Advertisement
| crohn's disease research studies: Ἀρεταίου Καππαδόκου Τὰ Σωζόμενα Ἀρεταῖος (Καππαδόκης), 1856 Garrison ranks Aretaeus second only to Hippocrates in his descriptions of disease. |
| crohn's disease research studies: Crohn's Disease and Ulcerative Colitis Daniel C. Baumgart, 2017-03-01 This new edition is a unique combined resource for physicians and scientists addressing the needs of both groups. In addition to stimulating exchange and collaboration and shortening the path between discovery and application of new knowledge, the book helps clinicians understand new therapeutic concepts from their origins. The volume serves as a comprehensive guide to the current diagnostic modalities, including enhanced imaging techniques such as MRI and CT enterography, virtual colonoscopy, ultrasound, and endomicroscopy, as well as conventional and complex immunomodulatory principles. The latest edition also includes revised chapters from the previous edition, as well as new chapters reflecting current developments in the field. Written by experts in their field, Crohn’s Disease and Ulcerative Colitis: From Epidemiology and Immunobiology to a Rational Diagnostic and Therapeutic Approach, Second Edition is of great value to gastroenterologists, surgeons, internists, pediatricians and gynecologists trainees, as well as all those involved in Crohn’s disease, ulcerative colitis, and related autoimmune disorders. |
| crohn's disease research studies: Advances in Inflammatory Bowel Diseases P. Rutgeerts, J-F. Colombel, S.B. Hanauer, J. Schölmerich, Guido Tytgat, A. van Gossum, 1998-12-31 Ulcerative colitis and Crohn's disease remain a great therapeutic challenge to the medical community. In recent years knowledge about the pathogenesis of these diseases has progressed rapidly but the cause of the diseases remains completely unknown. It has become clear that dysregulation of the mucosal immune system is the basis for the chronic evolution of the diseases in a genetically susceptible population. Exciting new therapeutic approaches have been attempted in the last couple of years and cytokine and anti-cytokine treatments in particular seem very promising, especially in intractable disease. The format of the Falk Symposium 106 on `Advances in Inflammatory Bowel Diseases', held in Brussels, Belgium, June 18-20, 1998, was somewhat innovative as each session attempted to link the new insights into pathogenetic mechanisms with new therapeutic approaches, resulting in optimal information transfer. The classic therapeutic schemes were updated with a special focus on step-wise build-up of therapy. |
| crohn's disease research studies: Pediatric Inflammatory Bowel Disease Petar Mamula, Jonathan E. Markowitz, Robert N. Baldassano, 2012-12-14 Pediatric Inflammatory Bowel Disease, Second Edition provides an essential reference with an emphasis on the unique pediatric issues of IBD. Chapters focus on complications of IBD specific to children and adolescents. Treatment recommendations are based on the latest clinical research available. The textbook also presents sections dedicated to the aspects of participation in clinical research unique to children and adolescents and the complicated yet vital process of successfully transitioning a patient from a pediatric to adult specialist. Controversies in pediatric IBD care such as the off-label use of medications are also covered. The format incorporates multiple tables, graphs, and figures to improve readability and make for an efficient reference for clinicians to use. Thoroughly revised and updated from the first edition, the volumes includes new therapies that are currently being used or tested for treatment of IBD, important areas regarding incidence and prevalence, immunization and response to vaccine administration as well as advancements in our understanding of growth and development with particular to the use of growth hormone therapy. Other new areas covered include important topics of complementary and alternative medicine use in IBD, immunization, and liver disease in IBD. Pediatric Inflammatory Bowel Disease, Second Edition is a valuable resource for pediatric gastroenterologists as well as adult gastroenterologists. |
| crohn's disease research studies: Interventional Inflammatory Bowel Disease: Endoscopic Management and Treatment of Complications Bo Shen, 2018-01-16 Interventional Inflammatory Bowel Diseases: Endoscopic Management and Treatment of Complications covers the preparation, principle, techniques, and damage control of complications in endoscopic therapy, providing the ultimate guidance in endoscopic management of IBD. With contributions from a panel of international leading experts in the field, perspectives are included from GI pathologists, GI radiologists, gastroenterologists, advanced endoscopists, IBD specialists and colorectal surgeons. Recommendations from experts are also included within each chapter. By bridging medical and surgical treatment modalities for IBD, this is the perfect reference for GI researchers, medical students, therapeutic GI endoscopists, IBD specialists, surgeons and advanced health care providers. - Incorporates state-of-the-art of research in the area of therapeutic endoscopy in Crohn's Disease and Ulcerative Colitis - Makes the connection between the understanding of the complex nature and disease course of IBD with corresponding advanced endoscopic procedures - Explores endoscopic treatment as the missing link between medical and surgical treatment for complex Crohn's Disease and Ulcerative Colitis - Contains access to videos demonstrating important procedural concepts |
| crohn's disease research studies: Moderate to Severe Psoriasis John Koo, Jashin Wu, Alice Gottlieb, Ethan Levin, Argentina Leon, 2014-03-18 Written by experts in the dermatology field, this new fourth edition of Moderate-to-Severe Psoriasis discusses the current use of biologics and other pharmacologic and phototherapy treatments for moderate-to-severe psoriasis. Illustrated with high quality color figures, this standalone text emphasizes safe and effective treatments for the psoriasis |
