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| crohn's stem cell therapy: Mesenchymal Stem Cell Therapy Lucas G. Chase, Mohan C Vemuri, 2012-12-12 Over the past decade, significant efforts have been made to develop stem cell-based therapies for difficult to treat diseases. Multipotent mesenchymal stromal cells, also referred to as mesenchymal stem cells (MSCs), appear to hold great promise in regards to a regenerative cell-based therapy for the treatment of these diseases. Currently, more than 200 clinical trials are underway worldwide exploring the use of MSCs for the treatment of a wide range of disorders including bone, cartilage and tendon damage, myocardial infarction, graft-versus-host disease, Crohn’s disease, diabetes, multiple sclerosis, critical limb ischemia and many others. MSCs were first identified by Friendenstein and colleagues as an adherent stromal cell population within the bone marrow with the ability to form clonogenic colonies in vitro. In regards to the basic biology associated with MSCs, there has been tremendous progress towards understanding this cell population’s phenotype and function from a range of tissue sources. Despite enormous progress and an overall increased understanding of MSCs at the molecular and cellular level, several critical questions remain to be answered in regards to the use of these cells in therapeutic applications. Clinically, both autologous and allogenic approaches for the transplantation of MSCs are being explored. Several of the processing steps needed for the clinical application of MSCs, including isolation from various tissues, scalable in vitro expansion, cell banking, dose preparation, quality control parameters, delivery methods and numerous others are being extensively studied. Despite a significant number of ongoing clinical trials, none of the current therapeutic approaches have, at this point, become a standard of care treatment. Although exceptionally promising, the clinical translation of MSC-based therapies is still a work in progress. The extensive number of ongoing clinical trials is expected to provide a clearer path forward for the realization and implementation of MSCs in regenerative medicine. Towards this end, reviews of current clinical trial results and discussions of relevant topics association with the clinical application of MSCs are compiled in this book from some of the leading researchers in this exciting and rapidly advancing field. Although not absolutely all-inclusive, we hope the chapters within this book can promote and enable a better understanding of the translation of MSCs from bench-to-bedside and inspire researchers to further explore this promising and quickly evolving field. |
| crohn's stem cell therapy: Non-Myeloablative Allogeneic Transplantation Asad Bashey, Edward D. Ball, 2002-02-28 Non-myeloablative allogeneic stem cell transplantation (also known as mini-transplantation or reduced-intensity conditioning transplantation) is a major advance in the field of hematopoietic transplantation within the last 5 years. This approach uses non-cytotoxic or reduced-intensity cytotoxic therapy to prepare patients for allografting of hematopoietic stem cells and lymphocytes. It has the potential to deliver the potent anti-tumor immunotherapy and bone marrow replacement capacity of allogeneic stem cell transplantation to patients with reduced treatment-related morbidity and mortality. It may also enable allogeneic transplantation in patients who would be considered ineligible for conventional transplants because of co-morbidity or advanced age. However, this approach may necessitate more careful monitoring of post-transplant chimerism and malignant disease-status than is usual with conventional allografting. There is also controversy regarding the best preparative regimen and graft-versus-host disease prophylaxis to use. |
| crohn's stem cell therapy: Hematopoietic Stem Cell Transplantation and Cellular Therapies for Autoimmune Diseases Richard K. Burt, Dominique Farge, Milton A. Ruiz, Riccardo Saccardi, John A. Snowden, 2021-11-17 This book summarizes the global progress in medical and scientific research toward converting traditionally chronic autoimmune diseases into a drug-free reversible illness using hematopoietic stem cell transplantation (HSCT) and other cellular therapies such as T regulatory cells (Treg), mesenchymal stromal/stem cells, and chimeric antigen receptor T (CAR T) cells in order to reintroduce sustained immune tolerance. This title provides information on different types of stem cells and immune cells; post-transplant immune regeneration; cellular regulatory requirements; ethical and economic considerations; and the advantages and disadvantages of HSCT in the treatment of a variety of autoimmune diseases versus current conventional treatments. Arranged by disease, the text provides a comprehensive guide to HSCT for all types of autoimmune/immune disorders including monogenetic autoimmune diseases; autoimmune aplastic anemia; neurologic immune diseases including multiple sclerosis, chronic inflammatory demyelinating polyneuropathy, neuromyelitis optica, and stiff person syndrome; rheumatologic diseases such as systemic sclerosis and systemic lupus erythematosus; dermatologic diseases such as pemphigus; gastrointestinal disorders such as Crohn’s disease and celiac disease; and immune-mediated endocrinologic disease type I diabetes mellitus. Guidance is provided on the transplantation technique, cell collection and processing, conditioning regimens, infections, and early and late complications. Key Features Outlines therapies and techniques for HSCT for autoimmune diseases Discusses the advantages of HSCT over conventional therapies Reviews the entire process of stem cell therapy from harvest and ethics to indications, efficacy, and regulatory oversight |
| crohn's stem cell therapy: Crohn's Disease and Ulcerative Colitis Daniel C. Baumgart, 2017-03-01 This new edition is a unique combined resource for physicians and scientists addressing the needs of both groups. In addition to stimulating exchange and collaboration and shortening the path between discovery and application of new knowledge, the book helps clinicians understand new therapeutic concepts from their origins. The volume serves as a comprehensive guide to the current diagnostic modalities, including enhanced imaging techniques such as MRI and CT enterography, virtual colonoscopy, ultrasound, and endomicroscopy, as well as conventional and complex immunomodulatory principles. The latest edition also includes revised chapters from the previous edition, as well as new chapters reflecting current developments in the field. Written by experts in their field, Crohn’s Disease and Ulcerative Colitis: From Epidemiology and Immunobiology to a Rational Diagnostic and Therapeutic Approach, Second Edition is of great value to gastroenterologists, surgeons, internists, pediatricians and gynecologists trainees, as well as all those involved in Crohn’s disease, ulcerative colitis, and related autoimmune disorders. |
| crohn's stem cell therapy: Hematopoietic Stem Cell Therapy Edward David Ball, Ping Law, 2000 This book will be the only current practical guide to a widely used procedure for treating leukemias and disseminated cancers. The contents are organized chronologically, to serve as a step-by-step guide throughout the transplant process. Comprehensive yet concise, it emphasizes the latest techniques, such as peripheral blood stem cell grafts. |
| crohn's stem cell therapy: Handbook of Stem Cell Therapy Khawaja Husnain Haider, 2022-11-07 The handbook comprehensively reviews the therapeutic potential of stem cells and stem cell secretome-based cell-free strategies in regenerative medicine. The chapters in section I and section II respectively discuss the diverse applications of mesenchymal stem cells and non- mesenchymal stem cells, including skeletal myoblasts, endothelial progenitor cells, adipose tissue-derived stem cells, induced pluripotent stem cells, and neuronal stem cells in myocardial repair, inflammatory bowel disease, cognitive deficits, wound healing, retinal disorders, and COVID-19. The subsequent chapters in section IIIprimarily focused on the fast-emerging cell-free therapy approach in regenerative medicine for tissue repair and regeneration. These chapters review the impact of stem cell-derived secretome on various biological processes such as angiogenesis, neurogenesis, tissue repair, immunomodulation, musculoskeletal pathologies, wound healing, anti-fibrotic, and anti-tumorigenesis for tissue maintenance and regeneration.Lastly, section IV summarizes miscellaneous aspects of cell-based therapy, includingthe treatment advantages, opportunities, and shortcomings in stem cell-based therapy, potentially helping to refine future studies and translate them from experimental to clinical studies. Moreover, this section also has chapters on cancer stem cells as novel targets in cancer therapeutics. This Major Reference Book (MRW) is a valuable resource for researchers involved in stem cell research to understand the multifaceted therapeutic applications of stem cells and their derivative secretome in regenerative medicine. |
