Cell Therapy For Autoimmune Diseases

cell therapy for autoimmune diseases: Hematopoietic Stem Cell Transplantation and Cellular Therapies for Autoimmune Diseases Richard K. Burt, Dominique Farge, Milton A. Ruiz, Riccardo Saccardi, John A. Snowden, 2021-11-17 This book summarizes the global progress in medical and scientific research toward converting traditionally chronic autoimmune diseases into a drug-free reversible illness using hematopoietic stem cell transplantation (HSCT) and other cellular therapies such as T regulatory cells (Treg), mesenchymal stromal/stem cells, and chimeric antigen receptor T (CAR T) cells in order to reintroduce sustained immune tolerance. This title provides information on different types of stem cells and immune cells; post-transplant immune regeneration; cellular regulatory requirements; ethical and economic considerations; and the advantages and disadvantages of HSCT in the treatment of a variety of autoimmune diseases versus current conventional treatments. Arranged by disease, the text provides a comprehensive guide to HSCT for all types of autoimmune/immune disorders including monogenetic autoimmune diseases; autoimmune aplastic anemia; neurologic immune diseases including multiple sclerosis, chronic inflammatory demyelinating polyneuropathy, neuromyelitis optica, and stiff person syndrome; rheumatologic diseases such as systemic sclerosis and systemic lupus erythematosus; dermatologic diseases such as pemphigus; gastrointestinal disorders such as Crohn’s disease and celiac disease; and immune-mediated endocrinologic disease type I diabetes mellitus. Guidance is provided on the transplantation technique, cell collection and processing, conditioning regimens, infections, and early and late complications. Key Features Outlines therapies and techniques for HSCT for autoimmune diseases Discusses the advantages of HSCT over conventional therapies Reviews the entire process of stem cell therapy from harvest and ethics to indications, efficacy, and regulatory oversight
cell therapy for autoimmune diseases: Stem Cell Therapy for Autoimmune Disease Richard K. Burt, 2019-11-11 Stem cell transplantation may be complicated by treatment-related mortality and like the immune system that it regenerates has equal potential to either create and preserve or destroy. The dual nature that defines stem cells is differentiation that ultimately leads to death and self-renewal, which leads to immortality. What types of stem cells are there? How are they collected? What are their attributes and characteristics? This textbook devotes many chapters to familiarize the reader with the basic science, clinical aspects, and new questions being raised in the field of stem cell biology. Blood stem cells for tolerance and tissue regeneration are a rapidly developing research and clinical field that is being applied to autoimmune diseases. In clinical trials, autologous hematopoietic (blood) stem cells are being used to reduce the cytopenic interval following intense immune suppressive transplant regimens. While as yet not delineated, some possible mechanisms and pathways leading to tolerance after hematopoietic stem cell transplantation are suggested in these chapters. Tissue regeneration from blood stem cells is also suggested by animal experiments on stem cell plasticity or metamoirosis (i.e., change in fate) as described within this textbook. Ongoing early clinical trials on tissue regeneration from blood stem cells are described in the chapter on stem cell therapy for cardiac and peripheral vascular disease. Whether autologous hematopoietic stem cells, through the process of mobilization and reinfusion, may be manipulated to contribute to tissue repair in autoimmune diseases is a future area for translational research.
cell therapy for autoimmune diseases: Gene Therapy of Autoimmune Disease Gerald J. Prud'homme, 2005-07-13 Autoimmune diseases are diverse and responsible for considerable morbidity. Their etiology remains largely unknown, and current therapy with anti-inflammatory drugs is prone to adverse effects, and rarely curative. New therapies with anti-cytokine antibodies or receptors are promising, but require frequent administration of expensive protein drugs. Gene Therapy of Autoimmune Diseases comprehensively reviews research in gene therapy for autoimmune diseases with viral or non-viral vectors. Gene therapy offers the possibility of long-term, continuous delivery of a wide variety of immunosuppressive, anti-inflammatory, or tolerance-inducing agents. Moreover, highly specific genetically modified cells can be produced. This book discusses the most promising avenues in this exciting new field.
cell therapy for autoimmune diseases: Autoimmune Neurology , 2016-03-11 Autoimmune Neurology presents the latest information on autoimmune neurologic disease, the immune response to the body where organs run wild, causing the immune system to attack itself. Autoimmunity is a main element in numerous nervous system diseases and can target any structure within the central or peripheral nervous system. Over the past 20 years, significant advances in our understanding of the pathophysiology of autoimmune disorders, including the use of biomarkers has led to new diagnosis and treatment options. Neurologic conditions associated with autoimmune reactions include dementia, neuromuscular disease, epilepsy, sleep disorders, diabetes, and other common neurologic disorders and disease. This current tutorial-reference will be a must-have title for clinical neurologists, research neurologists, neuroscientists, and any medical professional working with autoimmune disease and disorders. - Includes comprehensive coverage of autoimmune neurology - Details the latest techniques for the study, diagnosis, and treatment of diseases and disorders, including dementia, neuromuscular disease, epilepsy, and sleep disorders - Presents a focused reference for clinical practitioners and the clinical neurology and neurology research communities
cell therapy for autoimmune diseases: Hematopoietic Stem Cell Transplantation and Cellular Therapies for Autoimmune Diseases Richard K. Burt, Dominique Farge, Milton A. Ruiz, Riccardo Saccardi, John A. Snowden, 2021-11-17 Key Features Outlines therapies and techniques for HSCT for autoimmune diseases, and d Discusses its the advantages of HSCT over conventional therapies Reviews the entire process of stem cell therapy from harvest and ethics to indications of efficacy.
cell therapy for autoimmune diseases: Stem Cell Therapy: A Rising Tide: How Stem Cells Are Disrupting Medicine and Transforming Lives Neil H. Riordan, 2017-06-20 Stem cells are the repair cells of your body. When there aren't enough of them, or they aren't working properly, chronic diseases can manifest and persist. From industry leaders, sport stars, and Hollywood icons to thousands of everyday, ordinary people, stem cell therapy has helped when standard medicine failed. Many of them had lost hope. These are their stories. Neil H Riordan, author of MSC: Clinical Evidence Leading Medicine's Next Frontier, the definitive textbook on clinical stem cell therapy, brings you an easy-to-read book about how and why stem cells work, and why they're the wave of the future.