| crohn's disease research studies: Diagnosis and Control of Johne's Disease National Research Council, Division on Earth and Life Studies, Board on Agriculture and Natural Resources, Committee on Diagnosis and Control of Johne's Disease, 2003-08-13 Johne's Disease is a chronic, progressive intestinal disease caused by infection with Mycobacterium avium subspecies paratuberculosis (Map) that affects primarily ruminant animals. In recent decades there has been growing concern over the lack of effective control of this disease and questions have arisen regarding the possibility that Map infection could be a cause of some cases of Crohn's disease in humans. This report presents a broad outline of the steps that should be taken to control Johne's disease, reduce the spread of Map, and minimize effects of the disease in animals. The report also describes the weaknesses of our current research agenda and provides recommendations for a new research strategy to resolve the question of whether there is a link between Johne's and Crohn's diseases. |
| crohn's disease research studies: Endoscopy in Inflammatory Bowel Disease Richard Kozarek, Michael Chiorean, Michael Wallace, 2014-11-03 This book conjoins the latest advances on the use of endoscopy to diagnose, monitor, and treat patients with inflammatory bowel disease. Chapters include the historical use of rigid sigmoidoscopy, non-interventional imaging procedures, and the correlation of pathology and endoscopic visualization. This is the first book to include individual chapters in gastroenterology, colorectal surgery, and IBD texts, the preeminent role of endoscopic imaging in the management of chronic ulcerative colitis, and Crohn's disease. It also includes chapters on capsule endoscopy and balloon and overtube-assisted enteroscopy to define the presence and activity of Crohn's enteritis and additional chapters defining the use of random biopsies versus chromoendoscopy, and computer enhanced imaging to define possible dysplasia development. The book also includes access to online videos, making it the ultimate verbal and visual tool for all medical professionals interested in the advances in the field over the last several decades. Endoscopy in Inflammatory Bowel Disease is a concise text that is of great value to practicing endoscopists, gastroenterologists, general or colorectal surgeons, physicians in training, and all medical professionals caring for patients with inflammatory bowel disease. |
| crohn's disease research studies: Biomarkers in Inflammatory Bowel Diseases Nik Sheng Ding, Peter De Cruz, 2019-05-13 This book provides a comprehensive and complete overview of biomarkers in clinical practice for inflammatory bowel disease (IBD) bringing together the literature in a clear and concise manner. The book bridges the gap between growing knowledge at the bench and current and future applications of biomarkers in clinical practice. The central structure of the book focuses on prognostic and predictive biomarkers in IBD with an emphasis on the fields of research and scientific techniques (genomics, proteomics and metabonomics) that have led to biomarker discovery and places these biomarkers within a clinical context to help understand their utility in clinical practice. This book will be of use to clinicians who have an interest in using biomarkers in clinical practice as well as clinician researchers and scientists involved in the biomarker research pipeline. The author team comprises experts from around the world in order to bring together the literature in an effort to inform clinicians and researchers about the current state-of-the art in biomarker discovery. It is intended to assist future research efforts and indicate how biomarkers might be best applied to clinical practice both at present and in the future. |
| crohn's disease research studies: Planning Clinical Research Robert A. Parker, Nancy G. Berman, 2016-10-12 Planning clinical research requires many decisions. The authors of this book explain key decisions with examples showing what works and what does not. |
| crohn's disease research studies: The ASCRS Manual of Colon and Rectal Surgery David E. Beck, John L. Rombeau, Michael J. Stamos, Steven D. Wexner, 2009-06-12 The ASCRS Textbook of Surgery of the Colon and Rectum offers a comprehensive textbook designed to provide state of the art information to residents in training and fully trained surgeons seeking recertification. The textbook also supports the mission of the ASCRS to be the world’s authority on colon and rectal disease. The combination of junior and senior authors selected from the membership of the ASCRS for each chapter will provide a comprehensive summary of each topic and allow the touch of experience to focus and temper the material. This approach should provide the reader with a very open minded, evidence based approach to all aspects of colorectal disease. Derived from the textbook, The ASCRS Manual of Surgery of the Colon and Rectum offers a “hands on” version of the textbook, written with the same comprehensive, evidence-based approach but distilled to the clinical essentials. In a handy pocket format, readers will find the bread and butter information for the broad spectrum of practice. In a consistent style, each chapter outlines the condition or procedure being discussed in a concise outline format – easy to read, appropriately illustrated and referenced. |
| crohn's disease research studies: The European Agency for the Evaluation of Medicinal Products European Agency for the Evaluation of Medicinal Products, 1996 |
| crohn's disease research studies: Ileoscopy Antonello Trecca, 2011-12-01 This publication is dedicated to all the aspects involved in the endoscopic diagnosis of terminal ileum. The most experienced endoscopists, gastroenterologists and pathologists will focus on and discuss the principles of diagnosis and treatment of the main pathologies involved in this district. The technique of ileoscopy with all the newest advances in endoscopic imaging will be discussed. Another chapter will be dedicated to the possible flow chart of diagnosis of the principles diseases after ileoscopy, from capsule endoscopy to double balloon ileoscopy. A final session will be completely aimed at presenting clinical cases of relevant interest. |
