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| data science in pharmacy: The Era of Artificial Intelligence, Machine Learning, and Data Science in the Pharmaceutical Industry Stephanie K. Ashenden, 2021-04-23 The Era of Artificial Intelligence, Machine Learning and Data Science in the Pharmaceutical Industry examines the drug discovery process, assessing how new technologies have improved effectiveness. Artificial intelligence and machine learning are considered the future for a wide range of disciplines and industries, including the pharmaceutical industry. In an environment where producing a single approved drug costs millions and takes many years of rigorous testing prior to its approval, reducing costs and time is of high interest. This book follows the journey that a drug company takes when producing a therapeutic, from the very beginning to ultimately benefitting a patient's life. This comprehensive resource will be useful to those working in the pharmaceutical industry, but will also be of interest to anyone doing research in chemical biology, computational chemistry, medicinal chemistry and bioinformatics. - Demonstrates how the prediction of toxic effects is performed, how to reduce costs in testing compounds, and its use in animal research - Written by the industrial teams who are conducting the work, showcasing how the technology has improved and where it should be further improved - Targets materials for a better understanding of techniques from different disciplines, thus creating a complete guide |
| data science in pharmacy: Leveraging Data Science for Global Health Leo Anthony Celi, Maimuna S. Majumder, Patricia Ordóñez, Juan Sebastian Osorio, Kenneth E. Paik, Melek Somai, 2020-07-31 This open access book explores ways to leverage information technology and machine learning to combat disease and promote health, especially in resource-constrained settings. It focuses on digital disease surveillance through the application of machine learning to non-traditional data sources. Developing countries are uniquely prone to large-scale emerging infectious disease outbreaks due to disruption of ecosystems, civil unrest, and poor healthcare infrastructure – and without comprehensive surveillance, delays in outbreak identification, resource deployment, and case management can be catastrophic. In combination with context-informed analytics, students will learn how non-traditional digital disease data sources – including news media, social media, Google Trends, and Google Street View – can fill critical knowledge gaps and help inform on-the-ground decision-making when formal surveillance systems are insufficient. |
| data science in pharmacy: Lattice Deepayan Sarkar, 2008-02-15 Written by the author of the lattice system, this book describes lattice in considerable depth, beginning with the essentials and systematically delving into specific low levels details as necessary. No prior experience with lattice is required to read the book, although basic familiarity with R is assumed. The book contains close to 150 figures produced with lattice. Many of the examples emphasize principles of good graphical design; almost all use real data sets that are publicly available in various R packages. All code and figures in the book are also available online, along with supplementary material covering more advanced topics. |
| data science in pharmacy: Data Science for Healthcare Sergio Consoli, Diego Reforgiato Recupero, Milan Petković, 2019-02-23 This book seeks to promote the exploitation of data science in healthcare systems. The focus is on advancing the automated analytical methods used to extract new knowledge from data for healthcare applications. To do so, the book draws on several interrelated disciplines, including machine learning, big data analytics, statistics, pattern recognition, computer vision, and Semantic Web technologies, and focuses on their direct application to healthcare. Building on three tutorial-like chapters on data science in healthcare, the following eleven chapters highlight success stories on the application of data science in healthcare, where data science and artificial intelligence technologies have proven to be very promising. This book is primarily intended for data scientists involved in the healthcare or medical sector. By reading this book, they will gain essential insights into the modern data science technologies needed to advance innovation for both healthcare businesses and patients. A basic grasp of data science is recommended in order to fully benefit from this book. |
| data science in pharmacy: R for Health Data Science Ewen Harrison, Riinu Pius, 2020-12-31 In this age of information, the manipulation, analysis, and interpretation of data have become a fundamental part of professional life; nowhere more so than in the delivery of healthcare. From the understanding of disease and the development of new treatments, to the diagnosis and management of individual patients, the use of data and technology is now an integral part of the business of healthcare. Those working in healthcare interact daily with data, often without realising it. The conversion of this avalanche of information to useful knowledge is essential for high-quality patient care. R for Health Data Science includes everything a healthcare professional needs to go from R novice to R guru. By the end of this book, you will be taking a sophisticated approach to health data science with beautiful visualisations, elegant tables, and nuanced analyses. Features Provides an introduction to the fundamentals of R for healthcare professionals Highlights the most popular statistical approaches to health data science Written to be as accessible as possible with minimal mathematics Emphasises the importance of truly understanding the underlying data through the use of plots Includes numerous examples that can be adapted for your own data Helps you create publishable documents and collaborate across teams With this book, you are in safe hands – Prof. Harrison is a clinician and Dr. Pius is a data scientist, bringing 25 years’ combined experience of using R at the coal face. This content has been taught to hundreds of individuals from a variety of backgrounds, from rank beginners to experts moving to R from other platforms. |
| data science in pharmacy: Fundamentals of Clinical Data Science Pieter Kubben, Michel Dumontier, Andre Dekker, 2018-12-21 This open access book comprehensively covers the fundamentals of clinical data science, focusing on data collection, modelling and clinical applications. Topics covered in the first section on data collection include: data sources, data at scale (big data), data stewardship (FAIR data) and related privacy concerns. Aspects of predictive modelling using techniques such as classification, regression or clustering, and prediction model validation will be covered in the second section. The third section covers aspects of (mobile) clinical decision support systems, operational excellence and value-based healthcare. Fundamentals of Clinical Data Science is an essential resource for healthcare professionals and IT consultants intending to develop and refine their skills in personalized medicine, using solutions based on large datasets from electronic health records or telemonitoring programmes. The book’s promise is “no math, no code”and will explain the topics in a style that is optimized for a healthcare audience. |