cell therapy for autoimmune diseases: Mesenchymal Stem Cell Therapy Lucas G. Chase, Mohan C Vemuri, 2012-12-12 Over the past decade, significant efforts have been made to develop stem cell-based therapies for difficult to treat diseases. Multipotent mesenchymal stromal cells, also referred to as mesenchymal stem cells (MSCs), appear to hold great promise in regards to a regenerative cell-based therapy for the treatment of these diseases. Currently, more than 200 clinical trials are underway worldwide exploring the use of MSCs for the treatment of a wide range of disorders including bone, cartilage and tendon damage, myocardial infarction, graft-versus-host disease, Crohn’s disease, diabetes, multiple sclerosis, critical limb ischemia and many others. MSCs were first identified by Friendenstein and colleagues as an adherent stromal cell population within the bone marrow with the ability to form clonogenic colonies in vitro. In regards to the basic biology associated with MSCs, there has been tremendous progress towards understanding this cell population’s phenotype and function from a range of tissue sources. Despite enormous progress and an overall increased understanding of MSCs at the molecular and cellular level, several critical questions remain to be answered in regards to the use of these cells in therapeutic applications. Clinically, both autologous and allogenic approaches for the transplantation of MSCs are being explored. Several of the processing steps needed for the clinical application of MSCs, including isolation from various tissues, scalable in vitro expansion, cell banking, dose preparation, quality control parameters, delivery methods and numerous others are being extensively studied. Despite a significant number of ongoing clinical trials, none of the current therapeutic approaches have, at this point, become a standard of care treatment. Although exceptionally promising, the clinical translation of MSC-based therapies is still a work in progress. The extensive number of ongoing clinical trials is expected to provide a clearer path forward for the realization and implementation of MSCs in regenerative medicine. Towards this end, reviews of current clinical trial results and discussions of relevant topics association with the clinical application of MSCs are compiled in this book from some of the leading researchers in this exciting and rapidly advancing field. Although not absolutely all-inclusive, we hope the chapters within this book can promote and enable a better understanding of the translation of MSCs from bench-to-bedside and inspire researchers to further explore this promising and quickly evolving field.
cell therapy for autoimmune diseases: Innovative Medicine Kazuwa Nakao, Nagahiro Minato, Shinji Uemoto, 2015-10-13 This book is devoted to innovative medicine, comprising the proceedings of the Uehara Memorial Foundation Symposium 2014. It remains extremely rare for the findings of basic research to be developed into clinical applications, and it takes a long time for the process to be achieved. The task of advancing the development of basic research into clinical reality lies with translational science, yet the field seems to struggle to find a way to move forward. To create innovative medical technology, many steps need to be taken: development and analysis of optimal animal models of human diseases, elucidation of genomic and epidemiological data, and establishment of “proof of concept”. There is also considerable demand for progress in drug research, new surgical procedures, and new clinical devices and equipment. While the original research target may be rare diseases, it is also important to apply those findings more broadly to common diseases. The book covers a wide range of topics and is organized into three complementary parts. The first part is basic research for innovative medicine, the second is translational research for innovative medicine, and the third is new technology for innovative medicine. This book helps to understand innovative medicine and to make progress in its realization.
cell therapy for autoimmune diseases: Stem Cell Transplantation for Autoimmune Diseases and Inflammation Phuc Van Pham, 2019-08-13 This book introduces many new technologies and clinical applications of hematopoietic stem cells and mesenchymal stem cell transplantation for the treatment of autoimmune diseases and inflammatory diseases. Presented in two parts, Part 1 focuses on stem cell therapies for autoimmune disease treatment; Part 2 focuses on stem cell therapies and their application in the treatment of common inflammatory diseases, including chronic knee osteoarthritis, chronic obstructive pulmonary disease, liver cirrhosis, Crohn's Disease, Multiple Sclerosis, and more. This book is an essential source for all advanced students and researchers involved with these diseases, stem cells, or both. Stem Cell Transplantation for Autoimmune Diseases and Inflammation and the other books in the Stem Cells in Clinical Applications series are invaluable to scientists, researchers, advanced students and clinicians working in stem cells, regenerative medicine, or tissue engineering as well as cancer or genetics research.
cell therapy for autoimmune diseases: Janeway's Immunobiology Kenneth Murphy, Paul Travers, Mark Walport, Peter Walter, 2010-06-22 The Janeway's Immunobiology CD-ROM, Immunobiology Interactive, is included with each book, and can be purchased separately. It contains animations and videos with voiceover narration, as well as the figures from the text for presentation purposes.
cell therapy for autoimmune diseases: Tissue Engineering and Regenerative Medicine Phuc Van Pham, 2019-08-14 This new series, based on a bi-annual conference and its topics, represents a major contribution to the emerging science of cancer research and regenerative medicine. Each volume brings together some of the most pre-eminent scientists working on cancer biology, cancer treatment, cancer diagnosis, cancer prevention and regenerative medicine to share information on currently ongoing work which will help shape future therapies. These volumes are invaluable resources not only for already active researchers or clinicians but also for those entering these fields, plus those in industry. Tissue Engineering and Regenerative Medicine is a proceedings volume which reflects papers presented at the 3rd bi-annual Innovations in Regenerative Medicine and Cancer Research conference; taken with its companion volume Stem Cells: Biology and Engineering it provides a complete overview of the papers from that meeting of international experts.
cell therapy for autoimmune diseases: Non-Myeloablative Allogeneic Transplantation Asad Bashey, Edward D. Ball, 2002-02-28 Non-myeloablative allogeneic stem cell transplantation (also known as mini-transplantation or reduced-intensity conditioning transplantation) is a major advance in the field of hematopoietic transplantation within the last 5 years. This approach uses non-cytotoxic or reduced-intensity cytotoxic therapy to prepare patients for allografting of hematopoietic stem cells and lymphocytes. It has the potential to deliver the potent anti-tumor immunotherapy and bone marrow replacement capacity of allogeneic stem cell transplantation to patients with reduced treatment-related morbidity and mortality. It may also enable allogeneic transplantation in patients who would be considered ineligible for conventional transplants because of co-morbidity or advanced age. However, this approach may necessitate more careful monitoring of post-transplant chimerism and malignant disease-status than is usual with conventional allografting. There is also controversy regarding the best preparative regimen and graft-versus-host disease prophylaxis to use.
cell therapy for autoimmune diseases: The EBMT/EHA CAR-T Cell Handbook Nicolaus Kröger, John Gribben, Christian Chabannon, Ibrahim Yakoub-Agha, Hermann Einsele, 2022-02-07 This first open access European CAR-T Handbook, co-promoted by the European Society for Blood and Marrow Transplantation (EBMT) and the European Hematology Association (EHA), covers several aspects of CAR-T cell treatments, including the underlying biology, indications, management of side-effects, access and manufacturing issues. This book, written by leading experts in the field to enhance readers’ knowledge and practice skills, provides an unparalleled overview of the CAR-T cell technology and its application in clinical care, to enhance readers’ knowledge and practice skills.
cell therapy for autoimmune diseases: Breakthrough in Immunotherapy Baptiste Durand, Anders Olofson, Thomas Clark, 2024-08-22
cell therapy for autoimmune diseases: The European Blood and Marrow Transplantation Textbook for Nurses Michelle Kenyon, Aleksandra Babic, 2018-03-14 This book is open access under a CC BY 4.0 license. This textbook, endorsed by the European Society for Blood and Marrow Transplantation (EBMT), provides adult and paediatric nurses with a full and informative guide covering all aspects of transplant nursing, from basic principles to advanced concepts. It takes the reader on a journey through the history of transplant nursing, including essential and progressive elements to help nurses improve their knowledge and benefit the patient experience, as well as a comprehensive introduction to research and auditing methods. This new volume specifically intended for nurses, complements the ESH-EBMT reference title, a popular educational resource originally developed in 2003 for physicians to accompany an annual training course also serving as an educational tool in its own right. This title is designed to develop the knowledge of nurses in transplantation. It is the first book of its kind specifically targeted at nurses in this specialist field and acknowledges the valuable contribution that nursing makes in this area. This volume presents information that is essential for the education of nurses new to transplantation, while also offering a valuable resource for more experienced nurses who wish to update their knowledge.
