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  current biology impact factor: Current Protocols in Molecular Biology ,
  current biology impact factor: Hot Topics in Cell Biology José Becerra, Leonor Santos-Ruiz, 2012 Summary This book is a definitive overview of the current 'state of the art' in cell biology. It is based on papers presented by leading researchers at the Spanish Society for Cell Biology's XIV Congress - a Congress that strives to achieve scientific excellence. Each participant was asked to prepare a 'mini review' of current and likely future development in their area of research. This book is based on those reviews. As such, it is therefore an analysis of current and future trends. Key Features Contains contributions from some of the world's leading researchers. The book is multidisciplinary, covering almost all topics in cell biology: from basic to applied cell biology, and a wide variety of models: from in vitro to vivo models, ranging from fish to rodents and humans. Each 'mini review' is an easy-read piece, describing the state of the art on a topic with clear language and in a summary format. The mini review format makes the book attractive not only to readers involved in cell biology research and teaching, but also professionals from other disciplines and students. The book takes a truly multidisciplinary approach; it covers a wide array of topics, and the book reflects how cell biology interacts with other disciplines The Editors Jose Becerra is Professor of Cell Biology at the University of Málaga (Spain) since 1989. He has been Dean Secretary, Vice-Dean and Dean of the Faculty of Sciences of Málaga, and is now the Head of the Department of Cell Biology, Genetics and Physiology. From 2001 to 2003 he was the Director of the Andalusian Laboratory of Biology (LAB, Seville), which was converted in the Andalusian Centre for Developmental Biology (CABD) under his term. He is a member of the Technical Committee of the National Stem Cell Bank since 2007, patron of the Board of Trustees of IMABIS Foundation (Mediterranean Institute for the Advance of Biotechnology and Health Research), coordinator of the Biomaterials and Tissue Engineering Area of the the Biomedical Research Networking Center in Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), and member of the Direction Committee of the CIBER-BBN. Leonor Santos-Ruiz is Senior Researcher of the CIBER-BBN network at the Andalusian Center for Nanomedicine and Biotechnology (BIONAND). She started her career studying the cellular and molecular basis of lower vertebrates' amazing ability for tissue regeneration, with a special attention to bone and spinal cord repair. Readership Cell biology academics and researchers Contents Introduction Dynamics of cell compartments The intracellular trafficking Cell signaling Autophagy, apoptosis and cell homeostasis Cell biology of aging Plant cell biology Methods in cell biology Applied cell biology Cell biology of cancer Cell therapies and tissue engineering Neurodegeneration and cell biology Nanotechnology and cell biology: challenges and opportunities
  current biology impact factor: Invertebrate Neurobiology Geoffrey North, Ralph J. Greenspan, 2007 Emphasises on evolutionary aspects of neurobiology in model and non-model invertebrates. This work includes chapters on eye evolution, higher cognitive functions in insects, circadian rhythms and sleep, and more. Its covers techniques that allow manipulation of activity in specified neurons and investigation of behavior.
  current biology impact factor: Not in Our Genes Richard Lewontin, Steven Rose, Leon J. Kamin, 2017 Three eminent scientists analyze the scientific, social, and political roots of biological determinism.
  current biology impact factor: Biological Invasions Wolfgang Nentwig, 2007-02-13 This new volume on Biological Invasions deals with both plants and animals, differing from previous books by extending from the level of individual species to an ecosystem and global level. Topics of highest societal relevance, such as the impact of genetically modified organisms, are interlinked with more conventional ecological aspects, including biodiversity. The combination of these approaches is new and makes compelling reading for researchers and environmentalists.