| crohn's disease research studies: Textbook of Pediatric Gastroenterology, Hepatology and Nutrition Stefano Guandalini, Anil Dhawan, David Branski, 2015-09-30 This textbook provides a comprehensive and state-of-the-art overview of the major issues specific to the field of pediatric gastroenterology, hepatology, and nutrition. The first part of the book, Gastroenterology and Nutrition, presents in a systematic way the overall scope of issues encountered by children (newborn to teenagers) suffering from disorders of the gastrointestinal tract, pancreas and/or presenting nutritional issues. These chapters are structured in logical sections to facilitate consultation and include major topics ranging from congenital disorders to gastrointestinal problems of the newborn, infectious diseases of the gastrointestinal tract, and approach to nutritional problems in the various pediatric ages. The second part of the book, Hepatology, is articulated in a series of chapters which present a comprehensive review of congenital and acquired disorders of the biliary tract and liver. This section also includes a critical analysis of available diagnostic and therapeutic procedures and future perspectives. Written by experts in the field, Textbook of Pediatric Gastroenterology, Hepatology and Nutrition: A Comprehensive Guide to Practice constitutes a much needed, innovative resource combining updated, reliable and comprehensive information with agile consultation for a streamlined approach to the care of children with such disorders. |
| crohn's disease research studies: GI Surgery Annual Peush Sahni, Sujoy Pal, 2019-03-29 The 25th volume of this highly successful series covers a range of interesting topics, including biological therapy in inflammatory bowel disease, recent surgical approaches in rectal cancer, tumor markers in HPB and GI malignancies, bridging therapy for hepatocellular carcinoma, adjuncts to liver resection, IgG-related HPB diseases, ERCP-induced perforations and superior mesenteric artery syndrome. As in the previous volumes, the chapter on advances in GI surgery reviews the important new developments in the field. The GI Surgery Annual 25th Volume provides up-to-date information on current hot topics. |
| crohn's disease research studies: Personalizing Treatment In IBD: Hype or Reality In 2020? Fernando Gomollón, Edouard Louis, 2021-07-05 |
| crohn's disease research studies: Patient Engagement Guendalina Graffigna, Serena Barello, Stefano Triberti, 2016-01-01 Patient engagement should be envisaged as a key priority today to innovate healthcare services delivery and to make it more effective and sustainable. The experience of engagement is a key qualifier of the exchange between the demand (i.e. citizens/patients) and the supply process of healthcare services. To understand and detect the strategic levers that sustain a good quality of patients’ engagement may thus allow not only to improve clinical outcomes, but also to increase patients’ satisfaction and to reduce the organizational costs of the delivery of services. By assuming a relational marketing perspective, the book offers practical insights about the developmental process of patients’ engagement, by suggesting concrete tools for assessing the levels of patients’ engagement and strategies to sustain it. Crucial resources to implement these strategies are also the new technologies that should be (1) implemented according to precise guidelines and (2) designed according to a user-centered design process. Furthermore, the book describes possible fields of patients’ engagement application by describing the best practices and experiences matured in different fields |
| crohn's disease research studies: Mechanisms of Intestinal Inflammation R. Duchmann, 2004-04-30 In recent years considerable progress has been achieved in regard to our understanding of the induction and modulation of the immune response in the intestinal mucosa. It is clear that this mucosal immune reaction is predominantly steered by certain T-cell populations, which are characterized by their cytokine secretion profile. Less well known are the conditions under which the uptake and processing of a specific antigen leads to a certain immune response, whether it be protective, tolerant or inflammatory. However, here again distinct progress has been made in our understanding. Equally significant for immune regulation in the gut appears to be so-called innate immunity. Every shift of equilibrium in the highly regulated mucosal immune reaction is accompanied by an inflammatory reaction and destruction of the mucosa. In nearly all cases, this inflammatory response is dependent on the presence of bacterial intestinal flora. This book, the proceedings of Falk Symposium 133 on Mechanisms of Intestinal Inflammation: Implications for Therapeutic Intervention in IBD', held in Berlin, Germany, on 10-11 June 2003, summarizes present knowledge in the area of unspecific and specific immune reactions in the gut, recording the gaps in our knowledge and, in particular, presenting the possibilities of targeted intervention. The link to inflammatory bowel diseases - Crohn's disease and ulcerative colitis - is always in focus. Chapters by an international panel of basic scientists, clinical researchers and clinicians also record the problems which can originate through today's possible modulation of the immune reaction, setting the basis for review of clinical problems. This book is valuable readings for all scientists and physicians, who, from different perspectives, have an interest in research on IBD and in the clinical management of these diseases. |