| data science in pharmacy: Data Smart John W. Foreman, 2013-10-31 Data Science gets thrown around in the press like it'smagic. Major retailers are predicting everything from when theircustomers are pregnant to when they want a new pair of ChuckTaylors. It's a brave new world where seemingly meaningless datacan be transformed into valuable insight to drive smart businessdecisions. But how does one exactly do data science? Do you have to hireone of these priests of the dark arts, the data scientist, toextract this gold from your data? Nope. Data science is little more than using straight-forward steps toprocess raw data into actionable insight. And in DataSmart, author and data scientist John Foreman will show you howthat's done within the familiar environment of aspreadsheet. Why a spreadsheet? It's comfortable! You get to look at the dataevery step of the way, building confidence as you learn the tricksof the trade. Plus, spreadsheets are a vendor-neutral place tolearn data science without the hype. But don't let the Excel sheets fool you. This is a book forthose serious about learning the analytic techniques, the math andthe magic, behind big data. Each chapter will cover a different technique in aspreadsheet so you can follow along: Mathematical optimization, including non-linear programming andgenetic algorithms Clustering via k-means, spherical k-means, and graphmodularity Data mining in graphs, such as outlier detection Supervised AI through logistic regression, ensemble models, andbag-of-words models Forecasting, seasonal adjustments, and prediction intervalsthrough monte carlo simulation Moving from spreadsheets into the R programming language You get your hands dirty as you work alongside John through eachtechnique. But never fear, the topics are readily applicable andthe author laces humor throughout. You'll even learnwhat a dead squirrel has to do with optimization modeling, whichyou no doubt are dying to know. |
| data science in pharmacy: Bad Pharma Ben Goldacre, 2014-04 Originally published in 2012, revised edition published in 2013, by Fourth Estate, Great Britain; Published in the United States in 2012, revised edition also, by Faber and Faber, Inc. |
| data science in pharmacy: Healthcare Data Analytics Chandan K. Reddy, Charu C. Aggarwal, 2015-06-23 At the intersection of computer science and healthcare, data analytics has emerged as a promising tool for solving problems across many healthcare-related disciplines. Supplying a comprehensive overview of recent healthcare analytics research, Healthcare Data Analytics provides a clear understanding of the analytical techniques currently available |
| data science in pharmacy: Contemporary Research Methods in Pharmacy and Health Services Shane P. Desselle, Victoria Garcia Cardenas, Claire Anderson, Parisa Aslani, Aleda M. H. Chen, Timothy F. Chen, 2022-05-10 Emerging methods, as well as best practices in well-used methods, in pharmacy are of great benefit to researchers, graduate students, graduate programs, residents and fellows also in other health science areas. Researchers require a text to assist in the design of experiments to address seemingly age-old problems. New interventions are needed to improve medication adherence, patients' lived experiences in health care, provider-patient relationships, and even various facets of pharmacogenomics. Advances in systems re-engineering can optimize health care practitioners' roles. Contemporary Research Methods in Pharmacy and Health Services includes multi-authored chapters by renowned experts in their field. Chapters cover examples in pharmacy, health services and others transcendent of medical care, following a standardized format, including key research points; valid and invalid assumptions; pitfalls to avoid; applications; and further inquiry. This is a valuable resource for researchers both in academia and corporate R&D, primarily in pharmacy but also in health services, and other health disciplines. Social science researchers and government scientists can also benefit from the reading. - Provides multi-authored chapters by renowned experts in their field - Includes examples for pharmacy and health services and others that are transcendent of medical care - Covers key research points, valid and invalid assumptions, pitfalls to avoid, applications, and further inquiry |
| data science in pharmacy: Research Methods for Pharmaceutical Practice and Policy Rajender R. Aparasu, 2011 This text provides the theory and practice for conducting pharmaceutical policy research. It covers all aspects of scientific research from conceptualising to statistical analysis. It also provides scientific basis and a good understanding of the principles and practice of conducting pharmaceutical policy research. |
| data science in pharmacy: Demystifying Big Data and Machine Learning for Healthcare Prashant Natarajan, John C. Frenzel, Detlev H. Smaltz, 2017-02-15 Healthcare transformation requires us to continually look at new and better ways to manage insights – both within and outside the organization today. Increasingly, the ability to glean and operationalize new insights efficiently as a byproduct of an organization’s day-to-day operations is becoming vital to hospitals and health systems ability to survive and prosper. One of the long-standing challenges in healthcare informatics has been the ability to deal with the sheer variety and volume of disparate healthcare data and the increasing need to derive veracity and value out of it. Demystifying Big Data and Machine Learning for Healthcare investigates how healthcare organizations can leverage this tapestry of big data to discover new business value, use cases, and knowledge as well as how big data can be woven into pre-existing business intelligence and analytics efforts. This book focuses on teaching you how to: Develop skills needed to identify and demolish big-data myths Become an expert in separating hype from reality Understand the V’s that matter in healthcare and why Harmonize the 4 C’s across little and big data Choose data fi delity over data quality Learn how to apply the NRF Framework Master applied machine learning for healthcare Conduct a guided tour of learning algorithms Recognize and be prepared for the future of artificial intelligence in healthcare via best practices, feedback loops, and contextually intelligent agents (CIAs) The variety of data in healthcare spans multiple business workflows, formats (structured, un-, and semi-structured), integration at point of care/need, and integration with existing knowledge. In order to deal with these realities, the authors propose new approaches to creating a knowledge-driven learning organization-based on new and existing strategies, methods and technologies. This book will address the long-standing challenges in healthcare informatics and provide pragmatic recommendations on how to deal with them. |
| data science in pharmacy: Statistics for Health Data Science Ruth Etzioni, Micha Mandel, Roman Gulati, 2021-01-04 Students and researchers in the health sciences are faced with greater opportunity and challenge than ever before. The opportunity stems from the explosion in publicly available data that simultaneously informs and inspires new avenues of investigation. The challenge is that the analytic tools required go far beyond the standard methods and models of basic statistics. This textbook aims to equip health care researchers with the most important elements of a modern health analytics toolkit, drawing from the fields of statistics, health econometrics, and data science. This textbook is designed to overcome students’ anxiety about data and statistics and to help them to become confident users of appropriate analytic methods for health care research studies. Methods are presented organically, with new material building naturally on what has come before. Each technique is motivated by a topical research question, explained in non-technical terms, and accompanied by engaging explanations and examples. In this way, the authors cultivate a deep (“organic”) understanding of a range of analytic techniques, their assumptions and data requirements, and their advantages and limitations. They illustrate all lessons via analyses of real data from a variety of publicly available databases, addressing relevant research questions and comparing findings to those of published studies. Ultimately, this textbook is designed to cultivate health services researchers that are thoughtful and well informed about health data science, rather than data analysts. This textbook differs from the competition in its unique blend of methods and its determination to ensure that readers gain an understanding of how, when, and why to apply them. It provides the public health researcher with a way to think analytically about scientific questions, and it offers well-founded guidance for pairing data with methods for valid analysis. Readers should feel emboldened to tackle analysis of real public datasets using traditional statistical models, health econometrics methods, and even predictive algorithms. Accompanying code and data sets are provided in an author site: https://roman-gulati.github.io/statistics-for-health-data-science/ |