  current biology impact factor: Current Protocols Essential Laboratory Techniques Sean R. Gallagher, Emily A. Wiley, 2012-03-19 The latest title from the acclaimed Current Protocols series, Current Protocols Essential Laboratory Techniques, 2e provides the new researcher with the skills and understanding of the fundamental laboratory procedures necessary to run successful experiments, solve problems, and become a productive member of the modern life science laboratory. From covering the basic skills such as measurement, preparation of reagents and use of basic instrumentation to the more advanced techniques such as blotting, chromatography and real-time PCR, this book will serve as a practical reference manual for any life science researcher. Written by a combination of distinguished investigators and outstanding faculty, Current Protocols Essential Laboratory Techniques, 2e is the cornerstone on which the beginning scientist can develop the skills for a successful research career.
  current biology impact factor: Current Protocols in Bioinformatics Andreas D. Baxevanis, 2003 Current Protocols in Bioinformatics is the only publication that responds to the need for both a current and updateable source of bioinformatics methodology. This unique publication assures that you have access to a full range of bioinformatics protocols written by globally-recognized experts in the field, and that these proto-cols are updated and revised as new developments and innovations occur.
  current biology impact factor: Current Protocols in Stem Cell Biology ,
  current biology impact factor: Current Protocols in Chemical Biology Adam P. Arkin, 2009-09-22
  current biology impact factor: International Review of Cell and Molecular Biology Kwang W. Jeon, 2014-11-18 International Review of Cell and Molecular Biology presents comprehensive reviews and current advances in cell and molecular biology. Articles address structure and control of gene expression, nucleocytoplasmic interactions, control of cell development and differentiation, and cell transformation and growth. The series has a world-wide readership, maintaining a high standard by publishing invited articles on important and timely topics authored by prominent cell and molecular biologists. - Authored by some of the foremost scientists in the field - Provides comprehensive reviews and current advances - Wide range of perspectives on specific subjects - Valuable reference material for advanced undergraduates, graduate students and professional scientists
  current biology impact factor: Membrane Trafficking Ales Vancura, 2008-08-28 As membrane trafficking research has expanded over the past thirty years, a remarkable convergence of information has been gained by using genetic approaches in yeast cells with biochemical approaches in mammalian cells. This book reflects these advances by devoting one section of the book to yeast cells and the other to mammalian cells, with each section providing both classic and cutting-edge techniques to study macromolecular transport across the membranes.
  current biology impact factor: Progress in Molecular Biology and Translational Science David B. Teplow, 2018-10-16 Progress in Molecular Biology and Translational Science, Volume 159, provides the most topical, informative and exciting monographs available on a wide variety of research topics related to prions, viruses, bacteria and eukaryotes. The series includes in-depth knowledge on molecular biological aspects of organismal physiology, along with insights on how this knowledge may be applied to understand and ameliorate human disease. New chapters in this release discuss timely topics, such as Targeting recently deorphanized GPR83 for the treatment of infection, stress, and drug addiction, Arrestin Structure-Function, Arrestins in the Cardiovascular System, Analysis of biased agonism, and more. - Includes comprehensive coverage of molecular biology - Presents ample use of tables, diagrams, schemata, and color figures to enhance the reader's ability to rapidly grasp the information provided - Contains contributions from renowned experts in the field
  current biology impact factor: The Fourth Industrial Revolution Klaus Schwab, 2017-01-03 World-renowned economist Klaus Schwab, Founder and Executive Chairman of the World Economic Forum, explains that we have an opportunity to shape the fourth industrial revolu­tion, which will fundamentally alter how we live and work. Schwab argues that this revolution is different in scale, scope and complexity from any that have come before. Characterized by a range of new technologies that are fusing the physical, digital and biological worlds, the developments are affecting all disciplines, economies, industries and governments, and even challenging ideas about what it means to be human. Artificial intelligence is already all around us, from supercomputers, drones and virtual assistants to 3D printing, DNA sequencing, smart thermostats, wear­able sensors and microchips smaller than a grain of sand. But this is just the beginning: nanomaterials 200 times stronger than steel and a million times thinner than a strand of hair and the first transplant of a 3D printed liver are already in development. Imagine “smart factories” in which global systems of manu­facturing are coordinated virtually, or implantable mobile phones made of biosynthetic materials. The fourth industrial revolution, says Schwab, is more significant, and its ramifications more profound, than in any prior period of human history. He outlines the key technologies driving this revolution and discusses the major impacts expected on government, business, civil society and individu­als. Schwab also offers bold ideas on how to harness these changes and shape a better future—one in which technology empowers people rather than replaces them; progress serves society rather than disrupts it; and in which innovators respect moral and ethical boundaries rather than cross them. We all have the opportunity to contribute to developing new frame­works that advance progress.
