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| current issues in molecular biology: Current Protocols in Molecular Biology , |
| current issues in molecular biology: Environmental Epigenetics L. Joseph Su, Tung-chin Chiang, 2015-05-18 This book examines the toxicological and health implications of environmental epigenetics and provides knowledge through an interdisciplinary approach. Included in this volume are chapters outlining various environmental risk factors such as phthalates and dietary components, life states such as pregnancy and ageing, hormonal and metabolic considerations and specific disease risks such as cancer cardiovascular diseases and other non-communicable diseases. Environmental Epigenetics imparts integrative knowledge of the science of epigenetics and the issues raised in environmental epidemiology. This book is intended to serve both as a reference compendium on environmental epigenetics for scientists in academia, industry and laboratories and as a textbook for graduate level environmental health courses. Environmental Epigenetics imparts integrative knowledge of the science of epigenetics and the issues raised in environmental epidemiology. This book is intended to serve both as a reference compendium on environmental epigenetics for scientists in academia, industry and laboratories and as a textbook for graduate level environmental health courses. |
| current issues in molecular biology: Molecular Biology David P. Clark, Nanette J. Pazdernik, 2012-03-20 Molecular Biology, Second Edition, examines the basic concepts of molecular biology while incorporating primary literature from today's leading researchers. This updated edition includes Focuses on Relevant Research sections that integrate primary literature from Cell Press and focus on helping the student learn how to read and understand research to prepare them for the scientific world.The new Academic Cell Study Guide features all the articles from the text with concurrent case studies to help students build foundations in the content while allowing them to make the appropriate connections to the text. Animations provided deal with topics such as protein purification, transcription, splicing reactions, cell division and DNA replication and SDS-PAGE. The text also includes updated chapters on Genomics and Systems Biology, Proteomics, Bacterial Genetics and Molecular Evolution and RNA. An updated ancillary package includes flashcards, online self quizzing, references with links to outside content and PowerPoint slides with images.This text is designed for undergraduate students taking a course in Molecular Biology and upper-level students studying Cell Biology, Microbiology, Genetics, Biology, Pharmacology, Biotechnology, Biochemistry, and Agriculture. - NEW: Focus On Relevant Research sections integrate primary literature from Cell Press and focus on helping the student learn how to read and understand research to prepare them for the scientific world - NEW: Academic Cell Study Guide features all articles from the text with concurrent case studies to help students build foundations in the content while allowing them to make the appropriate connections to the text - NEW: Animations provided include topics in protein purification, transcription, splicing reactions, cell division and DNA replication and SDS-PAGE - Updated chapters on Genomics and Systems Biology, Proteomics, Bacterial Genetics and Molecular Evolution and RNA - Updated ancillary package includes flashcards, online self quizzing, references with links to outside content and PowerPoint slides with images - Fully revised art program |
| current issues in molecular biology: A History of Molecular Biology Michel Morange, 2000 Every day it seems the media focus on yet another new development in biology--gene therapy, the human genome project, the creation of new varieties of animals and plants through genetic engineering. These possibilities have all emanated from molecular biology. A History of Molecular Biology is a complete but compact account for a general readership of the history of this revolution. Michel Morange, himself a molecular biologist, takes us from the turn-of-the-century convergence of molecular biology's two progenitors, genetics and biochemistry, to the perfection of gene splicing and cloning techniques in the 1980s. Drawing on the important work of American, English, and French historians of science, Morange describes the major discoveries--the double helix, messenger RNA, oncogenes, DNA polymerase--but also explains how and why these breakthroughs took place. The book is enlivened by mini-biographies of the founders of molecular biology: Delbrück, Watson and Crick, Monod and Jacob, Nirenberg. This ambitious history covers the story of the transformation of biology over the last one hundred years; the transformation of disciplines: biochemistry, genetics, embryology, and evolutionary biology; and, finally, the emergence of the biotechnology industry. An important contribution to the history of science, A History of Molecular Biology will also be valued by general readers for its clear explanations of the theory and practice of molecular biology today. Molecular biologists themselves will find Morange's historical perspective critical to an understanding of what is at stake in current biological research. |