cell therapy for autoimmune diseases: Stem Cells – From Hype to Real Hope Khawaja Husnain Haider, Salim Aziz, MD, 2018-12-17 This book is a compilation of the bench experience of leading experts from various research labs involved in the cutting edge area of research. The authors describe the use of stem cells both as part of the combinatorial therapeutic intervention approach and as tools (disease model) during drug development, highlighting the shift from a conventional symptomatic treatment strategy to addressing the root cause of the disease process. The book is a continuum of the previously published book entitled Stem Cells: from Drug to Drug Discovery which was published in 2017.
cell therapy for autoimmune diseases: Innate Immunity in Health and Disease Shailendra K. Saxena, Hridayesh Prakash, 2021-08-25 The book focuses on various aspects and properties of innate immunity, whose deep understanding is integral for safeguarding the human race from further loss of resources and economies due to innate immune response-mediated diseases. Throughout this book, we examine the individual mechanisms by which the innate immune response acts to protect the host from pathogenic infectious agents and other non-communicable diseases. Written by experts in the field, the volume discusses the significance of macrophages in infectious disease, tumor metabolism, and muscular disorders. Chapters cover such topics as the fate of differentiated macrophages and the molecular pathways that are important for the pathologic role of macrophages.
cell therapy for autoimmune diseases: Rheumatology and Immunology Therapy Larry W. Moreland, 2004-07-20 Entries in a practical A to Z Format Highly therapy-focused Uniform and clearly arranged entries for ease of reference Comprehensive information on symptoms and therapeutical possibilities of rheumatologic and musculoskeletal diseases as well as drugs Written by leading experts in the field
cell therapy for autoimmune diseases: Immunopathogenesis and Immune-based Therapy for Selected Autoimmune Disorders Mourad Aribi, 2017-03-22 The book Immunopathogenesis and Immune-Based Therapy for Selected Autoimmune Disorders is a synthesis work that discusses two main aspects of autoimmunity: Immunopathogenesis and therapeutic approaches essentially based on the immunotherapies. This book deals with different topics on a number of autoimmune disorders, including type 1 diabetes, autoimmune cardiomyopathy, autoimmunity of gastrointestinal tract, systemic sclerosis, and myasthenia gravis. This book will be useful to clinicians, biologists, researchers, teachers, and students who are interested in immunology and immunopathology.
cell therapy for autoimmune diseases: Cytokines in Autoimmunity Fionula M. Brennan, Marc Feldmann, 1996 A review of the field of cytokines in autoimmunity written by 22 researchers suggesting diverse applications, and building on the successes of recent rheumatoid arthritis clinical trials. The contributors present and review findings on arthritis, diabetes, multiple sclerosis, thyroid disease, Sjogren's syndrome, Lupus, scleroderma, and psoriasis. The final sections concentrate on laboratory and clinical concerns working with knockout mice, transgenic mice, and cytokine therapy. Distributed by Chapman and Hall. CiP shows the title as Role of cytokines..... Annotation copyright by Book News, Inc., Portland, OR
cell therapy for autoimmune diseases: B Cell Receptor Signaling Tomohiro Kurosaki, Jürgen Wienands, 2015-12-26 This volume details our current understanding of the architecture and signaling capabilities of the B cell antigen receptor (BCR) in health and disease. The first chapters review new insights into the assembly of BCR components and their organization on the cell surface. Subsequent contributions focus on the molecular interactions that connect the BCR with major intracellular signaling pathways such as Ca2+ mobilization, membrane phospholipid metabolism, nuclear translocation of NF-kB or the activation of Bruton’s Tyrosine Kinase and MAP kinases. These elements orchestrate cytoplasmic and nuclear responses as well as cytoskeleton dynamics for antigen internalization. Furthermore, a key mechanism of how B cells remember their cognate antigen is discussed in detail. Altogether, the discoveries presented provide a better understanding of B cell biology and help to explain some B cell-mediated pathogenicities, like autoimmune phenomena or the formation of B cell tumors, while also paving the way for eventually combating these diseases.
cell therapy for autoimmune diseases: Thomas' Hematopoietic Cell Transplantation Stephen J. Forman, Robert S. Negrin, Joseph H. Antin, Frederick R. Appelbaum, 2015-12-14 Fully revised for the fifth edition, this outstanding reference on bone marrow transplantation is an essential, field-leading resource. Extensive coverage of the field, from the scientific basis for stem-cell transplantation to the future direction of research Combines the knowledge and expertise of over 170 international specialists across 106 chapters Includes new chapters addressing basic science experiments in stem-cell biology, immunology, and tolerance Contains expanded content on the benefits and challenges of transplantation, and analysis of the impact of new therapies to help clinical decision-making Includes a fully searchable Wiley Digital Edition with downloadable figures, linked references, and more References for this new edition are online only, accessible via the Wiley Digital Edition code printed inside the front cover or at www.wiley.com/go/forman/hematopoietic.
cell therapy for autoimmune diseases: The Autoimmune Diseases Noel R. Rose, Ian R. Mackay, 1998 The Autoimmune Diseases comprehensively describes the clinical expressions of all known autoimmune diseases, as well as the experimental bases of autoimmunity and failure of tolerance. The scientific chapters include mechanisms of natural tolerance, the genetic basis of autoimmunity, the significance of apoptosis, the influence of cytokines, environmental influences, and experimental models. The clinical chapters cover autoimmune endocrine deficiencies, insulin-dependent diabetes, rheumatic disorders, neurological diseases, and diseases of the blood, skin, eye, kidney, and liver.
cell therapy for autoimmune diseases: Moderate to Severe Psoriasis John Koo, Jashin Wu, Alice Gottlieb, Ethan Levin, Argentina Leon, 2014-03-18 Written by experts in the dermatology field, this new fourth edition of Moderate-to-Severe Psoriasis discusses the current use of biologics and other pharmacologic and phototherapy treatments for moderate-to-severe psoriasis. Illustrated with high quality color figures, this standalone text emphasizes safe and effective treatments for the psoriasis
cell therapy for autoimmune diseases: Kuby Immunology Jenni Punt, Sharon Stranford, Patricia Jones, Judy Owen, 2018-10-16 Janis Kuby’s groundbreaking introduction to immunology was the first textbook for the course actually written to be a textbook. Like no other text, it combined an experimental emphasis with extensive pedagogical features to help students grasp basic concepts. Now in a thoroughly updated new edition, Kuby Immunology remains the only undergraduate introduction to immunology written by teachers of the course. In the Kuby tradition, authors Jenni Punt, Sharon Stranford, Patricia Jones, and Judy Owen present the most current topics in an experimental context, conveying the excitement of scientific discovery, and highlight important advances, but do so with the focus on the big picture of the study of immune response, enhanced by unsurpassed pedagogical support for the first-time learner. Punt, Stranford, Jones, and Owen bring an enormous range of teaching and research experiences to the text, as well as a dedication to continue the experiment-based, pedagogical-driven approach of Janis Kuby. For this edition, they have worked chapter by chapter to streamline the coverage, to address topics that students have the most trouble grasping, and to continually remind students where the topic at hand fits in the study of immunology as a whole.