| crohn's disease research studies: Advances in Endoscopy in Inflammatory Bowel Disease Toshifumi Hibi, Tadakazu Hisamatsu, Taku Kobayashi, 2017-09-04 Advances in Endoscopy in Inflammatory Bowel Disease summarizes the recent progress made in endoscopy, an essential tool for the diagnosis and management of IBD. It goes on to provide an introduction of state-of-the-art endoscopic techniques, as well as an atlas of high-quality endoscopic images of IBD and related diseases. Among others, endoscopy is one of the clinical fields in which Asian countries are leading the way in the management of gastrointestinal disorders. As the number of patients with IBD is dramatically increasing in Asia, quality of patient care has been significantly improved. With diagnosis of intestinal Behcet, simple ulcers, and intestinal tuberculosis, which are unique to the Asian countries, this book offers the ideal standard textbook for IBD endoscopy in all Asian counties, while the superior quality of images also makes it a valuable resource for practitioners around the globe. This book will significantly help all physicians, endoscopists and researchers working on GI endoscopy, especially those focusing on IBD, to improve their knowledge of IBD endoscopy. |
| crohn's disease research studies: Molecular Genetics of Inflammatory Bowel Disease Mauro D'Amato, John D Rioux, 2013-10-05 Research in Crohn’s disease (CD) and ulcerative colitis (UC), together known as the inflammatory bowel diseases (IBD), has truly seen a revolution in the last 5-10 years. This book examines how these genetic discoveries have led to the identification of biological functions not previously associated with IBD pathophysiology (e.g. autophagy), how multiple genetic risk factors for IBD converge on given biological functions and that together the identified variants in these genes have predisposing and protective roles (e.g. the multiple variants in the receptor for the IL23 cytokine and its signaling cascade), and how having such a large number of known genetic risk factors has changed our understanding not only about the genetic and molecular overlap between CD and UC, but also between these diseases and other chronic inflammatory diseases (e.g. psoriasis, multiple sclerosis, type 1 diabetes and many others). |
| crohn's disease research studies: Breaking the Vicious Cycle Elaine Gloria Gottschall, 2016-09-05 |
| crohn's disease research studies: The Evaluation of Surrogate Endpoints Geert Molenberghs, Tomasz Burzykowski, Marc Buyse, 2005-02-28 Covers the latest research on a sensitive and controversial topic in a professional and well researched manner. Provides practical outlook as well as model guidelines and software tools that should be of interest to people who use the software tools described and those who do not. Related title by Co-author Geert Molenbergh has sold more than 3500 copies world wide. Provides dual viewpoints: from scientists in the industry as well as regulatory authorities. |
| crohn's disease research studies: The Management of Clinical Trials Hesham Abdeldayem, 2018-06-06 This concise book is addressed to researchers, clinical investigators, as well as practicing physicians and surgeons who are interested in the fields of clinical research and trials. It covers some important topics related to clinical trials including an introduction to clinical trials, some aspects concerning clinical trials in pediatric age group, and the unique aspects of the design of clinical trials on stem cell therapy. |
| crohn's disease research studies: The Exposome Gary W. Miller, 2013-11-16 The Exposome: A Primer is the first book dedicated to exposomics, detailing the purpose and scope of this emerging field of study, its practical applications and how it complements a broad range of disciplines. Genetic causes account for up to a third of all complex diseases. (As genomic approaches improve, this is likely to rise.) Environmental factors also influence human disease but, unlike with genetics, there is no standard or systematic way to measure the influence of environmental exposures. The exposome is an emerging concept that hopes to address this, measuring the effects of life-long environmental exposures on health and how these exposures can influence disease. This systematic introduction considers topics of managing and integrating exposome data (including maps, models, computation, and systems biology), -omics-based technologies, and more. Both students and scientists in disciplines including toxicology, environmental health, epidemiology, and public health will benefit from this rigorous yet readable overview. |
| crohn's disease research studies: Gutbliss Robynne Chutkan M.D., 2014-10-07 A renowned physician shares her complete 10-day digestive tune-up for women, with important revelations about good gastrointestinal health. Many so-called cures for women’s bloating and indigestion, from juice cleanses to specialty diets, are based on junk science. For women seeking true relief from that overall feeling of discomfort in any size jeans, Dr. Robynne Chutkan has the perfect plan for feeling light, tight, and bright in ten days. Gutbliss offers: A primer on the real reasons for gastrointestinal distress, and why it’s much more common in women A look at the debilitating side effects of supposedly healthy habits—from Greek yogurt to bloat-inducing aspirin An expert analysis of symptoms that could indicate a serious underlying condition An indispensable checklist to pinpoint the exact cause of your bloating Just a few small changes in diet, lifestyle, and exercise can make a huge difference in a woman’s digestive health, but the changes have to be the right ones. Going beyond the basics of top sellers such as Wheat Belly, Dr. Chutkan’s Gutbliss empowers women to take control of their gastrointestinal wellness. |
