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| cervical cancer targeted therapy: A Theranostic and Precision Medicine Approach for Female-Specific Cancers Rama Rao Malla, Ganji Purnachandra Nagaraju, 2020-11-25 A Theranostic and Precision Medicine Approach for Female-Specific Cancers provides information regarding ongoing research and clinical data surrounding female specific cancers (breast, cervical, ovarian and endometrial cancers). The book encompasses detailed descriptions about diagnostics and therapeutic options for easy understanding, focusing on the subject matter with a broader range of treatment options. In addition, it explores new theranostics, i.e., diagnostic, therapeutic and precision medicine strategies currently being developed for FSCs. This book is a valuable resource for cancer researchers, clinicians, graduate students and other members of biomedical field who need to understand the most recent and promising approaches to manage FSCs. Explores new diagnostic biomarkers surrounding the early detection and prognosis of FSCs Examines new genetic and molecularly targeted approaches for the treatment of these aggressive diseases Discusses new theranostic approaches that combine diagnosis and treatment through the use of nanotechnology in FSCs Addresses how these various advances can be integrated into a precision and personalized medicine approach that can eventually enhance patient care |
| cervical cancer targeted therapy: Comprehensive Cervical Cancer Control World Health Organization, 2006 Most women who die from cervical cancer, particularly in developing countries, are in the prime of their life. They may be raising children, caring for their family, and contributing to the social and economic life of their town or village. Their death is both a personal tragedy, and a sad and unnecessary loss to their family and their community. Unnecessary, because there is compelling evidence, as this Guide makes clear, that cervical cancer is one of the most preventable and treatable forms of cancer, as long as it is detected early and managed effectively. Unfortunately, the majority of women in developing countries still do not have access to cervical cancer prevention programmes. The consequence is that, often, cervical cancer is not detected until it is too late to be cured. An urgent effort is required if this situation is to be corrected. This Guide is intended to help those responsible for providing services aimed at reducing the burden posed by cervical cancer for women, communities and health systems. It focuses on the knowledge and skills needed by health care providers, at different levels of care. |
| cervical cancer targeted therapy: Cervical Cancer Jaime G. de la Garza-Salazar, Flavia Morales-Vásquez, Abelardo Meneses-Garcia, 2017-05-26 This book provides readers with a thorough review on cervical cancer, treatment guidelines and emerging therapies available for the disease. It reviews the epidemiology clinical features, diagnosis, and medical management of cervical cancer. Given the increasing need for preventive strategies, treatment optimization with collaborative and integrative work, this book improves the actual and integral knowledge in this neoplasm. Given the high prevalence of this disease in Latin America, this is an important text for clinicians in this region. This book outlines the state of the art in cervical cancer treatments and is an indispensable companion for oncologists, gynecologists, surgeons and medical students. |
| cervical cancer targeted therapy: Gynecologic Cancer Patricia J. Eifel, David M. Gershenson, John J. Kavanagh, Elvio G. Silva, 2005-12-21 Gynecologic cancer includes cancer of the female lower genital tract: vagina, vulva, cervix, endometrium, uterus, and ovaries. Gynecologic Cancer is the fourth volume in the M.D. Anderson Cancer Care Series, featuring the current standard approach to gynecologic cancer care from the experts at M.D. Anderson Cancer Center. Designed for the practicing oncologist, this clinical guidebook allows for quick, authoritative access to the latest and best multimodality therapies. Topics covered in this volume include primary prevention and early detection, preinvasive diseases of female lower genital tract, pathology and imaging of gynecologica malignancies, treatment of vaginal, cervical, endometrial, uterine cancers. Discussions also address fertility-sparing options for treatment of women with gynecologica cancers as well as sexuality in women with gyn malignancies. Each of the 20 chapters ends with an up-to-date list of suggested readings, as well as key practice points highlighting the most principles and practices of each chapter for at-a-glance reference. More than 80 illustrations complement the text. This thorough, practical volume is the essential clinical guide for the oncologists, surgeons, and all physicians involved in the care of patients with gynecologic cancer. |
| cervical cancer targeted therapy: Successes and Limitations of Targeted Cancer Therapy S. Peters, R.A. Stahel, 2014-02-19 The treatment of patients with advanced malignancies has undergone remarkable change in the last few years. While in the past decisions about systemic therapy were largely based on the performance status of a patient, oncologists today also take into account the pathological and molecular characteristics of the patient’s tumor. Targeting specific molecular pathways important for tumorigenesis has become the preferred way of treatment for many types of malignancies. With these advances come new challenges including the optimization of therapy, recognizing and dealing with side effects and, importantly, the development of resistance. This book provides an up-to-date overview of the advances and limitations of targeted therapy for several tumor entities including breast cancer, colon cancer, gastrointestinal stromal tumors, lung cancer, melanoma, ovarian cancer and renal cell carcinoma. Written by over a dozen internationally renowned scientists, the book is suitable for advanced students, postdoctoral researchers, scientists and clinicians who wish to update their knowledge of the latest approaches to targeted cancer therapies. |
| cervical cancer targeted therapy: Molecular Biology of the Cell , 2002 |
| cervical cancer targeted therapy: Surgical Management of Advanced Pelvic Cancer Desmond C. Winter, Michael E. Kelly, 2021-11-01 An innovative guide to the practice of pelvic exenterative surgery for the management of advanced pelvic neoplasms Exenterative surgery plays an important role in the management of advanced pelvic cancer. However, while a large body of evidence regarding outcomes following pelvic exenteration now exists, practical strategies and management options remain unclear. Surgical Management of Advanced Pelvic Cancer addresses this problem by assembling world-leaders in the field to provide insights into the latest techniques and best practices. It includes detailed coverage of: Surgical anatomy Operative approaches and exenterative techniques Reconstruction options Current evidence on survival and quality of life outcomes Featuring essential information for those managing patients with advanced pelvic neoplasms, Surgical Management of Advanced Pelvic Cancer consolidates the latest data and practical advice in one indispensable guide. |