cell therapy for autoimmune diseases: The EBMT Handbook Nicolaus Kröger, Mohamad Mohty, Carlo Dufour, 2020-10-08 This Open Access edition of the European Society for Blood and Marrow Transplantation (EBMT) handbook addresses the latest developments and innovations in hematopoietic stem cell transplantation and cellular therapy. Consisting of 93 chapters, it has been written by 175 leading experts in the field. Discussing all types of stem cell and bone marrow transplantation, including haplo-identical stem cell and cord blood transplantation, it also covers the indications for transplantation, the management of early and late complications as well as the new and rapidly evolving field of cellular therapies. This book provides an unparalleled description of current practices to enhance readers' knowledge and practice skills. This work was published by Saint Philip Street Press pursuant to a Creative Commons license permitting commercial use. All rights not granted by the work's license are retained by the author or authors.
cell therapy for autoimmune diseases: Hematopoietic Stem Cell Therapy Edward David Ball, Ping Law, 2000 This book will be the only current practical guide to a widely used procedure for treating leukemias and disseminated cancers. The contents are organized chronologically, to serve as a step-by-step guide throughout the transplant process. Comprehensive yet concise, it emphasizes the latest techniques, such as peripheral blood stem cell grafts.
cell therapy for autoimmune diseases: Cells Are the New Cure Robin L. Smith, 2017-10-24 The future of medicine is happening now. Revolutionary new science is providing cures that were considered science fiction just a few years ago—and not with pills, surgery, or radiation, but with human cells. Promising treatments now in extensive clinical trials could have dramatic impacts on cancer, autoimmune diseases, organ replacement, heart disease, and even aging itself. The key to these breakthroughs is the use of living cells as medicine instead of traditional drugs. Discover the advances that are alleviating the effects of strokes, Alzheimer's disease, and even allergies. Cells Are the New Cure takes you into the world of regenerative medicine, which enables doctors to repair injured and aging tissues and even create artificial body parts and organs in the lab. Cellular medicine experts Robin L. Smith, MD, and Max Gomez, PhD, outline the new technologies that make it possible to harness the immune system to fight cancer and reverse autoimmune diseases like multiple sclerosis, type 1 diabetes, and rheumatoid arthritis. CRISPR, a new technology for targeted gene editing, promises to eradicate genetic diseases, allowing us to live longer lives—possibly even beyond age 100 in good health. Cells Are the New Cure takes you on a tour of the most exciting and cutting-edge developments in medicine. The content inside these pages could save your life or the life of someone you love.
cell therapy for autoimmune diseases: HIV-1 Latency Guido Silvestri, Mathias Lichterfeld, 2018-10-11 This volume summarizes recent advances in understanding the mechanisms of HIV-1 latency, in characterizing residual viral reservoirs, and in developing targeted interventions to reduce HIV-1 persistence during antiretroviral therapy. Specific chapters address the molecular mechanisms that govern and regulate HIV-1 transcription and latency; assays and technical approaches to quantify viral reservoirs in humans and animal models; the complex interchange between viral reservoirs and the host immune system; computational strategies to model viral reservoir dynamics; and the development of therapeutic approaches that target viral reservoir cells. With contributions from an interdisciplinary group of investigators that cover a broad spectrum of subjects, from molecular virology to proof-of-principle clinical trials, this book is a valuable resource for basic scientists, translational investigators, infectious-disease physicians, individuals living with HIV/AIDS and the general public.
cell therapy for autoimmune diseases: CDC Yellow Book 2018: Health Information for International Travel Centers for Disease Control and Prevention CDC, 2017-04-17 THE ESSENTIAL WORK IN TRAVEL MEDICINE -- NOW COMPLETELY UPDATED FOR 2018 As unprecedented numbers of travelers cross international borders each day, the need for up-to-date, practical information about the health challenges posed by travel has never been greater. For both international travelers and the health professionals who care for them, the CDC Yellow Book 2018: Health Information for International Travel is the definitive guide to staying safe and healthy anywhere in the world. The fully revised and updated 2018 edition codifies the U.S. government's most current health guidelines and information for international travelers, including pretravel vaccine recommendations, destination-specific health advice, and easy-to-reference maps, tables, and charts. The 2018 Yellow Book also addresses the needs of specific types of travelers, with dedicated sections on: · Precautions for pregnant travelers, immunocompromised travelers, and travelers with disabilities · Special considerations for newly arrived adoptees, immigrants, and refugees · Practical tips for last-minute or resource-limited travelers · Advice for air crews, humanitarian workers, missionaries, and others who provide care and support overseas Authored by a team of the world's most esteemed travel medicine experts, the Yellow Book is an essential resource for travelers -- and the clinicians overseeing their care -- at home and abroad.
cell therapy for autoimmune diseases: Chimeric Antigen Receptor T-Cell Therapies for Cancer E-Book Daniel W. Lee, Nirali N. Shah, 2019-11-30 From patient referral to post-therapy management, Chimeric Antigen Receptor (CAR) T-Cell Therapies for Cancer: A Practical Guide presents a comprehensive view of CAR modified T-cells in a concise and practical format. Providing authoritative guidance on the implementation and management of CAR T-cell therapy from Drs. Daniel W. Lee and Nirali N. Shah, this clinical resource keeps you up to date on the latest developments in this rapidly evolving area. - Covers all clinical aspects, including patient referral, toxicities management, comorbidities, bridging therapy, post-CAR monitoring, and multidisciplinary approaches to supportive care. - Includes key topics on associated toxicities such as predictive biomarkers, infections, and multidisciplinary approaches to supportive care. - Presents current knowledge on FDA approved CAR T-cell products as well as developments on the horizon. - Editors and authors represent leading investigators in academia and worldwide pioneers of CAR therapy.
cell therapy for autoimmune diseases: Autoimmune Disease Models Irun R. Cohen, Ariel Miller, 1994 Because autoimmune disorders can wreak havoc in both humans and animals, these disorders are now the objects of intense and focused research. This book details specific animal models for a variety of autoimmune disorders. The contributors are recognized authorities who deal with the panoply of experimentally induced autoimmune disorders, including encephalomyelitis, allergic neuritis, uveoretinitis, myocarditis, and hepatitis. Also included are discussions of spontaneously appearing diseases such as autoimmune thyroiditis and systemic lupus erythematosus. Many other disorders are also covered in this comprehensive guide. Certain to be an aid in the planning of individual experiments and broader research programs, this book will be a valuable addition to the library of all practicing immunologists interested in immune system function and dysfunction.