  current biology impact factor: Molecular Biology of the Cell , 2002
  current biology impact factor: Our Society Journal , 1885
  current biology impact factor: Curing Genetic Diseases through Genome Reprogramming , 2021-06-24 Curing Genetic Diseases through Genome Reprogramming, Volume 182 captures an historic moment in the field of gene therapy—the dawn of a new age in which the dream of curing genetic diseases has become realizable. The volume presents the most clinically advanced gene therapy and genome editing approaches for the treatment of genetic diseases in specific organs, including difficult therapeutic targets, futuristic ideas of genetic interventions, and large scale human genome repair. An initial chapter addresses the complex ethical aspects involved in the very idea of modifying the human genome. - Provides a comprehensive view of gene therapy and genome editing technologies, including epigenetic editing - Describes the state-of-the-art and future directions for the treatment of genetic diseases, also considering economical aspects - Presents chapters that each give a thorough review of a specific disease, target organ or visionary approach, including ethical considerations
  current biology impact factor: Current Protocols in Immunology John E. Coligan, 1991 Current Protocols in Immunology is a three-volume looseleaf manual that provides comprehensive coverage of immunological methods from classic to the most cutting edge, including antibody detection and preparation, assays for functional activities of mouse and human cells involved in immune responses, assays for cytokines and their receptors, isolation and analysis of proteins and peptides, biochemistry of cell activation, molecular immunology, and animal models of autoimmune and inflammatory diseases. Carefully edited, step-by-step protocols replete with material lists, expert commentaries, and safety and troubleshooting tips ensure that you can duplicate the experimental results in your own laboratory. Bimonthly updates, which are filed into the looseleaf, keep the set current with the latest developments in immunology methods. The initial purchase includes one year of updates and then subscribers may renew their annual subscriptions. Current Protocols publishes a family of laboratory manuals for bioscientists, including Molecular Biology, Human Genetics, Protein Science, Cytometry, Cell Biology, Neuroscience, Pharmacology, and Toxicology.
  current biology impact factor: Emerging Model Systems in Developmental Biology , 2022-03-23 An ever-growing roster of model organisms is a hallmark of 21st century Developmental Biology. Emerging model organisms are well suited to asking some fascinating and important questions that cannot be addressed using established model systems. And new methods are increasingly facilitating the adoption of new research organisms in laboratories. This volume is written by some of the scientists who have played pivotal roles in developing new models or in significantly advancing tools in emerging systems. - Presents some of the most interesting additions to the core set of model organisms - Contains contributions from people who have developed new model systems or advanced tools - Includes personal stories about how and why model systems were developed
  current biology impact factor: Opportunities in Biology National Research Council, Division on Earth and Life Studies, Commission on Life Sciences, Board on Biology, Committee on Research Opportunities in Biology, 1989-01-01 Biology has entered an era in which interdisciplinary cooperation is at an all-time high, practical applications follow basic discoveries more quickly than ever before, and new technologiesâ€recombinant DNA, scanning tunneling microscopes, and moreâ€are revolutionizing the way science is conducted. The potential for scientific breakthroughs with significant implications for society has never been greater. Opportunities in Biology reports on the state of the new biology, taking a detailed look at the disciplines of biology; examining the advances made in medicine, agriculture, and other fields; and pointing out promising research opportunities. Authored by an expert panel representing a variety of viewpoints, this volume also offers recommendations on how to meet the infrastructure needsâ€for funding, effective information systems, and other supportâ€of future biology research. Exploring what has been accomplished and what is on the horizon, Opportunities in Biology is an indispensable resource for students, teachers, and researchers in all subdisciplines of biology as well as for research administrators and those in funding agencies.
