few studies on Saisiyat morphology, which level of complexity has been overlooked in the past. |
| cou-aa-302 study: Geriatric Oncology Martine Extermann, 2020-01-30 This book is intended as a comprehensive resource for clinicians and researchers seeking in-depth information on geriatric oncology. The coverage encompasses epidemiology, the biology and (patho)physiology of aging and cancer, geriatric assessment and management, hematologic malignancies, solid tumors, issues in patient care, and research methods. Since cancer is a disease of aging and people are living longer, most cancer patients are now aged 70 and older. Yet the more we age, the more diverse we become in terms of our health, biologic fitness, and cancer behavior. Typically, however, general oncology clinical trials address only a selected healthier and younger population of patients. Geriatric oncology is the area of oncology that addresses these issues but while a wealth of knowledge has been accumulated, information is often difficult to retrieve or insufficiently detailed. The SpringerReference program, in which this book is published, offers an ideal format for overcoming these limitations since it combines thorough coverage with access to living editions constantly updated chapter by chapter via a dynamic peer-review process, ensuring that information remains current and pertinent. |
| cou-aa-302 study: Biological Mechanisms and the Advancing Approaches to Overcoming Cancer Drug Resistance Andrew Freywald, Franco Vizeacoumar, 2020-12-02 Biological Mechanisms and the Advancing Approaches to Overcoming Cancer Drug Resistance, Volume 12, discusses new approaches that are being undertaken to counteract tumor plasticity, understand and tackle the interactions with the microenvironment, and disrupt the rewiring of malignant cells or bypass biological mechanism of resistance by using targeted radionuclide therapies. This book provides a unique opportunity to the reader to understand the fundamental causes of drug resistance and how different approaches are applied. It is a one-stop-shop to understand why it is so difficult to treat cancer, and why only a very few patients respond to therapy and a significant portion develop resistance. Despite a rapid development of more effective anti-cancer drugs and combination therapies, cancer remains the leading cause of lethality in the developed world. The main reason for this is the ability of heterogeneous subpopulations of tumor cells interacting with constantly evolving tumor microenvironment to resist elimination and eventually, trigger cancer relapse. In this book, experts review current concepts explaining molecular and biological mechanisms of cancer drug resistance and discussing advancing approaches for overcoming these therapeutic challenges. Provides the most updated knowledge on the mechanisms of cancer drug resistance and the emerging therapeutic approaches reviewed by experts in the field Brings detailed analyses of most important recently reported developments related to drug resistance and their relevance to overcoming it in cancer patients Discusses in-depth molecular mechanisms and novel concepts of cancer resistance to conventional and advanced therapies |
| cou-aa-302 study: Outdoor Air Pollution IARC Working Group on the Evaluation of Carcinogenic Risks to Humans, International Agency for Research on Cancer, 2016 This publication represents the views and expert opinions of an IARC Working Group on the Evaluation of Carcinogenic Risk to Humans, which met in Lyon, 8-15 October 2013. |
| cou-aa-302 study: Planning Algorithms Steven M. LaValle, 2006-05-29 Planning algorithms are impacting technical disciplines and industries around the world, including robotics, computer-aided design, manufacturing, computer graphics, aerospace applications, drug design, and protein folding. Written for computer scientists and engineers with interests in artificial intelligence, robotics, or control theory, this is the only book on this topic that tightly integrates a vast body of literature from several fields into a coherent source for teaching and reference in a wide variety of applications. Difficult mathematical material is explained through hundreds of examples and illustrations. |