| crohn's disease research studies: Living with Crohn's & Colitis Jessica Black, N.D., Dede Cummings, 2010-06-29 A wellness plan for those with inflammatory bowel diseases like Crohn’s and ulcerative colitis—with expert guidance on creating a gut-healthy diet, finding the right treatments for you, and much more Approximately 1.5 million people in the United States alone are afflicted with inflammatory bowel disease (IBD), a category of illnesses that includes Crohn’s disease and ulcerative colitis, and that number is steadily growing. Although there is not yet a cure for Crohn’s or ulcerative colitis, patients can help reduce their symptoms and improve their overall wellbeing by following a comprehensive wellness plan such as those outlined in Living with Crohn’s & Colitis. Living with Crohn’s & Colitis offers patient-focused, expert guidance on everything from the latest medical treatments, how to cope with a diagnosis, and tips for balancing diet with a busy lifestyle so you can form a personalized wellness plan. Also included: • Easy to understand information on the role of inflammation and the immune system on gut health • Traditional and alternative treatment options for a broad, full-body approach to wellness • A three-month wellness plan adjustable to each individual’s health needs • Over 25 delicious recipes designed for those with IBD Learning to live with the myriad aspects of Crohn’s and ulcerative colitis treatment, including dietary restrictions and medications, can seem overwhelming. Written by a naturopathic doctor and a Crohn’s patient, Living with Crohn’s & Colitis is a thoughtful, balanced resource to help you on your journey to wellness. |
| crohn's disease research studies: Nutrition Guide for Clinicians Neal D. Barnard, Rick Weissinger, MS, Brent J. Jaster, MD, 2009 Designed by medical professionals, this manual is a comprehensive, portable medical reference that covers nearly one hundred diseases and conditions, including risk factors, diagnoses, and typical treatments. Most importantly, it provides the latest evidence-based information on nutrition's role in prevention and treatment. |
| crohn's disease research studies: Colitis-Associated Cancer Masato Kusunoki, 2015-10-01 As the number of patients with colitis-associated cancer (CAC) is on the increase, the purpose of this book is to review the latest topics concerning management of the disease. In recent years, the diagnostic power of endoscopy and molecular pathology has also grown tremendously, as a result of which they now have a far greater influence on the treatment of CAC. At the moment, appropriate monitoring programs for ulcerative colitis and Crohn’s disease remain uncertain. At the same time, the latest findings on DNA methylation and microRNAs hold the promise of making revolutionary changes in these areas. Moreover, recent drug advances in the treatment of inflammatory bowel diseases have changed surgical indications. On the other hand, the indication of mucosectomy on colorectal cancer in ulcerative colitis and prophylactic abdominoperineal resection for Crohn’s disease remain controversial. This book provides the latest information on the remaining issues of CAC from the point of view of expert surgeons. |
| crohn's disease research studies: Integrative Gastroenterology Gerard E. Mullin, Marvin Singh, Alyssa Parian, 2019-09-27 Digestive complaints have become increasingly common. Recent statistics show that gastrointestinal complaints account for nearly a third of all visits to primary care doctors and that nearly one in two Americans suffer from digestive disease. Millions more suffer from conditions such as migraine headaches, arthritis, mood disorders, chronic fatigue, asthma, allergies, and menstrual dysfunction, which are all related to a disorder in digestive health. Despite the evidence in support of integrative approaches to treatment and prevention of digestive symptoms, these approaches are largely overlooked in treating gastrointestinal disorders. Rather, treatment plans tend to be exclusively pharmacologically based and have appreciable toxicity. Integrative Gastroenterology, Second edition, is a comprehensive guide to helping health care practitioners understand and appreciate how to manage patients with gastrointestinal conditions integrating conventional and complimentary approaches. This text reviews the latest advances in science and research with regards to the gut microbiome, physiology, and interconnections between the gut and other organ systems. Coverage includes a diverse range of treatment methods, such as probiotics, meditation, massage, yoga, supplements, special diets, energy medicine, homeopathy, and acupuncture, as well as a special section devoted to mind-body medicine in digestive health and disease. In discussing unconventional treatments, the authors address many of the controversies that surround the remedies. |
| crohn's disease research studies: Eat Right 4 Your Type (Revised and Updated) Dr. Peter J. D'Adamo, Catherine Whitney, 1997-01-06 THE NEW YORK TIMES BESTSELLING DIET BOOK PHENOMENON If you’ve ever suspected that not everyone should eat the same thing or do the same exercise, you’re right. In fact, what foods we absorb well and how our bodies handle stress differ with each blood type. Your blood type reflects your internal chemistry. It is the key that unlocks the mysteries of disease, longevity, fitness, and emotional strength. It determines your susceptibility to illness, the foods you should eat, and ways to avoid the most troubling health problems. Based on decades of research and practical application, Eat Right 4 Your Type offers an individualized diet-and-health plan that is right for you. In this revised and updated edition of Eat Right 4 Your Type, you will learn: • Which foods, spices, teas, and condiments will help maintain your optimal health and ideal weight • Which vitamins and supplements to emphasize or avoid • Which medications function best in your system • Whether your stress goes to your muscles or to your nervous system • Whether your stress is relieved better through aerobics or meditation • Whether you should walk, swim, or play tennis or golf as your mode of exercise • How knowing your blood type can help you avoid many common viruses and infections • How knowing your blood type can help you fight back against life-threatening diseases • How to slow down the aging process by avoiding factors that cause rapid cell deterioration INCLUDES A 10-DAY JUMP-START PLAN |