  current biology impact factor: Current Protocols in Molecular Biology , 1996
  current biology impact factor: Adolescent Development and the Biology of Puberty National Research Council and Institute of Medicine, Division of Behavioral and Social Sciences and Education, Commission on Behavioral and Social Sciences and Education, Forum on Adolescence, 1999-07-20 Adolescence is one of the most fascinating and complex transitions in the human life span. Its breathtaking pace of growth and change is second only to that of infancy. Over the last two decades, the research base in the field of adolescence has had its own growth spurt. New studies have provided fresh insights while theoretical assumptions have changed and matured. This summary of an important 1998 workshop reviews key findings and addresses the most pressing research challenges.
  current biology impact factor: Molecular To Global Photosynthesis Mary D Archer, James Barber, 2004-05-10 Green plants and photosynthetic organisms are the Earth's natural photoconverters of solar energy. In future, biomass and bioenergy will become increasingly significant energy sources, making a contribution both to carbon dioxide abatement and to the security, diversity and sustainability of global energy supplies. In this book, experts provide a series of authoritative chapters on the intricate mechanisms of photosynthesis and the potential for using and improving photosynthetic organisms, plants and trees to sequester carbon dioxide and to provide fuel and useful chemicals for the benefit of man./a
  current biology impact factor: Current Protocols in Protein Science , 1996
  current biology impact factor: Environmental Epigenetics L. Joseph Su, Tung-chin Chiang, 2015-05-18 This book examines the toxicological and health implications of environmental epigenetics and provides knowledge through an interdisciplinary approach. Included in this volume are chapters outlining various environmental risk factors such as phthalates and dietary components, life states such as pregnancy and ageing, hormonal and metabolic considerations and specific disease risks such as cancer cardiovascular diseases and other non-communicable diseases. Environmental Epigenetics imparts integrative knowledge of the science of epigenetics and the issues raised in environmental epidemiology. This book is intended to serve both as a reference compendium on environmental epigenetics for scientists in academia, industry and laboratories and as a textbook for graduate level environmental health courses. Environmental Epigenetics imparts integrative knowledge of the science of epigenetics and the issues raised in environmental epidemiology. This book is intended to serve both as a reference compendium on environmental epigenetics for scientists in academia, industry and laboratories and as a textbook for graduate level environmental health courses.
  current biology impact factor: Stem Cells Christine L. Mummery, Anja van de Stolpe, Bernard Roelen, Hans Clevers, 2014-05-23 The second edition of Stem Cells: Scientific Facts and Fiction provides the non-stem cell expert with an understandable review of the history, current state of affairs, and facts and fiction of the promises of stem cells. Building on success of its award-winning preceding edition, the second edition features new chapters on embryonic and iPS cells and stem cells in veterinary science and medicine. It contains major revisions on cancer stem cells to include new culture models, additional interviews with leaders in progenitor cells, engineered eye tissue, and xeno organs from stem cells, as well as new information on organs on chips and adult progenitor cells. In the past decades our understanding of stem cell biology has increased tremendously. Many types of stem cells have been discovered in tissues that everyone presumed were unable to regenerate in adults, the heart and the brain in particular. There is vast interest in stem cells from biologists and clinicians who see the potential for regenerative medicine and future treatments for chronic diseases like Parkinson's, diabetes, and spinal cord lesions, based on the use of stem cells; and from entrepreneurs in biotechnology who expect new commercial applications ranging from drug discovery to transplantation therapies. - Explains in straightforward, non-specialist language the basic biology of stem cells and their applications in modern medicine and future therapy - Includes extensive coverage of adult and embryonic stem cells both historically and in contemporary practice - Richly illustrated to assist in understanding how research is done and the current hurdles to clinical practice
  current biology impact factor: Chemical Genomics Haian Fu, 2012-02-13 Advances in chemistry, biology and genomics coupled with laboratory automation and computational technologies have led to the rapid emergence of the multidisciplinary field of chemical genomics. This edited text, with contributions from experts in the field, discusses the new techniques and applications that help further the study of chemical genomics. The beginning chapters provide an overview of the basic principles of chemical biology and chemical genomics. This is followed by a technical section that describes the sources of small-molecule chemicals; the basics of high-throughput screening technologies; and various bioassays for biochemical-, cellular- and organism-based screens. The final chapters connect the chemical genomics field with personalized medicine and the druggable genome for future discovery of new therapeutics. This book will be valuable to researchers, professionals and graduate students in many fields, including biology, biomedicine and chemistry.