cell therapy for autoimmune diseases: Treatment of Autoimmune Disorders Michael Sticherling, Enno Christophers, 2003 Progress in basic and clinical immunology within the last two decades has provided profound insight into the immune system and its role in preventing endogenous and exogenous damage. In contrast, disbalances within this system can result in autoimmune disorders which may affect diverse organs and result in distinct clinical pictures. In many of these, however, the individual etiopathogenetic mechanisms are poorly understood and even more their clinical symptoms are hard to treat. The book offers insight into basic mechanisms of autoimmune disorders. It includes neurological, gastrointestinal, ophthalmological and skin diseases as well as current and future therapeutic options including immunomodulatory drugs and different vaccination strategies. By addressing diverse organ systems, both singular and shared features are elaborated. Thus an exchange of ideas is intended across research on single organ systems within a truly interdisciplinary setting.
cell therapy for autoimmune diseases: Bioelectronic Medicine Valentin A. Pavlov, 2019 Cold Spring Harbor perspectives in medicine.
cell therapy for autoimmune diseases: Microbiology Nina Parker, OpenStax, Mark Schneegurt, AnhHue Thi Tu, Brian M. Forster, Philip Lister, 2016-05-30 Microbiology covers the scope and sequence requirements for a single-semester microbiology course for non-majors. The book presents the core concepts of microbiology with a focus on applications for careers in allied health. The pedagogical features of the text make the material interesting and accessible while maintaining the career-application focus and scientific rigor inherent in the subject matter. Microbiology's art program enhances students' understanding of concepts through clear and effective illustrations, diagrams, and photographs. Microbiology is produced through a collaborative publishing agreement between OpenStax and the American Society for Microbiology Press. The book aligns with the curriculum guidelines of the American Society for Microbiology.--BC Campus website.
cell therapy for autoimmune diseases: Cancer and Autoimmunity M.E. Gershwin, Yehuda Shoenfeld, 2000-03-27 Of the two disciplines in parallel development for two decades, tumor immunology and transplantation immunology, the latter has thrived and has led to some of the most critical discoveries in immunobiology. The former continues to thwart both scientists and clinicians alike.The goal of immunologists in modern day research is to develop a simple and effective means to manipulate cancer in vivo, possibly encompassing several venues: identifying a phenotypic marker and the use of either active or passive immunization; include the use of passive reagents carrying warheads to selectively destroy cancer cells; or altering the basic process of cell survival.This excellent multidiscipline-authored volume presents a theme which has not been well described before. The papers include both basic and clinical science and range from sophisticated molecular biology to little more than phenomenology (e.g. the increased association of cancer in some autoimmune diseases and increased presentation of autoimmune phenomena in malignant condition). This, however, is state-of-the-art.This collection of themes will be of use not only to bench scientists, but also to clinicians who treat patients. The book represents progress at the cutting edge of this discipline, and points the way to further developments in the black box of immunology.
cell therapy for autoimmune diseases: Vaccines and Autoimmunity Yehuda Shoenfeld, Nancy Agmon-Levin, Lucija Tomljenovic, 2015-07-07 In light of the discovery of Autoimmune Syndrome Induced by Adjuvants, or ASIA, Vaccines and Autoimmunity explores the role of adjuvants – specifically aluminum in different vaccines – and how they can induce diverse autoimmune clinical manifestations in genetically prone individuals. Vaccines and Autoimmunity is divided into three sections; the first contextualizes the role of adjuvants in the framework of autoimmunity, covering the mechanism of action of adjuvants, experimental models of adjuvant induced autoimmune diseases, infections as adjuvants, the Gulf War Syndrome, sick-building syndrome (SBS), safe vaccines, toll-like receptors, TLRS in vaccines, pesticides as adjuvants, oil as adjuvant, mercury, aluminum and autoimmunity. The following section reviews literature on vaccines that have induced autoimmune conditions such as MMR and HBV, among others. The final section covers diseases in which vaccines were known to be the solicitor – for instance, systemic lupus erythematosus – and whether it can be induced by vaccines for MMR, HBV, HCV, and others. Edited by leaders in the field, Vaccines and Autoimmunity is an invaluable resource for advanced students and researchers working in pathogenic and epidemiological studies.
cell therapy for autoimmune diseases: The Mosaic of Autoimmunity Yehuda Shoenfeld, David Isenberg, 1989 This book comprehensively sets out the common aetiopathogenetic mechanisms shared by many, apparently diverse, diseases of the immune system. Unlike most other texts it does not emphasise the differences between autoimmune diseases, but establishes their many common links including hormonal effects, dietary and immunogenetic influences, complement deficiencies and environmental factors. Special attention is given to the effects of ageing and the relationship with malignancies. The scope of the book is very broad so as to cover the integration of the many diverse components which interact to cause autoimmunity, and it contains many 1988 and 1989 references and over 100 figures and tables, offering an attractive, up-to-date guide to modern concepts. It will greatly assist immunologists wishing to enter the field of autoimmunity, and will serve as an invaluable reference work for those already working in it.
cell therapy for autoimmune diseases: Allogeneic Stem Cell Transplantation Hillard M. Lazarus, Mary J. Laughlin, 2010-03-02 Since the original publication of Allogeneic Stem Cell Transplantation: Clinical Research and Practice, Allogeneic hematopoietic stem cell transplantation (HSC) has undergone several fast-paced changes. In this second edition, the editors have focused on topics relevant to evolving knowledge in the field in order to better guide clinicians in decision-making and management of their patients, as well as help lead laboratory investigators in new directions emanating from clinical observations. Some of the most respected clinicians and scientists in this discipline have responded to the recent advances in the field by providing state-of-the-art discussions addressing these topics in the second edition. The text covers the scope of human genomic variation, the methods of HLA typing and interpretation of high-resolution HLA results. Comprehensive and up-to-date, Allogeneic Stem Cell Transplantation: Clinical Research and Practice, Second Edition offers concise advice on today's best clinical practice and will be of significant benefit to all clinicians and researchers in allogeneic HSC transplantation.
cell therapy for autoimmune diseases: Cell Biology and Translational Medicine, Volume 2 Kursad Turksen, 2018-11-28 Much research has focused on the basic cellular and molecular biological aspects of stem cells. Much of this research has been fueled by their potential for use in regenerative medicine applications, which has in turn spurred growing numbers of translational and clinical studies. However, more work is needed if the potential is to be realized for improvement of the lives and well-being of patients with numerous diseases and conditions. This online first book series 'Cell Biology and Translational Medicine (CBTMED)' as part of SpringerNature’s longstanding and very successful Advances in Experimental Medicine and Biology book series, has the goal to accelerate advances by timely information exchange. Emerging areas of regenerative medicine and translational aspects of stem cells are covered in each volume. Outstanding researchers are recruited to highlight developments and remaining challenges in both the basic research and clinical arenas. This current book is the second volume of a continuing series.
CAR-T cell therapy embarks on autoimmune disease - Nature
CAR-T therapy heralds a new era in autoimmune disease management, offering a targeted and potent immunomodulatory approach that holds promise for inducing durable remissions