| cou-aa-302 study: String Theory and M-Theory Katrin Becker, Melanie Becker, John H. Schwarz, 2006-12-07 String theory is one of the most exciting and challenging areas of modern theoretical physics. This book guides the reader from the basics of string theory to recent developments. It introduces the basics of perturbative string theory, world-sheet supersymmetry, space-time supersymmetry, conformal field theory and the heterotic string, before describing modern developments, including D-branes, string dualities and M-theory. It then covers string geometry and flux compactifications, applications to cosmology and particle physics, black holes in string theory and M-theory, and the microscopic origin of black-hole entropy. It concludes with Matrix theory, the AdS/CFT duality and its generalizations. This book is ideal for graduate students and researchers in modern string theory, and will make an excellent textbook for a one-year course on string theory. It contains over 120 exercises with solutions, and over 200 homework problems with solutions available on a password protected website for lecturers at www.cambridge.org/9780521860697. |
| cou-aa-302 study: The Ocean and Cryosphere in a Changing Climate Intergovernmental Panel on Climate Change (IPCC), 2022-04-30 The Intergovernmental Panel on Climate Change (IPCC) is the leading international body for assessing the science related to climate change. It provides policymakers with regular assessments of the scientific basis of human-induced climate change, its impacts and future risks, and options for adaptation and mitigation. This IPCC Special Report on the Ocean and Cryosphere in a Changing Climate is the most comprehensive and up-to-date assessment of the observed and projected changes to the ocean and cryosphere and their associated impacts and risks, with a focus on resilience, risk management response options, and adaptation measures, considering both their potential and limitations. It brings together knowledge on physical and biogeochemical changes, the interplay with ecosystem changes, and the implications for human communities. It serves policymakers, decision makers, stakeholders, and all interested parties with unbiased, up-to-date, policy-relevant information. This title is also available as Open Access on Cambridge Core. |
| cou-aa-302 study: Flight Stability and Automatic Control Robert C. Nelson, 1998 This edition of this this flight stability and controls guide features an unintimidating math level, full coverage of terminology, and expanded discussions of classical to modern control theory and autopilot designs. Extensive examples, problems, and historical notes, make this concise book a vital addition to the engineer's library. |
| cou-aa-302 study: The National Vietnam Veterans Readjustment Study Richard A. Kulka, 1990 |
| cou-aa-302 study: Privatization in Latin America World Bank, 2005 This publication examines the empirical evidence on the privatisation measures introduced in the Latin American region since the 1980s, in light of recent criticisms of the record of privatisation and allegations of corruption, abuse of market power and neglect of the poor. It includes case studies on the privatisation debate in Argentina, Bolivia, Brazil, Chile, Colombia, Mexico, and Peru; and sets out recommendations for future reforms. |
| cou-aa-302 study: Research on Work-related Stress Tom Cox, Amanda Griffiths, Eusebio Rial-González, European Agency for Safety and Health at Work, 2000 Stress at work is a priority issue of the European Agency of Safety and Health at Work. The report addresses the following issues and questions: the nature of stress at work; stress management strategies; does work stress affect health and well-being and, if so, how?; the implications of existing research for the management of work-related stress. This report examines the difficulties involved in placing work stress in the context of other life stress factors. It is stated that work stress is a current and future health and safety issue, and, as such, should be dealt with in the same logical and systematic way as other health and safety issues. |
| cou-aa-302 study: Passive Nondestructive Assay of Nuclear Materials Doug Reilly, Norbert Ensslin, Hastings Smith, 1991 |
| cou-aa-302 study: The ESC Textbook of Cardiovascular Medicine A. John Camm, 2019 |
Columbia Regional Airport
Columbia Regional Airport (COU) is served by American Airlines with non-stop flights from Columbia to Dallas/Fort Worth and Chicago O’Hare International Airports. Beginning Sept. 25, …
Arrivals & Departures - Columbia Regional Airport
3 days ago · Passengers are encouraged to check with their airline carrier for expected flight status more than 24 hours out. You can also sign up for American Airlines flight notification …
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Columbia Regional Airport - Wikipedia
Columbia Regional Airport (IATA: COU, ICAO: KCOU) [2] is a commercial passenger airport serving Columbia, Missouri. Located about 12 miles (19 km) southeast of Columbia in Boone …
COU Columbia Rgnl Airport (COU/KCOU) - FlightAware
Columbia Rgnl, Columbia, MO (COU/KCOU) flight tracking (arrivals, departures, en route, and scheduled flights) and airport status.