| current issues in molecular biology: Coping with Methuselah Henry Aaron, William B. Schwartz, 2004-01-20 Many medical authorities predict that average life expectancy could well exceed 100 years by mid century and rise even higher soon thereafter. This astonishing prospect, brought on by the revolution in molecular biology and information technology, confronts policymakers and public health officials with a host of new questions. How will increased longevity affect local and global demographic trends, government taxation and spending, health care, the workplace, Social Security, Medicare, and Medicaid? What ethical and quality-of-life issues are raised by these new breakthroughs? In Coping with Methuselah, a group of practicing scientists and public policy experts come together to address the problems, challenges, and opportunities posed by a longer life span. This book will generate discussion in political, social, and medical circles and help prepare us for the extraordinary possibilities that the future may hold. |
| current issues in molecular biology: Current Issues in Molecular Virology Victor Romanowski, 2013-11-20 This book is a collection of chapters dealing with examples of RNA and DNA viruses, and issues such as how these gene packages have learnt to take advantage of their hosts, molecular recognition events that hosts may use to counterattack the viruses, and how researchers have developed strategies to use viruses or their parts as tools for different purposes. |
| current issues in molecular biology: Protein Engineering and Design Paul R. Carey, 1996-06-21 The design and production of novel peptides and proteins occupy pivotal positions in science and technology and will continue to do so in the 21st century. Protein Engineering and Design outlines the rapid advances in computer-based modeling, protein engineering, and methods needed for protein and peptide preparation and characterization. This indispensable reference lays the groundwork for understanding this multidisciplinary activity while providing an introduction for researchers and students to the field of protein design. - Introduces and defines the techniques involved in protein engineering and design - Provides a concise overview of key technologies involved and demonstrates their contributions to the specialized design and production of novel proteins and peptides |
| current issues in molecular biology: Algorithms in Structural Molecular Biology Bruce R. Donald, 2023-08-15 An overview of algorithms important to computational structural biology that addresses such topics as NMR and design and analysis of proteins.Using the tools of information technology to understand the molecular machinery of the cell offers both challenges and opportunities to computational scientists. Over the past decade, novel algorithms have been developed both for analyzing biological data and for synthetic biology problems such as protein engineering. This book explains the algorithmic foundations and computational approaches underlying areas of structural biology including NMR (nuclear magnetic resonance); X-ray crystallography; and the design and analysis of proteins, peptides, and small molecules. Each chapter offers a concise overview of important concepts, focusing on a key topic in the field. Four chapters offer a short course in algorithmic and computational issues related to NMR structural biology, giving the reader a useful toolkit with which to approach the fascinating yet thorny computational problems in this area. A recurrent theme is understanding the interplay between biophysical experiments and computational algorithms. The text emphasizes the mathematical foundations of structural biology while maintaining a balance between algorithms and a nuanced understanding of experimental data. Three emerging areas, particularly fertile ground for research students, are highlighted: NMR methodology, design of proteins and other molecules, and the modeling of protein flexibility. The next generation of computational structural biologists will need training in geometric algorithms, provably good approximation algorithms, scientific computation, and an array of techniques for handling noise and uncertainty in combinatorial geometry and computational biophysics. This book is an essential guide for young scientists on their way to research success in this exciting field. |
| current issues in molecular biology: Opportunities in Biology National Research Council, Division on Earth and Life Studies, Commission on Life Sciences, Board on Biology, Committee on Research Opportunities in Biology, 1989-01-01 Biology has entered an era in which interdisciplinary cooperation is at an all-time high, practical applications follow basic discoveries more quickly than ever before, and new technologiesâ€recombinant DNA, scanning tunneling microscopes, and moreâ€are revolutionizing the way science is conducted. The potential for scientific breakthroughs with significant implications for society has never been greater. Opportunities in Biology reports on the state of the new biology, taking a detailed look at the disciplines of biology; examining the advances made in medicine, agriculture, and other fields; and pointing out promising research opportunities. Authored by an expert panel representing a variety of viewpoints, this volume also offers recommendations on how to meet the infrastructure needsâ€for funding, effective information systems, and other supportâ€of future biology research. Exploring what has been accomplished and what is on the horizon, Opportunities in Biology is an indispensable resource for students, teachers, and researchers in all subdisciplines of biology as well as for research administrators and those in funding agencies. |