Innovative cellular therapies for autoimmune diseases: expert …
Innovative cellular therapies for autoimmune diseases: expert-based position statement and clinical practice recommendations from the EBMT practice harmonization and guidelines …

Cell Therapy for Autoimmune Disease: Landscape Analysis
the cancer cell therapy space has become very crowded and drug developers are currently seeking to expand the field into autoimmunity, with biotech and pharmaceutical companies …

CAR T cells in autoimmune disease: On the road to remission
Dec 10, 2024 · Several recent studies have demonstrated that B cell-targeting chimeric antigen receptor (CAR) T cells offer a viable treatment option for patients with autoantibody-mediated …

CAR-T in Autoimmune Diseases - Moffitt Cancer Center
• Autoimmune disorders driven by autoreactive B and T cells. • Indefinite Monoclonal antibody therapy results in incomplete control • CAR-T cell therapy mitigates autoimmune diseases by …

Allogeneic CAR T cells for autoimmune diseases: a glimpse …
In a recent study published in Cell, Wang X et al.1reported the first use of allogeneic anti-CD19 CAR T cells in patients with therapy-resistant autoimmune diseases, demonstrating their...

CAR T Cell Therapy for Patients with Autoimmune Disease: An …
Autologous chimeric antigen receptor (CAR) T cell therapy is a type of immunotherapy that reprograms T cells to express a CAR that binds to a specific antigen on target cells, leading to …

CAR T-cell therapy in autoimmune diseases - The Lancet
In this paper, we discuss the evolving strategies for targeting autoreactive B cells via CAR T cells, which might be used for targeted therapy in autoimmune diseases.

Shifting gears with CAR T cells for autoimmune diseases
study testing CD19-directed chimeric antigen receptor (CAR) T cell therapy for autoreactive B cell diseases including systemic lupus ery-thematosus (SLE), idiopathic inﬂammatory myositis …

New dawn of cellular therapies in autoimmune diseases - Cell …
The adaptation of CD19-CAR T cell-based therapies to target B and plasma cells is only the next step in a long history of treat-ment approaches of malignant diseases translated to …

CAR T-cell therapy in autoimmune diseases: where are we and …
In this Review we critically discuss the current data available on the use of CAR-based therapy in systemic autoimmune diseases, the current challenges, and the potential next steps toward …

Chimeric antigen receptor T cell therapy for autoimmune …
Infusion of T cells engineered to express chimeric antigen receptors (CARs) that target B cells has proven to be a successful treatment for B cell malignancies. This success inspired the...