| cervical cancer targeted therapy: Metronomic Chemotherapy Guido Bocci, Giulio Francia, 2014-09-04 This book analyzes all aspects of metronomic chemotherapy, a new approach involving low-dose, long-term, and frequently administered therapy that has preclinical and clinical activity in various tumors. After an opening section on the pharmacological bases of metronomic chemotherapy, including its antiangiogenic effects and impact on immunity, preclinical studies on various classes of drug are discussed. Clinical applications of metronomic chemotherapy in a wide variety of tumors are then addressed in detail, with description of the results of all published studies. The clinical pharmacology of metronomic chemotherapy is also considered in depth, encompassing pharmacokinetics, pharmacogenetics, pharmacoeconomics, and adverse drug reactions. The book closes by describing the role of this therapy in the veterinarian clinic. |
| cervical cancer targeted therapy: Safety of Biologics Therapy Brian A. Baldo, 2016-08-12 This long overdue title provides a comprehensive, up-to-date, state-of-the art review of approved biologic therapies, with coverage of mechanisms of action, Indications for therapy, immunogenicity and a detailed examination of adverse effects and safety of the many and diverse therapeutic agents presented in a total of 13 chapters. It is predicted that by 2016, biologics will make up half of the world's 20 top-selling drugs and by 2018, biologic medicine sales will account for almost half of the world's 100 biggest selling drugs. Recombinant proteins dominate the growing list of the more than 200 approved biotherapeutic agents with targeted antibodies, fusion proteins and receptors; cytokines; hormones; enzymes; proteins involved in blood-clotting, homeostasis and thrombosis; vaccines; botulinum neurotoxins; and, more recently, biosimilar preparations, comprising the majority of approved biologics. Written with clinicians, other health care professionals, and researchers in mind, Safety of Biologics Therapy examines, in a single volume, the full range of issues surrounding the safety of approved biologic therapies. A good understanding of the risks and safety issues of modern biologics therapy is increasingly being demanded of all those connected with their development, handling, prescribing, administration and subsequent patient management. In addition to being of great value to clinicians in all branches of medicine, and to nurses, pharmacists and researchers, this book will prove invaluable for students taking undergraduate and graduate courses in the above disciplines and in the biomedical sciences. |
| cervical cancer targeted therapy: Comprehensive Gynecology Vern L. Katz, 2007 Formerly edited by Drs. Droegemueller, Stenchever, Mishell & Herbst - this trusted and tested reference provides complete, timely, and easy access to vital information on the medical and surgical issues affecting today's daily gynecology practice. Featuring the fresh perspectives of four new editors, along with new contributors, the text offers practical, in-depth coverage...helpful illustrations - many new to this edition...and clinically oriented guidance...page after page! Plus, access the complete contents online, fully searchable at www.compgyn.com - so you can find quick answers from an location. Access state-of-the-art guidance on the latest minimally invasive surgical techniques...the newest applications in diagnostic and interventional ultrasound...and many other essential aspects of today's practice. Access fresh practice perspectives from four new editors and new contributors. Effectively handle the emotional aspects of the specialty with unique new chapters covering rape * incest * and domestic violence, among others. Diagnose conditions accurately with the visual aid of nearly 1,000 illustrations - including more than 100 new full-color photos. Quickly find the information you need with user-friendly features including key terms, key points, and the use of color throughout. Exponentially boost your clinical reference power with access to the complete contents online - fully searchable - as well as all of the illustrations for use in electronic presentations. Visit www.compgyn.com for details. Presents the work of four new associate editors and many new contributors who offer fresh practice perspectives. Includes unique new chapters covering rape . incest . domestic violence . and other highly emotional aspects of the specialty. Features more than 100 new full-color photos that help you identify lesions and interpret pathologic findings. Provides expanded material on menopause, reflecting the ever-increasing aging patient population. |
| cervical cancer targeted therapy: Take Control of Your Cancer Risk John Whyte, MD, MPH, 2021-10-05 Something everyone has the power to do is reduce your cancer risk, and this book will show you just how easy it is to do it. Each year, over a million people in the United States alone hear the words no one ever wants to hear: You have cancer. But what if there was a way for fewer people to hear these words? One of the biggest myths regarding cancer is that it’s mostly genetic - meaning that you have no control over whether you get it. While genetics do have an impact, the truth is that your lifestyle and environment play the major role. Physician and Chief Medical Offer of WebMD John Whyte, MD, MPH, shares straightforward information and equips you with strategies to help you on a journey to better health. In Take Control of Your Cancer Risk, Dr. Whyte provides helpful tips including: assessing your cancer risk knowing which screenings you need, and when learning the role food, exercise, and sleep play understanding the relationship between stress and cancer Take Control of Your Cancer Risk is filled with practical advice that empowers you to really take control of our health. |
| cervical cancer targeted therapy: WHO Classification of Tumours of Female Reproductive Organs Robert J. Kurman, Centre international de recherche sur le cancer, 2014 WHO Classification of Tumours of Female Reproductive Organs is the sixth volume in the 4th Edition of the WHO series on histological and genetic typing of human tumours. This authoritative, concise reference book provides an international standard for oncologists and pathologists and will serve as an indispensable guide for use in the design of studies monitoring response to therapy and clinical outcome. Diagnostic criteria, pathological features, and associated genetic alterations are described in a strictly disease-oriented manner. Sections on all recognized neoplasms and their variants include new ICD-O codes, epidemiology, clinical features, macroscopy, pathology, genetics, and prognosis and predictive factors. The book, prepared by 91 authors from 19 countries, contains more than 400 colour images and tables, and more than 2100 references |