| data science in pharmacy: Healthcare Data Analytics and Management Nilanjan Dey, Amira S. Ashour, Simon James Fong, Chintan Bhatt, 2018-11-15 Healthcare Data Analytics and Management help readers disseminate cutting-edge research that delivers insights into the analytic tools, opportunities, novel strategies, techniques and challenges for handling big data, data analytics and management in healthcare. As the rapidly expanding and heterogeneous nature of healthcare data poses challenges for big data analytics, this book targets researchers and bioengineers from areas of machine learning, data mining, data management, and healthcare providers, along with clinical researchers and physicians who are interested in the management and analysis of healthcare data. - Covers data analysis, management and security concepts and tools in the healthcare domain - Highlights electronic medical health records and patient information records - Discusses the different techniques to integrate Big data and Internet-of-Things in healthcare, including machine learning and data mining - Includes multidisciplinary contributions in relation to healthcare applications and challenges |
| data science in pharmacy: Statistics and Machine Learning Methods for EHR Data Hulin Wu, Jose Miguel Yamal, Ashraf Yaseen, Vahed Maroufy, 2020-12-09 The use of Electronic Health Records (EHR)/Electronic Medical Records (EMR) data is becoming more prevalent for research. However, analysis of this type of data has many unique complications due to how they are collected, processed and types of questions that can be answered. This book covers many important topics related to using EHR/EMR data for research including data extraction, cleaning, processing, analysis, inference, and predictions based on many years of practical experience of the authors. The book carefully evaluates and compares the standard statistical models and approaches with those of machine learning and deep learning methods and reports the unbiased comparison results for these methods in predicting clinical outcomes based on the EHR data. Key Features: Written based on hands-on experience of contributors from multidisciplinary EHR research projects, which include methods and approaches from statistics, computing, informatics, data science and clinical/epidemiological domains. Documents the detailed experience on EHR data extraction, cleaning and preparation Provides a broad view of statistical approaches and machine learning prediction models to deal with the challenges and limitations of EHR data. Considers the complete cycle of EHR data analysis. The use of EHR/EMR analysis requires close collaborations between statisticians, informaticians, data scientists and clinical/epidemiological investigators. This book reflects that multidisciplinary perspective. |
| data science in pharmacy: Pharmacometrics Ene I. Ette, Paul J. Williams, 2013-03-14 Pharmacometrics is the science of interpreting and describing pharmacology in a quantitative fashion. The pharmaceutical industry is integrating pharmacometrics into its drug development program, but there is a lack of and need for experienced pharmacometricians since fewer and fewer academic programs exist to train them. Pharmacometrics: The Science of Quantitative Pharmacology lays out the science of pharmacometrics and its application to drug development, evaluation, and patient pharmacotherapy, providing a comprehensive set of tools for the training and development of pharmacometricians. Edited and written by key leaders in the field, this flagship text on pharmacometrics: Integrates theory and practice to let the reader apply principles and concepts. Provides a comprehensive set of tools for training and developing expertise in the pharmacometric field. Is unique in including computer code information with the examples. This volume is an invaluable resource for all pharmacometricians, statisticians, teachers, graduate and undergraduate students in academia, industry, and regulatory agencies. |
| data science in pharmacy: Remington Adeboye Adejare, 2020-11-03 The PCP's Bicentennial Edition Remington: The Science and Practice of Pharmacy, Twenty Third Edition, offers a trusted, completely updated source of information for education, training, and development of pharmacists. Published for the first time with Elsevier, this edition includes coverage of biologics and biosimilars as uses of those therapeutics have increased substantially since the previous edition. Also discussed are formulations, drug delivery (including prodrugs, salts, polymorphism. With clear, detailed color illustrations, fundamental information on a range of pharmaceutical science areas, and information on new developments in industry, pharmaceutical industry scientists, especially those involved in drug discovery and development will find this edition of Remington an essential reference. Intellectual property professionals will also find this reference helpful to cite in patents and resulting litigations. Additional graduate and postgraduate students in Pharmacy and Pharmaceutical Sciences will refer to this book in courses dealing with medicinal chemistry and pharmaceutics. - Contains a comprehensive source of principles of drug discovery and development topics, especially for scientists that are new in the pharmaceutical industry such as those with trainings/degrees in chemistry and engineering - Provides a detailed source for formulation scientists and compounding pharmacists, from produg to excipient issues - Updates this excellent source with the latest information to verify facts and refresh on basics for professionals in the broadly defined pharmaceutical industry |
| data science in pharmacy: Data Science Ivo D. Dinov, Milen Velchev Velev, 2021-12-06 The amount of new information is constantly increasing, faster than our ability to fully interpret and utilize it to improve human experiences. Addressing this asymmetry requires novel and revolutionary scientific methods and effective human and artificial intelligence interfaces. By lifting the concept of time from a positive real number to a 2D complex time (kime), this book uncovers a connection between artificial intelligence (AI), data science, and quantum mechanics. It proposes a new mathematical foundation for data science based on raising the 4D spacetime to a higher dimension where longitudinal data (e.g., time-series) are represented as manifolds (e.g., kime-surfaces). This new framework enables the development of innovative data science analytical methods for model-based and model-free scientific inference, derived computed phenotyping, and statistical forecasting. The book provides a transdisciplinary bridge and a pragmatic mechanism to translate quantum mechanical principles, such as particles and wavefunctions, into data science concepts, such as datum and inference-functions. It includes many open mathematical problems that still need to be solved, technological challenges that need to be tackled, and computational statistics algorithms that have to be fully developed and validated. Spacekime analytics provide mechanisms to effectively handle, process, and interpret large, heterogeneous, and continuously-tracked digital information from multiple sources. The authors propose computational methods, probability model-based techniques, and analytical strategies to estimate, approximate, or