Regulatory T-cell therapy for autoimmune and …
We review the current preclinical rationale supporting Treg cell therapy in a variety of disease settings ranging from tissue transplantation, autoimmune diseases, and non–immune …

Is there a place for engineered immune cell therapies in …
Translating CAR T cell therapy to autoimmune disease CAR T cells are a groundbreaking form of immunotherapy that has revolutionized the treatment of certain cancers, especially B cell …

CAR T-Cell Therapy: A Promising Modality for Autoimmune …
With promising results and approval for the treatment of hematological malignancies, we discuss the scope of this novel therapeutic modality in systemic autoimmune diseases and immune …

Autoimmune disease is the next frontier for CAR T cell therapy …
CAR T cell therapy has transformed the treatment of B cell cancers and is now being pursued by biotech companies for conditions as varied as systemic lupus erythematosus, diabetes and …

CAR T therapy extends its reach to autoimmune diseases
Nov 17, 2023 · CAR T cells that have been used to treat B cell leukemias and lymphomas are able to eliminate pathologic B cells in ﬁve patients with systemic lupus erythe- matosus. The …

Advancements and challenges in CAR T cell therapy in …
In this Review, we discuss important aspects of CAR T cell therapy in autoimmune disease, including considerations relating to patient selection, safety, eficacy and medical management.

World Journal of Stem Cells
212 Issues and opportunities of stem cell therapy in autoimmune diseases Műzes G, Sipos F 222 Application of mesenchymal stem cell therapy for the treatment of osteoarthritis of the knee: A …

CD137-expressing regulatory T cells in cancer and …
responses that occur in autoimmune diseases and chronic inﬂammation. Conversely, the abundance of Tregs in cancer is associated with impaired anti-tumor immunity, and tumor ...

Advance in chimeric antigen receptor T therapy in …
of autoimmune diseases, and the success of CAR T-cell therapy in the treatment of hematologic tumors such as B-lymphoblastic leukemia (14) has also given signiﬁcant inspiration to treat …

Critical Role of Tumor Necrosis Factor Signaling in ... - Frontiers
Cell-Based Therapy for Autoimmune and Inflammatory Diseases. Front. Immunol. 9:1658. doi: 10.3389/fimmu.2018.01658 Critical Role of Tumor Necrosis Factor Signaling in Mesenchymal …

CAR-engineered T cell therapy as an emerging strategy for …
2 CD19-targeted CAR-T cell therapy for autoimmune diseases Systemic lupus erythematosus (SLE) is a systemic autoimmune disease affecting various organs and tissues. A key role in …

Anti-CD20-mediated B-cell depletion in autoimmune …
widely used for the treatment of autoimmune diseases. This review will discuss mechanisms contributing to success or failure of B-cell depletion therapy in antibody-mediated autoimmune …

Regulatory T-cell therapy for autoimmune and …
development of Treg cell therapy and speculate how synthetic biology can be used to enhance the feasibility and efﬁcacy of Treg cell therapy for autoimmune and autoinﬂammatory …

Regulatory T cell therapies to treat autoimmune diseases …
Regulatory T cell therapies to treat autoimmune diseases and transplant rejection ... appropriate potency method for cell therapy products is especially challenging. In early

Current Perspectives of Umbilical Cord Stem Cell Therapy for …
Keywords: Autoimmune diseases; Stem cell therapy; Umbilical cord; T lymphocytes; Multipotent adult stem cells. Editor’s Note Rheumatoid Arthritis (RA) is a systemic and chronic disease in …

Perspective - Cell Press
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CAR‐T Cell Therapy in Autoimmune Setting: A New …
CAR-T Cell Therapy in Autoimmune Setting: A New Appealing Approach Extendable to Allergy? Federico Rossi1,2 ... also be used to treat autoimmune diseases. In this regard, Schett and …

Dawn of CAR-T cell therapy in autoimmune diseases
of hematological tumors, aiming to explore a safe and effective therapeutic option for relapsed/refractory autoimmune diseases. Keywords: CAR-T cell therapy; Autoimmune …

CAR-T AND autoimmune diseases in nervous system
Chimeric Antigen Receptor T-cell (CAR-T) therapy, an innovative method in cancer immunotherapy, has ... The mechanisms by which CAR-T therapy a ects autoimmune …

Single- cell analysis of anti- BCMA CAR T cell therapy in
May 10, 2024 · Chimeric antigen receptor (CAR) T cell therapy shows emerging potential in the long-term control of hematologic cancers ( –6). 4 Several studies have demonstrated its …

Review Article Targeted Immunotherapy for Autoimmune …
B cell depletion therapy using anti-CD20 mAbs has shown promising results in patients with neuroinflammatory diseases, and inhibition of B cell survival factors is approved for treatment …

FT522: A CAR NK Cell with the Unique Ability to Target …
Collectively, FT522 represents a promising off-the-shelf cell therapy for treatment of numerous autoimmune diseases while eliminating toxicities associated with patient conditioning. FT522 is …

BCMA-Targeted T-Cell–Engager Therapy for Autoimmune …
resistant autoimmune diseases.1,2 However, in some patients, disease may be anchored in long-lived plasma cells that express B-cell maturation antigen (BCMA) but not CD19.3 Thus, some …

1 2 8 1 3 4 2 1 3 1000 4 9 1 D 1200 1000 Peripheral ... - Fate …
of FT819 in B cell-mediated autoimmune diseases. Preclinically, FT819 co-cultured with CD19+ WIL2S lymphoma cell line demonstrated potent and specific CD19+ B cell killing in an in vitro …

Delivering progress on a cellular level - Bristol Myers Squibb
• As a leading cell therapy company and pioneer in modulating the body’s immune response, Bristol Myers Squibb is uniquely positioned to bring the potential of cell therapy into a new …

B cell depletion therapies in autoimmune diseases: …
autoimmune diseases usually utilize more than one mechanism in their pharmacological actions. 3 Targets of monoclonal antibodies in autoimmune diseases The mAbs used in ﬁeld of …

FROM BIOLOGY TO CLINICAL APPLICATION AUTOIMMUNE …
The 1.5-day in-person Cell Therapies for Autoimmune Diseases: CAR-T from Biology to Clinical Application Course is designed for clinicians, clinical scientists, medical students, and …

Targeting CD19 for the treatment of autoimmune with a …
designed TCE, has the potential to treat B cell-mediated diseases including autoimmune indications with possible better efficacy and less side effects in clinical practices. Introduction …

The advent of chimeric antigen receptor T Cell therapy in
therapy has demonstrated promising efﬁcacy in treating autoimmune conditions. 2 Mechanisms underlying CAR-T therapy in autoimmune diseases Pathologic cells associated with …

Local immune effector cell-associated toxicity syndrome in …
is known about autoimmune disease-specific side-effects of this new treatment approach. We searched PubMed for articles published in German or English between Jan 1, 2011, and Nov …

CAR-T cell therapy for juvenile-onset autoimmune diseases: …
CAR-T cell therapy for juvenile-onset autoimmune diseases: a promising future? Maurine Jouret1, Sebastien Viel 2,3, Benjamin Fournier4, Sarah Benezech2,5, Jérome Avouac6,7, Marc …

Cutting-edge approaches to B-cell depletion in autoimmune …
there is an abundance of recent literature describing cell therapy approaches for autoimmune diseases (3–5), the same is not true for TCEs. Therefore, additional focus on recent advances …

The application of gene therapy in autoimmune diseases
therapy in the treatment of autoimmune disease is to restore ‘immune homeostasis’ by countering the pro-inﬂammatory effects of the CD4 + T cells in the lesions of autoimmunity.