| cervical cancer targeted therapy: Stereotactic Body Radiation Therapy Simon S. Lo, Bin S. Teh, Jiade J. Lu, Tracey E. Schefter, 2012-08-28 Stereotactic body radiation therapy (SBRT) has emerged as an important innovative treatment for various primary and metastatic cancers. This book provides a comprehensive and up-to-date account of the physical/technological, biological, and clinical aspects of SBRT. It will serve as a detailed resource for this rapidly developing treatment modality. The organ sites covered include lung, liver, spine, pancreas, prostate, adrenal, head and neck, and female reproductive tract. Retrospective studies and prospective clinical trials on SBRT for various organ sites from around the world are examined, and toxicities and normal tissue constraints are discussed. This book features unique insights from world-renowned experts in SBRT from North America, Asia, and Europe. It will be necessary reading for radiation oncologists, radiation oncology residents and fellows, medical physicists, medical physics residents, medical oncologists, surgical oncologists, and cancer scientists. |
| cervical cancer targeted therapy: Gynaecological Malignancies Gwo Yaw Ho, Sophia Frentzas, 2020-06-17 “Gynaecological Malignancies - Updates and Advances” aims to present a review of the significant advances in the understanding and management of gynaecological malignancies. Major areas of importance in this field will be covered, incorporating new knowledge that has arisen due to the advancements in molecular techniques and the ability to correlate these molecular changes with clinical behaviour of gynaecologic tumours. The therapeutic implications of molecular subtyping to match appropriate therapies and the appreciation of the use of up to date radiotherapy techniques will be explored. |
| cervical cancer targeted therapy: Accelerated Partial Breast Irradiation David E. Wazer, Douglas W. Arthur, Frank Vicini, 2009-08-11 Accelerated partial breast irradiation (APBI) is being rapidly introduced into the clinical management of early breast cancer. APBI, in fact, encompasses a number of different techniques and approaches that include brachytherapy, intraoperative, and external beam techniques. There is currently no single source that describes these techniques and their clinical implementation. This text is a concise handbook designed to assist the clinician in the implementation of APBI. This includes a review of the principles that underlie APBI, a practical and detailed description of each technique for APBI, a review of current clinical results of APBI, and a review of the incidence and management of treatment related complications. |
| cervical cancer targeted therapy: CRISPR-Cas Enzymes , 2019-01-25 CRISPR-Cas Enzymes, Volume 616, the latest release in the Methods in Enzymology series, continues the legacy of this premier serial with quality chapters authored by leaders in the field. Topics covered in this release include CRISPR bioinformatics, A method for one-step assembly of Class 2 CRISPR arrays, Biochemical reconstitution and structural analysis of ribonucleoprotein complexes in Type I-E CRISPR-Cas systems, Mechanistic dissection of the CRISPR interference pathway in Type I-E CRISPR-Cas system, Site-specific fluorescent labeling of individual proteins within CRISPR complexes, Fluorescence-based methods for measuring target interference by CRISPR-Cas systems, Native State Structural Characterization of CRISRP Associated Complexes using Mass Spectrometry, and more. - Provides the authority and expertise of leading contributors from an international board of authors - Presents the latest release in the Methods in Enzymology series - Updated release includes the latest information on the CRISPR-Cas Enzymes |
| cervical cancer targeted therapy: Diagnosing and Treating Adult Cancers and Associated Impairments National Academies Of Sciences Engineeri, National Academies of Sciences Engineering and Medicine, Health And Medicine Division, Board On Health Care Services, Committee on Diagnosing and Treating Adult Cancers, 2021-11-10 Cancer is the second leading cause of death among adults in the United States after heart disease. However, improvements in cancer treatment and earlier detection are leading to growing numbers of cancer survivors. As the number of cancer survivors grows, there is increased interest in how cancer and its treatments may affect a person's ability to work, whether the person has maintained employment throughout the treatment or is returning to work at a previous, current, or new place of employment. Cancer-related impairments and resulting functional limitations may or may not lead to disability as defined by the U.S. Social Security Administration (SSA), however, adults surviving cancer who are unable to work because of cancer-related impairments and functional limitations may apply for disability benefits from SSA. At the request of SSA, Diagnosing and Treating Adult Cancers and Associated Impairments provides background information on breast cancer, lung cancer, and selected other cancers to assist SSA in its review of the listing of impairments for disability assessments. This report addresses several specific topics, including determining the latest standards of care as well as new technologies for understanding disease processes, treatment modalities, and the effect of cancer on a person's health and functioning, in order to inform SSA's evaluation of disability claims for adults with cancer. |
| cervical cancer targeted therapy: Advances of Targeted Therapy in Gynecologic Malignancies Haifeng Qiu, Kun Song, Lei Wang, Chunxiao Zhou, 2022-04-28 |
| cervical cancer targeted therapy: Upper Tract Urothelial Carcinoma Shahrokh F. Shariat, Evanguelos Xylinas, 2014-09-13 Upper Tract Urothelial Carcinoma represents the first book of its kind to be dedicated solely to UTUC. It's aim is to improve understanding and eventually care of a disease that is greatly understudied and underappreciated, yet commonly dealt with by many medical and urologic oncologists. The volume features new data regarding genetic susceptibility, gene expression studies and causative factors; contemporary concepts and controversies regarding diagnosis and staging of UTUC; prediction tools and their value in treatment decisions within each disease stage and patient selection and treatment options such as endoscopic management, distal ureterectomy, radical nephroureterectomy and chemotherapy. Up-to-date information regarding boundaries of surgical resection, indication and extent of lymphadenectomy is covered as well as the role of perioperative/neoadjuvant chemotherapy in patients with high-risk UTUC. Upper Tract Urothelial Carcinoma will be of great value to all Urologists, Medical Oncologists and fellows in Urologic Oncology as well as upper level residents in training in Urology and Medical Oncology. |