| crohn's disease research studies: Curbside Consultation in IBD David T. Rubin, Sonia Friedman, Francis A. Farraye, 2009 Are you looking for concise, practical answers to questions that are often left unanswered by traditional IBD references? Are you seeking brief, evidence-based advice for complicated cases or complications? Curbside Consultation in IBD: 49 Clinical Questions provides quick and direct answers to the thorny questions commonly posed during a curbside consultation between colleagues. Dr. David Rubin, Dr. Sonia Friedman and Dr. Francis A. Farraye have designed this unique reference, which offers expert advice, preferences, and opinions on tough clinical questions commonly associated with IBD. The unique Q&A format provides quick access to current information related to IBD with the simplicity of a conversation between two colleagues. Numerous images, diagrams, and references are included to enhance the text and to illustrate IBD. Curbside Consultation in IBD: 49 Clinical Questions provides information that high-volume clinicians will appreciate, and yet is basic enough for residents. Gastroenterologists, fellows and residents in training, surgical attendings, and surgical residents will benefit from the user-friendly and casual format and the expert advice contained within. Some of the questions that are answered: - Which patients might be better for a top down approach (using anti-TNF therapy before steroids or proven failure of oral thiopurines)? What clinical behavior or serological markers might you use to identify these patients? - When is it appropriate to switch to another biologic therapy? - Should I be using chromoendoscopy in my surveillance colonoscopy in IBD? How and which agent? Would narrow band imaging be an alternative for this? - Can we follow flat low-grade dysplasia? Is any dysplasia really flat or just a spectrum of depth and size? - If women continue infliximab therapy during pregnancy, what are the implications for the baby? What should we be telling our patients about vaccinations? |
| crohn's disease research studies: The Crohn's Disease and Ulcerative Colitis Fact Book Crohn's & Colitis Foundation, 1983-10-15 Advance praise for The Crohn's Disease and Ulcerative Colitis Fact Book: Crohn's disease nearly took my life and dream of running in the Olympics. This book is helping me control my disease and stay in training. —Rene Felton, Track and Field National Record Holder A much needed and valuable resource for IBD patients, their families, and physicians towards understanding IBD. —Kurt J. Isselbacher, M.D., Mallinckrodt Professor of Medicine, Harvard Medical School; Chief, Gastrointestinal Unit, Massachusetts General Hospital Since IBD has touched my family I can well understand how this book can offer understanding and hope to all of us. —Gary Collins, Host, Hour Magazine An invaluable book not only for patients but for doctors as well. Anyone connected with IBD will profit from reading it. —Henry D. Janowitz, M.D., Clinical Professor of Medicine and Director of IBD Unit, Mount Sinai School of Medicine This text gave me a better insight into my illness. I have found that knowing what to expect makes coping with the disease easier. —Rolf Benirschke, Placekicker, San Diego Chargers |
| crohn's disease research studies: Kirsner's Inflammatory Bowel Diseases Joseph B. Kirsner, 2004 This comprehensive New Edition describes all of the latest scientific and clinical advances in the field of inflammatory bowel disease (IBD). A new editorial team-joined by a superb group of international authorities-examine every aspect of IBD-including etiology and pathogenesis, diagnosis and evaluation, medical and surgical therapy, and more. A wealth of expanded coverage, additional international contributors, extensive updating throughout, and numerous diagnostic and therapeutic algorithms make this an essential resource. Emphasizes evidence-based medicine in the section on medical therapy. Features a detailed description of inflammatory and immunologic pathways, allowing the reader to fully understand the contributing influences to the inflammation of IBD. Presents separate chapters on molecular genetics and clinical genetics for more in-depth coverage of each aspect of inflammatory bowel disease genetics. Provides a comprehensive review of IBD through abundant, high-quality endoscopic, radiographic, and histologic photographs-placing the various diagnostic modalities in perspective. Offers extensive coverage of postoperative recurrence of Crohn's disease · pouchitis · microscopic colitis · perianal disease · and osteoporosis. Includes up-to-the-minute guidance (including many 2003 references). Features a new editorial team, joined by numerous new contributors who provide fresh, global perspectives. Includes nine new chapters. Offers expanded coverage throughout, and through revisions of all pre-existing chapters. With over 75 additional contributing experts. |
| crohn's disease research studies: Glioblastoma: State of the Art and Future Perspectives Ghazaleh Tabatabai, Hiroaki Wakimoto, 2020 Glioblastoma is an aggressive incurable primary tumor of the central nervous system. Median overall survival is in the range of 1.5 years even in selected clinical trials populations. Many features contribute to this therapeutic challenge including high intratumoral and intertumoral heterogeneity, resistance to therapy, migration and invasion, immunosuppression. With the access of novel highthroughput technologies, significant progress has been made to understand molecular and immunological signatures underlying the pathology of glioblastoma. Clinical trial designs have shifted from investigating broad “one-for-all” treatment approaches to precision oncology designs. The collection of contributions in this book aim at providing researchers and clinicians an update on different aspects of glioblastoma, i.e. progress in basic, preclinical and clinical research. |
| crohn's disease research studies: Clinical Gastroenterology and Hepatology Wilfred M. Weinstein, C. J. Hawkey, Jaime Bosch, 2005 Presents clinically focused, evidence-based coverage on the diagnosis and treatment of disorders of the digestive tract. Over 200 author provide concise guidance on patient management and explain how to apply the latest advances. Provides separate sections on symptoms, diseases, diagnosis and treatment. |