Home - Council of Ontario Universities
Learn all about the Council, including COU's mission, policies, annual reports, career opportunities and staff directory. Find out about COU’s 20 member universities, standing …
COU - What does COU Stand For? - Acronyms and Slang
What does COU mean? We know 67 definitions for COU abbreviation or acronym in 7 categories. Possible COU meaning as an acronym, abbreviation, shorthand or slang term vary from …
Flight Schedule - Columbia Regional Airport
4 days ago · At COU. At the Airport; COU’s New Terminal; Parking & Transportation; About COU; Airport Improvements and History; Master Plan; Title VI Information; ADA/504 Information; …
Airline Information - Columbia Regional Airport
COU passengers will be able to fly to Denver International Airport (DEN) and Chicago O’Hare International. Airport (ORD) with United Airlines beginning Sept. 25., 2025. 800-864-8331
COU's New Terminal - Columbia Regional Airport
This is a general timeline of the process to construct a new terminal at Columbia Regional Airport. A green box and paper airplane indicates completed step. A purple box and paper airplane …
Annals of Oncology original articles
of patients with mCRPC who were chemotherapy naïve in study COU-AA-302. For most patients in COU-AA-301, Gleason scores were determined before 2005, when the new scoring …
Effect of Prior Local Therapy on Response to First-line …
with RT. Another retrospective study by Patel et al [19] showed that patients with mCRPC who were previously treated with RP with/without postoperative RT had superior OS (HR: 0.70, …
地舒单抗在前列腺癌骨转移患者中的临床应用规范
cou-aa-302研究表明，在接受化疗的无症状或轻 度症状转移性去势抵抗性前列腺癌患者中，醋酸阿 比特龙＋泼尼松的总体临床效果优于安慰剂＋泼尼 松[31]。在使用或不使用骨靶向治疗的临床 …
Differences in clinical outcome between docetaxel and …
past decade.4 Notably, the roles of Tand AA in chemo-naïve mCRPC patients were established in the TAX 327 and SWOG 9916 studies and in the COU-AA-302 study, respectively.5e7 …
Differences in clinical outcome between docetaxel and …
past decade.4 Notably, the roles of Tand AA in chemo-naïve mCRPC patients were established in the TAX 327 and SWOG 9916 studies and in the COU-AA-302 study, respectively.5e7 …
Radiographic progression-free survival as a surrogate …
COU-AA-302 (2015), CABADOC (2021) 5) Excluding trials that did not report HR but KM-plots for at least one endpoint. 18. Studies omitted from the full analysis set: SWOG 9916 (2004), …
A Self-Fulfilling Prophecy: Comparing 177Lu-PSMA
Looking at the COU-AA 302 trial in 1st line mCRPC patients receiving abiraterone, OS was 34.7 months in the abiraterone group (4). Whilst 38% of the patients in the chemotherapy naïve group
Letter to the Editor
the COU-AA-302 study [1,2]. Furthermore, many clinicians are attracted by the use of chemotherapy-free strategies, given thatmany mCRPCpatientsneverreceive chemothera- ...
Subsequent Chemotherapy and Treatment Patterns After …
In trial COU-AA-302 (chemotherapy-naı¨ve men with mCRPC), abiraterone acetate plus prednisone (AA) ... ation of the study drug. Intervention: At the discretion of the investigator, …
Subsequent Chemotherapy and Treatment Patterns After …
is the same cutoff used for age subgroup analysis for COU-AA-302 [16] and COU-AA-301 [17] and is consistent with US regulatory guidance to define a geriatric population in clinical trials [18]. …
Chapter 7 Castration-Resistant Prostate Cancer: Mechanisms
In 2013, the COU-AA-302 study randomized 1088 patients with no visceral disease to treatment with abiraterone 1000 mg (qd) plus prednisone 5 mg (bid) or placebo plus prednisone 5 mg …
Beyond Approval: What Is the Most Appropriate Way to Use …
In addition to the COU-AA-302 trial, the Efficacy and Safety Study of Oral MDV3100 in Chemotherapy-naive Patients with Progressive Metastatic Prostate Cancer (PREVAIL) phase …
Improvingqualityoflifeinmetastatic castration …
Aug 15, 2023 · 2 assessinginstrumentdevelopedforusewiththeQLQ-C30to evaluateprostate-specificcharacteristicssuchaspainimpact on mobility, pain relief, drowsiness, hair loss, change in
Abiraterone acetate plus prednisone versus placebo plus …
castration-resistant prostate cancer (COU-AA-302): fi nal overall survival analysis of a randomised, double-blind, ... Methods In this placebo-controlled, double-blind, randomised …
Melanoma Keytruda Meets PFS, OS Endpoints in Phase III …
A phase III study investigating Keytruda patients with advanced melanoma met two primary endpoints, demonstrating improvements in ... double-blind, placebo-controlled COU-AA-302 …
LHRH sparing therapy in patients with chemotherapy-naïve, …