| cervical cancer targeted therapy: Cisplatin Bernhard Lippert, 1999 30 years after its discovery as an antitumor agent, cisplatin represents today one of the most successful drugs in chemotherapy. This book is intended to reminisce this event, to take inventory, and to point out new lines of development in this field. Divided in 6 sections and 22 chapters, the book provides an up-to-date account on topics such as - the chemistry and biochemistry of cisplatin, - the clinical status of Pt anticancer drugs, - the impact of cisplatin on inorganic and coordination chemistry, - new developments in drug design, testing and delivery. It also includes a chapter describing the historical development of the discovery of cisplatin. The ultimate question - How does cisplatin kill a cell? - is yet to be answered, but there are now new links suggesting how Pt binding to DNA may trigger a cascade of cellular reactions that eventually result in apoptosis. p53 and a series of damage recognition proteins of the HMG-domain family appear to be involved. The book addresses the problem of mutagenicity of Pt drugs and raises the question of the possible relevance of the minor DNA adducts, e.g. of interstrand cross-links, and the possible use of trans-(NH3)2Pt(II)-modified oligonucleotides in antisense and antigene strategies. Our present understanding of reactions of cisplatin with DNA is based upon numerous model studies (from isolated model nucleobases to short DNA fragments) and application of a large body of spectroscopic and other physico-chemical techniques. Thanks to these efforts there is presently no other metal ion whose reactions with nucleic acids are better understood than Pt. In a series of chapters, basic studies on the interactions of Pt electrophiles with nucleobases, oligonucleotides, DNA, amino acids, peptides and proteins are reported, which use, among others, sophisticated NMR techniques or X-ray crystallography, to get remarkable understanding of details on such reactions. Reactivity of cisplatin, once bound to DNA and formerly believed to be inert enough to stay, is an emerging phenomenon. It has (not yet) widely been studied but is potentially extremely important. Medicinal bioinorganic chemistry - the role of metal compounds in medicine - has received an enormous boost from cisplatin, and so has bioinorganic chemistry as a whole. There is hardly a better example than cisplatin to demonstrate what bioinorganic chemistry is all about: The marriage between classic inorganic (coordination) chemistry and the other life sciences - medicine, pharmacy, biology, biochemistry. Cisplatin has left its mark also on areas that are generally considered largely inorganic. The subject of mixed-valance Pt compounds is an example: From the sleeping beauty it made its way to the headlines of scientific journals, thanks to a class of novel Pt antitumor agents, the so-called platinum pyrimidine blues. In the aftermath diplatinum (III) compounds were recognized and studies in large numbers, and now an organometalic chemistry of these diplatinum (III) species is beginning to emerge. The final section of the book is concerned with new developments such as novel di- and trinuclear Pt(II) drugs with DNA binding properties different from those of cisplatin, with orally active Pt(IV) drugs which are presently in clinical studies, and with attempts to modify combinatorial chemistry in such a way that it may become applicable to fast screening of Pt antitumor drugs. The potential of including computational methods in solving questions of Pt-DNA interactions is critically dealt with in the concluding chapter. |
| cervical cancer targeted therapy: Translational Advances in Gynecologic Cancers Michael Birrer, Lorenzo Ceppi, 2017-01-25 Translational Advances in Gynecologic Cancers straddles the bench and bed divide by highlighting important and interesting research that is translatable to the clinic. The contents of this book cover the entire spectrum, from promising laboratory based research, to clinical trial efforts. Further, new therapeutic indications based upon randomized phase III trials are also included. Clinicians will learn about lab-based science that is about to enter the clinic, along with the rationale behind translational endpoints in trials. Researchers will be able to identify and understand the clinical needs of patients with these types of tumors to improve their research focus. - Provides a comprehensive description of all evolving translational gynecologic cancer research for clinicians - Identifies knowledge gaps to inform the next research direction - Ties together clinical research and patient needs to help both the researcher and clinician - Addresses genomics, new target therapies, novel tools, and more for ovarian, endometrial, and cervical cancer |
| cervical cancer targeted therapy: Life Over Cancer Keith Block, 2009-04-21 Dr. Keith Block is at the global vanguard of innovative cancer care. As medical director of the Block Center for Integrative Cancer Treatment in Evanston, Illinois, he has treated thousands of patients who have lived long, full lives beyond their original prognoses. Now he has distilled almost thirty years of experience into the first book that gives patients a systematic, research-based plan for developing the physical and emotional vitality they need to meet the demands of treatment and recovery. Based on a profound understanding of how body and mind can work together to defeat disease, this groundbreaking book offers: • Innovative approaches to conventional treatments, such as “chronotherapy”–chemotherapy timed to patients’ unique circadian rhythms for enhanced effectiveness and reduced toxicity • Dietary choices that make the biochemical environment hostile to cancer growth and recurrence, and strengthen the immune system’s ability to attack remaining cancer cells • Precise supplement protocols to tame treatment side effects, relieve disease-related symptoms, and modify processes like inflammation and glycemia that can fuel cancer if left untreated • A new paradigm for exercise and stress reduction that restores your strength, reduces anxiety and depression, and supports the body’s own ability to heal • A complete program for remission maintenance–a proactive plan to make sure the cancer never returns Also included are “quick-start” maps to help you find the information you need right now and many case histories that will support and inspire you. Encouraging, compassionate, and authoritative, Life over Cancer is the guide patients everywhere have been waiting for. |