simulate the complex time phases (kime directions). This allows transforming time-varying data, such as time-series observations, into higher-dimensional manifolds representing complex-valued and kime-indexed surfaces (kime-surfaces). The book includes many illustrations of model-based and model-free spacekime analytic techniques applied to economic forecasting, identification of functional brain activation, and high-dimensional cohort phenotyping. Specific case-study examples include unsupervised clustering using the Michigan Consumer Sentiment Index (MCSI), model-based inference using functional magnetic resonance imaging (fMRI) data, and model-free inference using the UK Biobank data archive. The material includes mathematical, inferential, computational, and philosophical topics such as Heisenberg uncertainty principle and alternative approaches to large sample theory, where a few spacetime observations can be amplified by a series of derived, estimated, or simulated kime-phases. The authors extend Newton-Leibniz calculus of integration and differentiation to the spacekime manifold and discuss possible solutions to some of the problems of time. The coverage also includes 5D spacekime formulations of classical 4D spacetime mathematical equations describing natural laws of physics, as well as, statistical articulation of spacekime analytics in a Bayesian inference framework. The steady increase of the volume and complexity of observed and recorded digital information drives the urgent need to develop novel data analytical strategies. Spacekime analytics represents one new data-analytic approach, which provides a mechanism to understand compound phenomena that are observed as multiplex longitudinal processes and computationally tracked by proxy measures. This book may be of interest to academic scholars, graduate students, postdoctoral fellows, artificial intelligence and machine learning engineers, biostatisticians, econometricians, and data analysts. Some of the material may also resonate with philosophers, futurists, astrophysicists, space industry technicians, biomedical researchers, health practitioners, and the general public. |
| data science in pharmacy: Research and Development in the Pharmaceutical Industry (A CBO Study) Congressional Budget Office, 2013-06-09 Perceptions that the pace of new-drug development has slowed and that the pharmaceutical industry is highly profitable have sparked concerns that significant problems loom for future drug development. This Congressional Budget Office (CBO) study-prepared at the request of the Senate Majority Leader-reviews basic facts about the drug industry's recent spending on research and development (R&D) and its output of new drugs. The study also examines issues relating to the costs of R&D, the federal government's role in pharmaceutical research, the performance of the pharmaceutical industry in developing innovative drugs, and the role of expected profits in private firms' decisions about investing in drug R&D. In keeping with CBO's mandate to provide objective, impartial analysis, the study makes no recommendations. David H. Austin prepared this report under the supervision of Joseph Kile and David Moore. Colin Baker provided valuable consultation... |
| data science in pharmacy: Data Scientists at Work Sebastian Gutierrez, 2014-12-12 Data Scientists at Work is a collection of interviews with sixteen of the world's most influential and innovative data scientists from across the spectrum of this hot new profession. Data scientist is the sexiest job in the 21st century, according to the Harvard Business Review. By 2018, the United States will experience a shortage of 190,000 skilled data scientists, according to a McKinsey report. Through incisive in-depth interviews, this book mines the what, how, and why of the practice of data science from the stories, ideas, shop talk, and forecasts of its preeminent practitioners across diverse industries: social network (Yann LeCun, Facebook); professional network (Daniel Tunkelang, LinkedIn); venture capital (Roger Ehrenberg, IA Ventures); enterprise cloud computing and neuroscience (Eric Jonas, formerly Salesforce.com); newspaper and media (Chris Wiggins, The New York Times); streaming television (Caitlin Smallwood, Netflix); music forecast (Victor Hu, Next Big Sound); strategic intelligence (Amy Heineike, Quid); environmental big data (André Karpištšenko, Planet OS); geospatial marketing intelligence (Jonathan Lenaghan, PlaceIQ); advertising (Claudia Perlich, Dstillery); fashion e-commerce (Anna Smith, Rent the Runway); specialty retail (Erin Shellman, Nordstrom); email marketing (John Foreman, MailChimp); predictive sales intelligence (Kira Radinsky, SalesPredict); and humanitarian nonprofit (Jake Porway, DataKind). The book features a stimulating foreword by Google's Director of Research, Peter Norvig. Each of these data scientists shares how he or she tailors the torrent-taming techniques of big data, data visualization, search, and statistics to specific jobs by dint of ingenuity, imagination, patience, and passion. Data Scientists at Work parts the curtain on the interviewees’ earliest data projects, how they became data scientists, their discoveries and surprises in working with data, their thoughts on the past, present, and future of the profession, their experiences of team collaboration within their organizations, and the insights they have gained as they get their hands dirty refining mountains of raw data into objects of commercial, scientific, and educational value for their organizations and clients. |
| data science in pharmacy: Pharmaceutical Analysis E-Book David G. Watson, 2015-12-24 Pharmaceutical analysis determines the purity, concentration, active compounds, shelf life, rate of absorption in the body, identity, stability, rate of release etc. of a drug. Testing a pharmaceutical product involves a variety of chemical, physical and microbiological analyses. It is reckoned that over £10 billion is spent annually in the UK alone on pharmaceutical analysis, and the analytical processes described in this book are used in industries as diverse as food, beverages, cosmetics, detergents, metals, paints, water, agrochemicals, biotechnological products and pharmaceuticals. This is the key textbook in pharmaceutical analysis, now revised and updated for its fourth edition. Worked calculation examples Self-assessment Additional problems (self tests) Practical boxes Key points boxes New chapter on electrochemical biosensors. New chapter on the quality control of biotechnologically produced drugs. Extended chapter on molecular emission spectroscopy. Now comes with an e-book on StudentConsult. Self-assessment is interactive in the accompanying online e-book. 65 online animations show concepts such as ionization partitioning of drug molecules etc. ~ |
| data science in pharmacy: The Essentials of Data Science: Knowledge Discovery Using R Graham J. Williams, 2017-07-28 The Essentials of Data Science: Knowledge Discovery Using R presents the concepts of data science through a hands-on approach using free and open source software. It systematically drives an accessible journey through data analysis and machine learning to discover and share knowledge from data. Building on over thirty years’ experience in teaching and practising data science, the author encourages a programming-by-example approach to ensure students and practitioners attune to the practise of data science while building their data skills. Proven frameworks are provided as reusable templates. Real world case studies then provide insight for the data scientist to swiftly adapt the templates to new tasks and datasets. The book begins by introducing data science. It then reviews R’s capabilities for analysing data by writing computer programs. These programs are developed and explained step by step. From analysing and visualising data, the framework moves on to tried and tested machine learning techniques for predictive modelling and knowledge discovery. Literate programming and a consistent style are a focus throughout the book. |