| crohn's stem cell therapy: Stem Cell Therapy for Autoimmune Disease Richard K. Burt, 2019-11-11 Stem cell transplantation may be complicated by treatment-related mortality and like the immune system that it regenerates has equal potential to either create and preserve or destroy. The dual nature that defines stem cells is differentiation that ultimately leads to death and self-renewal, which leads to immortality. What types of stem cells are there? How are they collected? What are their attributes and characteristics? This textbook devotes many chapters to familiarize the reader with the basic science, clinical aspects, and new questions being raised in the field of stem cell biology. Blood stem cells for tolerance and tissue regeneration are a rapidly developing research and clinical field that is being applied to autoimmune diseases. In clinical trials, autologous hematopoietic (blood) stem cells are being used to reduce the cytopenic interval following intense immune suppressive transplant regimens. While as yet not delineated, some possible mechanisms and pathways leading to tolerance after hematopoietic stem cell transplantation are suggested in these chapters. Tissue regeneration from blood stem cells is also suggested by animal experiments on stem cell plasticity or metamoirosis (i.e., change in fate) as described within this textbook. Ongoing early clinical trials on tissue regeneration from blood stem cells are described in the chapter on stem cell therapy for cardiac and peripheral vascular disease. Whether autologous hematopoietic stem cells, through the process of mobilization and reinfusion, may be manipulated to contribute to tissue repair in autoimmune diseases is a future area for translational research. |
| crohn's stem cell therapy: Stem Cells – From Hype to Real Hope Khawaja Husnain Haider, Salim Aziz, MD, 2018-12-17 This book is a compilation of the bench experience of leading experts from various research labs involved in the cutting edge area of research. The authors describe the use of stem cells both as part of the combinatorial therapeutic intervention approach and as tools (disease model) during drug development, highlighting the shift from a conventional symptomatic treatment strategy to addressing the root cause of the disease process. The book is a continuum of the previously published book entitled Stem Cells: from Drug to Drug Discovery which was published in 2017. |
| crohn's stem cell therapy: Current Medical Treatment Cyril William Holmes Havard, 1976 |
| crohn's stem cell therapy: Interventional Inflammatory Bowel Disease: Endoscopic Management and Treatment of Complications Bo Shen, 2018-01-16 Interventional Inflammatory Bowel Diseases: Endoscopic Management and Treatment of Complications covers the preparation, principle, techniques, and damage control of complications in endoscopic therapy, providing the ultimate guidance in endoscopic management of IBD. With contributions from a panel of international leading experts in the field, perspectives are included from GI pathologists, GI radiologists, gastroenterologists, advanced endoscopists, IBD specialists and colorectal surgeons. Recommendations from experts are also included within each chapter. By bridging medical and surgical treatment modalities for IBD, this is the perfect reference for GI researchers, medical students, therapeutic GI endoscopists, IBD specialists, surgeons and advanced health care providers. - Incorporates state-of-the-art of research in the area of therapeutic endoscopy in Crohn's Disease and Ulcerative Colitis - Makes the connection between the understanding of the complex nature and disease course of IBD with corresponding advanced endoscopic procedures - Explores endoscopic treatment as the missing link between medical and surgical treatment for complex Crohn's Disease and Ulcerative Colitis - Contains access to videos demonstrating important procedural concepts |
| crohn's stem cell therapy: Advances in Stem Cell Therapy Nagwa El-Badri, 2016-11-18 The book reviews the main approaches for generation of differentiated cells from various types of stem cells, including embryonic, placental and cord blood stem cells through marrow, adipose tissue and dental pulp. The book starts with an overview of experimental protocols applied to generate insulin secreting cells, neural cells, heart cells, and other tissue specific cells ex vivo and in experimental animals. This is followed by exhaustive review of clinical trials in these pathologies. It continues with a comparison of the merits of successful transplantation in humans versus animal experimentation, and highlights the most promising clinical applications in the field. Special chapters are devoted to the topic of tissue engineering and modern synthetic and biological scaffolds. It is essential reading for scientists and researchers in tissue engineering and stem cell research as well as clinicians who are involved in developing or testing stem cell therapies. |
| crohn's stem cell therapy: Crohn's Disease Roberto Tersigni, Cosimo Prantera, 2010-01-13 Crohn's disease is an inflammatory bowel disease, whose symptoms are similar to other intestinal disorders, such as irritable bowel syndrome and ulcerative colitis; it can therefore be difficult to diagnose. Its knowledge and understanding have increased considerably in the last years; new advances in genetics, medical and surgical management offer today new possibilities for patients suffering from an inflammatory bowel disease. However, Crohn's disease remains a difficult disease to deal with, both from a research and clinical point of view. This book provides general practitioners with a basic knowledge of the disease, offering in the same time an update on new facts about Crohn's disease to specialists. It can also be useful for residents willing to develop a deeper knowledge of inflammatory bowel diseases. |
| crohn's stem cell therapy: Tissue Engineering and Regenerative Medicine Phuc Van Pham, 2019-08-14 This new series, based on a bi-annual conference and its topics, represents a major contribution to the emerging science of cancer research and regenerative medicine. Each volume brings together some of the most pre-eminent scientists working on cancer biology, cancer treatment, cancer diagnosis, cancer prevention and regenerative medicine to share information on currently ongoing work which will help shape future therapies. These volumes are invaluable resources not only for already active researchers or clinicians but also for those entering these fields, plus those in industry. Tissue Engineering and Regenerative Medicine is a proceedings volume which reflects papers presented at the 3rd bi-annual Innovations in Regenerative Medicine and Cancer Research conference; taken with its companion volume Stem Cells: Biology and Engineering it provides a complete overview of the papers from that meeting of international experts. |
| crohn's stem cell therapy: Stem Cell-Dependent Therapies Gerhard Gross, Thomas Häupl, 2013-10-29 Multipotent mesenchymal stem cells (MSCs) are a heterogeneous population of cells which reside in a variety of tissues. They differentiate into several mesodermal lineages, secrete a multitude of trophic factors and contribute to tissue homeostasis. MSCs are able to exert immunosuppressive activities by interfering with inflammatory cytokine production and with T- and B-cell proliferation. These immunomodulating properties make MSCs promising candidates for the treatment of chronic inflammatory and autoimmune disorders. There are, however, certain caveats involved including inappropriate migration of cells in the body, immune rejection, tumor formation, or graft versus host disease (GvHD). This book investigates the current state of the MSC-dependent therapy of chronic inflammatory disorders and autoimmune diseases. Among the covered topics are GvHD, chronic kidney, liver and lung disease, ischemic heart and inflammatory bowel disease, diabetes, osteoarthritis, various rheumatic and neurological disorders and, lastly, tumors and solid organ transplantations. This book also questions the immunoprivileged status of MSCs, discusses the therapeutic role of MSCs in experimental animal disease models and their translation to the corresponding human disorders, envisions a role for MSCs in tumor interventions and, lastly, describes a systems biology approach for stem cells and inflammation. |