COU-AA 302 study [6]. Treatmentof mCRPCpatients with AA+P leads toan increasein median survival compared to P alone [7, 8]. Results from the COU-AA-302 study revealed that …
Abiraterone in the management of castration-resistant …
this review focuses on COU-AA-302. COU-AA-302: a phase III study of abiraterone in chemotherapy-naïve mCRPC COU-AA-302 study design and patient population COU-AA-302 …
UC San Francisco Previously Published Works - eScholarship
Radiographic Progression-Free Survival As a Response Biomarker in Metastatic Castration-Resistant Prostate Cancer: COU-AA-302 Results Michael J. Morris, Arturo Molina, Eric J. …
Abiraterone Acetate Therapy for mCRPC in Japanese Men 25
lower (40%) in JPN-201 study than in COU-AA-302 study in chemotherapy-naïve non-Japanese patients (48%) [5 , 6]. Hepatotoxicity is a known risk of treatment with AA; grade 3 or 4 …
Contemporary Management of Advanced Prostate Cancer: An …
docetaxel. In the COU-AA-302 study, 1088 men with M1 CRPC who had not received prior chemotherapy were randomly assigned to prednisone at 5 mg twice daily plus either …
ZYTIGA (abiraterone acetate) Use of ZYTIGA in Patients with ...
NYHA Class II to IV heart failure (in COU-AA-302 and LATITUDE) has not been established because these patients were excluded from these randomized clinical trials.3,5,6 • Two …
A Self-Fulfilling Prophecy: Comparing 177Lu-PSMA …
the COU-AA 302 cohort. Although it is impossible to compare these cohorts, the longer OS in the COU-AA 302 study is noted. It can be assumed that these patients, at least in part, could have …
AWMSG SECRETARIAT ASSESSMENT REPORT Abiraterone …
Table 2. Secondary end points from COU-AA-302 study third interim analysis1 AAP PP HR (95% CI)* p value† Median, months (95% CI) Endpoint Time to opiate use for cancer pain NE ¶ 23.7 …
A prognostic model for stratifying clinical outcomes in …
The COU-302 trial, which evaluated abiraterone in chemotherapy-naive patients with CRPC, showed a sig-nificantly longer OS than the post-chemotherapy COU-301 trial (34.7 vs 15.8 …
Vol. 33, Supl. 1 2019: 1-153 CÁNCER - Revisiones en Cáncer …
The Phase 3 COU-AA-302 Study of Abiraterone Acetate Plus Prednisone in Men with Chemotherapy-naïve Metastatic Castration-resistant Prostate Cancer: Stratified Analysis …
Abiraterone acetate plus prednisone versus prednisone alone …
preplanned interim analysis of the COU-AA-302 phase 3 trial in asymptomatic or mildly symptomatic, chemotherapy-naive patients with metastatic castration-resistant prostate …
Are urologists ready to manage castration-resistant disease?
Publication of the COU-AA-302 study marks an important advance in the manage - ment of men with CRPC. For the first time, we have therapies beyond first-line
Enzalutamide versus abiraterone acetate in the development …
ing a warning that AA has been associated with altered glucose metabolism [13, 14]. The HEAT study showed a higher rate of new-onset T2DM in patients receiving AA compared with those …
Abiraterone in Metastatic Prostate Cancer - ResearchGate
To the Editor: In their article on the COU-AA-302 study, Ryan et al. (Jan. 10 issue)1 report improved progression-free survival with abiraterone–pred-nisone as compared with prednisone …
Abiraterone acetate plus prednisone versus placebo plus …
recommended unblinding of the study and crossover of patients in the placebo group to receive abiraterone acetate plus prednisone. Eligibility criteria for patients receiving placebo plus …
Updated Interim Efficacy Analysis and Long-term Safety of …
(mCRPC). Study COU-AA-302 evaluated abiraterone acetate plus prednisone versus prednisone alone in mildly symptomatic or asymptomatic patients with progressive mCRPC without prior …
Is Low-Dose Abiraterone for Prostate Cancer An Attractive
A study on healthy volunteers showed that those taking AA with high fat meals attained a plasma concentration 4.6 times higher than those takingit withlow-fatmeals.8 …
Abiraterone survival benefit is independent of pain, prostate …
The Phase 3 COU-AA-302 Study of AA Acetate Plus Prednisone in Men with Chemotherapy-naïve Metastatic Castration-resistant Prostate Cancer: Stratified Analysis Based on Pain, …
Androgen receptor pathway inhibitors and drug-drug …
0.0001) were longer in the AA arm (Table 1). In the COU-AA-302 (NCT00887198) study, the efficacy of AA against placebo in chemotherapy-naive patients was assessed after the …
Abiraterone for the treatment of chemotherapy naïve …
In the quality assessment of the -AA-302 COUtrial, the study was assessed as not using an ITT analysis. This is not correct. Therefore, we have produced a corrected page 36, deleting ...