| data science in pharmacy: GAMP 5 Sion Wyn, 2008 GAMP 5 provides pragmatic and practical industry guidance to achieve compliant computerized systems fit for intended use in an efficient and effective manner. This technical document describes a flexible risk-based approach to compliant GxP regulated computerized systems, based on scalable specification and verification. It points to the future of computer systems compliance by centering on principles behind major industry developments such as PQLI; ICH Q8, Q9, Q10; and ASTM E2500. This revolutionary Guide addresses the entire lifecycle of an automated system and its applicability to a wide range of information systems, lab equipment, integrated manufacturing systems, and IT infrastructures. It contains new information on outsourcing, electronic batch recording, end user applications (such as spreadsheets and small database applications), and patch management. |
| data science in pharmacy: Pharmacokinetic and Pharmacodynamic Data Analysis: Concepts and Applications, Third Edition Johan Gabrielsson, Daniel Weiner, 2001-11-30 This is a revised and very expanded version of the previous second edition of the book. Pharmacokinetic and Pharmacodynamic Data Analysis provides an introduction into pharmacokinetic and pharmacodynamic concepts using simple illustrations and reasoning. It describes ways in which pharmacodynamic and pharmacodynamic theory may be used to give insight into modeling questions and how these questions can in turn lead to new knowledge. This book differentiates itself from other texts in this area in that it bridges the gap between relevant theory and the actual application of the theory to real life situations. The book is divided into two parts; the first introduces fundamental principles of PK and PD concepts, and principles of mathematical modeling, while the second provides case studies obtained from drug industry and academia. Topics included in the first part include a discussion of the statistical principles of model fitting, including how to assess the adequacy of the fit of a model, as well as strategies for selection of time points to be included in the design of a study. The first part also introduces basic pharmacokinetic and pharmacodynamic concepts, including an excellent discussion of effect compartment (link) models as well as indirect response models. The second part of the text includes over 70 modeling case studies. These include a discussion of the selection of the model, derivation of initial parameter estimates and interpretation of the corresponding output. Finally, the authors discuss a number of pharmacodynamic modeling situations including receptor binding models, synergy, and tolerance models (feedback and precursor models). This book will be of interest to researchers, to graduate students and advanced undergraduate students in the PK/PD area who wish to learn how to analyze biological data and build models and to become familiar with new areas of application. In addition, the text will be of interest to toxicologists interested in learning about determinants of exposure and performing toxicokinetic modeling. The inclusion of the numerous exercises and models makes it an excellent primary or adjutant text for traditional PK courses taught in pharmacy and medical schools. A diskette is included with the text that includes all of the exercises and solutions using WinNonlin. |
| data science in pharmacy: Beginning Data Science in R Thomas Mailund, 2017-03-09 Discover best practices for data analysis and software development in R and start on the path to becoming a fully-fledged data scientist. This book teaches you techniques for both data manipulation and visualization and shows you the best way for developing new software packages for R. Beginning Data Science in R details how data science is a combination of statistics, computational science, and machine learning. You’ll see how to efficiently structure and mine data to extract useful patterns and build mathematical models. This requires computational methods and programming, and R is an ideal programming language for this. This book is based on a number of lecture notes for classes the author has taught on data science and statistical programming using the R programming language. Modern data analysis requires computational skills and usually a minimum of programming. What You Will Learn Perform data science and analytics using statistics and the R programming language Visualize and explore data, including working with large data sets found in big data Build an R package Test and check your code Practice version control Profile and optimize your code Who This Book Is For Those with some data science or analytics background, but not necessarily experience with the R programming language. |
| data science in pharmacy: Applications of Machine Learning Prashant Johri, Jitendra Kumar Verma, Sudip Paul, 2020-05-04 This book covers applications of machine learning in artificial intelligence. The specific topics covered include human language, heterogeneous and streaming data, unmanned systems, neural information processing, marketing and the social sciences, bioinformatics and robotics, etc. It also provides a broad range of techniques that can be successfully applied and adopted in different areas. Accordingly, the book offers an interesting and insightful read for scholars in the areas of computer vision, speech recognition, healthcare, business, marketing, and bioinformatics. |
| data science in pharmacy: Data Science For Dummies Lillian Pierson, 2021-08-20 Monetize your company’s data and data science expertise without spending a fortune on hiring independent strategy consultants to help What if there was one simple, clear process for ensuring that all your company’s data science projects achieve a high a return on investment? What if you could validate your ideas for future data science projects, and select the one idea that’s most prime for achieving profitability while also moving your company closer to its business vision? There is. Industry-acclaimed data science consultant, Lillian Pierson, shares her proprietary STAR Framework – A simple, proven process for leading profit-forming data science projects. Not sure what data science is yet? Don’t worry! Parts 1 and 2 of Data Science For Dummies will get all the bases covered for you. And if you’re already a data science expert? Then you really won’t want to miss the data science strategy and data monetization gems that are shared in Part 3 onward throughout this book. Data Science For Dummies demonstrates: The only process you’ll ever need to lead profitable data science projects Secret, reverse-engineered data monetization tactics that no one’s talking about The shocking truth about how simple natural language processing can be How to beat the crowd of data professionals by cultivating your own unique blend of data science expertise Whether you’re new to the data science field or already a decade in, you’re sure to learn something new and incredibly valuable from Data Science For Dummies. Discover how to generate massive business wins from your company’s data by picking up your copy today. |
| data science in pharmacy: Artificial Intelligence in Drug Discovery Nathan Brown, 2020-11-04 Following significant advances in deep learning and related areas interest in artificial intelligence (AI) has rapidly grown. In particular, the application of AI in drug discovery provides an opportunity to tackle challenges that previously have been difficult to solve, such as predicting properties, designing molecules and optimising synthetic routes. Artificial Intelligence in Drug Discovery aims to introduce the reader to AI and machine learning tools and techniques, and to outline specific challenges including designing new molecular structures, synthesis planning and simulation. Providing a wealth of information from leading experts in the field this book is ideal for students, postgraduates and established researchers in both industry and academia. |