| crohn's stem cell therapy: Colitis-Associated Cancer Masato Kusunoki, 2015-10-01 As the number of patients with colitis-associated cancer (CAC) is on the increase, the purpose of this book is to review the latest topics concerning management of the disease. In recent years, the diagnostic power of endoscopy and molecular pathology has also grown tremendously, as a result of which they now have a far greater influence on the treatment of CAC. At the moment, appropriate monitoring programs for ulcerative colitis and Crohn’s disease remain uncertain. At the same time, the latest findings on DNA methylation and microRNAs hold the promise of making revolutionary changes in these areas. Moreover, recent drug advances in the treatment of inflammatory bowel diseases have changed surgical indications. On the other hand, the indication of mucosectomy on colorectal cancer in ulcerative colitis and prophylactic abdominoperineal resection for Crohn’s disease remain controversial. This book provides the latest information on the remaining issues of CAC from the point of view of expert surgeons. |
| crohn's stem cell therapy: Stem Cell Therapy: A Rising Tide: How Stem Cells Are Disrupting Medicine and Transforming Lives Neil H. Riordan, 2017-06-20 Stem cells are the repair cells of your body. When there aren't enough of them, or they aren't working properly, chronic diseases can manifest and persist. From industry leaders, sport stars, and Hollywood icons to thousands of everyday, ordinary people, stem cell therapy has helped when standard medicine failed. Many of them had lost hope. These are their stories. Neil H Riordan, author of MSC: Clinical Evidence Leading Medicine's Next Frontier, the definitive textbook on clinical stem cell therapy, brings you an easy-to-read book about how and why stem cells work, and why they're the wave of the future. |
| crohn's stem cell therapy: Stem Cell Transplantation for Autoimmune Diseases and Inflammation Phuc Van Pham, 2019-08-13 This book introduces many new technologies and clinical applications of hematopoietic stem cells and mesenchymal stem cell transplantation for the treatment of autoimmune diseases and inflammatory diseases. Presented in two parts, Part 1 focuses on stem cell therapies for autoimmune disease treatment; Part 2 focuses on stem cell therapies and their application in the treatment of common inflammatory diseases, including chronic knee osteoarthritis, chronic obstructive pulmonary disease, liver cirrhosis, Crohn's Disease, Multiple Sclerosis, and more. This book is an essential source for all advanced students and researchers involved with these diseases, stem cells, or both. Stem Cell Transplantation for Autoimmune Diseases and Inflammation and the other books in the Stem Cells in Clinical Applications series are invaluable to scientists, researchers, advanced students and clinicians working in stem cells, regenerative medicine, or tissue engineering as well as cancer or genetics research. |
| crohn's stem cell therapy: Stem Cells Mariusz Z. Ratajczak, 2020-01-02 Since different types of stem cells for therapeutic applications have recently been proposed, this timely volume explores various sources of stem cells for tissue and organ regeneration and discusses their advantages and limitations. Also discussed are pros and cons for using embryonic stem cells, induced pluripotent stem cells, and adult stem cells isolated from postnatal tissues. Different types of adult stem cells for therapeutic applications are also reviewed, including hematopoietic stem cells, epidermal stem cells, endothelial progenitors, neural stem cells, mesenchymal stem cells, and very small embryonic-like stem cells. This book also addresses paracrine effects of stem cells in regenerative medicine that are mediated by extracellular microvesicles and soluble secretome. Finally, potential applications of stem cells in cardiology, gastroenterology, neurology, immunotherapy, and aging are presented. This is an ideal book for students and researchers working in the stem cell research field. |
| crohn's stem cell therapy: Crohn’s Disease Alessandro Fichera, Mukta K. Krane, 2015-08-20 Crohn’s Disease: Basic Principles provides a comprehensive and state-of-the-art overview of the current diagnosis and treatment strategies for Crohn’s disease. Care of these patients and clinical conditions can be quite complex and often require a multidisciplinary approach. Sections of the book are based on the most current, evidenced-based resources and have been structured to review the etiology and diagnosis of Crohn’s disease, discuss advances in medical and surgical treatment, illustrate emerging technologies impacting the care of patients with Crohn’s disease, and examine functional and quality of life outcomes in this patient population. The text reviews our understanding of the influence of molecular and genetic factors in the development and pattern of Crohn’s disease. Current methods of diagnosis and strategies in the medical management of patients with Crohn’s disease are evaluated including the use of biologic agents. Resection and bowel sparing techniques for primary and recurrent disease as well as advances in endoscopy and laparoscopy are discussed in detail. In addition, factors influencing the quality of life of patients with Crohn’s disease are examined including nutrition, enterostomal care, fertility, and sexual function. Written by recognized experts in their field, Crohn’s Disease: Basic Principles highlights the integrated multidimensional aspect of caring for patients with Crohn’s disease and will be of great value to colon and rectal surgeons, general surgeons, gastroenterologists, internists, as well as fellows and upper level residents in training training. |
| crohn's stem cell therapy: Deer's Treatment of Pain Timothy R. Deer, Jason E. Pope, Tim J. Lamer, David Provenzano, 2019-08-01 Designed and written by a team of clinically established academics, this is a unique book that is an excellent manual for physicians practicing pain medicine or treating pain in neurosurgery, orthopedic, neurology, or family practice clinics. As a practical resource, this book is written to be more accessible to the reader and is designed to be more clinically-focused and useful in day-to-day practice. This 102 chapter volume is divided into seven separate sections: Anatomy and Physiology of Pain, Psychology of Pain, Pharmacological Treatment of Pain, Interventional Treatment of Pain, Adjuvant Therapies for Pain and Suggested Reading. The calculated organization of this book is supplemented by key photos, drawings and a self-assessment of four key questions at the end of each chapter -- thus making it an indispensable, pragmatic resource that will benefit anyone working in the pain management field. Deer's Treatment of Pain: An Illustrated Guide for Practitioners contains pearls for improving knowledge and improving one’s practice as a physician. |
| crohn's stem cell therapy: Fast Facts: Complex Perianal Fistulas in Crohn's Disease Janindra Warusavitarne, Paulo Gustavo Kotze, 2021-05-27 Over the course of their Crohn's disease, up to half of affected individuals will develop a perianal penetrating complication (either perianal fistula or abscess). Symptoms can be debilitating, and the impact on quality of life significant. This first edition of 'Fast Facts: Complex Perianal Fistulas in Crohn's Disease' explains how fistulas form, who is at risk and the principles of diagnosis and classification. Later chapters explore the medical and surgical options, including innovative therapies. The intention throughout is to emphasize the importance of ‘joined-up thinking’ when caring for patients. Perianal fistulas are often challenging to treat in patients with Crohn’s disease, and a multidisciplinary approach is needed to get the best outcomes. Table of Contents: • Epidemiology, etiology and pathology • Anatomy and classification • Diagnosis • Management principles • Medical treatment Local perianal surgical (sphincter-preserving) interventions • Innovative therapies • Managing complications |