Effects of metformin and statins on outcomes in men with …
analysis of COU-AA-301 and COU-AA-302 Brooke E. Wilson a,b,c , Andrew J. Armstrong d , Johann de Bono e , Cora N. Sternberg f , Charles J. Ryan g , Howard I. Scher h , Matthew R. …
Abiraterone acetate for treatment of metastatic castration …
the COU-AA-301 study at 775 death events, before crossover of patients from placebo to abiraterone acetate. Methods Patients Full details of the COU-AA-301 study are provided in the …
Letter to the Editor
the COU-AA-302 study [1,2]. Furthermore, many clinicians are attracted by the use of chemotherapy-free strategies, given thatmany mCRPCpatientsneverreceive chemothera- ...
Clinical Outcomes from Androgen Signaling–directed Therapy …
In the COU-AA-302 trial, abiraterone acetate plus prednisone significantly increased ... resistance to AA noted at study initiation [3] or secondary drug resistance via upregulation of …
Enzalutamide versus abiraterone acetate in the development …
ing a warning that AA has been associated with altered glucose metabolism [13, 14]. The HEAT study showed a higher rate of new-onset T2DM in patients receiving AA compared with those …
Practical guide to the use of abiraterone in castration resistant ...
naïve (COU-AA-302) and post-docetaxel treated men (COU-AA-301) have confirmed these findings, resulting in FDA approval of abiraterone for men with metastatic CRPC either before …
Multidisciplinary consensus: A practical guide for the …
was based on results from the pivotal, phase III COU-AA-302 study.16 Abiraterone plus low-dose prednisone (5 mg twice daily) resulted in significantly improved radiographic progression-free …
pan-Canadian Oncology Drug Review Final Clinical Guidance …
secondary hormonal therapy or chemotherapy. Recently, the COU-AA-302 study demonstrated an improvement in OS and rPFS in favour of abiraterone and prednisone compared with …
CURRICULUM VITAE - PROSTATEONCOLOGY.COM
COU-AA-302: A Phase III, Randomized, Double-blind, Placebo-controlled study of Abiraterone Acetate (CB7630) Plus Prednisone in Asymptomatic or Mildly Symptomatic Patients with …
Castration-resistant prostate cancer - National Cancer Institute
Study of Enzalutamide vs Placebo in mCRPC before chemotherapy. 24 Enzalutamide Toxicity ... COU-AA-301 Trial. 29 Abiraterone trial. 30 COU-AA-302. 31 Abiraterone Toxicity …
Recent Advances in the Treatment for Metastatic Castration
on the phase III COU-AA-302 study among 1088 chemotherapy-naïve, asymptomatic, or mildly symptomatic mCRPC patients who were randomised to receive abiraterone plus prednisone or …
Causal AI for Learning “Gemini Digital Twins” from Human …
A Cardiovascular Disease Case Study Bruce W. Church PhD Feb 29th, 2024. Blueprint of a Computer Chip. Genetic Circuitry in Cell Replication of Cancer . ... rks COU-AA-302 Trial …
Cost per median overall survival month associated with …
ORIGINAL ARTICLE Cost per median overall survival month associated with abiraterone acetate and enzalutamide for treatment of patients with metastatic castration-resistant