  current biology impact factor: The Psychology of Fake News Rainer Greifeneder, Mariela Jaffe, Eryn Newman, Norbert Schwarz, 2020-08-13 This volume examines the phenomenon of fake news by bringing together leading experts from different fields within psychology and related areas, and explores what has become a prominent feature of public discourse since the first Brexit referendum and the 2016 US election campaign. Dealing with misinformation is important in many areas of daily life, including politics, the marketplace, health communication, journalism, education, and science. In a general climate where facts and misinformation blur, and are intentionally blurred, this book asks what determines whether people accept and share (mis)information, and what can be done to counter misinformation? All three of these aspects need to be understood in the context of online social networks, which have fundamentally changed the way information is produced, consumed, and transmitted. The contributions within this volume summarize the most up-to-date empirical findings, theories, and applications and discuss cutting-edge ideas and future directions of interventions to counter fake news. Also providing guidance on how to handle misinformation in an age of “alternative facts”, this is a fascinating and vital reading for students and academics in psychology, communication, and political science and for professionals including policy makers and journalists.
  current biology impact factor: Stem Cells Mariusz Z. Ratajczak, 2020-01-02 Since different types of stem cells for therapeutic applications have recently been proposed, this timely volume explores various sources of stem cells for tissue and organ regeneration and discusses their advantages and limitations. Also discussed are pros and cons for using embryonic stem cells, induced pluripotent stem cells, and adult stem cells isolated from postnatal tissues. Different types of adult stem cells for therapeutic applications are also reviewed, including hematopoietic stem cells, epidermal stem cells, endothelial progenitors, neural stem cells, mesenchymal stem cells, and very small embryonic-like stem cells. This book also addresses paracrine effects of stem cells in regenerative medicine that are mediated by extracellular microvesicles and soluble secretome. Finally, potential applications of stem cells in cardiology, gastroenterology, neurology, immunotherapy, and aging are presented. This is an ideal book for students and researchers working in the stem cell research field.
  current biology impact factor: Exploring the Biological Contributions to Human Health Institute of Medicine, Board on Health Sciences Policy, Committee on Understanding the Biology of Sex and Gender Differences, 2001-07-02 It's obvious why only men develop prostate cancer and why only women get ovarian cancer. But it is not obvious why women are more likely to recover language ability after a stroke than men or why women are more apt to develop autoimmune diseases such as lupus. Sex differences in health throughout the lifespan have been documented. Exploring the Biological Contributions to Human Health begins to snap the pieces of the puzzle into place so that this knowledge can be used to improve health for both sexes. From behavior and cognition to metabolism and response to chemicals and infectious organisms, this book explores the health impact of sex (being male or female, according to reproductive organs and chromosomes) and gender (one's sense of self as male or female in society). Exploring the Biological Contributions to Human Health discusses basic biochemical differences in the cells of males and females and health variability between the sexes from conception throughout life. The book identifies key research needs and opportunities and addresses barriers to research. Exploring the Biological Contributions to Human Health will be important to health policy makers, basic, applied, and clinical researchers, educators, providers, and journalists-while being very accessible to interested lay readers.