The emerging role of regulatory cell-based therapy in …
Dec 14, 2022 · performed on cell-based therapy for various types of autoimmune diseases. Several types of immune cells, including Breg and Treg cells, regulatory dendritic cells (DCs), …

The Potential Role of CAR T Cell Therapy in Autoimmune …
the diversity of patients with autoimmune diseases, CAR T cell therapy cannot possibly achieve a “one size fits all” solution [24]. Therefore, the appropriate design of CAR T cells as well as …

T cells in health and disease - Nature
pathogenesis of autoimmune diseases. In this review, we summarize the current understanding of T cell development, CD4+ and CD8+ T cell classiﬁcation, and differentiation in physiological ...

Targeting CD19 for the treatment of B-cell related …
Feb 17, 2024 · Depletion of autoreactive B cells is efficacious for multiple autoimmune diseases in both preclinical models and clinical settings3. B cell targeted therapies have been approved for …

CAR-T cell therapy: new hope for systemic lupus …
application of B cell-targeting CAR-T cell therapy in severe autoimmune diseases. The main pathogenesis of SLE lies in the autoimmune response caused by immune imbalance, and the …

B Cell Targeted Therapies in Autoimmune Diseases - The …
known as B cell activating factor, is essential for the development of B cells. Monoclonal antibodies against BLyS or soluble receptor immunoglobulin (Ig) antago-nists are being …

Dendritic cell and co-stimulatory molecule targeted therapy …
Autoimmune diseases, dendritic cells, immune tolerance, co-stimulatory molecules, immunotherapy Introduction Autoimmune diseases affect around 5–10% of the world’s …

Engineered immune cells as therapeutics for autoimmune …
Nov 27, 2023 · Therefore, the ﬁeld of adoptive Treg cell therapy is switching to antigen-speciﬁc Treg cell therapy approaches where Tregs are engineered to have a preselected antigen …

Shining the light on clinical application of mesenchymal stem …
In recent years, stem cell-based therapy is progres-sively used as a therapeutic approach for various diseases such as autoimmune diseases. Stem cell transplantation, conventionally used …

Embryonic stem cell therapy applications for autoimmune, …
diseases. One such scientific advancement in bridging the gap is the use of stem cell therapy. In recent years, stem cell therapy has gained the spotlight in becoming a possible intervention for …

Potential and pitfalls of repurposing the CAR-T cell regimen …
CAR-T cell therapy is an evolving discipline in oncology, with many aspects under active investigation. Effective repurposing into autoimmune diseases, and especially SLE, requires …

Autoimmune Disease - medicalupdateonline.com
Autoimmune Disease Tolerability, Efficacy, Pharmacokinetics, and Pharmacodynamics of BMS-986353 (CC-97540), a CD19-Directed Chimeric Antigen Receptor (CAR) T Cell Therapy …

Shining the light on clinical application of mesenchymal stem …
In recent years, stem cell-based therapy is progres-sively used as a therapeutic approach for various diseases such as autoimmune diseases. Stem cell transplantation, conventionally used …

Safety and efficacy of CAR-T cell therapy in patients with …
cell therapy in autoimmune diseases with lower incidence of severe AEs like cytokine release syndrome (CRS) and immune eector cell associated neurotoxicity syndrome (ICANS) [16–21]. …

WJSC World Journal of Stem Cells - gentlegiantclinic.com
Issues and opportunities of stem cell therapy in autoimmune diseases Györgyi Műzes, Ferenc Sipos ORCID number: Györgyi Műzes (0000-0002-9099-0372); Ferenc Sipos (0000-0002 …

World Journal of Stem Cells - ResearchGate
Issues and opportunities of stem cell therapy in autoimmune diseases Györgyi Műzes, Ferenc Sipos ORCID number: Györgyi Műzes (0000-0002-9099-0372); Ferenc Sipos (0000-0002 …

Engineering CAR-T therapies for autoimmune disease and …
English et al., Sci. Transl. Med. 16, eado2084 (2024) 30 October 2024 Engineering CAR- T therapies for autoimmune disease and beyond Emily P. English1, Rachel N. Swingler1, Simran …

Editorial: Epigenetics and stem cell therapy in cancer and …
May 16, 2025 · cell therapy in cancer and diseases Sonia Coni*, Roberto Schirano, Camilla Manfredi, Paola Infante* ... Issues and opportunities of stem cell therapy in autoimmune …

Stem Cell Reports
cell therapy for immune-mediated diseases. Our group has previously demonstrated that MSCs induce immune tolerance by activating the endogenous immune regulatory system of the …

Two for one? CAR-T therapy for lymphoma benefits …
CAR19 -T cell therapy for some autoimmune rheumatologic ... Weill JC, Reynaud CA, Mahévas M. Anti-CD20-mediated B-cell depletion in autoimmune diseases: successes, failures and …

Editorial: Next generation B cell targeting therapies in …
In contrast, CAR-based therapy for autoimmune diseases is a relatively new therapeutic approach that is currently undergoing research and development. The de licate balance between …

Regulatory T-cell therapy for autoimmune and …
Regulatory T (Treg) cells are a small subset (5% to 10%) of peripheral CD4+ T cells that are essential for maintaining immunologic tolerance. Decreased Treg cell numbers or function …

Journal Pre-proof - Cell Press
3 30 Introduction 31 Autoimmune diseases, particularly rheumatoid arthritis (RA), are known to be closely linked to 32 alterations in antibody glycosylation.1–4 In RA patients, aberrant …

Cell Therapy For Autoimmune Diseases

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