| data science in pharmacy: Introducing Data Science Davy Cielen, Arno Meysman, 2016-05-02 Summary Introducing Data Science teaches you how to accomplish the fundamental tasks that occupy data scientists. Using the Python language and common Python libraries, you'll experience firsthand the challenges of dealing with data at scale and gain a solid foundation in data science. Purchase of the print book includes a free eBook in PDF, Kindle, and ePub formats from Manning Publications. About the Technology Many companies need developers with data science skills to work on projects ranging from social media marketing to machine learning. Discovering what you need to learn to begin a career as a data scientist can seem bewildering. This book is designed to help you get started. About the Book Introducing Data ScienceIntroducing Data Science explains vital data science concepts and teaches you how to accomplish the fundamental tasks that occupy data scientists. You’ll explore data visualization, graph databases, the use of NoSQL, and the data science process. You’ll use the Python language and common Python libraries as you experience firsthand the challenges of dealing with data at scale. Discover how Python allows you to gain insights from data sets so big that they need to be stored on multiple machines, or from data moving so quickly that no single machine can handle it. This book gives you hands-on experience with the most popular Python data science libraries, Scikit-learn and StatsModels. After reading this book, you’ll have the solid foundation you need to start a career in data science. What’s Inside Handling large data Introduction to machine learning Using Python to work with data Writing data science algorithms About the Reader This book assumes you're comfortable reading code in Python or a similar language, such as C, Ruby, or JavaScript. No prior experience with data science is required. About the Authors Davy Cielen, Arno D. B. Meysman, and Mohamed Ali are the founders and managing partners of Optimately and Maiton, where they focus on developing data science projects and solutions in various sectors. Table of Contents Data science in a big data world The data science process Machine learning Handling large data on a single computer First steps in big data Join the NoSQL movement The rise of graph databases Text mining and text analytics Data visualization to the end user |
| data science in pharmacy: Algorithms for Data Science Brian Steele, John Chandler, Swarna Reddy, 2016-12-25 This textbook on practical data analytics unites fundamental principles, algorithms, and data. Algorithms are the keystone of data analytics and the focal point of this textbook. Clear and intuitive explanations of the mathematical and statistical foundations make the algorithms transparent. But practical data analytics requires more than just the foundations. Problems and data are enormously variable and only the most elementary of algorithms can be used without modification. Programming fluency and experience with real and challenging data is indispensable and so the reader is immersed in Python and R and real data analysis. By the end of the book, the reader will have gained the ability to adapt algorithms to new problems and carry out innovative analyses. This book has three parts:(a) Data Reduction: Begins with the concepts of data reduction, data maps, and information extraction. The second chapter introduces associative statistics, the mathematical foundation of scalable algorithms and distributed computing. Practical aspects of distributed computing is the subject of the Hadoop and MapReduce chapter.(b) Extracting Information from Data: Linear regression and data visualization are the principal topics of Part II. The authors dedicate a chapter to the critical domain of Healthcare Analytics for an extended example of practical data analytics. The algorithms and analytics will be of much interest to practitioners interested in utilizing the large and unwieldly data sets of the Centers for Disease Control and Prevention's Behavioral Risk Factor Surveillance System.(c) Predictive Analytics Two foundational and widely used algorithms, k-nearest neighbors and naive Bayes, are developed in detail. A chapter is dedicated to forecasting. The last chapter focuses on streaming data and uses publicly accessible data streams originating from the Twitter API and the NASDAQ stock market in the tutorials. This book is intended for a one- or two-semester course in data analytics for upper-division undergraduate and graduate students in mathematics, statistics, and computer science. The prerequisites are kept low, and students with one or two courses in probability or statistics, an exposure to vectors and matrices, and a programming course will have no difficulty. The core material of every chapter is accessible to all with these prerequisites. The chapters often expand at the close with innovations of interest to practitioners of data science. Each chapter includes exercises of varying levels of difficulty. The text is eminently suitable for self-study and an exceptional resource for practitioners. |
| data science in pharmacy: Converging Pharmacy Science and Engineering in Computational Drug Discovery Tripathi, Rati Kailash Prasad, Tiwari, Shrikant, 2024-04-22 The world of pharmaceutical research is moving at lightning speed, and the age-old approach to drug discovery faces many challenges. It's a fascinating time to be on the cutting edge of medical innovation, but it's certainly not without its obstacles. The process of developing new drugs is often time-consuming, expensive, and fraught with uncertainty. Researchers are constantly seeking ways to streamline this process, reduce costs, and increase the success rate of bringing new drugs to market. One promising solution lies in the convergence of pharmacy science and engineering, particularly in computational drug discovery. Converging Pharmacy Science and Engineering in Computational Drug Discovery presents a comprehensive solution to these challenges by exploring the transformative synergy between pharmacy science and engineering. This book demonstrates how researchers can expedite the identification and development of novel therapeutic compounds by harnessing the power of computational approaches, such as sophisticated algorithms and modeling techniques. Through interdisciplinary collaboration, pharmacy scientists and engineers can revolutionize drug discovery, paving the way for more efficient and effective treatments. This book is an invaluable resource for pharmaceutical scientists, researchers, and engineers seeking to enhance their understanding of computational drug discovery. This book inspires future innovations by showcasing cutting-edge methodologies and innovative research at the intersection of pharmacy science and engineering. It contributes to the ongoing evolution of pharmaceutical research. It offers practical insights and solutions that will shape the future of drug discovery, making it essential reading for anyone involved in the pharmaceutical industry. |
| data science in pharmacy: Programming Skills For Data Science Freeman, Programming Skills for Data Science brings together all the foundation skills needed to transform raw data into actionable insights for domains ranging from urban planning to precision medicine, even if you have no programming or data science experience. Guided by expert instructors Michael Freeman and Joel Ross, this book will help learners install the tools required to solve professional-level data science problems, including widely used R language, RStudio integrated development environment, and Git version-control system. It explains how to wrangle data into a form where it can be easily used, analyzed, and visualized so others can see the patterns uncovered. Step by step, students will master powerful R programming techniques and troubleshooting skills for probing data in new ways, and at larger scales. |