| crohn's disease research studies: The Enteric Nervous System John Barton Furness, Marcello Costa, 1987 |
| crohn's disease research studies: Histopathologic Spectrum of Regional Enteritis and Ulcerative Colitis N. Karle Mottet, 1971 |
| crohn's disease research studies: Origins and Directions of Inflammatory Bowel Disease Joseph B. Kirsner, 2014-01-15 |
| crohn's disease research studies: Harrison's Principles of Internal Medicine Tinsley Randolph Harrison, 1998 Classic text for practitioners, residents, and students. |
| crohn's disease research studies: Crohn's Disease Gary R. Lichtenstein, 2024-06-01 Crohn’s Disease: The Complete Guide to Medical Management serves as the definitive source for medical management of Crohn’s Disease (CD). Dr. Gary R. Lichtenstein, along with Dr. Ellen J. Scherl, have collaborated with over 60 experts from around the world to provide gastroenterologists and those in training with the necessary information to successfully manage the patient with Crohn’s disease. Sections Include: • General o The role of the FDA in drug development; pediatric considerations; disease modifiers; and more • Medications o Antibiotic use in treatment of CD; oral budesonide; infliximab; novel biological and non biologic therapies for CD; and more • Specific Clinical Scenarios o Management of steroid unresponsive CD; management of enteric fistulae; use of pre- and probiotics; medical management of short bowel syndrome; maintenance therapy of CD; and more Features: • Color images, graphs, and tables • Extensive index that includes cross-referencing to Ulcerative Colitis: The Complete Guide to Medical Management • An appendix on Infliximab treatment • Comprehensive references at the end of each chapter Organized into an easy-to-reference format, Crohn’s Disease: The Complete Guide to Medical Management threads theory into practice and provides Gastroenterology professionals with the most comprehensive information available on this disease state. The other side of inflammatory bowel disease is covered in Drs. Gary R. Lichtenstein and Ellen J. Scherl’s Ulcerative Colitis: The Complete Guide to Medical Management. All gastroenterologists will find both books to be essential for future practice in the treatment and care of their patients with either Crohn’s disease or ulcerative colitis, as well as in the overall management of those with inflammatory bowel disease. |
Treatment strategies and biomarkers in Crohn's disease: the …
Extensive validation studies involving diverse patient populations, multiple clinical settings, and independent research groups are essential to ascertain the generalisability of biomarkers and …
SYSTEMATIC REVIEWS AND META-ANALYSES - Clinical …
We conducted a network meta-analysis to compare the efficacy of advanced therapies for achieving endoscopic outcomes in patients with moderate-to-severely active Crohn’s disease.
Challenges in IBD Research 2024: Pragmatic Clinical Research
Pragmatic clinical research is one of five focus areas of Challenges in IBD Research 2024, which also includes preclinical human inflammatory bowel disease (IBD) mechanisms, environmental …
Management of Crohn’s Disease: Future Research Needs
Crohn’s disease is characterized by chronic inflammation that can occur anywhere in the gastrointestinal tract, but most often affects the small bowel and colon. Typical symptoms …
Crohn Disease: Epidemiology, Diagnosis, and Management
Crohn disease is a chronic idiopathic inflammatory bowel disease condition characterized by skip lesions and transmural in ammation that can affect the entire gastrointestinal tract from the …
Gastro Hep Advances 2024;3:539 ORIGINAL RESEARCH …
BACKGROUND AND AIMS: Early biologic therapy treatment has demonstrated better outcomes in Crohn’s disease (CD). We evaluated the impact of CD duration in patients with moder-ately …
Metabolic alterations in Crohn s disease: A Systematic Review
Oct 3, 2024 · 53 Objective: To analyze Crohn's disease-specific metabolomic studies and available datasets to 54 identify a comprehensive signature of dysregulated metabolites and …
Crohn’s disease - The Lancet
Crohn’s disease is a chronic inflammatory disease of the gastrointestinal tract that might lead to progressive bowel damage and disability. The exact cause of Crohn’s disease is unknown, but …
A review of the therapeutic management of Crohn’s disease
Abstract: Crohn’s disease is a chronic inflammatory, relapsing-remitting, and progressive gastrointestinal disorder with an often-negative impact on the physical, emotional, and …
Diagnostic Accuracy of Non-Invasive Biomarkers and Imaging …
Jun 2, 2025 · Postoperative Recurrence in Crohn’s Disease, Clinical Gastroenterology and Hepatology (2025), doi: https://doi.org/10.1016/j.cgh.2025.03.030. This is a PDF file of an …
Genome‐wide association studies in Crohn's disease: Past, …
Sep 12, 2017 · Over the course of the past decade, genome-wide association studies (GWAS) have revolutionised our understanding of complex disease genetics.
Effectiveness and safety of Ustekinumab for the treatment of …
Background: The aim of this meta-analysis was to estimate the effectiveness and safety of Ustekinumab in Crohn’s disease (CD) reported by observational studies. Research design and …
Evaluating a Prediction Tool and Decision Aid for Patients with …
Crohn’s disease is a chronic inflammatory bowel disease that has significant impact on the quality of life of an estimated 500,000 Americans. Recent studies have taught us that earlier, more …
Placebo Rates in Crohn's Disease Randomized Clinical Trials: …
We assessed placebo rates and associated factors using individual patient data from Crohn’s disease trials. METHODS: We conducted a meta-analysis of phase 2/3 placebo-controlled …
Comparative Safety and Effectiveness of Biologic Therapy for …
With a paucity of head-to-head trials, real-world evidence can inform the comparative effectiveness and safety of biologic therapies for the management of Crohn’s disease (CD).