  current biology impact factor: Loose Ends...false Starts Sydney Brenner, 2019-07-16 Sydney Brenner was born in South Africa and educated at the University of Witwatersrand, Johannesburg (Medicine and Science). He then moved to Oxford and received a D.Phil in 1952, before joining the MRC Unit in the Cavendish Laboratory in Cambridge in 1956. His various accomplishments include serving as the Director of MRC Laboratory of Molecular Biology in Cambridge, founding the Molecular Science Institute in Berkeley, holding the position of Distinguished Professor at the Salk Institute, La Jolla. And during his last years, Sydney Brenner played a key role in shaping research and development in the biomedical sector in Singapore as A*Star Senior Fellow.He was one of the greatest biologists of the 20th century and was awarded the Nobel Prize in 2002 for his pioneering work in the field of molecular biology. He was also known for his boundless curiosity, sharp intellect and courage to speak with clarity and characteristic wit as evident in this delightful book which is a compilation of the columns that he wrote for Current Biology in the late '90s.
  current biology impact factor: Biological & Agricultural Index , 1919
  current biology impact factor: Scientific Frontiers in Developmental Toxicology and Risk Assessment National Research Council, Commission on Life Sciences, Board on Environmental Studies and Toxicology, Committee on Developmental Toxicology, 2000-12-21 Scientific Frontiers in Developmental Toxicology and Risk Assessment reviews advances made during the last 10-15 years in fields such as developmental biology, molecular biology, and genetics. It describes a novel approach for how these advances might be used in combination with existing methodologies to further the understanding of mechanisms of developmental toxicity, to improve the assessment of chemicals for their ability to cause developmental toxicity, and to improve risk assessment for developmental defects. For example, based on the recent advances, even the smallest, simplest laboratory animals such as the fruit fly, roundworm, and zebrafish might be able to serve as developmental toxicological models for human biological systems. Use of such organisms might allow for rapid and inexpensive testing of large numbers of chemicals for their potential to cause developmental toxicity; presently, there are little or no developmental toxicity data available for the majority of natural and manufactured chemicals in use. This new approach to developmental toxicology and risk assessment will require simultaneous research on several fronts by experts from multiple scientific disciplines, including developmental toxicologists, developmental biologists, geneticists, epidemiologists, and biostatisticians.
  current biology impact factor: Working Memory and Education , 2006-05-22 Psychologists have been trying to understand the factors that underpin children's success and failure in different educational domains for many years. One psychological function that has been found to play an important role in educational achievement is 'working memory', the processes involved in the temporary maintenance and manipulation of information. This book provides the reader with an up-to-date review of the research that has identified how working memory relates to academic attainment in: reading, reading comprehension, arithmetic and writing, as well as looking at how children with difficulties relating to hearing impairment and attention deficits differ in terms of their working memory. Other chapters focus on how working memory is called upon in classroom settings, how working memory can be assessed, and approaches to remediation. The opening chapter of the book provides an account of working memory from the architect of the model that has dominated psychological theory for over two decades. This book is a valuable resource for psychologists, educationalists, and anyone seeking to understand more about the cognitive basis of educational achievement in children.* It brings together in one volume information that would normally be found in different sources* It brings together two disciplines that are highly relevant to one another (psychology and education) but not often linked directly* Provides psychologists with a perspective on educational practice* Provides educationalists with a well-established psychological framework for viewing educational phenomena* It provides information about up-to-date research techniques* It provides suggestions on how psychological theory can be translated into practice in educational settings
  current biology impact factor: Current Protocols in Mouse Biology Online Johan Auwerx, 2011-03-24
  current biology impact factor: Intelligence, Genes, and Success Bernie Devlin, Stephen E. Fienberg, Daniel P. Resnick, Kathryn Roeder, 1997-08-07 A scientific response to the best-selling The Bell Curve which set off a hailstorm of controversy upon its publication in 1994. Much of the public reaction to the book was polemic and failed to analyse the details of the science and validity of the statistical arguments underlying the books conclusion. Here, at last, social scientists and statisticians reply to The Bell Curve and its conclusions about IQ, genetics and social outcomes.