| crohn's stem cell therapy: The EBMT Handbook Nicolaus Kröger, Mohamad Mohty, Carlo Dufour, 2020-10-08 This Open Access edition of the European Society for Blood and Marrow Transplantation (EBMT) handbook addresses the latest developments and innovations in hematopoietic stem cell transplantation and cellular therapy. Consisting of 93 chapters, it has been written by 175 leading experts in the field. Discussing all types of stem cell and bone marrow transplantation, including haplo-identical stem cell and cord blood transplantation, it also covers the indications for transplantation, the management of early and late complications as well as the new and rapidly evolving field of cellular therapies. This book provides an unparalleled description of current practices to enhance readers' knowledge and practice skills. This work was published by Saint Philip Street Press pursuant to a Creative Commons license permitting commercial use. All rights not granted by the work's license are retained by the author or authors. |
| crohn's stem cell therapy: The ASCRS Manual of Colon and Rectal Surgery David E. Beck, John L. Rombeau, Michael J. Stamos, Steven D. Wexner, 2009-06-12 The ASCRS Textbook of Surgery of the Colon and Rectum offers a comprehensive textbook designed to provide state of the art information to residents in training and fully trained surgeons seeking recertification. The textbook also supports the mission of the ASCRS to be the world’s authority on colon and rectal disease. The combination of junior and senior authors selected from the membership of the ASCRS for each chapter will provide a comprehensive summary of each topic and allow the touch of experience to focus and temper the material. This approach should provide the reader with a very open minded, evidence based approach to all aspects of colorectal disease. Derived from the textbook, The ASCRS Manual of Surgery of the Colon and Rectum offers a “hands on” version of the textbook, written with the same comprehensive, evidence-based approach but distilled to the clinical essentials. In a handy pocket format, readers will find the bread and butter information for the broad spectrum of practice. In a consistent style, each chapter outlines the condition or procedure being discussed in a concise outline format – easy to read, appropriately illustrated and referenced. |
| crohn's stem cell therapy: Stem Cells: Basics and Clinical Translation Robert Chunhua Zhao, 2015-09-14 This book provides a comprehensive review of the properties of various stem cell types, the mechanisms of their behaviors and their potential clinical application. Stem cells have a great capacity of self-renewal and differentiation. They represent new paradigms for disease treatment in the field of regenerative medicine since the day they were discovered. As stem cell research is complicated and making progress rapidly, it is important to have expertise in this field to share their views and perspectives. This book provides a wonderful platform for those who are interested in stem cells to learn from and communicate with experts. Particularly, it highlights the roles of stem cell based therapy for a variety of diseases. Furthermore, this book gives a detailed introduction to the great works related to stem cells in China. The readers could gain a profound knowledge of the state-of-art research done by scientists in the field of stem cells. Overall, this book will be a valuable reference resource for both experienced investigators pursuing stem cell research as well as those are just entering into this field. Dr. Robert Chunhua Zhao, a Cheung Kong Professor of Stem Cell Biology, is Professor of Cell Biology at the Institute of Basic Medical Sciences & School of Basic Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College (PUMC), Beijing, China. He is Director of the Center for Tissue Engineering, PUMC and Chief Scientist of the National Basic Research Program of China (“973 Program”). He also serves as Regional Editor of Stem Cells and Development. |
| crohn's stem cell therapy: Digestive System Diseases Maria Gazouli, George E. Theodoropoulos, 2019-03-27 This book reviews recent knowledge of the role of stem cells in the gastrointestinal system. It covers extensive topics for each organ, including the pancreas, esophagus, liver, and colon, while also discussing the contributions of stem cells to therapeutic approaches toward gastrointestinal diseases, including inflammatory bowel diseases. Comprehensive and cutting-edge, Digestive System Diseases: Stem Cell Mechanisms and Therapies deepens a reader’s theoretical expertise in gastrointestinal stem cell biology. It furthers scientists’ understanding of gastrointestinal stem cells and, most importantly, the development of novel therapeutic targets. Graduate and postdoctoral students, medical doctors (including gastroenterologists and surgeons), and principal investigators in both academia and industry will benefit from this book. In particular, it is a valuable resource for professionals within the fields of gastrointestinal research, pharmaceutical science, molecular biology, regenerative medicine, and genetics. |
| crohn's stem cell therapy: Intestinal Stem Cell Niche , 2018-04-24 Advances in Stem Cells and Their Niches addresses stem cells during development, homeostasis, and disease/injury of the respective organs, presenting new developments in the field, including new data on disease and clinical applications. Video content illustrates such areas as protocols, transplantation techniques, and work with mice. Explores not only reviews of research, but also shares methods, protocols, and transplantation techniques Contains video content to illustrate such areas as protocols, transplantation techniques, and work with mice Each volume concentrates on one organ, making this a unique publication |
| crohn's stem cell therapy: The SAGE Encyclopedia of Stem Cell Research Eric E. Bouhassira, 2015-06-15 The SAGE Encyclopedia of Stem Cell Research, Second Edition is filled with new procedures and exciting medical breakthroughs, including executive orders from the Obama administration reversing barriers to research imposed under the Bush administration, court rulings impacting NIH funding of research based on human embryonic stem cells, edicts by the Papacy and other religious leaders, and the first success in cloning human stem cells. Stem cell biology is clearly fueling excitement and potential in traditional areas of developmental biology and in the field of regenerative medicine, where they are believed to hold much promise in addressing any number of intractable medical conditions. This updated second edition encyclopedia will expand on information that was given in the first edition and present more than 270 new and updated articles that explore major topics in ways accessible to nonscientists, thus bringing readers up-to-date with where stem cell biology stands today, including new and evolving ethical, religious, legal, social, and political perspectives. This second edition reference work will serve as a universal resource for all public and academic libraries. It is an excellent foundation for anyone who is interested in the subject area of stem cell biology. Key Features: Reader’s Guide, Further Readings, Cross References, Chronology, Resource Guide, Index A Glossary will elucidate stem cell terminology for the nonscientist Statistics and selected reprints of major journal articles that pertain to milestones achieved in stem cell research Documents from Congressional Hearings on stem cells and cloning Reports to the President’s Council on Bioethics, and more |
| crohn's stem cell therapy: Encyclopedia of Stem Cell Research , 2008 Provides an understanding of the basic concepts in stem cell biology and addresses the politics, ethics, and challenges currently facing the field--From publisher description. |