| current issues in molecular biology: Molecular Approaches in Plant Biology and Environmental Challenges Sudhir P. Singh, Santosh Kumar Upadhyay, Ashutosh Pandey, Sunil Kumar, 2019-10-01 This book discusses molecular approaches in plant as response to environmental factors, such as variations in temperature, water availability, salinity, and metal stress. The book also covers the impact of increasing global population, urbanization, and industrialization on these molecular behaviors. It covers the natural tolerance mechanism which plants adopt to cope with adverse environments, as well as the novel molecular strategies for engineering the plants in human interest. This book will be of interest to researchers working on the impact of the changing environment on plant ecology, issues of crop yield, and nutrient quantity and quality in agricultural crops. The book will be of interest to researchers as well as policy makers in the environmental and agricultural domains. |
| current issues in molecular biology: Genetics of Adaptation Rodney Mauricio, 2005-07-20 An enduring controversy in evolutionary biology is the genetic basis of adaptation. Darwin emphasized many slight differences as the ultimate source of variation to be acted upon by natural selection. In the early 1900’s, this view was opposed by Mendelian geneticists, who emphasized the importance of macromutations in evolution. The Modern Synthesis resolved this controversy, concluding that mutations in genes of very small effect were responsible for adaptive evolution. A decade ago, Allen Orr and Jerry Coyne reexamined the evidence for this neo-Darwinian view and found that both the theoretical and empirical basis for it were weak. Orr and Coyne encouraged evolutionary biologists to reexamine this neglected question: what is the genetic basis of adaptive evolution? In this volume, a new generation of biologists have taken up this challenge. Using advances in both molecular genetic and statistical techniques, evolutionary geneticists have made considerable progress in this emerging field. In this volume, a diversity of examples from plant and animal studies provides valuable information for those interested in the genetics and evolution of complex traits. |
| current issues in molecular biology: Molecular Biology of the Cell , 2002 |
| current issues in molecular biology: Molecular Biology of Cancer Lauren Pecorino, 2012-04-26 Demonstrating how the malfunction of normal molecular pathways and components can lead to cancer, this text explores how our understanding of these defective mechanisms can be harnessed to develop new targeted therapeutic agents. |
| current issues in molecular biology: Biological & Agricultural Index , 1919 |
| current issues in molecular biology: Molecular Biology of the Cell 6E - The Problems Book John Wilson, Tim Hunt, 2014-11-21 The Problems Book helps students appreciate the ways in which experiments and simple calculations can lead to an understanding of how cells work by introducing the experimental foundation of cell and molecular biology. Each chapter reviews key terms, tests for understanding basic concepts, and poses research-based problems. The Problems Book has be |
| current issues in molecular biology: Beyond the Molecular Frontier National Research Council, Division on Earth and Life Studies, Board on Chemical Sciences and Technology, Committee on Challenges for the Chemical Sciences in the 21st Century, 2003-03-19 Chemistry and chemical engineering have changed significantly in the last decade. They have broadened their scopeâ€into biology, nanotechnology, materials science, computation, and advanced methods of process systems engineering and controlâ€so much that the programs in most chemistry and chemical engineering departments now barely resemble the classical notion of chemistry. Beyond the Molecular Frontier brings together research, discovery, and invention across the entire spectrum of the chemical sciencesâ€from fundamental, molecular-level chemistry to large-scale chemical processing technology. This reflects the way the field has evolved, the synergy at universities between research and education in chemistry and chemical engineering, and the way chemists and chemical engineers work together in industry. The astonishing developments in science and engineering during the 20th century have made it possible to dream of new goals that might previously have been considered unthinkable. This book identifies the key opportunities and challenges for the chemical sciences, from basic research to societal needs and from terrorism defense to environmental protection, and it looks at the ways in which chemists and chemical engineers can work together to contribute to an improved future. |
| current issues in molecular biology: Cellular and Molecular Immunology Abul K. Abbas, Andrew H. Lichtman, 2005 The 5th Edition of this comprehensive title continues the tradition of delivering an accessible, engaging, and current introduction to this essential subject. The authors describe the principles of basic and applied immunology in a concise, straightforward manner, while incorporating the most up-to-date information. Over 400 illustrations help readers quickly and easily grasp key concepts. The entire text has been revised and includes new information about the organization of lymphoid organs and the mechanisms of innate immunity. (Midwest). |