| cervical cancer targeted therapy: Head and Neck Cancer Louis B. Harrison, Roy B. Sessions, Waun Ki Hong, 2009 This comprehensive, multidisciplinary text addresses all aspects of head and neck cancer and represents a wide spectrum of specialists, including surgical, radiation, and medical oncologists, dentists, pathologists, radiologists, and nurses. The book focuses on a two-part approach to treatment that maximizes the chance for a cure while maintaining a strong emphasis on quality of life. This Third Edition's updated techniques section includes new radiation techniques such as IMRT and IGRT and new endoscopic and laser surgical techniques. Other highlights include a new chapter on reconstructive techniques; significant updates to all site-specific chapters; updates on chemoprevention and molecular targeting; and discussions of new imaging modalities such as fused PET/CT. A companion Website will offer the fully searchable text with all images. |
| cervical cancer targeted therapy: Apoptosis and Cancer Chemotherapy John A. Hickman, Caroline Dive, 1999-04-08 The past few years have witnessed an astonishing international effort that established the role of some 20 new molecules in apoptosis and added activation or suppression of apoptosis to the accepted biological functions of a great many others already familiar in cancer biology. Some of these molecules are receptors, transducing cytokine-mediated signals; others appear to intensify or diminish the risk that a compro mised cell will fire its apoptosis effector mechanism. All are of interest as potential targets for tumor therapy, and some may prove to be control points influenced in the pathogenesis of cancer and other diseases as diverse as viral infection, neurodegenerative disorders, and stroke. Sometimes, in the midst of these developments, a kind of euphoria ap pears to have gripped the research community, with the expectation that apoptosis will afford explanations to many unsolved questions in cellu lar regulation. This book, in a series of thoughtful and provocative ar ticles--some from established leaders in the field, and others from younger scientists--seeks to redress the balance. |
| cervical cancer targeted therapy: Human Papillomavirus and Cervical Cancer International Agency for Research on Cancer, 1989 This volume reviews the evidence for a causal link between sexually transmitted infection with human papillomavirus (HPV) and the occurrence of cervical cancer, from a variety of different angles. Epidemiological studies and clinical, pathological, and cytological aspects of HPV infection are reviewed. Modern methods for analyzing HPV-DNA types by molecular biological techniques are described, and the statistical problems to be overcome in epidemiological work are explained. The volume was prepared by a broad team of experts from around the world, who met in Copenhagen in March 1988 to reach a consensus on the present state of understanding and to establish directions for future work. |
| cervical cancer targeted therapy: Interstitial Brachytherapy Interstitial Collaborative Working Group, 1990 |
| cervical cancer targeted therapy: Targeted Therapies in Cancer Marc Lacroix, 2016 Besides surgery, radiation therapy, endocrine therapy or chemotherapy, which were widely used in cancer patients for decades, the 21st century has seen the emergence of targeted therapy, resulting from the identification of molecular pathways in cells and their alterations in tumors. An increasing number of compounds targeting specific molecules or cancer cells have been developed and, for some of them, approved by the United States Food and Drug Administration (FDA) as well as other regulators in EU and Japan Additional new and more efficient types of compounds, are still in clinical trials, but are expected to gain future approval. More than eighty FDA-approved targeted therapies are described here, along with about eighty other promising compounds. These drugs are members of various therapy classes, including tyrosine kinase inhibitors; serine/threonine kinase inhibitors; dual specificity kinase inhibitors; lipid kinase inhibitors; poly ADP ribose polymerase inhibitors; monoclonal antibodies; microtubule targeting agents; histone deacetylase inhibitors; proteasome inhibitors; antimetabolites; immunomodulatory agents; DNA methyltransferase inhibitors; hedgehog pathway inhibitors; enzymes; protein translation inhibitors; vaccines, oncolytic viruses; chimeric antigen receptor T-cells (CAR-T); and so on. A series of companion diagnostics intended to be used as an indication for specific therapies, and approved to this aim are also mentioned. The book aims to present the broad landscape of compounds and companion diagnostics that are expected to pave the way towards a future of hope for cancer patients. |
| cervical cancer targeted therapy: Strategies for Overcoming Chemotherapy Resistance in Cervical Cancer Zodwa Dlamini, 2024-01-23 Strategies for Overcoming Chemotherapy Resistance in Cervical Cancer: From Molecular Insights to Precision Solutions, Volume 21 highlights different strategies to reverse chemotherapy resistance in cervical cancer. The book puts a strong focus on strategies to reverse chemotherapy resistance as well as strategies for early detection of the resistance, enhancing precision oncology in terms of patient care and maximizing patient management. The book also looks at virally induced resistance to chemotherapy and recommends combination therapies that can maximize the reversal of this resistance.In 10 chapters, the book not only gives an overview of cervical cancer and chemotherapy as treatment, but also investigates resistance to chemotherapy and treatment for resistance. It defines treatment mechanisms, options, and limitations to beat chemotherapy resistance and the reversal of the resistance mechanisms. It gives insights into future directions of cervical cancer treatment using epigenetic silencing, chemotherapy splicing, the involvement of MicroRNAs to chemotherapy resistance, and the application of Artificial Intelligence. - Discusses strategies to reverse and detect resistance to chemotherapy at an early stage - Investigates the applications of Artificial Intelligence in the study of cervical chemotherapy resistance - Presents research and applications developed to overcome cancer resistance |