| crohn's stem cell therapy: STEM CELLS Logeswari Selvaraj, 2019-06-06 The basic definition of stem cells is that they are the engine room of multicellular organisms for both plants and animals. These cells are surrounded by intricate signals that allow them to divide so as to self-renew and to produce a progeny to make a specific type of tissue. In 1855, Rudolph Virchow, a German pathologist, explained the idea that all living things come from other living cells and thus paved the way for the current definition of stem cells.Initially it was described that the embryonic carcinoma cells are the primitive stem cells that can make all types of body tissue—the hair, bone and the brain. In 1896, E.D.Wilson was the first person who coined the term“stem cell”. In 1950’s the stem cell science was first initiated when bone marrow was transplanted into irradiated mice and shown to reconstitute the stem cell population. Thereafter several scientists showed research interests using stem cells in the molecular processes of neurological diseases and drug delivery systems in vivo.In 2007, researchers showed the ‘universal’ type of stem cell that was isolated and characterized from mouse embryos. These embryonic stem cells divided in in vitro cultures maintaining the potential to create the tissues in one system. This research on stem cells provided a widespread data which enlightens to learn every basic concepts about stem cells.This book contains the basics of stem cells, their scientific aspects in the latest applied areas. The chapters are presented in a sequential organization for effective learning. It is hopeful that this book provides detail for the needs of students and faculty members. |
| crohn's stem cell therapy: Scientific Principles of Adipose Stem Cells Lauren Kokai, Kacey Marra, J. Peter Rubin, 2021-08-19 Scientific Principles of Adipose Stem Cells provides readers with in-depth and expert knowledge on adipose stem cells, their developmental biologic origins, foundational research on ASC signaling mechanisms and immunomodulatory properties, and clinical insights into applications in regenerative medicine. Topics covered include basic adipose stem cell developmental biology and mechanisms of regulating self-renewal and activation in the stem cell niche, important methods for isolation and characterizing ASCs, and data on the impact on human demographics (age, sex, BMI) on ASC phenotype. A section devoted to ASC biology, ASCs for stem cell therapy and regenerative medicine, and ASCs in tissue engineering applications are also included. The book is written for scientists and clinicians who are broadly familiar with stem cells and basic cell biology principles and those seeking advanced information on adipose stem cells. - Coverage of basic adipose stem cell developmental biology (maturation process during embryogenesis) and mechanisms of regulating self-renewal and activation in the stem cell niche - Includes important methods for isolation and characterizing ASCs, as well as known data any impact of human demographics (age, sex, BMI) on ASC phenotype - An entire section dedicated to ASC biology, additional sections will be devoted to ASCs for stem cell therapy and regenerative medicine, as well as ASCs in tissue engineering applications |
| crohn's stem cell therapy: Emerging Therapeutic Targets and Drug Delivery Approaches in IBD , 2024-11-12 Emerging Therapeutic Targets and Drug Delivery Approaches in IBD, Volume 101 in this ongoing series, highlights new advances, with this volume presenting interesting chapters on timely topics, including Fibrosis in IBD – AXL as a Promising Therapeutic Target, Developing a pathway to test anti-fibrotic drugs in Crohn's disease, Emerging therapeutics for the management of intestinal fibrosis and strictures, GCPII for IBD, Fistulas/stem cell products for IBD/Crohn's, The landscape of new therapeutic opportunities for IBD, TL1A : A Model For The Use Of Precision Medicine For The Treatment of Crohn's Disease and Ulcerative Colitis, Dectin-1 as a therapeutic target for IBD, and more.Additional sections cover BRD4 as an Emerging Epigenetic Therapeutic Target for Inflammatory Bowel Diseases, Scripps - S1P, The potential of targeting TREM-1 in Inflammatory Bowel Disease, and Microbiome therapies. - Provides the latest information on emerging therapeutic targets and drug research - Offers outstanding and original reviews on a range of emerging therapeutic targets and drug research topics - Serves as an indispensable reference for researchers and students alike |
| crohn's stem cell therapy: Inflammatory Bowel Disease, An Issue of Gastrointestinal Endoscopy Clinics Simon Lichtiger, 2019-05-11 Dr. Charles Lightdale selected top expert Dr. Charles Lichtiger to serve as Guest Editor for this issue of Gastrointestinal Endoscopy Clinics devoted to Inflammatory Bowel Disease. The issue uniquely addresses the questions that arise when trying to treat and diagnose IBD. Further, it provides information on what the future might look like for endoscopists. Articles are devoted to the following topics: The Era of Anti-TNF’s is Over: What do we know, don’t know, and yearn to know; Prognostigating the Course of IBD- Is it an art or Science; Treat to Target: What is Target and How do we Treat; The Microbiota and the Immune Response: What is the Chicken and What is the Egg; The Role of the Radiologist in Determining Disease Severity; Capsule Endoscopy and Small Bowel Enteroscopy: Have they Rendered the Radiologist Obsolete; Dysplasia Surveillance; Endoscopic Submucosal Dissection: Are We Transitioning to it; Strictures in Crohn’s Diagnosis and UC: Is there a role for the gastroenterologist, endoscopist, or is it always the surgeon; Endoscopy in the Postoperative Patient with CD or UC: Does it Translate to better Outcomes; The Role of Histology in Determining Disease Activity, Treatment, and Prognosis: Are we there yet; Perianal Disease: The role of Endoscopy, EUS, EUA, Laser Therapy, Sealing Agents, and Stem Cells; Imaging of Mucosal Inflammation: Current Developments and Future Perspectives for IBD; Surgery in IBD: Is there any need for Open Procedures. Readers will come away with a state-of-the-art understanding about the current and future clinical picture for endoscopy in IBD. |
| crohn's stem cell therapy: Mesenchymal Stem Cell Derived Exosomes Yaoliang Tang, Buddhadeb Dawn, 2015-09-02 Mesenchymal stem cell-derived exosomes are at the forefront of research in two of the most high profile and funded scientific areas – cardiovascular research and stem cells. Mesenchymal Stem Cell Derived Exosomes provides insight into the biofunction and molecular mechanisms, practical tools for research, and a look toward the clinical applications of this exciting phenomenon which is emerging as an effective diagnostic. Primarily focused on the cardiovascular applications where there have been the greatest advancements toward the clinic, this is the first compendium for clinical and biomedical researchers who are interested in integrating MSC-derived exosomes as a diagnostic and therapeutic tool. - Introduces the MSC-exosome mediated cell-cell communication - Covers the major functional benefits in current MSC-derived exosome studies - Discusses strategies for the use of MSC-derived exosomes in cardiovascular therapies |
| crohn's stem cell therapy: Advances in Inflammatory Bowel Diseases P. Rutgeerts, J-F. Colombel, S.B. Hanauer, J. Schölmerich, Guido Tytgat, A. van Gossum, 1998-12-31 Ulcerative colitis and Crohn's disease remain a great therapeutic challenge to the medical community. In recent years knowledge about the pathogenesis of these diseases has progressed rapidly but the cause of the diseases remains completely unknown. It has become clear that dysregulation of the mucosal immune system is the basis for the chronic evolution of the diseases in a genetically susceptible population. Exciting new therapeutic approaches have been attempted in the last couple of years and cytokine and anti-cytokine treatments in particular seem very promising, especially in intractable disease. The format of the Falk Symposium 106 on `Advances in Inflammatory Bowel Diseases', held in Brussels, Belgium, June 18-20, 1998, was somewhat innovative as each session attempted to link the new insights into pathogenetic mechanisms with new therapeutic approaches, resulting in optimal information transfer. The classic therapeutic schemes were updated with a special focus on step-wise build-up of therapy. |