| current issues in molecular biology: Curing Genetic Diseases through Genome Reprogramming , 2021-06-24 Curing Genetic Diseases through Genome Reprogramming, Volume 182 captures an historic moment in the field of gene therapy—the dawn of a new age in which the dream of curing genetic diseases has become realizable. The volume presents the most clinically advanced gene therapy and genome editing approaches for the treatment of genetic diseases in specific organs, including difficult therapeutic targets, futuristic ideas of genetic interventions, and large scale human genome repair. An initial chapter addresses the complex ethical aspects involved in the very idea of modifying the human genome. - Provides a comprehensive view of gene therapy and genome editing technologies, including epigenetic editing - Describes the state-of-the-art and future directions for the treatment of genetic diseases, also considering economical aspects - Presents chapters that each give a thorough review of a specific disease, target organ or visionary approach, including ethical considerations |
| current issues in molecular biology: The Resolution Revolution: Recent Advances In cryoEM , 2016-08-26 cryoEM, a new volume in the Methods in Enzymology series, continues the legacy of this premier serial with quality chapters authored by leaders in the field. This volume covers research methods and new developments in recording images, the creation, evaluation and validation of 3D maps from the images, model building into maps and refinement of the resulting atomic structures, and applications of essentially single particle methods to helical structures and to sub-tomogram averaging. - Continues the legacy of this premier serial with quality chapters authored by leaders in the field - Covers research methods that determine the structures of biological molecules, a vital step for understanding their function - Contains the technical developments underpinning the advances of cryoEM and captures the exciting insights that have resulted |
| current issues in molecular biology: Catalyzing Inquiry at the Interface of Computing and Biology National Research Council, Division on Engineering and Physical Sciences, Computer Science and Telecommunications Board, Committee on Frontiers at the Interface of Computing and Biology, 2006-01-01 Advances in computer science and technology and in biology over the last several years have opened up the possibility for computing to help answer fundamental questions in biology and for biology to help with new approaches to computing. Making the most of the research opportunities at the interface of computing and biology requires the active participation of people from both fields. While past attempts have been made in this direction, circumstances today appear to be much more favorable for progress. To help take advantage of these opportunities, this study was requested of the NRC by the National Science Foundation, the Department of Defense, the National Institutes of Health, and the Department of Energy. The report provides the basis for establishing cross-disciplinary collaboration between biology and computing including an analysis of potential impediments and strategies for overcoming them. The report also presents a wealth of examples that should encourage students in the biological sciences to look for ways to enable them to be more effective users of computing in their studies. |
| current issues in molecular biology: Cell Biology by the Numbers Ron Milo, Rob Phillips, 2015-12-07 A Top 25 CHOICE 2016 Title, and recipient of the CHOICE Outstanding Academic Title (OAT) Award. How much energy is released in ATP hydrolysis? How many mRNAs are in a cell? How genetically similar are two random people? What is faster, transcription or translation?Cell Biology by the Numbers explores these questions and dozens of others provid |
| current issues in molecular biology: Current Protocols in Bioinformatics Andreas D. Baxevanis, 2003 Current Protocols in Bioinformatics is the only publication that responds to the need for both a current and updateable source of bioinformatics methodology. This unique publication assures that you have access to a full range of bioinformatics protocols written by globally-recognized experts in the field, and that these proto-cols are updated and revised as new developments and innovations occur. |
| current issues in molecular biology: BIO2010 National Research Council, Division on Earth and Life Studies, Board on Life Sciences, Committee on Undergraduate Biology Education to Prepare Research Scientists for the 21st Century, 2003-02-13 Biological sciences have been revolutionized, not only in the way research is conductedâ€with the introduction of techniques such as recombinant DNA and digital technologyâ€but also in how research findings are communicated among professionals and to the public. Yet, the undergraduate programs that train biology researchers remain much the same as they were before these fundamental changes came on the scene. This new volume provides a blueprint for bringing undergraduate biology education up to the speed of today's research fast track. It includes recommendations for teaching the next generation of life science investigators, through: Building a strong interdisciplinary curriculum that includes physical science, information technology, and mathematics. Eliminating the administrative and financial barriers to cross-departmental collaboration. Evaluating the impact of medical college admissions testing on undergraduate biology education. Creating early opportunities for independent research. Designing meaningful laboratory experiences into the curriculum. The committee presents a dozen brief case studies of exemplary programs at leading institutions and lists many resources for biology educators. This volume will be important to biology faculty, administrators, practitioners, professional societies, research and education funders, and the biotechnology industry. |