Comparative efficacy and safety of biologic therapies for …
safety of biologics in patients with Crohn’s disease. Methods. We did a systematic review and network meta-analysis of phase 2 and phase 3 randomised controlled trials done in adults (≥18 …
Crohn’s Disease and Ulcerative Colitis Patient Perspectives on …
Participants self-reported a diagnosis of Crohn’s disease or ulcerative colitis. Results: The five focus groups included a total of 34 participants. Participants discussed several barriers, …
Global Hospitalization Trends for Crohn's Disease and …
We systematically reviewed Medline and Embase for population-based studies reporting hos-pitalization rates for IBD, Crohn’s disease (CD), or ulcerative colitis (UC) in the 21st century. …
Physical Activity in Adults With Crohn s Disease: A Scoping …
We conducted a scoping review of descriptive, cross-sectional, and experimental studies to synthesize evidence regarding PA rates, determinants, health consequences, and …
Risankizumab as induction therapy for Crohn's disease: results …
We present the results of two phase 3 induction studies of intravenous risankizumab (600 mg and 1200 mg) in patients with moderately to severely active Crohn’s disease, who had previously …
Treatment strategies and biomarkers in Crohn's disease: the …
Extensive validation studies involving diverse patient populations, multiple clinical settings, and independent research groups are essential to ascertain the generalisability of biomarkers and …
SYSTEMATIC REVIEWS AND META-ANALYSES - Clinical …
We conducted a network meta-analysis to compare the efficacy of advanced therapies for achieving endoscopic outcomes in patients with moderate-to-severely active Crohn’s disease.
Challenges in IBD Research 2024: Pragmatic Clinical Research
Pragmatic clinical research is one of five focus areas of Challenges in IBD Research 2024, which also includes preclinical human inflammatory bowel disease (IBD) mechanisms, environmental …
Management of Crohn’s Disease: Future Research Needs
Crohn’s disease is characterized by chronic inflammation that can occur anywhere in the gastrointestinal tract, but most often affects the small bowel and colon. Typical symptoms …
Crohn Disease: Epidemiology, Diagnosis, and Management
Crohn disease is a chronic idiopathic inflammatory bowel disease condition characterized by skip lesions and transmural in ammation that can affect the entire gastrointestinal tract from the …
Gastro Hep Advances 2024;3:539 ORIGINAL RESEARCH …
BACKGROUND AND AIMS: Early biologic therapy treatment has demonstrated better outcomes in Crohn’s disease (CD). We evaluated the impact of CD duration in patients with moder-ately …
Metabolic alterations in Crohn s disease: A Systematic Review
Oct 3, 2024 · 53 Objective: To analyze Crohn's disease-specific metabolomic studies and available datasets to 54 identify a comprehensive signature of dysregulated metabolites and …
Crohn’s disease - The Lancet
Crohn’s disease is a chronic inflammatory disease of the gastrointestinal tract that might lead to progressive bowel damage and disability. The exact cause of Crohn’s disease is unknown, but …
A review of the therapeutic management of Crohn’s disease
Abstract: Crohn’s disease is a chronic inflammatory, relapsing-remitting, and progressive gastrointestinal disorder with an often-negative impact on the physical, emotional, and …
Diagnostic Accuracy of Non-Invasive Biomarkers and …
Jun 2, 2025 · Postoperative Recurrence in Crohn’s Disease, Clinical Gastroenterology and Hepatology (2025), doi: https://doi.org/10.1016/j.cgh.2025.03.030. This is a PDF file of an …
Genome‐wide association studies in Crohn's disease: Past, …
Sep 12, 2017 · Over the course of the past decade, genome-wide association studies (GWAS) have revolutionised our understanding of complex disease genetics.
Effectiveness and safety of Ustekinumab for the treatment of …
Background: The aim of this meta-analysis was to estimate the effectiveness and safety of Ustekinumab in Crohn’s disease (CD) reported by observational studies. Research design and …
Evaluating a Prediction Tool and Decision Aid for Patients …
Crohn’s disease is a chronic inflammatory bowel disease that has significant impact on the quality of life of an estimated 500,000 Americans. Recent studies have taught us that earlier, more …
Placebo Rates in Crohn's Disease Randomized Clinical …
We assessed placebo rates and associated factors using individual patient data from Crohn’s disease trials. METHODS: We conducted a meta-analysis of phase 2/3 placebo-controlled …
Comparative Safety and Effectiveness of Biologic Therapy for …
With a paucity of head-to-head trials, real-world evidence can inform the comparative effectiveness and safety of biologic therapies for the management of Crohn’s disease (CD).
Comparative efficacy and safety of biologic therapies for …
safety of biologics in patients with Crohn’s disease. Methods. We did a systematic review and network meta-analysis of phase 2 and phase 3 randomised controlled trials done in adults …
Crohn’s Disease and Ulcerative Colitis Patient Perspectives …
Participants self-reported a diagnosis of Crohn’s disease or ulcerative colitis. Results: The five focus groups included a total of 34 participants. Participants discussed several barriers, …
Global Hospitalization Trends for Crohn's Disease and …
We systematically reviewed Medline and Embase for population-based studies reporting hos-pitalization rates for IBD, Crohn’s disease (CD), or ulcerative colitis (UC) in the 21st century. …
Physical Activity in Adults With Crohn s Disease: A Scoping …
We conducted a scoping review of descriptive, cross-sectional, and experimental studies to synthesize evidence regarding PA rates, determinants, health consequences, and …
Risankizumab as induction therapy for Crohn's disease: …
We present the results of two phase 3 induction studies of intravenous risankizumab (600 mg and 1200 mg) in patients with moderately to severely active Crohn’s disease, who had previously …