| crohn's stem cell therapy: Stem Cell Therapy for Organ Failure Indumathi Somasundaram, 2015-01-02 The book “STEM CELL THERAPY FOR ORGAN FAILURES” edited by Dr. S. Indumathi demonstrates the In Vitro and In vivo therapeutic strategies and applications of pre- and post-natal stem cells for treating the failures of various organ systems of our body in a wide perspective. It explores the past, present and the futuristic approach of the exciting field of stem cells and its intriguing properties involved in tissue repair and regeneration. The prime focus of this volume is to unravel the basic, advanced, therapeutic and translational approaches put-forth so far in the field of stem cells and regenerative medicine at research, pre-clinical and clinical levels. Stem cells has ushered in widespread interest and exciting possibilities for cell based therapies, albeit failures do prevail and small uncontrolled phase I/II studies are only signals generating, rather than definite proof of concept thereby limiting its applicability in curative therapeutics. Despite certain initiatives and meticulous untiring efforts, bringing this basic bench side research into advanced transitional bedside remained a challenge. Thus, this book embarked upon the expanding researches in these areas that seem decisive in improvising regenerative medical therapeutics, thereby leading to further path-breaking studies that cure all health challenges facing mankind. Overall, this book reveals the imperativeness of various stem cell sources and its utility in curative therapeutics. |
| crohn's stem cell therapy: Anal Fistula Herand Abcarian, 2013-11-26 Anal Fistula: Principles and Management provides a comprehensive and state of the art review of major issues specific and related to the treatment of anal fistulas. An important section of the book covers the large number of alternative procedures which have been developed in the last two decades. Needless to say, none of these procedures have been uniformly successful, otherwise there would be no need for all the different operations. The book addresses each alternative procedure, discusses the benefits of each procedure, includes the most up-to-date results. Other important chapters cover the causes and failure of treatment and operations for fistulas. Also included is a Cochrane Review of all available randomized controlled trials with levels of evidence culled from the literature. Written by specialists in their respective fields, Anal Fistula: Principles and Management fills a void in available texts on a subject matter very commonly encountered by surgeons, physicians and specialists. |
| crohn's stem cell therapy: Therapeutic Advances in Inflammatory Bowel Disease: Current Therapies and Future Directions Giulia Roda, Marjorie Argollo, 2023-10-23 Inflammatory bowel diseases (IBD), are chronic and progressive diseases. Long-term complications are demolition surgery and colon-rectal cancer (CRC). A treat-to-target approach aims to modify the natural course of these diseases. Targets are pre-defined therapeutic goals demonstrated to prevent end-organ disfunction and disability in the long-term period. According to the Selecting Therapeutic Targets in Inflammatory Bowel Disease (STRIDE) indications, mucosal healing (MH) and clinical remission are the main targets in IBDs. Recently, the concept of remission and evidence on new targets included histological remission and transmural healing as future new targets. It remains controversial whether achieving these targets is associated with significantly better long-term disease outcomes. In this Research Topic, we aim to systematically review current evidence and future perspectives on therapeutic targets in IBD including mucosal and transmural healing. |
| crohn's stem cell therapy: Stem Cell Revolution Joseph Christiano, 2018 The Answer to Your Health Problems IS NOT WHAT YOU EXPECT What is adult stem cell therapy? Are there different adult stem cell treatment options? What type of conditions does adult stem cell therapy treat? What is the success rate? How much does it cost? Are there any risks or side effects? What's so great about adult stem cell therapy? Joseph Dr. Joe Christiano clears away the confusion surrounding this groundbreaking new treatment. Discover how stem cell activators target adult stem cells to reverse twenty-six conditions that may be adversely affecting your health. IT'S TIME TO JOIN THE REVOLUTION! |
| crohn's stem cell therapy: Ideal Plate Composition Wilma Kirsten, 2019-03-28 At the heart of this book is the simple message that food is a powerful ally and best friend in our search for wellbeing. Food can be the tool that transforms people's lives, not just in the moment, but forever. For each person, and for their counterpart at home, turning to this book in a desperate search for clarity on a subject so overwhelmed by half-baked and sensational 'advice', there is a simple health strategy based on nothing other than food. Real, appetising, nutritious, easily accessible food. Whatever your issue - digestive problems, hormonal imbalances, weight concerns - or even if there is no issue, this book offers a unique opportunity for you to take charge of your health and to invest in a way of eating that will change your life for the better. Now and forever. |
| crohn's stem cell therapy: Cell Biology and Translational Medicine, Volume 17 Kursad Turksen, 2022-11-01 Much research has focused on the basic cellular and molecular biological aspects of stem cells. Much of this research has been fueled by their potential for use in regenerative medicine applications, which has in turn spurred growing numbers of translational and clinical studies. However, more work is needed if the potential is to be realized for improvement of the lives and well-being of patients with numerous diseases and conditions. This book series 'Cell Biology and Translational Medicine (CBTMED)' as part of Springer Nature’s longstanding and very successful Advances in Experimental Medicine and Biology book series, has the goal to accelerate advances by timely information exchange. Emerging areas of regenerative medicine and translational aspects of stem cells are covered in each volume. Outstanding researchers are recruited to highlight developments and remaining challenges in both the basic research and clinical arenas. This current book is the 17th volume of a continuing series. |
Stem Cell Therapeutics for Crohn’s Disease - nhsjs.com
Stem cell studies and clinical trials have proven the potential to modulate immunity and achieve efficacy in treating CD. This review provides an overview of the regenerative capabilities of stem …
Efficacy and safety of stem cell therapy for Crohn’s disease: a …
Accumulating evidence derived from preclinical studies and pilot clinical trials has demonstrated the potential of stem cell therapy (SCT) to impede intestinal inflamma-tion, foster sustained healing …
Stem cells in treatment of crohn's disease: Recent advances
Results and conclusion: Nowadays, stem cell therapy is widely implied in treating CD. Although mesenchymal and adipose-derived tissue stem cells proved to be safe in treating Crohn's …
Advancing Crohn's Disease Treatment: The Potential of Stem …
Crohn's disease, stem cell therapy aims to harness these capabilities to mitigate inflammation, repair damaged intestinal tissue, and restore normal gastrointestinal function.
Fifteen Cell Therapies/Stem Cell Therapies in Phase III
GlaxoSmithKline’s 2696273, although listed as a stem cell therapy, uses an ADA gene transfer into hematopoietic stem/progenitor cells for the treatment of Adenosine Deaminase Severe …
New study on promising stem cell-based therapy for Crohn's …
To study the therapeutic effects and mechanism of action of mesenchymal stem cells (MSC), the researchers used a mouse model known as SAMP-1/YitFc (SAMP). SAMP represents a model of …
Role of mesenchymal stem cell therapy in Crohn’s disease
In this review, we will discuss the results of clinical trials using a novel treatment in the form of Mscs for treatment of cD and related complications. success of these phase I, II, and III...
Reparative immunological consequences of stem cell …
Autologous haematopoietic stem cell transplantation (SCT) is an emerging therapy for medically refractory CD though the mechanisms through which it circumvents refractory pathophysiology …
hUC-MSCs therapy for Crohn's disease: efficacy in TNBS …
Our objective was to determine the safety and ef cacy of a fi new mode of HUC-MSCs therapy in patients with refractory CD and explore the rationale and possible mechanism.
Long-term Efficacy and Safety of Stem Cell Therapy
We performed a randomized placebo-controlled trial to determine the long-term ef cacy and safety. of a single local administration of allogeneic expanded adipose-derived stem cells (Cx601) in …
Guide to Stem Cell and Exosome Therapy for for Inflammatory …
In this guide, we’ll go through the basics of how stem cells and exosomes work for IBD relief, the latest research, and what to expect regenerative procedure. Conventional treatments for …
Stem cell therapy feasible, safe and beneficial for fistulizing …
Local injection of mesenchymal stromal cells (MSCs) has potential as a therapy for refractory fistulizing Crohn’s disease, offering hope to patients who have this notoriously difficult to...