| current issues in molecular biology: Research at the Intersection of the Physical and Life Sciences National Research Council, Division on Earth and Life Studies, Division on Engineering and Physical Sciences, Board on Chemical Sciences and Technology, Board on Life Sciences, Board on Physics and Astronomy, Committee on Research at the Intersection of the Physical and Life Sciences, 2010-03-25 Traditionally, the natural sciences have been divided into two branches: the biological sciences and the physical sciences. Today, an increasing number of scientists are addressing problems lying at the intersection of the two. These problems are most often biological in nature, but examining them through the lens of the physical sciences can yield exciting results and opportunities. For example, one area producing effective cross-discipline research opportunities centers on the dynamics of systems. Equilibrium, multistability, and stochastic behavior-concepts familiar to physicists and chemists-are now being used to tackle issues associated with living systems such as adaptation, feedback, and emergent behavior. Research at the Intersection of the Physical and Life Sciences discusses how some of the most important scientific and societal challenges can be addressed, at least in part, by collaborative research that lies at the intersection of traditional disciplines, including biology, chemistry, and physics. This book describes how some of the mysteries of the biological world are being addressed using tools and techniques developed in the physical sciences, and identifies five areas of potentially transformative research. Work in these areas would have significant impact in both research and society at large by expanding our understanding of the physical world and by revealing new opportunities for advancing public health, technology, and stewardship of the environment. This book recommends several ways to accelerate such cross-discipline research. Many of these recommendations are directed toward those administering the faculties and resources of our great research institutions-and the stewards of our research funders, making this book an excellent resource for academic and research institutions, scientists, universities, and federal and private funding agencies. |
| current issues in molecular biology: Molecular Biology of B Cells Tasuku Honjo, Michael Reth, Andreas Radbruch, Frederick Alt, 2014-12-22 Molecular Biology of B Cells, Second Edition is a comprehensive reference to how B cells are generated, selected, activated and engaged in antibody production. All of these developmental and stimulatory processes are described in molecular, immunological, and genetic terms to give a clear understanding of complex phenotypes. Molecular Biology of B Cells, Second Edition offers an integrated view of all aspects of B cells to produce a normal immune response as a constant, and the molecular basis of numerous diseases due to B cell abnormality. The new edition continues its success with updated research on microRNAs in B cell development and immunity, new developments in understanding lymphoma biology, and therapeutic targeting of B cells for clinical application. With updated research and continued comprehensive coverage of all aspects of B cell biology, Molecular Biology of B Cells, Second Edition is the definitive resource, vital for researchers across molecular biology, immunology and genetics. |
| current issues in molecular biology: Hot Topics in Cell Biology José Becerra, Leonor Santos-Ruiz, 2012 Summary This book is a definitive overview of the current 'state of the art' in cell biology. It is based on papers presented by leading researchers at the Spanish Society for Cell Biology's XIV Congress - a Congress that strives to achieve scientific excellence. Each participant was asked to prepare a 'mini review' of current and likely future development in their area of research. This book is based on those reviews. As such, it is therefore an analysis of current and future trends. Key Features Contains contributions from some of the world's leading researchers. The book is multidisciplinary, covering almost all topics in cell biology: from basic to applied cell biology, and a wide variety of models: from in vitro to vivo models, ranging from fish to rodents and humans. Each 'mini review' is an easy-read piece, describing the state of the art on a topic with clear language and in a summary format. The mini review format makes the book attractive not only to readers involved in cell biology research and teaching, but also professionals from other disciplines and students. The book takes a truly multidisciplinary approach; it covers a wide array of