| cervical cancer targeted therapy: Comprehensive Cervical Cancer Control World Health Organization, 2016-11-11 This publication gives a broad vision of what a comprehensive approach to cervical cancer prevention and control means. In particular, it outlines the complementary strategies for comprehensive cervical cancer prevention and control, and highlights the need for collaboration across programs, organizations and partners. This new guide updates the 2006 edition and includes the recent promising developments in technologies and strategies that can address the gaps between the needs for and availability of services for cervical cancer prevention and control. In the last few years, there has been an emergence of ground-breaking new strategies in cervical cancer prevention and control. Because such strategies require evidence-based evaluation for decision-making in clinical practice and program planning, a World Health Organization (WHO) Steering Committee and a group of invited experts met in Geneva, Switzerland, in September 2010, to ensure that the WHO's guidance on cervical cancer continues to encompass all the relevant technologies and strategies. This edition of the guide has two new chapters: Chapter 2: Essentials for cervical cancer prevention and control programs and Chapter 4: HPV vaccination. One chapter has been newly organized: Chapter 5: Screening and treatment of cervical pre-cancer. All other chapters have been thoroughly updated and edited as needed. This guide aims to assist those responsible for providing services aimed at reducing the burden of cervical cancer on women, their communities and health systems. It focuses on the knowledge, best practices and communication skills needed by health-care providers working at community and primary and secondary levels of care to offer quality services for prevention, screening, treatment and palliative care for cervical cancer: the full continuum of care. The guide is intended primarily for health-care providers in health centers and district hospitals who deal with women's health and/or adolescent's health, but it may also be of interest to community-based and tertiary-level providers. Providers and managers at the sub-national level whose responsibilities may include program planning would be interested in Chapter 2 on program essentials, which covers implementation, monitoring and evaluating, and/or supervising and training other health-care providers. National-level decision-makers will find updated evidence-based information in this guide on what works in cervical cancer prevention and control programs, which may be of use as a basis for updating their own guidelines and protocols. |
| cervical cancer targeted therapy: Cancer in Sub-Saharan Africa D. M. Parkin, J. Ferlay, A. Jemal, M. Borok, S. S. Manraj, G. G. N'Da, F. Bray, B. Liu, F. J. Ogunbiyi, 2018 The Cancer in Sub-Saharan Africa volume brings together population-based cancer incidence data from 25 cancer registries in 20 sub-Saharan African countries that are part of the African Cancer Registry Network. The compiled data in this volume, presented and commented upon by covered population and by anatomical site, are of tremendous value to the assessment of the pattern and evolution of cancer in Africa, as a means of elucidating, confirming, and evaluating causes of the disease. |
| cervical cancer targeted therapy: Role of Radiotherapy in the Era of Targeted Therapy and Precision Oncology Kevin X. Liu, Daphne Haas-Kogan, Anne Laprie, 2022-02-03 |
| cervical cancer targeted therapy: A Beginner's Guide to Targeted Cancer Treatments and Cancer Immunotherapy Elaine Vickers, 2024-10-15 Demystifying the science behind new cancer treatments A clear and accessible guide written in everyday language for nurses and other healthcare professionals A Beginner’s Guide to Targeted Cancer Treatments and Cancer Immunotherapy helps readers understand the science behind many of the newer drug treatments for cancer. Assuming only a basic familiarity with cell biology, this easy-to-digest guide describes how our increased understanding of cancer has been translated into the creation of new cancer treatments with a wide range of targets. Gifted communicator and educator Dr. Elaine Vickers helps you understand the mechanisms of a wide range of individual targeted therapies and immunotherapies — enabling you to communicate effectively with your colleagues and patients. Concise chapters explain how new cancer drugs and immunotherapies work, discuss their benefits, identify their limitations, and more. Now in its second edition, this popular handbook is fully revised to reflect the latest developments in targeted drug therapies and immunotherapies. Entirely new chapters on advancements in various immunotherapies are accompanied by more than 100 new and updated color illustrations. Provides an up-to-date overview of relevant treatment targets for all major cancer types, including hematological cancers Describes cancer biology and the relationship between cancer and the immune system Offers valuable insights into cell communication pathways as a common target Covers small molecule drugs, antibody-based treatments, and cellular therapies, including novel immunotherapies A Beginner’s Guide to Targeted Cancer Treatments and Cancer Immunotherapy is a must-have resource for trainees, practicing nurses, and other healthcare professionals involved in the care of cancer patients, as well as non-specialists who encounter cancer data or cancer terminology in their field. |
| cervical cancer targeted therapy: Treatment Landscape of Targeted Therapies in Oncology Pawan Kumar Maurya, Vikas Saini, 2023-07-29 Treatment Landscape of Targeted Therapies in Oncology: Challenges and Opportunities provides up-to-date knowledge on antitumor-targeted therapies and immunotherapy. The book's chapters are written by researchers dynamically working/focusing on cancer treatment. The content is designed to help those who are new to the field (beginners) and various specialized scientists and researchers involved in cancer research. For decades, the hallmark of cancer treatment has been conventional chemotherapy. But with the rapid increase in our understanding of the immune system, more and more small molecules, peptides, recombinant antibodies, vaccines and cellular therapeutic modalities are being applied to manipulate the immune response for cancer treatment. - Covers basic concepts and updated knowledge of the latest anticancer drugs - Brings comprehensive understanding of the treatment of cancer in context of immunotherapy and targeted therapy - Introduces the latest drugs and advancements in the treatment of cancer - Includes detailed diagrams to give insight to the mechanisms of action |