Efficacy of stem cells therapy for Crohn’s fistula: a meta …
Background: Fistulas have puzzled us all the time and stem cell therapy for it is still in its infancy. We conducted a meta-analysis and systematic review to evaluate the efficacy of stem cells and …
Editorial: Mesenchymal stem cell therapy for perianal fistulizing …
Bacsur and colleagues reported on the effectiveness and safety of locally injected allogenic, adipose- derived mesenchymal stem cells (MSC) (Darvadstrocel) for treatment of complex PFCD …
Umbilical Cord Mesenchymal Stem Cell Treatment for Crohn’s …
In recent years, stem cell transplantation has emerged as a promising treatment, which is characterized by regulating im- munity, repairing injury, and controlling inflammation.
Stem cell therapy for Crohn’s disease: systematic review and …
In recent years, developments in stem cell (SC) biol- ogy and regenerative medicine have revealed that SCs unexpectedly can be used to treat autoimmune diseases.
Autologous stem-cell transplantation in treatment-refractory …
We now assess HSCT in patients enrolled in the ASTIC trial using endpoints that are traditional for clinical trials in Crohn’s disease, and identify factors that predict benefit or harm.
Long-Term Results of Adipose-Derived Stem Cell Therapy for …
Long-Term Results of Adipose-Derived Stem Cell Therapy for the Treatment of Crohn's Fistula
Early research finds hope in stem cell therapy for perianal …
"Our hope with this research is to advance a cell-based therapy toward daily clinical care that would be easy to implant in the operating room and offer a new option for patients with unmet...
Systematic review with meta-analysis: the efficacy and safety …
Stem cell therapy (SCT) for the treatment of Crohn’s disease (CD) is still in its infancy, and whether SCT is associated with improved outcomes is unclear. We performed a meta-analysis to evaluate …
Systematic review with meta-analysis: the efficacy and safety …
Background and aims: Stem cell therapy (SCT) for the treatment of Crohn s disease (CD) is still in its infancy, and whether SCT is associated with improved outcomes is unclear. We performed …
Hematopoietic stem cell transplantation and Crohn’s disease …
stem cell transplantation and cell therapy in this disease. Keywords – Crohn’s disease; inflammatory bowel diseases; stem cell transplantation; hematopoietic stem cell …
Umbilical Cord Mesenchymal Stem Cell Treatment for …
Background/Aims: Stem cell therapy has been applied to treat a variety of autoimmune diseases, including Crohn’s disease (CD), but few studies have examined the use of umbilical cord …
Autologous stem cell transplantation in refractory Crohn’s …
Keywords: Crohn s disease, Autologous stem cell transplant, Randomised controlled trial, Observational study Background Intestinal inflammation in Crohn s disease (CD) is caused
Autologous adipose-derived stem cells for the treatment of …
Keywords: Autologous adipose-derived stem cells, Stem cell transplantation, Crohn’s fistula-in-ano, Efficacy, Safety Introduction Crohn’s disease is a lifelong chronic nonspecific intestinal …
Mesenchymal Stem Cell Therapy Awareness, Knowledge, and …
Mesenchymal Stem Cell Therapy Awareness, Knowledge, and Use for the Treatment of Fistulizing Crohn’s Disease: An International Survey Among Gastroenterologists and …
Mesenchymal stem cell therapy for therapy refractory …
Conclusion MST is a promising treatment strategy for therapy refractory Crohn’s perianal fistulas, resulting in >40% radiological remission, clinical closure in 70% and a significant improvement …
Immune Reconstitution After Autologous Hematopoietic …
Hematopoietic Stem Cell Transplantation in Crohn’s Disease: Current Status and Future Directions. ... Therapy Evaluation trial, which is designed to test the hypothesis that auto …
Stem Cells and Stem Cell-Derived Factors for the Treatment …
Mesenchymal stem cell therapy has proven safe and eective in perianal stulizing Crohn’s disease. Mesenchymal stem cell and/or Treg therapy may be eective for luminal disease. 1 Introduction …
Stem cell therapy: light in the tunnel for penetrating Crohn’s …
On the other hand, stem cell therapy has been a developing interest in the treatment of CD-related fistulas. Many trials have revealed promising results using topical stromal cell and stem …
hUC-MSCs therapy for Crohn's disease: efficacy in TNBS …
eShanghai Institute of Stem Cell Research and Clinical Translation, Shanghai 200120, China Summary Background The use of mesenchymal stem cells (MSCs) has recently emerged as a …
Diseases of the Colon & Rectum Publish Ahead of Print DOI: …
Mesenchymal stem cells (MSCs), which have now demonstrated safety and efficacy for perianal Crohn’s disease across several phase I,1–5 phase II,4,6,7 8and phase III clinical trials, act as …
Successful Anti-TNF-Alpha Therapy for Crohn’s Disease
Tohoku J. Exp. Med., 2020, 251, 81-85 Anti-TNF-Alpha Therapy for Crohn’s Disease 1 81 Received April 9, 2020; revised and accepted May 20, 2020. ... received salvage therapy …
Allogenic stem cells for Crohn's anal fistulas: Treating early …
of Crohn's disease <3 years was significantly associated with deep remission (OD 4.5 [1.0–19.1], p = 0.04). Conclusion: Darvadstrocel injection resulted in a clinical response for two thirds of …
Cellular immunotherapies and immune cell depleting …
Figure 2 New approaches for therapy: schematic of CAR-T cell therapy from cell generation to application is shown (left side). Furthermore, the mode of action of T regulatory cells (Treg) …
Short-Term Clinical Response and Changes in the Fecal …
with Crohn’s Disease After Stem Cell Infusions Fan Yang, Xiaofang Zheng, Weicheng Liang, Beibei Ni, Jianxi Lu, Qiuli Liu, Ruixuan Xu, Yizhan He, Mary Miu Yee Waye, Qi Zhang, Yufeng …
Biotech Daily
“Stem cell therapy is a cornerstone of modern medicine,” the company says. “Stem cells have the unique ability to develop into different cell types in the body and are often hailed as the body’s …
Genetic engineering meets hematopoietic stem cell biology …
Review Genetic engineering meets hematopoietic stem cell biology for next-generation gene therapy Samuele Ferrari, 1Erika Valeri, Anastasia Conti, 1Serena Scala, Annamaria Aprile, …
Autologous Adipose Tissue-Derived Stem Cells Treatment …
topoietic stem cells [16–18], autologous or allogenic adipose tissue-derived stem cells (ASCs) [14, 19-23] have been stud-ied for management of Crohn’s disease and other disorders. Of …
Technologies involved in Cell Therapy for Perianal Fistulas
Technologies involved in Cell Therapy for Perianal Fistulas Stem Cell Harvesting Seed and Selection Liposuction isolation Bone-Marrow harvesting Cryopreservation Cell Implant Cell …
Stem cell therapy for Crohn’s disease: systematic review and …
Stem cell therapy for Crohn’s disease: systematic review and meta-analysis of preclinical and clinical studies Ruo Wang 1,2, Qigu Yao 1,2, Wenyi Chen 1,2, Feiqiong Gao1,2, Pan Li1,2, …
Editorial: Mesenchymal Stem Cell Therapy for Perianal …
Editorial: Mesenchymal Stem Cell Therapy for Perianal Fistulising Crohn's Disease—Effective or Hype? Authors' Reply Péter Bacsur1,2 ... mesenchymal stem cell treatment for fistulising …
Stem Cell Therapy for Liver Failure, Cirrhosis and Hepatitis
• Crohn’s Disease • Degenerative Disc Disease • Diabetes • Erectile Dysfunction • Failed Back Surgery • Fibromyalgia • Heart Failure ... life changing stem cell therapy. R3 Stem Cell …
Chapter 18 Stem Cell Transplantation for Crohn’s Disease
been pointed out in the perspective. All in all, stem cell transplantation might be a revolution treatment for the IBD patients, but needs more confirmative, in-depth, and long-term studies …
Mesenchymal stem cell therapy for Crohn's perianal …
Crohn's disease, mesenchymal stem cell therapy, perianal fistula. WHITE ET AL. | 103 remain unsatisfactory, and treatment is often inadequate because of ... [ 2]. Medical therapies, mostly …
ADVANCES IN IBD - gastroenterologyandhepatology.net
stem cell therapy compared with placebo. Healing rates were greater than 50% with stem cell therapy compared with approximately 33% in the placebo group. Healing is thought to be …
Management of Crohn s Disease: Advances in Mesenchymal …
Cite this article: Ali A, Kumar S, Sayyed Z, Shakuntulla NFN, Khetpal R, et al. (2018) Management of Crohn’s Disease: Advances in Mesenchymal Stromal Cell Therapy. JSM …
Heliyon - Cell Press
Recent studies of large patient cohorts have shown Crohn’s Disease (CD) to associated with polygenic mutations involving im- ... [6–9]. Two case series of patients with leukemia and CD …
Editorial: Mesenchymal stem cell therapy for perianal …
mesenchymal stem cell treatment for fistulising Crohn's disease. We analysed 223 patients in an international, multicentre set-ting, who underwent darvadstrocel treatment [ 1, 2]. They clearly …
Crohn's disease: Cell transplant stems IBD - Nature
autologous stem cell transplantation (SCT) can induce remission in patients with refractory Crohn’s disease, according to ... predictor of favourable outcome in Crohn’s disease therapy.” ...