topics, and the book reflects how cell biology interacts with other disciplines The Editors Jose Becerra is Professor of Cell Biology at the University of Málaga (Spain) since 1989. He has been Dean Secretary, Vice-Dean and Dean of the Faculty of Sciences of Málaga, and is now the Head of the Department of Cell Biology, Genetics and Physiology. From 2001 to 2003 he was the Director of the Andalusian Laboratory of Biology (LAB, Seville), which was converted in the Andalusian Centre for Developmental Biology (CABD) under his term. He is a member of the Technical Committee of the National Stem Cell Bank since 2007, patron of the Board of Trustees of IMABIS Foundation (Mediterranean Institute for the Advance of Biotechnology and Health Research), coordinator of the Biomaterials and Tissue Engineering Area of the the Biomedical Research Networking Center in Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), and member of the Direction Committee of the CIBER-BBN. Leonor Santos-Ruiz is Senior Researcher of the CIBER-BBN network at the Andalusian Center for Nanomedicine and Biotechnology (BIONAND). She started her career studying the cellular and molecular basis of lower vertebrates' amazing ability for tissue regeneration, with a special attention to bone and spinal cord repair. Readership Cell biology academics and researchers Contents Introduction Dynamics of cell compartments The intracellular trafficking Cell signaling Autophagy, apoptosis and cell homeostasis Cell biology of aging Plant cell biology Methods in cell biology Applied cell biology Cell biology of cancer Cell therapies and tissue engineering Neurodegeneration and cell biology Nanotechnology and cell biology: challenges and opportunities |
| current issues in molecular biology: Creating a Physical Biology Phillip R. Sloan, Brandon Fogel, 2011-12-15 Despite its historical impact on the biological sciences, the paper entitled 'On the Nature of Gene Mutation and Gene Structure' has remained largely inaccessible because it was only published in a short-lived German periodical. This book makes the 'Three Man' Paper available in English for the first time. |
| current issues in molecular biology: Molecular Epidemiology Paul A. Schulte, Frederica P. Perera, 2012-12-02 This book will serve as a primer for both laboratory and field scientists who are shaping the emerging field of molecular epidemiology. Molecular epidemiology utilizes the same paradigm as traditional epidemiology but uses biological markers to identify exposure, disease or susceptibility. Schulte and Perera present the epidemiologic methods pertinent to biological markers. The book is also designed to enumerate the considerations necessary for valid field research and provide a resource on the salient and subtle features of biological indicators. |
| current issues in molecular biology: Current Protocols in Immunology John E. Coligan, 1991 Current Protocols in Immunology is a three-volume looseleaf manual that provides comprehensive coverage of immunological methods from classic to the most cutting edge, including antibody detection and preparation, assays for functional activities of mouse and human cells involved in immune responses, assays for cytokines and their receptors, isolation and analysis of proteins and peptides, biochemistry of cell activation, molecular immunology, and animal models of autoimmune and inflammatory diseases. Carefully edited, step-by-step protocols replete with material lists, expert commentaries, and safety and troubleshooting tips ensure that you can duplicate the experimental results in your own laboratory. Bimonthly updates, which are filed into the looseleaf, keep the set current with the latest developments in immunology methods. The initial purchase includes one year of updates and then subscribers may renew their annual subscriptions. Current Protocols publishes a family of laboratory manuals for bioscientists, including Molecular Biology, Human Genetics, Protein Science, Cytometry, Cell Biology, Neuroscience, Pharmacology, and Toxicology. |
| current issues in molecular biology: Intestinal Stem Cell Niche , 2018-04-24 Advances in Stem Cells and Their Niches addresses stem cells during development, homeostasis, and disease/injury of the respective organs, presenting new developments in the field, including new data on disease and clinical applications. Video content illustrates such areas as protocols, transplantation techniques, and work with mice. Explores not only reviews of research, but also shares methods, protocols, and transplantation techniques Contains video content to illustrate such areas as protocols, transplantation techniques, and work with mice Each volume concentrates on one organ, making this a unique publication |
| current issues in molecular biology: A New Biology for the 21st Century National Research Council, Division on Earth and Life Studies, Board on Life Sciences, Committee on a New Biology for the 21st Century: Ensuring the United States Leads the Coming Biology Revolution, 2009-11-20 Now more than ever, biology has the potential to contribute practical solutions to many of the major challenges confronting the United States and the world. A New Biology for the 21st Century recommends that a New Biology approach-one that depends on greater integration within biology, and closer collaboration with physical, computational, and earth scientists, mathematicians and engineers-be used to find solutions to four key societal needs: sustainable food production, ecosystem restoration, optimized biofuel production, and improvement in human health. The approach calls for a coordinated effort to leverage resources across the federal, private, and academic sectors to help meet challenges and improve the return on life science research in general. |