| data science in pharmacy: Data Science for Genomics Amit Kumar Tyagi, Ajith Abraham, 2022-11-27 Data Science for Genomics presents the foundational concepts of data science as they pertain to genomics, encompassing the process of inspecting, cleaning, transforming, and modeling data with the goal of discovering useful information, suggesting conclusions and supporting decision-making. Sections cover Data Science, Machine Learning, Deep Learning, data analysis, and visualization techniques. The authors then present the fundamentals of Genomics, Genetics, Transcriptomes and Proteomes as basic concepts of molecular biology, along with DNA and key features of the human genome, as well as the genomes of eukaryotes and prokaryotes. Techniques that are more specifically used for studying genomes are then described in the order in which they are used in a genome project, including methods for constructing genetic and physical maps. DNA sequencing methodology and the strategies used to assemble a contiguous genome sequence and methods for identifying genes in a genome sequence and determining the functions of those genes in the cell. Readers will learn how the information contained in the genome is released and made available to the cell, as well as methods centered on cloning and PCR. - Provides a detailed explanation of data science concepts, methods and algorithms, all reinforced by practical examples that are applied to genomics - Presents a roadmap of future trends suitable for innovative Data Science research and practice - Includes topics such as Blockchain technology for securing data at end user/server side - Presents real world case studies, open issues and challenges faced in Genomics, including future research directions and a separate chapter for Ethical Concerns |
| data science in pharmacy: Data Science in Chemistry Thorsten Gressling, 2020-11-23 The ever-growing wealth of information has led to the emergence of a fourth paradigm of science. This new field of activity – data science – includes computer science, mathematics and a given specialist domain. This book focuses on chemistry, explaining how to use data science for deep insights and take chemical research and engineering to the next level. It covers modern aspects like Big Data, Artificial Intelligence and Quantum computing. |
| data science in pharmacy: Sharing Clinical Trial Data Institute of Medicine, Board on Health Sciences Policy, Committee on Strategies for Responsible Sharing of Clinical Trial Data, 2015-04-20 Data sharing can accelerate new discoveries by avoiding duplicative trials, stimulating new ideas for research, and enabling the maximal scientific knowledge and benefits to be gained from the efforts of clinical trial participants and investigators. At the same time, sharing clinical trial data presents risks, burdens, and challenges. These include the need to protect the privacy and honor the consent of clinical trial participants; safeguard the legitimate economic interests of sponsors; and guard against invalid secondary analyses, which could undermine trust in clinical trials or otherwise harm public health. Sharing Clinical Trial Data presents activities and strategies for the responsible sharing of clinical trial data. With the goal of increasing scientific knowledge to lead to better therapies for patients, this book identifies guiding principles and makes recommendations to maximize the benefits and minimize risks. This report offers guidance on the types of clinical trial data available at different points in the process, the points in the process at which each type of data should be shared, methods for sharing data, what groups should have access to data, and future knowledge and infrastructure needs. Responsible sharing of clinical trial data will allow other investigators to replicate published findings and carry out additional analyses, strengthen the evidence base for regulatory and clinical decisions, and increase the scientific knowledge gained from investments by the funders of clinical trials. The recommendations of Sharing Clinical Trial Data will be useful both now and well into the future as improved sharing of data leads to a stronger evidence base for treatment. This book will be of interest to stakeholders across the spectrum of research-from funders, to researchers, to journals, to physicians, and ultimately, to patients. |
| data science in pharmacy: Data Science at the Command Line Jeroen Janssens, 2014-09-25 This hands-on guide demonstrates how the flexibility of the command line can help you become a more efficient and productive data scientist. You’ll learn how to combine small, yet powerful, command-line tools to quickly obtain, scrub, explore, and model your data. To get you started—whether you’re on Windows, OS X, or Linux—author Jeroen Janssens introduces the Data Science Toolbox, an easy-to-install virtual environment packed with over 80 command-line tools. Discover why the command line is an agile, scalable, and extensible technology. Even if you’re already comfortable processing data with, say, Python or R, you’ll greatly improve your data science workflow by also leveraging the power of the command line. Obtain data from websites, APIs, databases, and spreadsheets Perform scrub operations on plain text, CSV, HTML/XML, and JSON Explore data, compute descriptive statistics, and create visualizations Manage your data science workflow using Drake Create reusable tools from one-liners and existing Python or R code Parallelize and distribute data-intensive pipelines using GNU Parallel Model data with dimensionality reduction, clustering, regression, and classification algorithms |
| data science in pharmacy: Basic Principles of Drug Discovery and Development Benjamin E. Blass, 2021-03-30 Basic Principles of Drug Discovery and Development presents the multifaceted process of identifying a new drug in the modern era, which requires a multidisciplinary team approach with input from medicinal chemists, biologists, pharmacologists, drug metabolism experts, toxicologists, clinicians, and a host of experts from numerous additional fields. Enabling technologies such as high throughput screening, structure-based drug design, molecular modeling, pharmaceutical profiling, and translational medicine are critical to the successful development of marketable therapeutics. Given the wide range of disciplines and techniques that are required for cutting edge drug discovery and development, a scientist must master their own fields as well as have a fundamental understanding of their collaborator's fields. This book bridges the knowledge gaps that invariably lead to communication issues in a new scientist's early career, providing a fundamental understanding of the various techniques and disciplines required for the multifaceted endeavor of drug research and development. It provides students, new industrial scientists, and academics with a basic understanding of the drug discovery and development process. The fully updated text provides an excellent overview of the process and includes chapters on important drug targets by class, in vitro screening methods, medicinal chemistry strategies in drug design, principles of in vivo pharmacokinetics and pharmacodynamics, animal models of disease states, clinical trial basics, and selected business aspects of the drug discovery process. - Provides a clear explanation of how the pharmaceutical industry works, as well as the complete drug discovery and development process, from obtaining a lead, to testing the bioactivity, to producing the drug, and protecting the intellectual property - Includes a new chapter on the discovery and development of biologics (antibodies proteins, antibody/receptor complexes, antibody drug conjugates), a growing and important area of the pharmaceutical industry landscape - Features a new section on formulations, including a discussion of IV formulations suitable for human clinical trials, as well as the application of nanotechnology and the use of transdermal patch technology for drug delivery - Updated chapter with new case studies includes additional modern examples of drug discovery through high through-put screening, fragment-based drug design, and computational chemistry |