  current biology impact factor: The Promise of Adolescence National Academies of Sciences, Engineering, and Medicine, Health and Medicine Division, Division of Behavioral and Social Sciences and Education, Board on Children, Youth, and Families, Committee on the Neurobiological and Socio-behavioral Science of Adolescent Development and Its Applications, 2019-07-26 Adolescenceâ€beginning with the onset of puberty and ending in the mid-20sâ€is a critical period of development during which key areas of the brain mature and develop. These changes in brain structure, function, and connectivity mark adolescence as a period of opportunity to discover new vistas, to form relationships with peers and adults, and to explore one's developing identity. It is also a period of resilience that can ameliorate childhood setbacks and set the stage for a thriving trajectory over the life course. Because adolescents comprise nearly one-fourth of the entire U.S. population, the nation needs policies and practices that will better leverage these developmental opportunities to harness the promise of adolescenceâ€rather than focusing myopically on containing its risks. This report examines the neurobiological and socio-behavioral science of adolescent development and outlines how this knowledge can be applied, both to promote adolescent well-being, resilience, and development, and to rectify structural barriers and inequalities in opportunity, enabling all adolescents to flourish.
  current biology impact factor: Molecular Mechanisms of Neural Development and Insights into Disease , 2021-03-09 Neural Development and Disease, Volume 142 in the Current Topics in Developmental Biology series highlights new advances in the field, with this new volume presenting interesting chapters by one or more members of an international board of authors. Sections in this new release cover The role of primary cilia in neural development and disease, Mechanisms of axon guidance receptor regulation and signaling, Synaptic recognition molecules in development and disease, The regulation of cortical neurogenesis, Axon guidance in the developing spinal cord, The role of astrocytes in synapse formation and maturation, Development of motor circuits, Molecular mechanisms that mediate dendrite morphogenesis, and more. - Provides the authority and expertise of leading contributors from an international board of authors - Presents the latest release in the Current Topics in Developmental Biology series
  current biology impact factor: Current Protocols in Nucleic Acid Chemistry Serge L. Beaucage, 2000 Good methods must be reliable, well-tested, and honed to minimize the time and expense required to achieve the desired results. CPNC provides a continuously growing and evolving set of protocols that allows researchers to benefit from the experience of other researchers around the world. The core manual provides a comprehensive set of protocols that have been compiled, revised, and streamlined over the last 6 years. Quarterly updates provide new protocols in emerging areas of research as well as continued advances and new applications for fundamental methods. The book is designed to grow and change with the field of nucleic acid chemistry. Fundamental nucleoside chemistry methods include sugar-base condensation, phosphorylation, and nucleoside protection. Methods for oligonucleotide synthesis include H-phosphonate and phosphoramidite approaches, solid-phase and solution-phase synthesis, large-scale synthesis, synthesis for modified and unmodified oligonucleotides, conjugation of oligonucleotides, synthesis without base protection, and synthesis on microarrays. More specialized synthetic methods include synthesis of biologically active nucleosides and prodrugs. Purification and characterization methods are detailed. Advanced methods include biophysical analysis, combinatorial methods, and nanotechnology. Each protocol includes rationale for choosing appropriate methods, step-by-step procedures, complete recipes, anticipated results, characterization data, and troubleshooting, as well as background and recommended reading. The level of procedural detail is far beyond that found in the research literature, and tips and comments from authors are geared towards ensuring reliable duplication in the laboratory.
  current biology impact factor: Current Protocols on CD-ROM. , 1997
  current biology impact factor: New Trends in Biotechnology Nanjappa Shamanna Subba Rao, 1992
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