| current issues in molecular biology: Type IV Secretion in Gram-Negative and Gram-Positive Bacteria Steffen Backert, Elisabeth Grohmann, 2018-03-13 Type IV secretion systems (T4SSs) are highly versatile membrane-associated transporter machines used by Gram-negative and Gram-positive bacteria to deliver substrate molecules to a large variety of target cells. This volume summarizes our current knowledge of the large variety and structural diversity of T4SSs in pathogenic Escherichia, Agrobacterium, Legionella, Coxiella, Bartonella, Helicobacter, Enterococcus and other species. Divided into 13 chapters contributed by leading experts, it presents findings that significantly enhance our understanding of how various pathogens manipulate host cell functions to trigger bacterial uptake, promote intracellular growth, suppress defense mechanisms and of how bacteria spread antibiotic resistances, thus facilitating bacterial colonization and disease development. The book is an invaluable source of information for researchers and clinicians. |
| current issues in molecular biology: Regulating with RNA in Bacteria and Archaea Gisela Storz, Kai Papenfort, 2018-11-01 Revealing the many roles of RNA in regulating gene expression For decades after the discoveries of messenger RNA, transfer RNA, and ribosomal RNA, it was largely assumed that the role of RNA in the cell was limited to shuttling the genomic message, chaperoning amino acids, and toiling in the ribosomes. Eventually, hints that RNA molecules might have regulatory roles began to appear. With the advent of genomics and bioinformatics, it became evident that numerous other RNA forms exist and have specific functions, including small RNAs (sRNA), RNA thermometers, and riboswitches to regulate core metabolic pathways, bacterial pathogenesis, iron homeostasis, quorum sensing, and biofilm formation. All of these functions, and more, are presented in Regulating with RNA in Bacteria and Archaea, written by RNA biologists from around the globe. Divided into eight sections-RNases and Helicases, Cis-Acting RNAs, Cis Encoded Base Pairing RNAs, Trans-Encoded Base Pairing RNAs, Protein Titration and Scaffolding, General Considerations, Emerging Topics, and Resources-this book serves as an excellent resource for established RNA biologists and for the many scientists who are studying regulated cellular systems. It is no longer a fair assumption that gene expression regulation is the provenance of proteins only or that control is exerted primarily at the level of transcription. This book makes clear that regulatory RNAs are key partners along with proteins in controlling the complex interactions and pathways found within prokaryotes. |
| current issues in molecular biology: Scientific Frontiers in Developmental Toxicology and Risk Assessment National Research Council, Commission on Life Sciences, Board on Environmental Studies and Toxicology, Committee on Developmental Toxicology, 2000-12-21 Scientific Frontiers in Developmental Toxicology and Risk Assessment reviews advances made during the last 10-15 years in fields such as developmental biology, molecular biology, and genetics. It describes a novel approach for how these advances might be used in combination with existing methodologies to further the understanding of mechanisms of developmental toxicity, to improve the assessment of chemicals for their ability to cause developmental toxicity, and to improve risk assessment for developmental defects. For example, based on the recent advances, even the smallest, simplest laboratory animals such as the fruit fly, roundworm, and zebrafish might be able to serve as developmental toxicological models for human biological systems. Use of such organisms might allow for rapid and inexpensive testing of large numbers of chemicals for their potential to cause developmental toxicity; presently, there are little or no developmental toxicity data available for the majority of natural and manufactured chemicals in use. This new approach to developmental toxicology and risk assessment will require simultaneous research on several fronts by experts from multiple scientific disciplines, including developmental toxicologists, developmental biologists, geneticists, epidemiologists, and biostatisticians. |
| current issues in molecular biology: Current Protocols in Chemical Biology Adam P. Arkin, 2009-09-22 |
| current issues in molecular biology: Protein Kinase Factsbook D. Grahame Hardie, 1995 How do you keep track of basic information on the proteins you work with? Where do you find details of their physicochemical properties, amino acid sequences, gene organization? Are you tired of scanning review articles, primary papers and databases to locate that elusive fact?The Academic Press FactsBook series will satisfy scientists and clinical researchers suffering from information overload. Each volume provides a catalogue of the essential properties of families of molecules. Gene organization, amino acid sequences, physicochemical properties, and biological activity are presented using a common, easy to follow format. Taken together they compile everything you wanted to know about proteins but were too busy to look for. The Protein Kinase FactsBook: Protein - Tyrosine Kinases contains over 130 entries on members of the family from vertebrates, Drosophila , higher plants, yeasts, nematodes, slime moulds and other organisms. Key Features* Subunit structure and isoforms* Genetics* Sequence database accession numbers* Domain structures* Amino acid sequences* Homologues in other species* Patterns of expression* Physiological substrates and specificity determinants* Assays* Enzyme activators and inhibitors* References. |