| cervical cancer targeted therapy: Cervical Cancer: Contemporary Management Shalini Rajaram, K Chitrathara, Amita Maheshwari, 2012-12-15 Cervical Cancer: Contemporary Management is indeed a state-of-the-art textbook on cervix cancer. The contents are organized into 8 sections and 33 chapters with the latter consistently and sequentially structured with an initial outline, introduction, descriptive but focused narrative complemented by quality figures, diagrams, tables and photographs and supported by contemporary references affording ease of access to appropriate resource information. This may be the only book of its kind comprehensively addressing all aspects of cervical cancer beginning with screening, diagnosis and management of pre-invasive disease which includes screening in low resource countries, recent advances in screening technology, HPV carcinogenesis, molecular markers and of course primary prevention with HPV vaccination. Staging protocols, imaging techniques and sentinel node evaluation have been discussed in detail. Surgical management of cervical cancer is complete in all respects. All surgical techniques ranging from radical trachelectomy, radical abdominal hysterectomy, laparoscopic nerve-sparing radical hysterectomy, radical vaginal hysterectomy and the complications of surgery are described in detail. Emphasis in many chapters is on nerve-sparing radical hysterectomy which is known to reduce bladder, rectal and sexual dysfunction postoperatively. Postradiation hysterectomy and pelvic exenterations have been extensively covered. Renowned national and international surgeons have contributed well-written chapters which speak for their experience and expertise. Likewise, the radiation arm of cancer cervix therapy is extensive and ranges from radiation therapy: principles and techniques, chemoradiation, neoadjuvant chemotherapy, management of recurrent disease by both chemotherapy and radiation and interstitial brachytherapy. Image-guided techniques and treatment planning have been described wherever appropriate. This book is valuable and finds itself on the bookshelves of all those who practice gynecologic oncology, postgraduate students and fellows specializing in this field. |
| cervical cancer targeted therapy: Current Applications for Overcoming Resistance to Targeted Therapies Myron R. Szewczuk, Bessi Qorri, Manpreet Sambi, 2019-07-15 Targeted therapies were initially developed to exploit the upregulation and dependence on key oncogenic pathways critical to cancer progression. Additionally, they also presented as a method to overcome chemoresistance by supplementing conventional therapeutic regimens with targeted therapies. However, the development of resistance to these combinatorial approaches has led to the reassessment of currently available therapeutic options to overcome resistance to targeted therapy. This book aims to provide an update on the advancements in the therapeutic arms race between cancer, clinicians and scientists alike to overcome resistance to targeted therapies. Subject experts provide a comprehensive overview of the challenges and solutions to resistance to several conventional targeted therapies in addition to providing a discussion on broad topics including targeting components of the tumor microenvironment, emerging therapeutic options, and novel areas to be explored concerning nanotechnology and the epigenome. |
| cervical cancer targeted therapy: Cervical Cancer Ethan D., 2024-03-11 Navigate the complexities of cervical cancer with the definitive guide, Cervical Cancer: A Comprehensive Resource for Patients and Families. This book is an essential ally for those facing the diagnosis, providing clarity and support every step of the way. Understanding the BasicsBegin with a clear, concise introduction to cervical cancer, including types, prevalence, and the anatomy of the cervix. This foundational knowledge sets the stage for a deeper exploration of the condition. Risk Factors and PreventionLearn about the critical connection between HPV and cervical cancer, recognize lifestyle factors that can influence risk, and understand the life-saving potential of preventive measures like vaccinations. Early Detection and DiagnosisDiscover the importance of early symptoms and the lifesaving role of regular Pap tests and HPV screenings. Follow detailed discussions on diagnostic procedures and what to expect during the staging process. Treatment PathwaysExplore treatment options from surgery to chemotherapy, and understand the latest in targeted treatments. This book provides insight into making informed decisions that align with personal health goals. Emotional Well-beingAddress the emotional impact of a cervical cancer diagnosis with resources for coping, counseling, and finding support groups. Recognize the importance of emotional health for patients and their loved ones. Navigating Fertility and WomanhoodTackle the sensitive issues of fertility and sexuality with informed guidance. Understand the impact of cervical cancer on feminine identity and sexual health, and explore the options available. A Roadmap Through TreatmentGet practical advice for navigating the healthcare system and understanding the role of patient advocacy. This book helps demystify the journey through treatment and the importance of being an informed participant in your care. Survivorship and BeyondLook forward to life after treatment with information on managing long-term side effects and maintaining wellness. Survivorship is a key focus, providing strategies for a fulfilling life post-cancer. Understanding RecurrenceGain insights into the risks of recurrence and the strategies for ongoing monitoring and living with uncertainty, offering readers a pragmatic approach to long-term care. Advances in Cervical Cancer ResearchStay up-to-date with current research and emerging therapies. This book highlights the promise of the future of cervical cancer care and the advancements that are on the horizon. Palliative Care and DecisionsApproach palliative care and end-of-life decisions with sensitivity. This book offers compassionate advice for managing symptoms and navigating these challenging discussions. Advocacy and AwarenessUnderstand the power of education, advocacy, and global policy change in the fight against cervical cancer. This book encourages readers to become advocates for cervical health, emphasizing the importance of community and public health initiatives. Cervical Cancer: A Comprehensive Resource for Patients and Families is the essential guide for those looking to understand this disease, providing not just medical facts but a source of comfort and hope for patients, families, and caregivers. |
| cervical cancer targeted therapy: Surgical Horizons in Cervical Cancer Giuseppe Vizzielli, Alberto Farolfi, Valerio Gallotta, 2022-08-08 |
| cervical cancer targeted therapy: Targeted Therapies in Oncology Giuseppe Giaccone, Jean-Charles Soria, 2013-10-21 Since the last edition of this book, major advances have been made in our understanding of key pathways that control tumor progression. This has led to the development of new anticancer agents that have the ability to block the activity of proteins involved in neoplastic cell development and proliferation. Targeted Therapies in Oncology, Second Edi |