Stem cell therapy for Crohn’s disease: systematic review and …
Stem cell therapy for Crohn’s disease: systematic review and meta-analysis of preclinical and clinical studies Ruo Wang 1,2, Qigu Yao 1,2, Wenyi Chen 1,2, Feiqiong Gao1,2, Pan Li1,2, …
Mesenchymal stromal cells: Putative microenvironmental …
microenvironmental modulators become cell therapy Mauro Krampera1 ,*and Katarina Le Blanc2 3 ... treatment of graft-versus-host and Crohn’s fistular diseases, but not in the United States …
Systematic review with meta-analysis: the efficacy and safety …
Keywords: Crohn’s disease, Stem cells, Meta-analysis, Efficacy, Adverse effects Background Crohn's disease (CD) is a chronic relapsing inflammatory condition of the gastrointestinal tract …
STUDY PROTOCOL Open Access Autologous stem cell
Autologous stem cell transplantation in refractory Crohn’s disease – low intensity therapy evaluation (ASTIClite): study protocols for a multicentre, randomised
TMEM219 signaling promotes intestinal stem cell death and …
Crohn’s disease (CD, marginal and inflamed areas), responders in remission phase, nonresponders, or controls (n = 6–10/group). (C). Transcriptome profile delineating the stem …
Received: 2015.11.02 Human Embryonic Stem Cell Therapy …
efficacy of human embryonic stem cell therapy in a patient with Crohn’s disease. Case Report: A 21-year-old male with chief complaints of intolerance to specific foods, abdominal pain, and ...
Stem cells for Crohn's disease: New perspectives for …
1. García-Olmo D, García-Arranz M, García LG, et al. Autologous stem cell trans-plantation for treatment of rectovaginal fistula in perianal Crohn’s disease: a new cell-based therapy. Int J …
Autologous stem-cell transplantation in treatment-refractory …
stem-cell transplantation (HSCT) compared with mobilisation followed by conventional therapy using a stringent primary endpoint (steroid-free clinical remission for 3 months with no …
Original Article Metabolic pathways in anal fistula: paving the …
Stem cell therapy has emerged as a novel treat - ment modality for complex anal fistulas, partic-ularly those associated with Crohn’s disease. Adipose-derived stem cells have demonstrated …
Human umbilical cord-derived mesenchymal stem cells …
Yang et al. Stem Cell Research & Therapy Page 2 of 14 Introduction Crohn’s disease (CD) is a subtype of inammatory bowel disease (IBD) characterized by chronic recur-rent colonic …
Evaluation of the Effectiveness and Safety of Mesenchymal …
Keywords: Crohn's disease | darvadstrocel | mesenchymal stem cell treatment | perianal disease ABSTRACT Background: Perianal fistulas of Crohn's disease (CD) create a significant burden …
The reparative immunologic consequences of stem cell …
Feb 17, 2025 · Autologous hematopoietic stem cell transplantation (SCT) is an emerging therapy for medically-refractory CD though the mechanisms through which it ... therapy for refractory …
Mesenchymal Stem Cell Therapy Awareness, Knowledge, and …
Crohn’s Disease: An International Survey Among Gastroenterologists and Colorectal Surgeons Paul Williams. Catherine Klersy. Chitra Karki. Dimitri Bennett. ... Mesenchymal Stem Cell …
Stem Cell Injection for Complex Refractory Perianal Fistulas in …
Colombo et al. Stem Cells for Perianal Crohn’s Disease FIGURE 1 | Surgical procedure. Panel (A) shows the fistula’s internal orifice closure with a 2/0 absorbable stitch. Panel (B) shows the …
Stem Cell Transplantation: Non-Cancer Disorders - Cigna
Cell-Based Therapy for Cardiac and Peripheral . Donor Lymphocyte Infusion and Hematopoietic Progenitor Cell (HPC) Boost ... • Crohn’s disease • cryptogenic cirrhosis • dermatomyositis ...
REVIEW Open Access Stem cell therapy for Crohn s disease: …
Stem cell therapy for Crohn s disease: systematic review and meta-analysis of preclinical and clinical studies Ruo Wang 1,2, Qigu Yao 1,2, Wenyi Chen 1,2, Feiqiong Gao 1,2, Pan Li 1,2, …
Safety and efficacy of autologous haematopoietic stem-cell ...
Crohn’s disease frequently recurs despite postoperative medication. Surgery for refractory colonic Crohn’s disease or complications at critical parts of the bowel can Haematopoietic stemcell …
Autologous stem cell transplantation for treatment of …
source of stem cells. Results: Al-though Crohn’s disease is the worst condition for a surgical approach in ... in perianal Crohn’s disease: a new cell-based therapy Introduction
Umbilical cord mesenchymal stem cells in ulcerative colitis
ity of stem cell therapy and the potential tumorigenicity of MSCs. Adipose-derived stem cells (Cx-601) have been reported to effectively induce and maintain fistula clo-sure in patients with …
Chapter 18 Stem Cell Transplantation for Crohn’s Disease
been pointed out in the perspective. All in all, stem cell transplantation might be a revolution treatment for the IBD patients, but needs more confirmative, in-depth, and long-term studies …