| current issues in molecular biology: Current Issues in Plant Molecular and Cellular Biology M. Terzi, R. Cella, A. Falavigna, 2012-12-06 Plant cell and tissue culture is a relevant area of experimental biology that has been developed for some decades to become an indispensable tool of plant biotechnology. Progress in this area, sometimes tumultuous, has been regularly recorded by the proceedings of the congresses of the International Association for Plant Tissue Culture which have been held every four years in several continents. This book reports plenary lectures, keynote lectures and invited oral presentations given at the last congress held in Florence. It is a useful reference guide both for established scientists and students on both traditional and emerging fields of plant biology. The following topics are covered: In vitro Culture and Plant Regeneration; Plant Propagation; Haploids; Somatic Hybridisation; Reproductive Systems; Genetic Variability; Gene Transfer; Organelles; Biotechnology of Tropical and Subtropical Species; Agronomic Traits; Somatic Embryogenesis; Meristems; Cell Surface; Growth Regulators; Reception and Transduction of Signals; Gene Expression under Extreme Conditions; Primary Metabolism; Secondary Metabolism; Transport; Large Scale Production. |
| current issues in molecular biology: Issues in Life Sciences: Molecular Biology: 2011 Edition , 2012-01-09 Issues in Life Sciences: Molecular Biology / 2011 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Life Sciences—Molecular Biology. The editors have built Issues in Life Sciences: Molecular Biology: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Life Sciences—Molecular Biology in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Issues in Life Sciences: Molecular Biology: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/. |
| current issues in molecular biology: Current Protocols in Protein Science , 1996 |
| current issues in molecular biology: Bacterial Viruses Aidan Coffey, 2020 |
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Jul 11, 2022 · To start, I am an unemployed, disabled veteran. I am returning to school to try and work towards a job that I am capable of. currently I am in need of an iPhone for school instead …
Which companies are currently on the list for Att sponsored data?
Oct 3, 2016 · I just read about how to opt in for sponsored data on my Att app, but what does this include? Netflix, Pandora, etc?
Phone ready for upgrade - AT&T Community Forums
Jul 13, 2020 · My phone is paid off and available for an upgrade. I'm on a family plan, do I have to get the upgrade through AT&T or can I buy a phone from an outside source and have it …
Unlimited Elite plan (current plan) vs. Unlimited Elite Plan (new …
Jan 20, 2022 · I currently have the Unlimited Elite® plan (lowercase "p"). On the "Enjoy 5g access" page in Wireless Support, I selected my address and then initiated the "Device …
Upgrading current router | AT&T Community Forums
Feb 18, 2015 · I currently have Uverse Internet and Cable via a 2Wire 3800HGV-B router. How do I upgrade to an "N" compatible router?
NEED AN UP TO DATE ROUTER! - AT&T Community Forums
Oct 31, 2020 · my current router, 2Wire 3801 HGV-B, it's OLD and I NEED A BETTER REPLACEMENT! HOW CAN I GET A NEW MODEL? has an issue with intermittently resetting …
Galaxy S20 5G current security patch | AT&T Community Forums
Apr 16, 2020 · I've had my S20 5G for over a month but it is still showing February 1, 2020 as the security patch. Can anyone verify if this is correct? My S9 for work is at March 1, 2020.My …
Question about Terminating Contract and upgrading
May 23, 2014 · Hi, if I terminate my 2 year contract with my current smartphone and pay my ETF, can I upgrade to a new 2 year contract on the same day? Or is there a wait period? Oh and …
Bring your own device for a current account holder
May 22, 2018 · Let AT&T help you elebrate your dad with Father's Day Gifts that connect us.
How do I post or send message to a ATT manager who can help …
Aug 7, 2018 · We went into the ATT store and were told about a promotion for a free iPhone 7. If we turned in our iPhone 6 we could get a free iPhone 7.
Need help! - AT&T Community Forums
Jul 11, 2022 · To start, I am an unemployed, disabled veteran. I am returning to school to try and work towards a job that I am capable of. currently I am in need of an iPhone for school instead …
Which companies are currently on the list for Att sponsored data?
Oct 3, 2016 · I just read about how to opt in for sponsored data on my Att app, but what does this include? Netflix, Pandora, etc?
Phone ready for upgrade - AT&T Community Forums
Jul 13, 2020 · My phone is paid off and available for an upgrade. I'm on a family plan, do I have to get the upgrade through AT&T or can I buy a phone from an outside source and have it …