| data science in pharmacy: Machine Learning: A Gateway to Data Science Mrs.S.N.Santhalakshmi, Dr.Goutam Panigrahi, Dr. Saibal Majumder, Dr. Chandan Bandyopadhyay, 2024-05-16 Mrs.S.N.Santhalakshmi, Assistant Professor & Head of The Department, Department of Computer Applications, Nandha Arts & Science College, Erode, Tamil Nadu, India. Dr.Goutam Panigrahi, Assistant Professor, Department of Mathematics, National Institute of Technology, Durgapur, West Bengal, India. Dr. Saibal Majumder, Assistant Professor, Department of Computer Science and Engineering(Data Science), Dr. B.C. Roy Engineering College, Durgapur, West Bengal, India. Dr. Chandan Bandyopadhyay, Associate Professor & Head of the Department, Department of Computer Science and Engineering(Data Science), Dr. B.C. Roy Engineering College, Durgapur, West Bengal, India. |
| data science in pharmacy: Pharmaceutical Medicine Adrian Kilcoyne, Phil Ambery, Daniel O'Connor, 2013-05-23 The breadth of the pharmaceutical medicine can be daunting, but this book is designed to navigate a path through the speciality. Providing a broad overview of all topics relevant to the discipline of pharmaceutical medicine, it gives you the facts fast, in a user-friendly format, without having to dive through page upon page of dense text. With 136 chapters spread across 8 sections, the text offers a thorough grounding in issues ranging from medicines regulation to clinical trial design and data management. This makes it a useful revision aid for exams as well as giving you a taster of areas of pharmaceutical medicine adjacent to your current role. For healthcare professionals already working in the field, this book offers a guiding hand in difficult situations as well as supplying rapid access to the latest recommendations and guidelines. Written by authors with experience in the industry and drug regulation, this comprehensive and authoritative guide provides a shoulder to lean on throughout your pharmaceutical career. |
| data science in pharmacy: The Pharmacy Informatics Primer Doina Dumitru, 2008-09-30 The information technology revolution has fueled the demand in hospitals and health systems for accomplished experts who can help select, implement and maintain CPOE, BCMA, EHR and other systems. As the use of IT in healthcare expands and the complexity of medication therapy increases, there has been a correspondingly rapid growth in the practice of pharmacy informatics and a basic need for an understanding of key elements. The Pharmacy Informatics Primer provides a foundational understanding and offers “pearls of wisdom” for pharmacy professionals involved in informatics. This introductory resource outlines key concepts in understanding, developing, implementing, and maintaining clinical information and automation systems. This essential guide is designed for all pharmacists and covers an introduction to major concepts of informatics such as ePrescribing, CPOE, bar-coding, smart pumps, and the pharmacist’s role in EHR. Chapter features include key terms and definitions, and a comprehensive table of pearls, specific to each subject to present a clear understanding of all concepts. |
Data and Digital Outputs Management Plan (DDOMP)
Data and Digital Outputs Management Plan (DDOMP)
Building New Tools for Data Sharing and Reuse through a …
Jan 10, 2019 · The SEI CRA will closely link research thinking and technological innovation toward accelerating the full path of discovery-driven data use and open science. This will enable a …
Open Data Policy and Principles - Belmont Forum
The data policy includes the following principles: Data should be: Discoverable through catalogues and search engines; Accessible as open data by default, and made available with minimum time …
Belmont Forum Adopts Open Data Principles for Environmental …
Jan 27, 2016 · Adoption of the open data policy and principles is one of five recommendations in A Place to Stand: e-Infrastructures and Data Management for Global Change Research, released in …
Belmont Forum Data Accessibility Statement and Policy
The DAS encourages researchers to plan for the longevity, reusability, and stability of the data attached to their research publications and results. Access to data promotes reproducibility, …
Climate-Induced Migration in Africa and Beyond: Big Data and …
CLIMB will also leverage earth observation and social media data, and combine them with survey and official statistical data. This holistic approach will allow us to analyze migration process from …
Advancing Resilience in Low Income Housing Using Climate …
Jun 4, 2020 · Environmental sustainability and public health considerations will be included. Machine Learning and Big Data Analytics will be used to identify optimal disaster resilient …
Belmont Forum
What is the Belmont Forum? The Belmont Forum is an international partnership that mobilizes funding of environmental change research and accelerates its delivery to remove critical barriers …
Waterproofing Data: Engaging Stakeholders in Sustainable Flood …
Apr 26, 2018 · Waterproofing Data investigates the governance of water-related risks, with a focus on social and cultural aspects of data practices. Typically, data flows up from local levels to …
Data Management Annex (Version 1.4) - Belmont Forum
A full Data Management Plan (DMP) for an awarded Belmont Forum CRA project is a living, actively updated document that describes the data management life cycle for the data to be collected, …
Data and Digital Outputs Management Plan (DDOMP)
Data and Digital Outputs Management Plan (DDOMP)
Building New Tools for Data Sharing and Reuse through a …
Jan 10, 2019 · The SEI CRA will closely link research thinking and technological innovation toward accelerating the full path of discovery-driven data use and open science. This will …
Open Data Policy and Principles - Belmont Forum
The data policy includes the following principles: Data should be: Discoverable through catalogues and search engines; Accessible as open data by default, and made available with …
Belmont Forum Adopts Open Data Principles for Environmental …
Jan 27, 2016 · Adoption of the open data policy and principles is one of five recommendations in A Place to Stand: e-Infrastructures and Data Management for Global Change Research, …
Belmont Forum Data Accessibility Statement and Policy
The DAS encourages researchers to plan for the longevity, reusability, and stability of the data attached to their research publications and results. Access to data promotes reproducibility, …
Climate-Induced Migration in Africa and Beyond: Big Data and …
CLIMB will also leverage earth observation and social media data, and combine them with survey and official statistical data. This holistic approach will allow us to analyze migration process …
Advancing Resilience in Low Income Housing Using Climate …
Jun 4, 2020 · Environmental sustainability and public health considerations will be included. Machine Learning and Big Data Analytics will be used to identify optimal disaster resilient …
Belmont Forum
What is the Belmont Forum? The Belmont Forum is an international partnership that mobilizes funding of environmental change research and accelerates its delivery to remove critical …
Waterproofing Data: Engaging Stakeholders in Sustainable Flood …
Apr 26, 2018 · Waterproofing Data investigates the governance of water-related risks, with a focus on social and cultural aspects of data practices. Typically, data flows up from local levels …
Data Management Annex (Version 1.4) - Belmont Forum
A full Data Management Plan (DMP) for an awarded Belmont Forum CRA project is a living, actively updated document that describes the data management life cycle for the data to be …