| cervical cancer targeted therapy: Cancer Stem Cell Resistance to Targeted Therapy Cristina Maccalli, Matilde Todaro, Soldano Ferrone, 2019-06-04 This book represents an up-dated summary of the state of the art of the characterization of cancer stem cell/ cancer initiating cell (CSC/CIC) properties. An overview of the definition and biological properties of CSCs/CICs as well as the role of these cells in determining the resistance to standard and immune-based therapies is provided. It also discusses limitations in the achievement of a definitive biological characterization of CSCs/CICs due to their high extent of plasticity and heterogeneity that is also mutually driven by the interaction of these cells with the tumor microenvironment. The limitations in targeting CSCs/CICs with immunotherapy are also explained together with explorative combination approaches that could increase the susceptibility of these cells to the recognition by immune cells. This book is conceived for a broad audience, including students, teachers, scientific experts. The critical revision of available results in terms of immunological profile of CSCs/CICs and the efficacy in targeting these cells by immunological approaches, results in a comprehensive and up to date recapitulation of the field and provides interesting suggestions on how to focus future investigations in order to assess the role of CSCs/CICs as prognostic and predictive biomarkers of responsiveness to therapies for cancer patients. |
| cervical cancer targeted therapy: Targeted Therapy in Translational Cancer Research Apostolia-Maria Tsimberidou, Razelle Kurzrock, Kenneth C. Anderson, 2015-10-14 Targeted Therapy in Translational Cancer Research for the Translational Oncology series provides a comprehensive overview of recent developments in our understanding of tumor biology, elucidates the roles of targets and pathways involved in carcinogenesis, and describes current state-of-the-art anticancer therapy, as well as the most promising areas of translational research and targeted therapy. Introduces cutting-edge ‘bench to bedside and back’ breakthroughs which have transformed the diagnosis, prognosis, and treatment of cancer Covers basic principles of targeted therapy, including immunotherapy and the roles of cancer stem cells, the microenvironment, angiogenesis, epigenetics, microRNAs, and functional imaging in precision medicine Summarises major advances in therapeutic management of hematologic malignancies and solid tumors using conventional therapy, targeted therapy, immunotherapy, or novel treatment modalities |
Cervical Spine (Neck): What It Is, Anatomy & Disorders - Cleveland …
Cervical spinal cord compression (cervical spondylotic myelopathy). This is a condition in which there’s pressure on your spinal cord in the cervical area of your spine. One of the most common …
Cervical Spine Anatomy - Spine-health
The neck, also called the cervical spine, is a well-engineered structure of bones, nerves, muscles, ligaments, and tendons. The cervical spine is delicate—housing the spinal cord that sends …
Cervical pain: Causes, Risk Factors, Symptoms, Treatment
Cervical pain, also known as neck pain, is a common condition that affects many individuals. It refers to discomfort or soreness in the neck area, usually caused by muscle strain, poor posture, …
Cervical Vertebrae (Cervical Spine) – Anatomy, Function, & Diagram
May 24, 2022 · Find out about the cervical vertebrae - definition, numbers of neck bones in humans, with anatomy, parts, functions, and labeled pictures.
Cervical Spine: Anatomy, Functions, & Diseases - WebMD
Sep 27, 2024 · The cervical spine consists of seven vertebrae and acts as bony protection for the spinal cord. This is important because injuries to the spinal cord can be devastating and result in …
Cervical spine: Anatomy, ligaments, nerves and injury | Kenhub
Nov 14, 2023 · This article covers the anatomy of the cervical spine/vertebrae, such as nerves, ligaments, muscles, and injuries. Click now to learn more at Kenhub!
Cervical Spine - AANS
Apr 5, 2024 · Learn about cervical spine anatomy, diseases and conditions which may affect the cervical spine and what treatments neurosurgeons can provide.
Cervical Spine Anatomy | University of Maryland Medical Center
The cervical spine is made up of the first seven vertebrae in the spine. It starts just below the skull and ends just above the thoracic spine. The cervical spine has a lordotic curve (a backward C …
Cervical Spine Anatomy: Overview, Gross Anatomy - Medscape
Feb 6, 2025 · The cervical spine is made up of the first seven vertebrae, referred to as C1-C7 (see the images below). It functions to provide mobility and stability to the head while connecting it to …
Cervical Spine Anatomy, Diagram & Function | Body Maps
Jan 19, 2018 · The cervical spine consists of seven vertebrae, which are the smallest and uppermost in location within the spinal column. Together, the vertebrae support the skull, move …
Cervical Spine (Neck): What It Is, Anatomy & Disorders - Cleveland …
Cervical spinal cord compression (cervical spondylotic myelopathy). This is a condition in which there’s pressure on your spinal cord in the cervical area of your spine. One of the most common …
Cervical Spine Anatomy - Spine-health
The neck, also called the cervical spine, is a well-engineered structure of bones, nerves, muscles, ligaments, and tendons. The cervical spine is delicate—housing the spinal cord that sends …
Cervical pain: Causes, Risk Factors, Symptoms, Treatment
Cervical pain, also known as neck pain, is a common condition that affects many individuals. It refers to discomfort or soreness in the neck area, usually caused by muscle strain, poor …
Cervical Vertebrae (Cervical Spine) – Anatomy, Function, & Diagram
May 24, 2022 · Find out about the cervical vertebrae - definition, numbers of neck bones in humans, with anatomy, parts, functions, and labeled pictures.
Cervical Spine: Anatomy, Functions, & Diseases - WebMD
Sep 27, 2024 · The cervical spine consists of seven vertebrae and acts as bony protection for the spinal cord. This is important because injuries to the spinal cord can be devastating and result …
Cervical spine: Anatomy, ligaments, nerves and injury | Kenhub
Nov 14, 2023 · This article covers the anatomy of the cervical spine/vertebrae, such as nerves, ligaments, muscles, and injuries. Click now to learn more at Kenhub!
Cervical Spine - AANS
Apr 5, 2024 · Learn about cervical spine anatomy, diseases and conditions which may affect the cervical spine and what treatments neurosurgeons can provide.
Cervical Spine Anatomy | University of Maryland Medical Center
The cervical spine is made up of the first seven vertebrae in the spine. It starts just below the skull and ends just above the thoracic spine. The cervical spine has a lordotic curve (a backward C …
Cervical Spine Anatomy: Overview, Gross Anatomy - Medscape
Feb 6, 2025 · The cervical spine is made up of the first seven vertebrae, referred to as C1-C7 (see the images below). It functions to provide mobility and stability to the head while connecting it …
Cervical Spine Anatomy, Diagram & Function | Body Maps
Jan 19, 2018 · The cervical spine consists of seven vertebrae, which are the smallest and uppermost in location within the spinal column. Together, the vertebrae support the skull, move …
